the treatment of adult acute lymphoblastic leukemia all risk stratification and strategies
Báo cáo khoa học: "Exogenous pulmonary surfactant for the treatment of adult patients with acute respiratory distress syndrome: results of a meta-analysis" pot
... ratio)), the number of ventilation-free days, and the mean duration of ventilation Furthermore, the following data were extracted: method of randomization; inclusion and exclusion criteria; details of ... case we applied a random effects model We examined the influence of the method of delivery and the type of surfactant on all trials using predetermined sensitivity analyses All statistical analyses ... Specifically, in the trial by Spragg and colleagues [19] the surfactant group chosen for analysis was the group who were given the same dose of surfactant as the two other trials [20] using the same...
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báo cáo khoa học: " Plasma levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18G A and leptin receptor genes K109R and Q223R, in survivors of childhood acute lymphoblastic leukemia" docx
... 85), the respective proportion at the time of the present study was 31% The prevalence of the overweight status at the time of ALL diagnosis/ after ALL treatment in patients treated with and without ... Q223R, and overweight status at ALL diagnosis and after ALL treatment was found No statistically significant correlation between variants of the tested genes and intensity of ALL treatment, CRT and ... determine the polymorphisms of leptin and leptin receptor genes and plasma levels of leptin and leptin soluble receptors in survivors of childhood ALL The study assessed the influence of chemo- and...
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Báo cáo y học: "Safety assessment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsis" pot
... for 39.2% (58/148) of the total number of events (Table 5) The incidence of serious bleeding events was highest during the first day of therapy and decreased thereafter for all drotrecogin alfa ... associated with the use of drotrecogin alfa (activated) The primary limitation of these analyses was the lack of placebo treatment groups for five of the seven studies reported, and no comparison ... clinical staff at the Vanderbilt Coordinating Center; to all of the investigators, study coordinators, and pharmacists who participated in the clinical trials reported; and to the product development...
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Báo cáo y học: "Human T-cell leukemia virus type I (HTLV-I) infection and the onset of adult T-cell leukemia (ATL)" pps
... suppressed expression of Tax [34] On the other hand, p30 binds to tax/rex transcripts, and retains them in the nucleus [35] The HBZ gene is encoded by the complementary strand of HTLV-I, and contains ... http://www.retrovirology.com/content/2/1/27 Treatment of ATL – the remaining mission and challenges Regardless of intensive chemotherapies, the prognosis of ATL patients has not so improved The median survival time of acute or ... expression Rex binds to Rex-responsive element (RxRE) in the U3 and R regions of the 3'-LTR, and enhances the transport of the unspliced gag/pol and the singly spliced env transcripts By this mechanism,...
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Báo cáo y học: " Challenges in implementing individualized medicine illustrated by antimetabolite therapy of childhood acute lymphoblastic leukemia" ppt
... both the therapy-patient axis and the therapy-patient axis is likely to modify the therapy Patient and disease interact directly via immune responses, bone marrow stroma support of leukemia, and ... addressed Childhood acute lymphoblastic leukemia In the industrialized countries cancer is the most common medical cause of death in children above the age of 1.0 year and ALL is the most common ... of the high -risk patients that did not experience toxicity with standard treatment) and how should these gains and losses be balanced? Certainly, the weighing should include both the number and...
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Báo cáo khoa học: "Recombinant activated factor VIIa for the treatment of bleeding in major abdominal surgery including vascular and urological" doc
... analysis and interpretation of the data, and drafting of the article SJ and CS contributed to the conception and design of the work, sampling of data, interpretation of the data, and revision of the ... to the conception and design of the work, interpretation of the data, and revision of the article for content K-DW contributed to the analysis and interpretation of the data, revision of the ... article for content, and approval of the version to be published DJ contributed to the conception and design of the work, sampling of data, interpretation of the data, and drafting of the article JK...
