this device confers some degree of flaccidity but is not always easy to inflate and deflate
Báo cáo Y học: The cytoplasmic C-terminus of the sulfonylurea receptor is important for KATP channel function but is not key for complex assembly or trafficking pdf
Ngày tải lên :
31/03/2014, 08:20
... electrophysiological effect of tolbutamide using the whole cell configuration of the patch clamp (Fig 4B.C) Concentrations of tolbutamide (100 lM) known to act selectively by binding to SUR1 and not to have significant ... containing NBD2 is mutated in persistent hyperinsulinaemic hypoglycaemia of infancy The disease is autosomal recessive and is characterized by profound neonatal hypoglycaemia and Fig Analysis of channel ... profound disturbances in the function of the mutant channel complex The ATP sensitivity is not significantly disturbed and this is supported by more detailed studies in Xenopus laevis oocytes...
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Báo cáo y học: "Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 " ppt
Ngày tải lên :
13/08/2014, 05:21
... did not reveal any gross histopathology (data not shown), and offspring from this hCycT1-tg line have generally been healthy The expression pattern of hCycT1 was examined in select tissues and ... pathogenesis and the testing of antiviral strategies have been hampered by the lack of an immunocompetent small animal that is fully permissive for infection The host range and cell tropism of HIV-1 is ... transcriptional deficit also in this rodent had only partially been overcome by hCycT1 transgenesis Of note, this analysis required a secondary T-cell receptor stimulation to circumvent a peri-integrational...
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Báo cáo y học: "Circulating adenosine increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and subsequent organ injury" pdf
Ngày tải lên :
14/08/2014, 07:21
... inflammation-induced cytokine release and (b) tissue injury However, in the presence of caffeine, a non-selective adenosine receptor antagonist, this mechanism of protection is lost and inflammation-induced tissue ... anti-inflammatory potential in humans in vivo However, this is not likely, given the consistent findings in animal studies and isolated cell studies and given the observation that administration of exogenous ... concentrations of pro- and anti-inflammatory cytokines (TNF-a, IL-6, IL-10, and IL1RA) are shown in Figure Thus, caffeine administration and the presence of the 34C > T variant of the AMPD1 gene did not...
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Báo cáo y học: " Epigenetic regulation: DNA confers identity but is not enough to maintain it" pps
Ngày tải lên :
14/08/2014, 16:20
... and thought-provoking talk by John Gurdon (University of Cambridge, UK), one of the pioneers in this field, started off a session on this topic He showed that nuclei from both neuroectoderm and ... maintained chromosome-wide? To investigate this he is looking at X-autosome translocations, in which the spreading of X inactivation beyond the X-autosome breakpoint is often limited Previous data ... increasingly clear that many diseases are due to defects that are not genetically encoded, understanding these mechanisms and to what extent they apply to disease is of utmost importance Also, using...
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Study of some species of mollusks living clung, perforated on the tree mangrove and management capabilities in reducing their harm
Ngày tải lên :
10/06/2016, 09:33
... line and then hit the bottom or sticking to animals (fish, shrimp ) Often we cling to fins, gills of fish as parasites, and after about 20 days to leave the hosts hit the bottom to grow to the ... ability of ectoparasitic on other animals to mollusks larvae may use to expand food and dispersal ability of species distribution 3.3.3 The invation and symptomatic on trees when mollusks clung and ... studied and described some of the biological characteristics of species of brown shell (Modiolus philippinarum Hanley, 1843) in the waters of NinhThuan By 2003, this author continues to research and...
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the method of investment appraisal which may be applied to evaluated and rank potential investment opportunities and their relative merits and limitations
Ngày tải lên :
17/02/2014, 13:02
... thrive and either way this affects the bottom line of their investment • Economy of scale According to Ansof (1971), acquisitions were in general unprofitable, as they did not contribute to increase ... project is not reliable NPV must be used for this type of project III- The nature of gearing and the potential effects of high gearing on perceived risk and cost of capital 11 There are some ways to ... is very easy to calculate and allow managers and stakeholders an easy understanding when the initial investment will be recouped This allows information to decision making based on simple cutoff...
