... effects
of
a
body
is
equal
to
the
change
of
the
function
of
state,
U, i.e.
the
alge-
braic sum is independent
of
the
choice
of
path
A-+oB.
1·8. Expression of
the
first ... show
the
number
of
foot-pounds
of
work
needed
to
raise
the
temperature
of
1lb.
of
water
by
1 °F. The result
of
the
most accurate series
of
experiments, those with
the
paddles, ... other
of
them (depending on whether
the cycle
is
in
the
direction
of
the
arrows
in
Fig. 4, or
in
the reverse
direction) corresponds
to
heat
actually
taken
in
and
the
other...
... spasticity 159
the back with the ultrasound probe at the level of L1–
L4. The thickness and width ofthe muscle are then
determined. The block is made in the medial part
of the muscle near the vertebral ... treatment
effect is often enhanced bythe additional infiltration
of the proximal third ofthe muscle. The superficial
placement ofthe injection may result in the dener-
vation ofthe gracilis muscle ... indicated for the
relief of knee flexors spasticity.
Block ofthe musculo-cutaneous nerve
of the arm
This nerve is a continuation ofthe lateral cord of
the brachial plexus. It innervates the biceps...
... as
suggested by the manufacturer. By taking into account the
dead volume ofthe transporting line after adding all reactants
and the flow rate ofthe N
2
gas, it can be deduced that the
chemicals in the reaction ... when there is only 4-DMAP dissolved in
the solvent. The absence ofthe 4-DMAP signal during the
reaction can be explained by the involvement of 4-DMAP in
the catalytic cycle. Afterwards, the regenerated ... addition of a second molecule
of acrylonitrile to PEAP.
10
We monitored the reaction products continuously at the
start ofthe reaction to determine the delay between the
changes in solution and the...
... in the Gulf
War. The subsequent disclosure ofthe CBW capabilities ofthe for-
mer Soviet Union, the discovery of an Iraqi CBW capability after the
Gulf War, and the recognition that a number of ... and the correct dose in humans
can be determined from the data. The regulation also requires post-
marketing studies.
The Challenges of Acquisition 27
DATSD(CBD); the ASD(HA); the Office ofthe ... development because ofthe increased apprecia-
tion ofthe threat of biological weapons. The CBW threat, both to
national and homeland security, raises the question of whether cur-
rent FDA regulations...
... [11,12]. The study of these events is
taxing, as the biosynthesis of glycoproteins is not tem-
plate driven. This results in the formation of so-called
‘glycoforms’ [11,12], proteins with the same ... 1957
catalyze enhanced hydrolytic degradation ofthe target
protein.
More recently, the glycoMTS method has allowed
the synthesis ofthe first examples of a homogeneous
protein bearing symmetrically ... can limit their versatility and general applica-
tion to modified protein (glycoprotein) synthesis.
Chemical strategies in glycoprotein
synthesis
The chemical attachment of glycans offers an alterna-
tive,...
... some of these phenomena may
be interconnected within the catalytic mechanism of
the enzyme.
Structural insights into the mechanochemical
nature of a-CT catalysis
A more detailed analysis ofthe ... (nucleophilicity) for
the in silico creation ofthe various glycoconjugates was
determined by calculating the electrostatic potentials (EP)
for the N
e
of the lysine residues of a-CT at pH 9 were the
chemical ... within a cutoff distance (r
c
¼ 6.0 A
˚
). The dynamics of
the resulting network are then defined by the Ni · Nj Kir-
chhoff connectivity matrix of interresidue contacts (G)
where the off diagonal...
... of
a4v over the entire sequence defines the aggregation
profile ofthe polypeptide. The hot-spot threshold
(HST) was defined as the average ofthe a3v ofthe 20
natural amino acids weighted by their ... [36].
Thus, there are three scales which allow the predic-
tion of amyloidogenic regions in a protein sequence
(or rather, the ability of a peptide to be amyloido-
genic): the scale ofthe packing ... propensity enter the scoring function
as a physical property term S
physprop
consisting of the
sum ofthe products ofthe amino acid frequency with
the normalized property value ofthe respective...
