the vagaries in ambulatory patients adherence to prescribed drug dosing regimens and some of their clinical and economic consequences

báo cáo khoa học: " Platinum resistance in breast and ovarian cancer cell lines Niels Eckstein" pptx

Ngày tải lên : 10/08/2014, 10:21

... palliative nature, thus, intending to delay disease progression, reduce pain, and maintain quality of life [67] Clinical findings show that the development of resistance to therapy of ovarian cancer ... latter induced by specific ligand-receptor interaction (for instance FasL - Fas interaction) The intrinsic apoptotic signaling cascade triggeres cell death induced by cytotoxic drugs Accordingly, ... of the p50 subunit in the nucleus, thereby allowing the transcription factor to bind DNA [33] TRX in general regulates protein-nucleic acid interactions through the redox regulation of cystein...

11
373
0

Báo cáo khoa học: "Giant breast tumors: Surgical management of phyllodes tumors, potential for reconstructive surgery and a review of literature" potx

Ngày tải lên : 09/08/2014, 07:22

... Collaterals in the skin supplied the tumor, and no deep invasion was identified The superior and inferior skin flaps included skin that had been overlying the tumor The tumor was excised along with the ... obvious mass of the right breast The mass measured 36 × 30 cm at the time of presentation The skin of the breast was blue at the apex of the mass, and the nipple was massively enlarged and excoriated ... skin grafting in patient A and allowed placement of a tissue expander in patient B The ability to preserve the overlying skin flaps is an important consideration in the surgical management of...

8
276
0

báo cáo hóa học:" Emerging role of microRNAs in diagnosis and treatment of various diseases including ovarian cancer" pdf

Ngày tải lên : 20/06/2014, 07:20

... Recently, there has been considerable interest in understanding the mechanism of the RNA regulatory phenomena and how miRNA functions in carcinogenesis Specifically, determining how the regulation of ... redistribution or changes in the levels of Gemin and Figure Systematic miRNA biosysnthesis and trafficking to cytoplasm Systematic miRNA biosysnthesis and trafficking to cytoplasm Using RNA immunoprecipitation ... loss of dopaminergic neurons, it could be possible that miRNAs play a role in the disease pathogenesis These investigators [8] hypothesized that inducing alterations in the miRNA networks of the...

9
440
0

Báo cáo y học: "2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema" pdf

Ngày tải lên : 08/08/2014, 21:20

... reported in HAE therapy and these have led to the licensing of pdC1INH in many parts of the world including Europe and the United States, bradykinin receptor antagonist Icatibant in Europe, and kallikrein ... University of Manitoba, Winnipeg, Manitoba, Canada 31University of Auckland, Auckland, New Zealand 32Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA 33Department of Clinical ... published together as a thematic publication grouping on HAE in the official journal of the Canadian Society of Allergy and Clinical Immunology: Allergy Asthma Clinical Immunology; 2010 (in press...

13
718
0

Báo cáo khoa học: "Outcomes of resection and non-resection strategies in management of patients with advanced colorectal cancer" doc

Ngày tải lên : 09/08/2014, 04:21

... 90% of 336 reported cases with technical failure reported in 8% of cases and perforation in 4% [12] In this series the technique of stenting was introduced and developed in the unit during the ... period and in the future may reduce the need for emergency surgical intervention and stoma formation in patients presenting with malignant large bowel obstruction One of the concerns in managing patients ... I or II and a median age of 72 The elective operative mortality of 14% is high but given the small number of patients in this series is in keeping with the figure of 12% reported in the ACPGBI...

7
327
0

Báo cáo khoa học: "Surgical management of giant Brunner''''s gland hamartoma: case report and literature review" ppsx

Ngày tải lên : 09/08/2014, 04:21

... entirety of the specimen The lesion was composed of back to back mature Brunner's glands Discussion Brunner's glands are alkaline-secreting glands located in the submucosal layer of the duodenum The ... gender and race distribution with the age of presentation typically in the fifth or sixth decade of life BGH is often an incidental finding during EGD or imaging studies as the majority of patients ... final pathology Competing interests Figure at 10× Hamartoma stained with Hematoxylin and Eosin and viewed Histopathological Appearance of a Giant Brunner's Gland Histopathological Appearance of...