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''''This Is Not a Game'''': Immersive Aesthetics and Collective Play pdf
Ngày tải lên :
07/03/2014, 17:20
... named Cabel Sasser1, one of thousands of movie fans who had started to notice a series of digitally distributed clues and narratives that seemed to be some kind of game, but one without clear rules, ... genre is able to dissolve effectively not only the boundary between "game" and "reality," but also the boundary between "perceived game" and "real game," because the rhetoric of "This is not a ... quite used to being told "This is not a game" does not back off easily, and they are currently still investigating the 8March2003 (non)game Sometimes, however, the desire of immersive fans to see...
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Báo cáo Y học: Regulation of RAS in human platelets Evidence that activation of RAS is not sufficient to lead to ERK1-2 phosphorylation pot
Ngày tải lên :
08/03/2014, 16:20
... response to thrombin and convulxin This is consistent with the observation that TPO, which is unable to induce activation of PKC, does not stimulate activation of ERK in platelets This result ... RAF–MEK and ERK In platelets, phosphorylation of ERK2 in response to thrombin and GPVI agonists is dependent on PKC ([7] and this study) In contrast, we found that a PKC inhibitor did not affect ... expression of the isoform ki- and N-RAS was not excluded [5] Activated RAS was detected with an anti-(pan RAS) Ig, which does not distinguish the various isoforms of RAS In Regulation of RAS in platelets...
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Báo cáo khoa học: A distinct sequence in the adenine nucleotide translocase from Artemia franciscana embryos is associated with insensitivity to bongkrekate and atypical effects of adenine nucleotides on Ca2+ uptake and sequestration pdf
Ngày tải lên :
29/03/2014, 00:20
... Drosophila, mouse isoforms 1, 2, and 4, rat isoforms and 2, bovine isoforms 1, 2, 3, and 4, and human isoforms 1, 2, 3, and 4) is shown in Fig (lower panel) It is evident that region 198–225 of Artemia ... precipitous opening of Atypical Artemia ANT the PTP As shown in Fig 2A, this was not observed in mitochondria isolated from embryos of A franciscana It is of note that, in the presence of oligomycin ... sensitive to BKA (trace b) From this experiment, we concluded that Xenopus liver mitochondria have a classical PTP that is induced by Ca2+ and is sensitive to cyclosporin A and BKA ANT of A franciscana...
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Báo cáo y học: "Ethics of randomised controlled trials – not yet time to give up on equipoise Richard E Ashcroft" pps
Ngày tải lên :
09/08/2014, 01:24
... the offer of randomisation is not suboptimal The defect of the Fries–Krishnan claim (that trials can be ethical if there is positive expected benefit) is that this need not be maximal: doctors, ... events, the tolerability of known side-effects, adherence to treatment, quality -of- life issues) If this is the purpose of phase III trials, then this will mean that different types of design and different ... this approach to the decision to run a trial, and to design in it a particular way, involves subjective judgements about what is important and about what it is fair to offer patients This then involves...
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Báo cáo y học: "Use of methotrexate therapy is not associated with decreased prevalence of metabolic syndrome" potx
Ngày tải lên :
09/08/2014, 14:22
... means (± standard deviations) in cases of normal distribution or as medians (interquartile ranges) in cases of nonnormal distribution BMI, body mass index; CRP, C-reactive protein; DAS28, disease ... DMARD, diseasemodifying antirheumatic drug; ESR, erythrocyte sedimentation rate; HCQ, hydroxychloroquine; MTX, methotrexate; RA, rheumatoid arthritis; SSZ, sulfasalazine; TNF, tumour necrosis factor ... hydroxychloroquine only, tumour necrosis factor-blocking agents, combination of disease-modifying antirheumatic drugs, pack-years, smoking, erosions, DAS28 (disease activity score using 28 joint...
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Báo cáo y học: "Use of methotrexate therapy is not associated with decreased prevalence of metabolic syndrome – authors’ respons" pps
Ngày tải lên :
09/08/2014, 14:22
... 18848 to TET) and an Arthritis Research Campaign infrastructure support grant (grant number 17682, given to the Dudley Group of Hospitals NHS Foundation Trust, Department of Rheumatology) HJ is ... prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60: more than just an anti-inflammatory effect? A crosssectional study Arthritis Res Ther 2009, 11:R110 Toms TE, ... Lack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study Arthritis Res Ther 2008, 10:R145 Page of (page...