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CLINICAL EPIDEMIOLOGY OF ACUTE LYMPHOBLASTIC LEUKEMIA - FROM THE MOLECULES TO THE CLINIC docx
... pothesis have attempted to include these theories [5-8] The theory of Greaves and that of Kinlen have been discussed in one of the chapters in this book One of the limitations of the theory of ... of Acute Lymphoblastic Leukemia - From the Molecules to the Clinic ies that have been specifically designed to test the hypothesis of the involvement of infectious agents in the development of ... in ALL samples and to study the microbiota of patients All these efforts together will result in a better understanding of the role of infectious agents in childhood ALL, their mechanisms of...
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báo cáo hóa học: " Impaired sleep affects quality of life in children during maintenance treatment for acute lymphoblastic leukemia: an exploratory study" pdf
... analysis and drafted the manuscript JHU, GJK and RJG helped to design the study, made contributions to the interpretation of data and were involved in the drafting and critical revision of the manuscript ... cancer treatment, and the results of this study suggest that impaired sleep might be one of the contributing factors Better counseling and treatment of sleep problems might improve QoL It is therefore ... for all scales except for family cohesion and off-dex mental health See table There were no statistically significant differences in QoL measured with the CHQ and the PedsQL between on-dex and off-dex...
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Báo cáo y học: "A meta-analysis of CAG (cytarabine, aclarubicin, G-CSF) regimen for the treatment of 1029 patients with acute myeloid leukemia and myelodysplastic syndrome" ppsx
... most of the studies The standard of supportive care for AML has changed dramatically over the decade The toxicity data from this analysis may therefore overestimate the adverse events of the regimens ... performed a systematic review and meta-analysis to assess the overall treatment efficacy and the adverse events of the CAG regimen Materials and Methods Data source The databases of PubMed, Wanfang Data, ... Majority of the studies were small (only of the 35 studies had 50 or more subjects) Although all the studies used similar CAG regimens, the dosage of aclarubicin was variable Due to the small sample...
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báo cáo khoa học: "A homoharringtonine-based induction regimen for the treatment of elderly patients with acute myeloid leukemia: a single center experience from China" pptx
... designed the research, supervised the research, analyzed the data, wrote and revised the paper SL analyzed the data and wrote the paper; JY, XS, LC, CH, JH, WZ treated part of the patients and collected ... Characteristics of the patients Characteristics of the patients at the time of diagnosis are listed in Table The median age of these patients was 70 (60–84) years Seven patients had history of myelodysplastic ... study, the response results of HA are comparable with these and other reported results in elderly patients with AML [15-21] The response rates of HA are also comparable with the data of elderly...
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báo cáo khoa học: "Analysis of the expression pattern of the BCL11B gene and its relatives in patients with T-cell acute lymphoblastic leukemia" doc
... family genes of the mitochondrial pathway, and the TRAIL (TNFSF10) gene of the death receptor signaling pathway [22], furthermore, in our previous study, the genes (SPP1 and CREBBP) of the TGF-b ... (BCL2L1) for The relative amounts of the genes of interest and the b2M reference gene were measured in two independent assays The 2(-ΔΔCT) method was used to present the data of the genes of interest ... Page of All procedures were conducted in accordance with the guidelines of the Medical Ethics committees of the health bureau of Guangdong Province, PR China RNA extraction and cDNA synthesis...
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báo cáo hóa học: " Health-related quality of life assessment in Indonesian childhood acute lymphoblastic leukemia" potx
... children and their guardians to facilitate their coping with the disease and its treatment Abbreviations ALL: acute lymphoblastic leukemia; HRQOL: healthrelated quality of life; PedsQL™: the Pediatric ... status, SES, ALL risk stratification, and phase of treatment The average age of all patients was 6.6 years (SD = 3.7), median years, range 2–16 years Most respondents of proxy reports were mothers (n ... status, SES, position of the child in the family, and medical groups of treatment (risk stratification, phase of treatment) were measured using Independent-Sample T test All analyses were performed...
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báo cáo hóa học:" Health-related quality of life assessment in Indonesian childhood acute lymphoblastic leukemia" docx
... children and their guardians to facilitate their coping with the disease and its treatment Abbreviations ALL: acute lymphoblastic leukemia; HRQOL: healthrelated quality of life; PedsQL™: the Pediatric ... status, SES, ALL risk stratification, and phase of treatment The average age of all patients was 6.6 years (SD = 3.7), median years, range 2–16 years Most respondents of proxy reports were mothers (n ... status, SES, position of the child in the family, and medical groups of treatment (risk stratification, phase of treatment) were measured using Independent-Sample T test All analyses were performed...
