... loss of penicillin binding Arginines 306 and 307 Fig Proposed binding mode for penicillin N to the iron(II)-2-oxoglutarate complex of DAOCS, showing possible involvement of selected residues The ... The third type of mutant, represented by arginines 306 and 307, are located inthe C-terminus They appear to modulate the activity ofthe C-terminus, which encloses the DAOCS active site during ... proposed mode of penicillin binding by DAOCS [1,12] a key feature of which is that arginines 160 and 162 bind to the carbonyl and/ or carboxylate ofthe bicyclic b-lactam nucleus, with the pro-S methyl...
... game theories New findings out ofthe thesis This thesis presents the following new findings (1) New findings related to theory (a) A new economic equation to relate two levels of sustainable ... to the right of OS line as long as the points are to the left ofthe vertical S line which represents the general sustainability line Gist of Chapter 2: ENVIRONMENTAL CONSERVATION AND TRADE The ... agreements mathematically in terms of environmental conservation The proposed thesis is, therefore, unique, original and very challenging in this aspect The followings are some ofthe important...
... depending on the organism andthe amino acid In C glutamicum, both the histidine and serine biosynthetic genes are under strong positive stringent control [18], andthe his operon in E coli and ... interpretation ofthe results since the changes observed include responses both to the increase in ppGpp concentration, and to the ppGppindependent effects of starvation The levels of ppGpp produced in this ... ppGpp-repressed andthe ppGpp-induced gene lists, including five from the cda cluster All appear repressed inthe 30 minute sample, but induced inthe 60 and 90 minute samples, possibly reflecting different...
... shown inthe Figure 1.3 Inthe case of public goods, the amount supplied into the market is larger than that of private goods Inthe Figure 1.5, Q2 is the amount of supply The cost of purchasing ... economic theories which are introduced inthe Chapter ofthe thesis By applying economic theories, the roles and mechanisms of international agreements in conservation of global environmental assets ... reform and intellectual property rights, are also discussed inthe Chapter ofthe Thesis (2) Limitation ofthe Study However, there are a few limitations in writing the proposed thesis Functions of...
... that the point mutations of C22 or C28 affect either cell surface binding or appropriate trafficking of virions during infection Campos and Ozbun observed indistinguishable cell surface binding and ... bridging or for hydrogen bonding, we tested the impact of C22S and C28S mutations upon both RG-1 binding and viral infectivity Either ofthe C22S and C28S mutations prevented the recognition of ... differences in binding and trafficking between the wild type andthe C22S or C28S mutant HPV16 pseudovirions as viewed at h, h or 20 h post infection by immunofluorescent staining ofthe virions...
... respectively, we examined the effect of IL-17 on the production of M-CSF and TNF-a inthe presence of indomethacin to block the effect of endogenous PGE2 Inthe presence of indomethacin, IL-17 significantly ... resolution of inflammation Page of 11 Proinflammatory cytokines, including IL-17 and TNF-a, play a critical roleinthe progression of synovitis and joint destruction, mainly through activation of NF-B, ... IL-8 and matrix metalloproteinases (MMPs), in FLS Among other cytokines, both TNF-a and IL-6 have been shown to play a pivotal roleinthe progression of RA The importance of TNF-a and IL6 in the...
... expression of sPLA2-III in normal rat CNS were at the highest level inthe brainstem and spinal cord It was localized inthe spinal trigeminal nucleus, further supporting its roleinthe nociceptive ... mRNA and protein expression of sPLA2-IIA were at high levels inthe brainstem and spinal cord Moreover, sPLA2-IIA was also localized inthe spinal trigeminal nucleus ofthe brainstem andthe dorsal ... cell bodies and dendrites inthe spinal trigeminal nucleus andthe dorsal and ventral horns ofthe spinal cord Electron microscopy ofthe spinal cord showed that sPLA2-IIA was localized in dendrites...
... immunolabeling of sPLA2-IIA inthe spinal trigeminal nucleus ofthe brainstem and dorsal horn ofthe cervical spinal cord is consistent with previous findings of an important roleof sPLA2 in nociceptive ... the normal CNS Ofthe isoforms, sPLA2-IIA mRNA expression was highest inthe brainstem and spinal cord suggesting that this could be the most relevant isoform inthe ascending pain pathway Western ... showed bands at 14 kDa of sPLA2-IIA in homogenates from brainstem and spinal cord and a second band at approximately 30 kDa inthe spinal cord The second band could be due to dimerization of sPLA2-IIA...
... levels of mRNA and protein inthe brainstem and spinal segments sPLA2-IIA was also localized to the dendrites in spinal trigeminal nucleus and dorsal horn of spinal cord The expressions of sPLA2-IIA ... highest levels inthe brainstem and spinal segments The enzyme was localized to dendrites in spinal trigeminal nucleus, supporting its rolein ascending pain pathway External application of sPLA2-III ... as orofacial pain (McNeill and Dubner 2001) Orofacial pain is one ofthe most widespread pains experienced by an individual and is different from the pain sensation derived from the rest of the...
... transmission inthe CNS likely to occur prior to the secretion ofthe sPLA2 domain ofthe sPLA2-III into the extracellular space (Murakami et al 2005) The presence of either C or N or both terminals ofthe ... Chapter Roleof Group IIA sPLA2 in nociception In contrast to the forebrain, dense labeling for sPLA2-IIA was detected inthe brainstem and spinal cord Dense labeling was observed in neurons ofthe ... well-established rolein inflammation and inflammatory diseases (Nevalainen et al 2000) and thus, inhibition of sPLA2 would prevent the formation of inflammatory eicosanoids prior to the COX reaction in which...