4
323
0

Báo cáo y học: "Non-invasive neurosensory testing used to diagnose and confirm successful surgical management of lower extremity deep distal posterior compartment syndrome" potx

Ngày tải lên : 10/08/2014, 10:20

... after 10 minutes of running on a treadmill – the time interval to reproduce his symptoms Following the running, there was widening of two point discrimination in the distribution of the calcaneal ... complain of tightness and a dull aching pain that progressed to severe pain eventually causing him to stop exercising His pain was also associated with paresthesias and numbness in the soles of ... touch and to measure two point discrimination in the skin innervated by medial plantar and medial calcaneal branches of the tibial nerve (Figures and 2) The anterior lateral dorsum of the foot and...

6
334
0

Báo cáo y học: " Intricacies in the surgical management of appendiceal mucinous cystadenoma: a case report and review of the literature" ppt

Ngày tải lên : 11/08/2014, 12:20

... operating on patients with appendiceal mucoceles Page of It is important to exercise care in handling tissues intraoperatively to reduce the risk of dissemination of mucinproducing epithelium ... is instrumental in achieving an accurate diagnosis Herein, lies the dilemma for the surgeon because of the nebulous nature of the distinction between these entities in the pre-operative setting ... (hematoxylin and eosin stain) There are no significant epithelial atypia and no invasion into the deeper tissue contrast enhancing nodules on CT scans may be suggestive of cystadenocarcinomas...

4
427
0

Báo cáo y học: " Surgical management of abdominal compartment syndrome; indications and techniques" potx

Ngày tải lên : 13/08/2014, 23:20

... skin, be readily available and inexpensive, and maintain the abdominal domain In addition, the preservation of the accessibility to the abdominal cavity and the feasibility of gradual closure of ... before skin grafting, early application of the skin graft over the bowel seems to enhance the tuning down of the inflammatory process sustained by the large raw surface, and to make the subsequent ... techniques, the selection of the technique has to be individualized and based on common sense and weighing the pros and cons of each technique The midline laparostomy is relatively safe, easy to perform...

5
272
0

Association analysis of genetic variation of estrogen related candidate genes in breast and endometrial cancers

Ngày tải lên : 09/09/2015, 17:58

... activities of SERMs (53) Also, the type of interaction (tethered or DNA direct binding) and the expression levels of coregulators determine the distinct patterns of coregulator recruitment to the ligandreceptor-gene ... cofactor protein complexes allows for a temporal- and tissue-specific modulation of the combinatorial cofactor and histone codes for single genes, which further increases the complexity of their ... testing results involves the quantitative system (based on proportion of cells stained), the scoring systems (based on proportion of cells stained and the intensity of the staining), and the...

158
422
0

The functional investigation of forkhead factor FOXQ1 in human breast and colon cancers

Ngày tải lên : 10/09/2015, 15:51

... lobules and glands are connected by thin ducts These ducts channel milk to openings in the nipple The lobules are secretory units of breast, each lobule consists of a certain number of acini, or glands, ... Depending on the different functional consequences and the various origins of this transition process, EMT is parsed into three distinct biological settings In a 2007 meeting in Poland and a ... within loose connective tissue and connecting to the intralobule duct Each acinus is composed of two types of cells, namely epithelial and myoepithelial cells The epithelial cells form glandular...

255
378
0

Báo cáo y học: "surgical Management of Hidradenitis Suppurativa"

Ngày tải lên : 26/10/2012, 08:57

... sites) involving the axilla, 20,3% (11 sites) involving the gluteal area, %24,2 (13 sites) involving the perineal area and 12,9% (7 sites) involving the inguinal region Hurley’s clinical staging ... poor in most of the patients 18 of the 21 (85%) male patients and of the (37%) female patients were smokers patients (2 female, male) had insulin-dependent diabetes mellitus (See Table 1) Most of ... Int J Med Sci 2010, The sinuses can dissect deep into tissue, involving muscle, fascia and bowel forming a labyrinth of tracts in advanced cases.8 However, as the abscesses extend deeper into...

