the role of supraspinal gaba and glutamate in the mediation and modulation of pain
Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx
... N-linked oligosaccharide side-chains are important for the GABA transport activity 1-Deoxymannojirimycin inhibits the GABA- uptake of GAT1 In order to gain further insight into the role of the ... N-glycans, in particular their terminal structures, are involved in regulating the GABA translocation of GAT1, but not in binding of GAT1 to GABA Transport of GABA by GAT1 across the cell membrane ... activity of the GABA transporter Defective N-glycosylation results in reduction of the stability of GAT1 In order to study the in uence of the N-glycosylation and N-linked oligosaccharides on protein...
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Báo cáo lâm nghiệp: " The role of glutamine synthetase, glutamate synthase and glutamate dehydrogenase in ammonia assimilation by the mycorrhizal fungus Pisolithus tinctorius" ppt
... primarily into the amide of glutamine by the activity of GS, and transferred to glutamate- amino by glutamate synthase activity Inhibition of GS and glutamate synthase blocked the synthesis of glutamine ... marked increase in the and glutamine pools after h in the fresh medium (Fig 3a) Glutamate levels remained constant after h but the glutamine concentration continued to increase up to h indicating ... thus there was no incorporation of ammonia into glutamate by GDH After h the glutamine concentration peaked and remained stable, indicating feedback control of GS Inhibition of aminotransferases...
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Báo cáo y học: "Enhanced glutamate, IP3 and cAMP activity in the cerebral cortex of Unilateral 6-hydroxydopamine induced Parkinson’s rats: Effect of 5-HT, GABA and bone marrow cell supplementation" ppsx
... http://www.jbiomedsci.com/content/18/1/5 by linear regression analysis by plotting the specific binding of the radioligand on the X-axis and bound/free on the Y-axis The maximal binding is a measure of the total number of receptors ... present in the tissue and the equilibrium dissociation constant is the measure of the affinity of the receptors for the radioligand The Kd is inversely related to receptor affinity Quantification of ... acid) was infused into the right Substantia nigra Pars compacta (SNpc) at a flow rate of 0.2 μl/min After stopping the infusion of the toxin, the probe was kept in the same position for a further...
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Circuit theory of finance and the role of incentives in financial sector reform
... profitability is declining The internalization of information within the same institution may thus enhance intra-circuit and inter-circuit stability by reducing the incentive to overfinancing The ... searching, inspecting, testing, evaluating, interpreting and judging are parts of the production process of information; disseminating information to the general public through reports or advertising ... placing money with investment financial institutions in the capital market, and hold the remaining share in noninterest bearing, short-term bank deposits (eq 7) The share of savings going to the...
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Facts of Vietnam Freight forwarding industry and the role of Vietnam Freight Forwarders Association (VIFFAS) to the industry in international economic integration processhelpful to Oristar.doc
... The aims concentrate on co-operating, co-associating and helping members in developing professional skills, improving business efficiency and protecting the legal interest of the members in the ... forwarding activities of the S.R of Vietnam, and on this basis to integrate with such professional colleagues on the world The Association has the role of coordinating the activities of the members ... experts involving in Freight Forwarding and having high professional skills and abilities to contribute to the realization of the objectives and duties of the Association, may be invited to join the...
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The role of language in adult education and poverty reduction in Botswan
... Botswana maintains the hegemony and the gap between the poor and the rich, the major and minority groups In order to redress poverty the adult education program needs to be aware of the social ... knowledge of the minority and poor people and use them to mobilize the poor and minorities who are struggling for the betterment of their conditions It could mobilize the so called minorities ... oppose their status and challenge the hegemony of the majority communities in Botswana 31 In most parts of the world, education is for the most part the preserve of the few (elites) The choice of...
