the sky is falling novel by sidney sheldon
The Sky Is Falling pdf
Ngày tải lên :
15/03/2014, 17:20
... Poor
devils. They think this is some kind of heaven. They tell me this is easy
work compared to the type they had to undergo. The Satheri like to get
big bunches through in one conjuration, like the haul ... labor
gangs.
The idiots must be trying to reach the sky with their pyramid. There
could be no other answer to the immense bulk planned for this structure.
Like the pride-maddened men of Babel, they were ... rushed upwards. Another began to rise,
and another. In seconds, more than half of those who had waited were
screaming upwards toward the hole in the sky. They disappeared in the
distance.
Those who...
- 90
- 670
- 1
Tài liệu Báo cáo khoa học: The thioredoxin-independent isoform of chloroplastic glyceraldehyde-3-phosphate dehydrogenase is selectively regulated by glutathionylation docx
Ngày tải lên :
19/02/2014, 05:20
... site-directed
mutagenesis of Cys153. Mutation of Cys149 was not
attempted, because this residue is known to be abso-
lutely essential for catalysis [20]. On the other hand,
the activity of the purified recombinant ... significant role in the protection of
A
n
B
n
GAPDH isoforms against oxidative stress.
Discussion
The aims of the present study were to establish whe-
ther chloroplastic GAPDH isoforms undergo gluta-
thionylation ... in
higher plants displays the A
n
B
n
structure and is regula-
ted by metabolites and thioredoxin f (TRX f), a small
disulfide oxidoreductase involved in the activation of
the Calvin cycle by light [29–33]....
- 15
- 515
- 0
Tài liệu Báo cáo Y học: Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation ppt
Ngày tải lên :
21/02/2014, 01:21
... have not been
entirely encompassed by the drug-treatment. Such a hypo-
thesis is further confirmed by the observation that, differ-
ently from the effect of serum, the stimulatory effect of
PMA on ... the molecular mechanisms by which this novel
ruthenium complex exerts its antimetastatic activity are
largely unknown.
In this study, we attempted at elucidating the molecular
target(s) and the ... counteracting DNA
synthesis over a 1–200 l
M
range (Fig. 1B).
Further analysis of the inhibitory response elicited by
NAMI-A on ECV304 growth was accomplished by inves-
tigating the effect of NAMI-A...
- 10
- 703
- 0
Tài liệu THE ENTITLED A novel by Frank Deford doc
Ngày tải lên :
21/02/2014, 06:20
... fashion do, with the ability to choose
clothes that manage to work so perfectly that they
count twice––once for how they look and then again
because they proclaim to the world: this lady knows
what’s ... Muzak. Then, though, a
pianist takes the stage, and can you believe this: he
plays only with his left hand. First Ravel, then Strauss.
Who would believe this? Who would have known that
there are ... know, like in the Olympics where they throw
that Frisbee-type thing. The famous sculpture.”
The discus thrower,” one of the more learned writ-
ers said.
“Right. I’m tellin’ ya, if the sonuvabitch...
- 294
- 295
- 0
Báo cáo khoa học: Phosphorylation of the Saccharomyces cerevisiae Grx4p glutaredoxin by the Bud32p kinase unveils a novel signaling pathway involving Sch9p, a yeast member of the Akt / PKB subfamily pot
Ngày tải lên :
07/03/2014, 04:20
... based on
the assumption that the transient interaction between
the enzyme and its substrate is strengthened if the
course of the catalytic reaction is hampered. In accor-
dance with this, the low ... 1B).
The partial phosphorylation of Grx4p still observed
in the case of the two mutants (corresponding to
30–40% of that of the wild-type) could be explained
either by the intervention of another ... contributes to the full functionality of Grx4p in vivo.We
also show that this regulatory system is influenced by the phosphorylation
of Bud32p at Ser258, which is specifically mediated by the Sch9p...
- 15
- 414
- 0
Báo cáo khoa học: Xenopus Rbm9 is a novel interactor of XGld2 in the cytoplasmic polyadenylation complex pptx
Ngày tải lên :
07/03/2014, 05:20
... participate in the
translational enhancement mediated by introns.
Indeed, the presence of the PAP Gld2 on the messen-
ger, targeted by a protein of the Rbm9 family, may
allow the polyadenylation of the ... mammalian Rbm9 is
unclear and is dependent on the isoform and the tissue
examined; however, it appears to be mainly nuclear in
cell lines and brain where, nevertheless, there is addi-
tional ... oocytes. The
antibodies, by interacting with their target proteins,
could disrupt this masking complex, alleviate the
repression and allow the translation of maturation-
required proteins before the...