8
512
1

Báo cáo y học: "Management of HCV Infection and Liver Transplantation"

Ngày tải lên : 31/10/2012, 17:08

... discontinue therapy Often the only way of maintaining Int J Med Sci 2006, the blood counts is to aggressively use hematopoietic growth factors The often poor tolerability of this population to any interferon ... HCV infection hepatocellular function improves and in turn leads to rejection There have been increasing reports of pegylated interferon and ribavirin therapy possibly increasing the rates of ... Associate Professor of Medicine, Medical Director of Liver Transplantation and Director of Clinical Hepatology at The Mount Sinai Medical Center, New York His current research interests include the diagnosis...

5
491
0

Surgical management of spasticity

Ngày tải lên : 01/11/2013, 10:20

... the incision, to mm in depth, down the upper layers of the dorsal horn (d) The line of incision is opened (between the two tips of the bipolar forceps) and reveals its depth and the apex of the ... spasticity in the wrist and the hand – the aim being to open the hand and improve prehension As the fascicular organization of the median and ulnar nerves does not allow for differentiation of motor ... standing and/ or walking; and improvement in urinary function The muscles in which there was a harmful excess of tone and their – anatomically – corresponding lumbosacral roots (i.e those to be...

21
372
0

Tài liệu Report on The Management of Non-Muscle-Invasive Bladder Cancer ppt

Ngày tải lên : 14/02/2014, 21:20

... little information deﬁning the optimal dose, number and timing of instillations or the in uence of long-term maintenance therapy Randomized studies supporting the use of maintenance BCG therapy ... percent of patients) Periodic monitoring of the upper urinary tract is necessary, and studies are needed to better determine the efficacy of administration of chemotherapy or immunotherapy to the ... difference in the recurrence rate (Beisland and Seland, 1986) Page 18 Thiotepa Introduced in 1961, thiotepa is the oldest and one of the least expensive of the intravesical drugs It is an alkylating...

68
425
1

Tài liệu Carrots, Sticks, and Promises: A Conceptual Framework for the Management of Public Health and Social Issue Behaviors docx

Ngày tải lên : 18/02/2014, 02:20

... up their bingeing habits during their junior and senior years The manager's goals here are to minimize the number of freshmen who begin to binge drink and to maximize the number of juniors and ... discern the reward in doing so Dickson (1992) discusses the invisible hand of competition that constrains the self-interest of the firm and forces the firm to serve the interests of customers ... genetic testing by setting up test sites in shopping malls and in exchange, could offer counseling on the topic of family planning using the test results and other issues of concern to the family...

14
780
0

Tài liệu NASA’S MANAGEMENT OF MOON ROCKS AND OTHER ASTROMATERIALS LOANED FOR RESEARCH, EDUCATION, AND PUBLIC DISPLAY doc

Ngày tải lên : 18/02/2014, 05:20

... destroyed during testing, and the Meteorite Curator continues to investigate the status of the remaining sample 16 During our audit fieldwork, we notified the Stardust Curator about the two missing Stardust ... obtaining funding for their research Others told us that it never occurred to them to return the samples after they had conducted their research Still others stated that they held the samples in ... a minimum, NASA should consider requiring researchers to maintain a record of samples in their custody and supply NASA the inventory for reconciliation with the Curation Office’s records In addition,...

46
466
0

Tài liệu Alcohol-use disorders: diagnosis, assessment and management of harmful drinking and alcohol dependence docx

Ngày tải lên : 21/02/2014, 11:20

... attainment and attendance history of abuse and trauma risk to self and others readiness to change and belief in the ability to change obtaining consent to treatment developing a care plan and ... paid to the feasibility of the measures in routine care and the training required to obtain satisfactory levels of accuracy and predictive validity The programme needs to be large enough to encompass ... (including personal and social functioning) and the acceptability of the intervention The study needs to be large enough to determine the presence or absence of clinically important effects, and...

51
476
0

The management of harmful drinking and alcohol dependence in primary care potx

Ngày tải lên : 08/03/2014, 14:20

... SYMPTOM-TRIGGERED DOSING Although there are studies of the efficacy of symptom-triggered dosing and/ or loading dosing in inpatients, there is no evidence regarding the use of these methods in ... drinking counselling and therapy for the individual counselling and therapy for the family treatment options including medication to relieve the physical effects of stopping drinking and to help to ... experts as linked to heavy drinking, such as injuries (including in the elderly), tremor of the hands and tongue, and excessive capillarisation of the facial skin and conjunctivae.16,17 The exact...

44
381
0