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Tài liệu The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States: A Joint Statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices docx
... useful in determining a) the efficacy of BCG vaccine in HCWs or b) the effects on efficacy of the vaccine strain administered Vol 45 / No RR-4 MMWR and the vaccinee’s age at the time of vaccination ... Control and Prevention The role of BCG vaccine in the prevention and control of tuberculosis in the United States: a joint statement by the Advisory Council for the Elimination of Tuberculosis and the ... resurgence in the incidence of TB occurred in the United States and included increases in the number of TB cases among adults and children and outbreaks of multidrug-resistant TB (MDR-TB) involving...
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Tài liệu Egypt''''s Water Warriors : Water Pollution in Egypt and the Role of NGOs in Reaching Integrated Management ppt
... chemical and microbiological properties of groundwater in Saint Katherine, South Sinai, Egypt and exploring the diversity, occurrence and distribution of fungal taxa in groundwater in South Sainai, ... to the natural protectorate law and the decision of the Prime Minister regulating to activities inside the protectorates in addition to the inefficiency of the biological treatment project of ... Azeem was one of a few Media reported the progress in increasing interest.[19],[20].to investigate the amount and seriousness of pollution caused by factories dumping their waste in the Egyptian...
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Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf
... confirming the role of endogenous FDX + FDXR in supporting the activity To further confirm the role of endogenous FDX + FDXR in supporting the catalytic activity, we transformed the FDX (Yah1)- and ... mitochondria-targeting signal in the yeast system Mitochondrial localization of intact CYP2E1 in yeast cells Because of the existing ambiguity in the literature on the nature and extent of CYP2E1 import into ... Protein targeting to the microsomes requires the cotranslational insertion of the newly synthesized protein into the microsomal membrane, where the N-terminal hydrophobic signal sequence of the...
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Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
... enthalpies of binding and stoichiometries were determined from the binding isotherm by fitting a : binding model to the data using the software provided by the manufacturer Results Reaction of fosfomycin ... replacement of R120 by lysine reduces the probability of forming the fully closed form of the protein The results obtained with the K22V/R120K double mutant protein point toward a central role of arginine ... chain of K22 participates in fosfomycin binding, thus providing a rationale for the loss of fosfomycin binding to the K22V and K22E mutant proteins However, two other positively charged amino...
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Tài liệu Báo cáo khoa học: The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase) pptx
... supercomplexes and the effect of the absence of intact complex I, but the results are too preliminary in this regard Heterologous expression of the ESSS-HA subunit The localization of the ESSS subunit in the ... N-terminal domain is involved in protein–protein interactions with other hydrophilic domains of neighboring integral membrane subunits, and interspecies interactions are incompatible From the comparative ... to form a domain on the matrix side, and 36 form a domain extending into the intermembrane space In the third mutant (V79-G35) one might expect a protein to be inserted into the inner membrane,...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
... iron-peroxo intermediate [11] The sum of these ndings points at the involvement of more than one active oxidant in the diverse types of P450-catalyzed substrate processing [1215] The goal of the present ... alterations in the environment can cause drastic changes in the reactivity of the active species [76] Further support in favour of the idea of the involvement of a high-valent iron-oxene in P450 ... oxygen into the benzene ring of aniline to yield p-aminophenol [151] Formation of the oxygenating species has been recognized to be facilitated by the binding to HbO2 of aniline and some of its derivatives,...
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Tài liệu Báo cáo khoa học: The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins pdf
... at the base of the loop and may interact with other residues in the adjacent b2 and b3 strands, affecting conformation and tightness of the loop Next to this phenylalanine, the arginine residue ... domain in the processing of membrane-tethered mucins The mechanism by which the heavily glycosylated portion of these molecules is released at epithelial surfaces within the airway, the intestine ... shown in bold PCR conditions were as described previously The fragments were then cloned into the SpeI ⁄ XhoI sites of the polylinker in MUC1FDTR The remaining portions of the polylinker introduced...