- 14
- 502
- 0
Báo cáo khóa học: SUT2 is a novel multicopy suppressor of low activity of the cAMP/protein kinase A pathway in yeast docx
Ngày tải lên :
07/03/2014, 15:20
... his3:hisG/his3::hisG trp1::hisG/trp1::hisG This study
MR211 S1278b; MATa ura3–52 his3:hisG leu2::hisG ras2::kanMX
MR298 S1278b; MATa/a ras2::kanMX/ras2::kanMX ura3–52/ura3–52 his3:hisG/his3:hisG
leu2::hisG ... his3:hisG/his3:hisG
leu2::hisG leu)2::hisG
This study
AR2 S1278b; MATa/a sut2::S.pombe his5
+
/sut2::S.pombe
his5
+
ura3–52/ura3–52 his3:hisG/his3:hisG leu2::hisG/LEU2 TRP1/trp1::hisG
This study
MR287 S1278b; ... ura3–52 his3:hisG leu2::hisG FLO11::lacZ This study
AR3 S1278b; MATa ura3–52 his3:hisG leu2::hisG ras2::kanMX FLO11::lacZ This study
AR4 S1278b; MATa ura3–52 his3:hisG leu2::hisG sut2::S.pombe his5
+
FLO11::lacZ...
- 8
- 485
- 0
Báo cáo khoa học: Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines docx
Ngày tải lên :
07/03/2014, 16:20
... kinases was induced by leptin. The weak
response of STAT5 to leptin compared to that elicited
by GH can be partially explained by the rather ineffec-
tive transfection of the HIT-T15 cells (estimated ... lg each of the luciferase reporter construct and
the b-galactosidase reporter control plasmid pSVb-gal
(Promega). Transcription of the lacZ gene in this control
vector is driven by the SV40 early ... analysis are consistent with findings
obtained with other cytokine receptors: the position
after the phosphotyrosine (P +1) is critical for binding
of STAT5 but not of STAT1 or STAT3, whereas the
glutamine...
- 11
- 420
- 0
Báo cáo khoa học: An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist docx
Ngày tải lên :
07/03/2014, 21:20
... mutagenesis of the
N-terminus of the V
1a
R; this revealed that a single residue
(Arg46) located in the distal segment of this domain is
critical for high affinity agonist binding but not antag-
onist ... than the wildtype
V
1a
R but once the agonist bound, the receptor was more
likely to signal. This dual role suggests that binding of the
agonist releases the Arg46-mediated constraint on the
ground ... rescued
by a chimeric construct in which the N-terminus of the
OTR is replaced with the corresponding sequence of
the V
1a
R [10]. The role of the N-terminus has been
addressed recently by alanine-scanning...
- 8
- 487
- 0
Báo cáo khoa học: The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors pdf
Ngày tải lên :
15/03/2014, 00:20
... of the regula-
tion of the Muc5b promoter by TTF-1 and GATA
factors. Using this approach, we aimed to show the
transcriptional regulation of Muc5b by these two tran-
scription factors, thereby ... pathophysiology.
The analysis of the promoter sequences of the
murine Muc5b and human MUC5B genes showed
that they are highly similar over the first 170 nucleo-
tides and, more importantly, that the TATA box is
identical. ... in the primitive gut [8]. TTF-1 and GATA-6
are required for the formation and differentiation of
distal epithelium [20,44,45]. In normal adult tissue,
MUC4 is preferentially expressed by the...
- 13
- 240
- 0
By the Light of the SoulMary Eleanor Wilkins-Freeman..By the Light of the Soul A Novel By Mary E. Wilkins Freeman Author of “The Debtor” “The Portion of Labor” “Jerome” “A New England Nun” Etc. etc.1907To Harriet and Carolyn Alden..By the Light o pptx
Ngày tải lên :
16/03/2014, 18:20
... with the sweetness of the midsummer night, and the
By the Light of the Soul
13
“No sicker than usual,” replied her mother. Then she drew the
delicate little figure close to her, and kissed ... said her father.
Maria looked at her father in a bewildered sort of way. “I guess the
coffee is in the other canister,” said she, meekly.
“Why didn’t you say so then?” demanded her father.
Maria ... coffee at the price it is now? I guess she doesn’t,”
said her father. He poured the coffee-pot full of boiling water from
the tea-kettle, then he tipped the coffee canister into his hand, and...
- 488
- 398
- 0
Báo cáo khoa học: A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells potx
Ngày tải lên :
16/03/2014, 23:20
... binding
site. There is no typical TATA or CAAT box in the
putative promoter region. The putative signal sequence
is encoded by the first exon, and the pro-enzyme frag-
ment is encoded by exons 1 and 2. The ... prosemin is expressed strongly in the pancreas, but
weakly in the prostate and cerebellum (Fig. 4). The
nucleotide sequences of the cDNA and the cosmid
clone are identical. A comparison of the cDNA ... [29]. Northern blot analysis showed
that, of the normal tissues, prosemin is abundantly
expressed in the pancreas (Fig. 4). All the pancreatic
cancer cell lines tested secreted prosemin into the con-
ditioned...
- 13
- 483
- 0
Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf
Ngày tải lên :
17/03/2014, 10:20
... 2002
determination of k
diss
by the method used for papain, in
which the displacement was monitored by chromatography.
Therefore, only upper limits of k
diss
for the binding of these
mutants to cathepsin L ... agreement
with the calculated k
diss
(Table 2). The L73G mutation
markedly affected the rate of dissociation of the complex
with cathepsin B, increasing k
diss
by 8000-fold. The P74G
mutation ... are
formed. This conclusion is indicated by the L73G mutation
appreciably decreasing the affinity of cystatin A for the
proteases by increasing the rate constants for dissociation
of the complexes...
- 10
- 533
- 0
