... satisfactory inthe evaluation of nodal status in this patient group Since the highly cellular tissue in reactive lymph nodes may also show increased intensity, theroleof DWI and ADC in distinguishing ... tissue inthe uterine cervix and endometrium Inthe uterine myometrium, the ADC value may play a limited role due to the large overlap between sarcomas and benign leiomyomas Theroleof DWI for the ... enhancing cervical cancer (arrow) The tumor invades the cervical stroma (arrowhead) c DWI with b = 1,000 s/mm2 shows a well-defined hyperintensity mass inthe cervical area The shape ofthe uterine...
... Protein targeting to the microsomes requires the cotranslational insertion ofthe newly synthesized protein into the microsomal membrane, where the N-terminal hydrophobic signal sequence ofthe ... mitochondria-targeting signal inthe yeast system Mitochondrial localization of intact CYP2E1 in yeast cells Because ofthe existing ambiguity inthe literature on the nature and extent of CYP2E1 import into ... consistent with the model suggesting a transmembrane topology of CYPs with a single N-terminal membrane anchor and most ofthe remaining protein exposed to the cytosolic side [15,17,30,31] The intramitochondrial...
... lysine reduces the probability of forming the fully closed form ofthe protein The results obtained with the K22V/R120K double mutant protein point toward a central roleof arginine 120 inthe ... enthalpies of binding and stoichiometries were determined from the binding isotherm by fitting a : binding model to the data using the software provided by the manufacturer Results Reaction of fosfomycin ... chain of K22 participates in fosfomycin binding, thus providing a rationale for the loss of fosfomycin binding to the K22V and K22E mutant proteins However, two other positively charged amino...
... iron-peroxo intermediate [11] The sum of these ndings points at the involvement of more than one active oxidant inthe diverse types of P450-catalyzed substrate processing [1215] The goal ofthe present ... reect ring opening of an epoxide intermediate at either of its two C-O bonds [219,220] The sum of these ndings strongly invokes the notion of oxygen activation during redox cycling ofthe diverse ... alterations inthe environment can cause drastic changes inthe reactivity ofthe active species [76] Further support in favour ofthe idea ofthe involvement of a high-valent iron-oxene in P450...
... Regional Learning Alliance – workforce development and training/collaborations with business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern Allegheny ... $28,000 in average annual salary) Preserving Value Continuing education is important to preserving the market value of specialized education – particularly in professional fields Continuing education ... Shippensburg University Small Business Initiative inthe Frehn Center for Management; offering information and assistance to individuals and groups planning to start a new business Best Practice Highlights...
... Amino–aromatic interactions in proteins FEBS Lett 203, 139–143 19 Chakrabarti, P & Samanta, U (1995) CH/, p interaction inthe packing ofthe adenine ring in protein structures Advan Protein ... determined as part ofthe investigation into the shielding from solvent ofthe electrostatic interaction between Asp113 and His210 With increasing NaCl, the maximum activity decreased, while the ... deviation, the solvent ASA ofthe side-chain of His210 increased with the decrease in size ofthe side-chain at residue 169 (Table and Fig 3A) However, the ASAs of Asp113 and His57 remained constant...
... Ala219 ofthe catalytic site and His135 ofthe Mg2+ binding site The most striking result was the loss ofthe psychrophilic character of mutant W260K/A219N (as reflected by a threefold increase ofthe ... value in this temperature range is considerably lowered On the basis ofthe model, the behavior ofthe G261A variant can be interpreted in terms of constraints introduced by the Ala side chain The ... our incomplete understanding ofthe relation between enzyme properties and conformational flexibility limits the exploitation ofthe full potential of protein engineering inthe redesign of psychrophilic...
... by the C domain ofthe initiation module of daptomycin That DptE and DptF are involved inthe lipidation process of daptomycin was first shown by Miao et al [1] In their work, the daptomycin gene ... tryptophan ofthe nonribosomally synthesized peptide is necessary Here, we report the results of a steady -state kinetic analysis of DptE The aim of this kinetic study was to determine the specificity of ... is GLDSV, indicating that this putative ACP domain is one ofthe few ACPs in which valine replaces isoleucine (I) or leucine (L) inthe conserved sequence To determine whether DptF is the putative...
... evaluate the OS-fitness ofthe clone, the ratio ofthe specific absorbance inthe presence of 10 lgÆmL)1 HEL to that inthe absence of HEL was taken as an index To analyze the effect ofthe type of each ... clarify the effect ofthe interface mutations on the antigenbinding affinity To investigate systematically this unsought relationship between the antigen-binding affinity of Fv and the VH ⁄ VL interaction ... antigen binding, this ‘increasing the affinity by increasing the VH ⁄ VL interaction’ might represent a mechanism of increasing Fv affinity This is also supported by the kinetic study of purified...