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Tài liệu Báo cáo khoa học: Local stability identification and the role of a key aromatic amino acid residue in staphylococcal nuclease refolding pdf
... both the wild-type protein and mutants E142O and K133A Thermal analysis of protein unfolding The DSC curves of the wild-type protein and the mutants K133A, E142O, W140A and W140O are shown in Fig ... located in the C-terminal loop of SNase plays an important role in protein stability and conformational integrity During protein unfolding ⁄ refolding, the addition of 2.5 protons (both E75 and E129 ... been interested in demonstrating this concept by using N-terminal and C-terminal fragments of SNase as models for the study of folding and unfolding pathways For example, Choy & Kay [22] using...
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Tài liệu Báo cáo khoa học: A possible role of mitochondria in the apoptotic-like programmed nuclear death of Tetrahymena thermophila Takashi Kobayashi and Hiroshi Endoh docx
... in the process of DNA laddering (as is the case with EndoG) rather than in the production of large-sized DNA fragments, considering the timing of uptake of the mitochondria in the autophagosome, ... becomes acidic in the final step of PND [22,23] DePsipher staining of the macronucleus appeared initially during the stage of autophagosome formation, and persisted until resorption of the parental ... which appear to be involved in the final resorption of the parental macronucleus during PND in T thermophila, and suggested the involvement of mitochondria in this process [19] In mammalian apoptosis,...
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Tài liệu The Role of Public Regional Universities in Community and Economic Development doc
... business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern Allegheny County West Chester University Institute for Education, Excellence, and ... Collaboration with business and government Economic Development Programs and Initiatives Business accelerators and/ or entrepreneurial initiatives Linking teaching and research to business opportunities ... stable supply of knowledge and skills in high need areas Increase the size, diversity of skills and productivity of the labor force Dimensions of Social and Economic Value Regional public institutions...
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Tài liệu Investigating the Role of Poultry in Livelihoods and the Impact of Avian Flu on Livelihoods Outcomes in Africa docx
... et al 2008; Aning, Turkson, and Asuming-Brempong 2008; Obi, Oparinde, and Maina 2008; Omiti and Okuthe 2008) Therefore, information regarding the role of poultry in the livelihoods of small-scale ... culled No information is available on the costs of culling, diagnostic testing of samples, cleaning and disinfection, and other administrative costs (Obi, Oparinde, and Maina 2008) Regarding the impacts ... detail the role of poultry (both as a source of income and as an asset) in the entirety of the households’ income and asset portfolios Regarding the sources of data used in this study, for the West...
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Tài liệu Báo cáo Y học: Role of electrostatics in the interaction between plastocyanin and photosystem I of the cyanobacterium Phormidium laminosum ppt
... expected contributions of binding and electron transfer to DHà and DSà and estimate their relative importance in the light of the data in Table The contributions to DHà from binding are expected to ... between Cyt f and plastocyanin and/ or plastocyanin and photosystem I, and subsequently the nature of the interactions in the two lineages (hydrophobic in cyanobacteria, electrostatic in chloroplasts) ... the reaction up, and neutralizing or inverting the charge on basic residues slowed it down (Fig in [1], Fig in this paper) This indicates that the interacting sites on plastocyanin used for the...
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Tài liệu Báo cáo Y học: Steady-state kinetics of the glutaminase reaction of CTP synthase from Lactococcus lactis The role of the allosteric activator GTP in coupling between glutamine hydrolysis and CTP synthesis potx
... activation on the basis of the kinetic constants in Table 1, and those obtained for the glutaminase reaction in the presence of 0.1 mM each of UTP and ATP-cS (data not shown) Apparently, the value of Ka, ... 4C and Table 2) In another experiment similar to that in Fig 4C, the GTP activation of the glutaminase reaction and CTP synthesis was compared (Fig 5) In the absence of GTP, the rate of glutamine ... of enzyme activity prior to injection j, tj)1 is the time between injection j)1 and j, [S]syr is the concentration of the injectant in the syringe Analysis of initial velocity data Analysis of...
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Tìm thêm: xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008