... at the last base, G to A, abolished
the interaction of HIPPI, so the last motif would not
interact with HIPPI. The other two motifs might be
the target of HIPPI. In the upstream sequenceof the
Table ... confirmed the in vitro result
that mutation ofthe motif abolished the binding of
HIPPI to the specific sequenceofthe caspase-1 gene
upstream sequence, and the increased expression of
caspase-1 ... decrease in
the fluorescence intensity of 6X(HN)-pDED due to
the addition ofthe 60 bp region ofthe caspase-1 gene
upstream sequence was observed. Addition of the
caspase-1 gene upstream 60 bp sequence...
... indicative
of the loss of Zn(SCys)
4
chromophores and thus of the
removal of Zn(II) from the corresponding proteins.
Although these two features, the common evolution of the
three MTs and the loss of ... synthesis of more protein, in agreement with the
function of Zn(II) as primary inductor ofthe synthesis of
MT [32,33]. High concentrations of MT should thus
contribute to the sequestration of ... to
the end ofthe titration, which is identified by the saturation
of the CD features. This occurs for the addition of 16
MeHg(II) eq to the aMT fragment, 14 to the bMT
fragment, and 22 to the...
... localization in
the ER [19]. We found that the TMD of UGT1A pro-
teins appended to the C-terminus ofthe ectodomain of
CD4 plasma membrane glycoprotein was able to retain
the chimeric protein in the ER ... together, these data indicated that the
TMD domain of UGT1A was sufficient to retain the
ectodomain of CD4 protein in the ER. Because
the carbohydrate moieties of proteins that are trans-
ported to the ... in combination with that of the
TMD did not prevent membrane targeting and
insertion ofthe enzyme. These findings resulted in the
identification of an internal signal sequence localized
between...
... FEBS
fungal sequences is clearly distant from the other bran-
ches, which was indeed predicted. The other main
group, obtained 97% ofthe time in 20 740 explored
trees, contained the DIDO PHD sequences ... analyses
The localization ofthe DIDO1 gene in the context
of chromatin stability was addressed experimentally.
Although the experiments conducted were preliminary,
they indicated the involvement of ... from the CGBP family (Figs 1,
3 and S1); otherwise, the fungal sequences could well
constitute CGBP homologues.
The presence of a TFS2M domain is also indicative
of a possible function for the...
... however, the lower S/N ratio
of the spectra in Fig. 4E than in 4B that has an effect on the
accuracy ofthe deconvoluted spectrum.
Lability ofthe Asn residues in the autoregulatory
sequence
The 28-residue ... neighbour
amino acids and the loop structure are the same in the two
proteins.
The perturbation ofthe overall conformation ofthe loop
structure as a result of deamidation of Asn32 to Asp/isoAsp
have ... loop
region ofthe N-terminal autoregulatory sequence (residues
19–33) of wt-hPAH, are among the susceptible residues.
First, on MALDI-TOF mass spectrometry ofthe 24 h
expressed enzyme, the E. coli...
... applied, which makes
the process economically unfeasible. The introduction
of the catalyst results in both the reduction of oxidation
reaction energy and the reduction ofthe costs of the
process
w
30
x
.
Alumina ... and
PZC
purity), pH ofthe solution, ionic strength, composition of water and the physicochemical properties of adsorbates. The aim of
this paper is to give a brief review ofthe properties of alumina ... water.
However in the presence of PO , the efficiency of
2y
4
catalytic ozonation decreased, due to the adsorption of
PO ions on the alumina surface and the blockage of
2y
4
active surface sites of alumina
w
26
x
.
The...
... detailed picture ofthe rotational diffusion
was derived from the NMR
15
N relaxation data. To
monitor the effect ofthe real shape ofthe molecule
on its tumbling, the values ofthe apparent rotational
diffusion ... UK). Estimates of hydrodynamic
radii ofthe expected molecular species were calculated with
the software hydropro [26]. The structures of monomers
and dimers ofthe human CD69 in the present study, ... reduced availabil-
ity for the reaction with the cellular form of CD69 at
the surface ofthe killer lymphocytes. This should
result in the protection of these critical cells of antitu-
mor immunity...