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Báo cáo khoa học: "Helical tomotherapy in the treatment of pediatric malignancies: a preliminary report of feasibility and acute toxicitty" doc
... Radiation therapy is an integral part in the treatment of 40-60% of childhood cancer patients [1] Although many childhood malignancies are cured, the acute toxicity of therapy and significant late treatment ... examined at least weekly during treatment The acute and subacute toxicity was defined and graded according to the RTOG criteria After the radiation therapy, all the patients underwent follow-up ... than 14 years old underwent HT at the Tomotherapy Unit of the Grupo IMO in the context of multidisciplinary national and international treatment protocols All the patients were treated with curative...
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Báo cáo khoa học: "Mitochondrial DNA alterations of peripheral lymphocytes in acute lymphoblastic leukemia patients undergoing total body irradiation therapy" ppt
... targeted the CD breakpoint and measured the abundance of the CD in the samples The level of CD was normalized using mtDNA amount and was expressed as a ratio to the mitochondrial DNA amounts In other ... Comparison of intensive chemotherapy, allogeneic or autologous stem cell transplantation as post-remission treatment for adult patients with high -risk acute lymphoblastic leukemia Final results of the ... for the lymphocyte samples The level of the common mitochondrial deletion in the lymphocyte samples is within the linear range of the standard curve Figure Relative change of mtDNA content (A) and...
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báo cáo khoa học: "Persistence of TEL-AML1 fusion gene as minimal residual disease has no additive prognostic value in CD 10 positive B-acute lymphoblastic leukemia: a FISH study" doc
... Journal of Hematology & Oncology 2008, 1:17 Background Acute lymphoblastic leukemia (ALL) is the most common malignancy of childhood Cure of many of these children is difficult to predict and is ... Study Group for Adult Acute Lymphoblastic Leukemia: Clinical significance of minimal residual disease quantification in adult patients with standard -risk acute lymphoblastic leukemia Blood 2006, ... relationship of the MRD level of TEL-AML1 fusion and prognosis shows heterogeneity and further investigation is required to evaluate their association and to design risk adapted therapeutic approaches...
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Báo cáo y học: "Acute liver toxicity with ifosfamide in the treatment of sarcoma: a case report" doc
... notes and literature and drafted the manuscript RLJ and IJ were responsible for the clinical care of the patient and reviewed the manuscript IJ conceived of the article and supervised the report ... well as abnormal liver synthetic function and renal function (Table 2) The Page of development of encephalopathy within seven days of the onset of jaundice constitutes hyperacute liver failure She ... F, Van den Brande J, Schrijvers D, Prové A, Vermorken JB: Methylene blue in the treatment and prevention of ifosfamide-induced encephalopathy: report of 12 cases and a review of the literature...
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Báo cáo y học: "European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD" docx
... about the clinical presentation and the consequences of ADHD across the lifespan Another reason for underdiagnosis and treatment of ADHD in adults is the age-dependent change in the presentation of ... is the first step in the treatment plan and involves educating the patient and ideally also the partner or family about ADHD symptoms and impairment, the prevalence in children and adults, the ... decades of undiagnosed and unmet needs, the diagnosis offers an explanation for their problems which is valuable to a lot of patients and their family Treatment of adult ADHD can influence Page 11 of...
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Báo cáo y học: "Efficacy and safety of non-invasive ventilation in the treatment of acute cardiogenic pulmonary edema – a systematic review and meta-analysis" docx
... Mebazaa A: Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: the Task Force on Acute Heart Failure of the European Society of Cardiology Eur Heart J 2005, ... Materials and methods Study design A systematic review and meta-analysis of RCTs focusing on the effect of CPAP and NPPV in the treatment of ACPE was undertaken The methodological approach included the ... patients to the intervention by covering the control panel of the ventilator Almost none of the studies reported or commented on blinding strategies Most of them reported on strategies for standardization...
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