... Cardie, Vincent Ng, David Pierce, Chris Buckley Examining theroleof statistical and linguistic knowledge sources in a general-knowledge que stion answering systemIn Proceedings ofthe 6th Applied ... hypernyms inthe answer semantic form Step 3: The assessment ofthe similarities of dependencies Inthe third step, two classes of similar dependencies are considered, generating unications ofthe ... example, inthe case of question Q209: Who invented the paper clip ?, the expected answer type is P ERSON and so is the subject ofthe verb invented , lexicalized as the nominalization inventor...
... change their brand attitude, may suggest an interesting implication for the new brand advertising strategy Instead of focusing on the content ofthe message which only emphasizes the benefits ofthe ... situational conditions of gift-giving may differ according to characteristics ofthe gift-giving occasion, whether the presentation ofthe gift is public, private, or anonymous, and whether the gift is ... of mixed feelings Merton and Barber (1976) described the sociological ambivalence as follows: “ the ambivalence is located inthe social definition of roles and statuses, not inthe feeling-state...
... important for explaining wilt Inthe case of income, youth living in low-income households experience higher levels of wilt (45%) than youth living in either modest-income (35%) or high-income (23%) ... financing school Conley (2001) finds that a doubling of net worth results in an 8.3% increase inthe probability of attending college Further, when net worth is included inthe model, Black youth are ... youth Youth savings Youth were asked in 2002 whether they had a savings or bank account in their name If they had an account, they were also asked whether they were saving some of this money for...
... that the increase of Glc6P inthe presence of S4048 was caused by the inhibition of Glc6P hydrolysis inthe absence of detectable changes in glucose phosphorylation S4048 causes inactivation of ... [31], for evaluating theroleof Glc6P, we determined the effect of different inhibitor concentrations on the Glc6P content and the rate of glycogen synthesis in hepatocytes incubated with 15 ... Harndahl et al ¨ levels through the interaction of glucokinase with binding proteins [5,6] The glucokinase regulatory protein (GKRP) is a specific inhibitor of glucokinase [5] and also a nuclear...
... is causing increased weather volatility with the effects increasing in intensity in coming years Warming may induce sudden shifts in regional weather patterns such as the monsoon rains in South ... here for theprivatesector are discussed above in this chapter The contributions envisaged inthe table provide a useful segue into conceptualizing theroleofthe public sector and of international ... and other privatesector financing for climate adaptation investments and catalyze ongoing sustainable investments in these sectors beyond the initial PPCR investments Financial Sustainability:...
... the short ones) have all zeroes in them In other words, none ofthe bigrams from the training set appears in these reviews This suggests that the main problem with the bigram model is likely to ... Following Pang et al (2002), we use frequency as presence In other words, the ith element ofthe document vector is if the corresponding unigram is present inthe document and otherwise The resulting ... relation is capturing two different situations, one in which the author himself likes the movie, and inthe other, the author’s cousin likes the movie The overgeneralization resulting from these “stemmed”...
... strong indications for the involvement of a bacterial P450 inthe hydroxylation of octane in Rhodococcus rhodochrous, theroleof bacterial P450s in alkane degradation in addition to the well-established ... biological functions The proteins displaying the lowest similarity to the other P450s are those involved in oxylipin biosynthesis (2–6% amino acid identity) This can be explained in part by their bifunctional ... enzymes The FUM6 protein (CYP505B1) intervenes in one ofthe first steps in fumonisin synthesis by hydroxylation ofthe polyketide-amino acid at C-14 and C-15 (Fig 3) Fum6 deletion mutants of F verticilloides...
... the transaction from the vantage point of firm A, the floatingrate payer The cost of synthetic floating-rate financing is determined by the cost of servicing fixed-rate debt plus the net cost ofthe ... to the desire on the part of firms to hedge cash flows against the effects of interest rate volatility The timing ofthe appearance of interest rate swaps, coming as it did during a period of volatile ... systemof margin requirements, along with the guarantee ofthe exchange clearinghouse (which, in turn, is jointly backed by the paid -in capital ofthe clearinghouse member firms) This system of...
... unfolding of one ofthe I27 modules inthe chain Unfolding then extends the overall length ofthe protein, relaxing the pulling force to a low value As the slack inthe length is removed by further ... gain insight into theroleof solvent hydrogen bonds in protein unfolding, we repeated these SMD simulations of force unfolding ofthe I27 protein in D2O The simulations were completed using the ... b-strands near the amino terminus ofthe protein domain causes an initial extension ofthe protein, before the unfolding transition state is reached.[53] The hump observed both inthe force-extension...