... during the acute phase of infection In conclusion, our findings provide new insight into theroleof PTX3 in acute alphaviral infection The newly identified roleof PTX3 in enhancing RRV infection ... N-terminal domain is crucial for PTX3 binding to RRV and PTX3-mediated enhancement of RRV infection However, removal ofthe C-terminal domain did affect the ability ofthe N-terminal domain of PTX3 ... early infection and assists in rapid recovery inthe latter stages ofdisease Additionally, the absence of PTX3 also reduced the level of viremia and viral load inthe ankle joints of RRV-infected...
... hypothesized that H2S may also play a similar role to NO in wound healing inthe rat 1.3 Thesis Overview and Scope The aim ofthe work presented in this thesis is to determine theroleof H2S in ... inhibitor of H2S synthesizing and H2S donor; assembly of hydrogel in wound dressing andthe study ofthe PAG-incorporated hydrogel The details of materials and methods for this project are contained in ... time points to examine tissue H2S synthesizing activity and inflammation inthe exponential and post-exponential phase inthe wound healing process H2S synthesizing activities in liver and skin for...
... institutions educating medical doctors inthe United Republic of Tanzania, although one of them was still in start-up phase andthe other inthe middle of an administrative crisis, so these institutions ... the influence of training institutions As, at the time of writing, these students are not yet working out inthe field, however, it is not possible to examine the residency training factors Rural ... wrong in developing training programs that ultimately leave their students demotivated? Have the medical training institutions failed to meet the training needs of “clinically-oriented” students and...
... tract of fish could offer new possibilities inthe removal of nitrogen compounds in aquaculture Themicrobiotaofthe GI tract plays an important roleinthe digestion and chemical processing ofthe ... lower the amount of fish meal, one ofthe major components of fish food, inthe food for these fish Furthermore, it shows that the gut microbes are probably important inthe protection ofthe host ... vitamin B12 producing ability ofthe intestinal microflora of fresh-water fish Aquaculture 92:267–276 Sugita H, Miyajima C, Kobayashi H, Deguchi Y (1990) Distribution of microflora inthe intestinal...
... ability of ICAs to succeed, strengthening their sense of accomplishment, and reinforcing the fact that assistance was at hand Table lists in more detail the essence of establishing and maintaining ... because ofthe need for ongoing dialogue and collaboration, and as contingent in terms ofthe pre-determined evidence-based goal ofthe QUERI project, the complexity of involved changes, andthe ... various roles of "intermediaries and influentials" inthe transfer of knowledge were reviewed, revealing persistent confusion regarding both standard definitions of individual roles and cross-role...
... focussing on the individual traits of a person as well as the situation the individual found themselves in (Hollander and Julian, 1970) These theories are also known as contingency theories of leadership ... Hence, the behavioural theories can be viewed as limited in raising the profile of women in management However, during this period of research, there was an emerging recognition ofthe importance of ... and enabling of others to help achieve the goals ofthe organisation Furthermore, the ability to control others is given no prominence in this recent definition of leadership A brief review of...
... on supply and demand of funds inthe rural areas andthe risk of lending; the floating band for lending rate of urban financial institutions will be further expanded while control of general ... booking system ofthe CGSDTC andthe bond trading system ofthe inter-bank lending centre The trading system ofthe national inter-bank lending centre provides pricing information, settle the bond ... bonds Inthe case ofthe latter, commercial banks trade with investors at the prices they offer through their outlets, and provide depositing and clearing services to the investors B Roles of the...
... involved in ligand binding, presumably abolishing the interaction with signaling partners The remaining mutations alter amino acids located outside the ligand-binding pocket and reduce protein ... the linker B kinase region of SYK The PH domain of TFKs usually binds to phosphatidylinositol-3,4,5-trisphosphate, thereby bringing them in close proximity to other membrane-tethered signaling ... SH2 and kinase domains of BTK with coloring of residues affected by missense mutations Top left: locations ofthe missense mutation inthe BTK PH domain; arginine 28 is in dark blue, encircled in...
... useful in determining a) the efficacy of BCG vaccine in HCWs or b) the effects on efficacy ofthe vaccine strain administered Vol 45 / No RR-4 MMWR andthe vaccinee’s age at the time of vaccination ... for Disease Control and Prevention Theroleof BCG vaccine inthe prevention and control of tuberculosis inthe United States: a joint statement by the Advisory Council for the Elimination of ... million vaccinees in Sweden and Finland, respectively (46 ) Regional increases inthe incidence of BCG osteitis have been noted following changes in either the vaccine strain or the method TABLE...
... Philip, and James Weston 1998 “Small Business Lending andthe Changing Structure ofthe Banking Industry,” Journal of Banking and Finance, August Sullivan, Richard J 2000 “How Has the Adoption of Internet ... Berger, Allen N., and Gregory F Udell 1998 The Economics of Small Business Finance: The Roles of Private Equity and Debt Markets inthe Financial Growth Cycle,” Journal of Banking and Finance, August, ... understanding issues facing community banks I THE CURRENT ROLEOF COMMUNITY BANKS The banking system inthe United States has always been unique inthe sense of containing large numbers of small...