... was introduced into DT40cells. Ig-b gene expression, acetylation of H3 and H4histones, and the remaining DHSs inthe deleted cellswere examined to determine the roles of these DHSson the ... appeared to beinvolved inthe transactivation ofthe region which had the highest enhancing activity ofthe three DHSs. The state of acetylation in H3 and H4 histones and dime-thylation inthe H3 histone ... state ofthe cells with anydeletion inthe regions I–IV inthe Ig-b locus, judgedby DHSs as the indicator, was the same as that in pre-deletion cells, the region required for the maintenanceof...
... to be involved in binding of the surface acarbose caused reduction of enzymeadsorption on starch, proving that these amino acidsare involved in starch binding site in spite differing in a key ... accuracy, shows clearly the in uence of cryo-cooling, which is manifested in shrinkage ofthe mole-cule and lowering the volume ofthe unit cell. Inthe structure ofthe com-plex, two acarbose ... atwo-domain structure, the small domain playing the roleof binding the enzyme to starch, allowing the lar-ger catalytic domain to hydrolyze the starch substrate.We showed previously that the S....
... basis to integrate with such professional colleagues on the world. The Association has theroleof coordinating the activities ofthe members in order to protect the interests ofthe members ... members in developing professional skills, improving business efficiency and protecting the legal interest of the members inthe import-export goods freight forwarding activities ofthe S.R. of ... out relatively small and growing, learning and expanding. With their experiences, they have learned the value of offering quality services. Inthe way of growing, they have also open branches...
... UniversityRegional Learning Alliance – workforce development and training/collaborations with business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern Allegheny ... providing assistance to disadvantaged businesses in securing PennDOT contracts Impact of University OperationsInvestments in higher education help create sustainable economic development leading ... business and industry/entrepreneurial activity; providing business development assistance TheRoleof Public Regional Universities in Community and Economic Development December 6, 2005 Indirect...
... designed on the basis of side-chain packing criteriafrom a modelled structure ofthe enzyme resulted in restor-ation ofthe energy of activation to the levels ofthe nativeenzyme and in an increased ... 1). The mutantG261A/Y269A exhibits an Eaalmost the same as inthe case ofthenativeenzyme(Table1).Thermal inactivation of mutant and wild-type enzymes In order to investigate the effects of ... flexibility limits the exploitation ofthe fullpotential of protein engineering inthe redesign of psychro-philic enzyme properties [15]. In particular, the effects of local flexibility in psychrophilic...
... antigen in itself [7,20]. Atleast for these antibodies, theroleofthe VLdomainmight be to increase the affinity by supporting the VHdomain. The phenomenon may also be observed in the chain ... Although the Fv was designed based on HyHEL-10, it is not clearwhether or not H39 is dominantly tuning the VH⁄ VLinteraction of other Fvs, including HyHEL-10. In addition, the effect ofthe H39 ... clarify the effect ofthe interface mutations on the antigen-binding affinity. To investigate systematically thisunsought relationship between the antigen-bindingaffinity of Fv and the VH⁄ VLinteraction...
... example, inthecaseof questionQ209: “Who invented the paper clip ?”, the expected answer type is PERSON and so is the subject ofthe verb invented , lexicalized as the nominalization inventor. ... mountain; (b) lava IS-PART of vol-cano, and moreover it is a part coming from the inside; and (c) fragments of lava have all the prop-erties of lava, the following question semantic TheRoleof ... “Where did the ukulele originate ?”, the expected answer type isLOCATION. Inthe paragraph the ukulele intro-duced from Portugal into the Hawaiian islands”contains two named entities ofthe category...
... of GSK3 (using Li or SB-415286)appears to be sufficient for inducing activation of GS in muscle and fat cells, and that inhibition ofthe kinasepotentiates insulin action in muscle of insulin-resistant ... (1994) The inhibition of glycogensynthase kinase-3 by insulin or IGF-1 inthe rat skeletal muscle cellline L6 by wortmannin, but not rapamycin: evidence that wort-mannin blocks activation ofthe ... phosphatidylinositol3-kinase, p70, S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement ofthe mammaliantarget of rapamycin (mTOR) pathway in the L-leucine-inducedup-regulation...
... their brand attitude, may suggest an interesting implication for the new brand advertising strategy. Instead of focusing on the content ofthe message which only emphasizes the benefits of ... gift giving is instrumental in maintaining social ties and serves as a mean of symbolic communication in social relationship. Most ofthe researches before and after the appearance of Sherry’s ... described in details the stages ofthe whole gift-exchange processes, researchers have examined the influence of many variables within these stages. This model divides gifting activities into...
... school. Conley (2001) finds that a doubling of net worth results in an 8.3% increase inthe probability of attending college. Further, when net worth is included inthe model, Black youth are ... Beyond these basic demographic factors, economic factors may also be important for explaining wilt. Inthecaseof income, youth living in low-income households experience higher levels of wilt ... youth. Youth savings. Youth were asked in 2002 whether they had a savings or bank account in their name. If they had an account, they were also asked whether they were saving some of this money...
... that the increase of Glc6P inthe presence of S4048 was caused by the inhibition of Glc6P hydro-lysis inthe absence of detectable changes in glucosephosphorylation.S4048 causes inactivation of ... glu-cokinase and hexokinase I in distinct pools [3,24], orby the involvement of mechanisms, additional toGlc6P, in mediating the effects of glucokinase over-expression. As glucokinase binds ... control of glycolysis and glycogen synthesis by glucokinase overexpres-sion. The validity of S4048 for testing theroleof Glc6P was supported byits lack of effect on glucokinase binding and...
... documents and find that the fea-ture vectors corresponding to some of these docu-ments (particularly the short ones) have all zeroes in them. In other words, none ofthe bigrams from the training set ... cap-turing two different situations, one in which the author himself likes the movie, and inthe other, the author’s cousin likes the movie. The over-generalization resulting from these “stemmed” ... available.612 Proceedings ofthe COLING/ACL 2006 Main Conference Poster Sessions, pages 611–618,Sydney, July 2006.c2006 Association for Computational LinguisticsExamining theRoleof Linguistic Knowledge...
... tightbinding affinity was demonstrated towards lauric acid,resulting inthe synthesis of mainly x-1 hydroxylatedlauric acid, suggesting a roleinthe lipid oxidativemetabolism. Interestingly, the ... occurring in the soil. Furthermore, branched chain fatty acids make up80% ofthe fatty acid content ofthe Bacillus sp. mem-branes and when the hydroxylation of these substrateswas studied in ... enzymes. The FUM6 protein (CYP505B1) inter-venes in one ofthe first steps in fumonisin synthesis byhydroxylation ofthe polyketide-amino acid at C-14and C-15 (Fig. 3). Fum6 deletion mutants of F....
... the transaction from the vantage point of firm A, the floating-rate payer. The cost of synthetic floating-rate financing is determined by the cost of servicing fixed-rate debt plus the net cost of ... to the desire on the part of firms to hedge cash flows against the effects of interest rate volatility. The timing ofthe appearance of interest rate swaps, coming as it did during a pe-riod of ... argue, trading in interest rate swaps has helped to complete forward markets and to lower the cost to firms of managing their exposure to interest rate risk. The Role for Hedging inthe Theory of Corporate...