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báo cáo khoa học: " Transcriptomic identification of candidate genes involved in sunflower responses to chilling and salt stresses based on cDNA microarray analysis" pps
Ngày tải lên :
12/08/2014, 05:20
... inhibition of photosynthesis in a broad range of plants including tomato, cucumber and maize Several elements contributing to this inhibition have been identified [66] Damage to the reducing side of ... stress (C) and salinity stress (S) a distance -to- the-origin above the percentile 70th of the distance -to- the-origin distribution (Figure 3) This cut-off criterion was selected taking into account ... MALDI-TOF analysis of cold stress induction in rice seedlings [97] This tomato's chaperone seems to play a role in copper mobilization from decaying organs towards reproductive structures, contributing...
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Báo cáo y học: " The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion" potx
Ngày tải lên :
13/08/2014, 06:20
... binding to DC and DC-mediated transmission As previously reported, the 386 sugar contributes to 2G12 binding, but we show here that this contribution is not direct The main finding of our study is ... inhibitors of receptor interactions Inhibition by inhibitors of receptor interactions A Locations of mutations and reversions on the structure of gp120 relative to the receptors binding sites In this ... are grateful to Dennis Burton, James Binley and William Olson for reagents This work was sponsored in part by the Dutch AIDS fund (#5003 and #2005021 to BB and #1028 to InekeB), and by grants...
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Báo cáo sinh học: "Second chromosome polymorphism of Drosophila buzzatii in a natural population is not associated with gametic selection and does not affect mating pattern" potx
Ngày tải lên :
14/08/2014, 20:20
... importance of undertaking these studies We are indebted to Dr G Tell and L M Giurfa for the French translation of the title and summary The English language of this paper was improved by the revision of ... lack of differential attraction of flies to the collecting baits; and iv), lack of selection in the laboratory (see Ruiz et al, 1986) In the present work we report the results of the analysis of ... observed mating frequencies of second chromosome karyotypes did not depart significantly from those expected, giving support to the assumption of random mating This result is in agreement with those...
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PURIFICATION OF SIMPL ANTIBODY AND IMMUNOFLUORESCENCE OF SIMPL SUB-CELLULAR LOCALIZATION IN RESPONSE TO TNFα- AND IL-1
Ngày tải lên :
24/08/2014, 12:43
... method of confirming the identity of the bands would be to isolate them from the gel and to perform mass spectrometry analysis, but none has been performed as of yet Alternatively, isolation of the ... secretion of cytokines to promote growth and even metastasis (DeNardo and Coussens 2007) The effect of inflammation on various diseases is currently an intense area of research C Production of knockout ... there is a dark band at 27-29 kDa in the littermate testes tissue lane that is not present in the SIMPL KO testes tissue lane The two negative control lanes also appeared to be clear of this band...
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schechter - the crime of our time; why wall street is not too big to jail (2010)
Ngày tải lên :
03/11/2014, 16:57
... unquestioning This work is not only time-consuming but demands a sense of mission, which easily morphs into obsession This is not always an easy world to decipher either, as I came to discover first ... sensitive to, and THE CRIME OF OUR TIME xx critical of, our media’s failure to monitor this aspect of the financial crisis, failure to delve into the many crimes behind it, and failure to warn ... that is often so intimidating and foreign to most of our lives I was well aware of all the years of predictions of the coming collapse of capitalism I, too, had scoffed at it as the mechanistic and...
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Ethnicity, society and religion the spread of sanshan guowang cult from eastern guangdong to singapore and malaysia
Ngày tải lên :
09/09/2015, 11:20
... Guowang from their homeland in Southeast China to Singapore and Malaysia The main purpose of my study is to analyze the historical development of the Sanshan Guowang belief and its transitions from ... timely assistance, I was able to access and collect a wealth of materials and relevant research data for my study I would also like to acknowledge all the administration staff and librarians of the ... like me to conduct a number of fieldtrips to Taiwan and i Malaysia Using the funds, I have visited Taiwan to collect data form the libraries of National Central Library, and College of Hakka...
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