... look forward to seeing relevant demonstration ofthe usefulness of this novel psychometric method in HRQOL research that fully encompasses the intent ofthe taxonomy, integrates the relevant properties ... addressed inthe Hankins' paper, and there is no explanation for how the use of Ferguson's Delta would enhance interpretability Although the use of Ferguson's Delta may someday improve our understanding ... References Hankins M: How discriminating are discriminative instruments? Health and quality of life outcomes 2008, 6(1):36 Kirshner B, Guyatt G: A methodological framework for assessing health indices...
... 'Understanding theRoleof Discriminative Instruments in HRQoL Research: Can Ferguson's Delta Help?' to which the answer is a definitive yes, subject to the constraints previously discussed Finally, ... Delta then indexes the degree to which the instrument makes valid discriminations Wyrwich suggests that the results of another study [6], in which the dichotomous scoring method ofthe GHQ-12 was ... were meaningful Recall that the value of Delta is derived from ordinal comparisons of persons that classify them as either the same or different Therefore, if a researcher doubts that an instrument...
... understanding of, and insight into, health outcomes Identification of a core set of psychological variables from the increasingly large number on offer, and consensus on the instruments used to measure them, ... emerging from the manuscript of Brionez and colleagues is how to deal with theroleof psychological variables in self-reported outcomes in ankylosing spondylitis and likely in rheumatology in ... critically reading the manuscript and Dr Wojciechowski, clinical psychologist, for the interesting discussion Competing interests The author declares that they have no competing interests Published:...
... Adjustment and theRoleof Bank Credit in Russia: Evidence from a 420 Firm's Qualitative Survey The main underlying question inthe above-mentioned conclusions rather brings back to the issue ofthe adjustment ... access-to-input for the worst in this sub-pool Conversely, the overbearing influence ofthe financial constraints inthe lower half is statistically associated with a rather low occurrence of real ... evolution ofthe same type of variables; their judgement on their actual and future behavior, including the type of constraints they face Some sets of answers are strongly cardinal, as for the current...
... of machine translation In Proceedings of HLT/NAACL Franz Josef Och and Hermann Ney 2002 Discriminative training and maximum entropy models for statistical machine translation In Proceedings of ... of a genuine improvement in translation quality This begs the question as to whether this is only a theoretical concern or whether Bleu’s inadequacies can come into play in practice Inthe next ... gives the interpretations ofthe scores When first evaluating fluency, the judges are shown only the hypothesis translation They are then shown a reference translation and are asked to judge the...
... i.e it is involved inthe maintenance of an ongoing Th1 response rather than part ofthe initial immunological decision-making process Inthe current study, the finding that production of IL-12 ... Western blot technique [16], the former being able to offer the high throughput of EIA combined with the individual protein testing capacity ofthe Western blotting Discussion To extend our knowledge ... each other in a variety of ways [20,24,25] The dominance of one of these subsets results in either a predominantly cellular (Th1-mediated) or an antibody (Th2-mediated) response [9] Therefore, the...
... expectations in some domains explained up to 13% ofthe variance in total joint replacement outcome [11,12], measured using either generic, joint-specific or painscale instruments In neither of these ... combination of both Either way, these findings in relation to the overestimation ofthe probable result of surgery highlight the importance of both routine outcome assessment and longitudinal studies of ... appeared to offer one ofthe most comprehensive, but simple and efficient, means of assessing the many domains/constructs of interest in arthroplasty patients Most ofthe individual scales inthe questionnaire...
... [3] The reason for these is based in a couple of problems First, there is a significant interobserver variability in histological typing [2,6] Second, determination of precise cut-off points ... Immunhistochemical Staging Hematoxylin-eosin-stained sections of all patients were available for the re-evaluation ofthe histologic diagnosis according to the commonly known WHO schema of 1999 [2-4] ... experience in clinical treatment of thymomas as a result of a retrospective single centre analysis done within a European university setting Theroleof a pseudocapsula and its clinical significance...
... (Ang-1) and angiopoietin-2 (Ang-2), play a fundamental roleinthe maintenance of vessel integrity Angiopoietin-1 (Ang-1) and Ang-2 are ligands ofthe endothelial receptor tyrosine kinase Tie-2, which ... regulator of endothelial function [14] Binding of circulating Ang-1 to the Tie-2 receptor protects the vasculature from inflammation and leakage, whereas binding of Ang-2 antagonizes Tie-2 signaling ... Although the number of controls in our study was small, the inclusion of a comparator group allows the assessment of possible effects of other asymptomatic coinfections, such as helminths and...
... raising the profile of women in management However, during this period of research, there was an emerging recognition ofthe importance of a concern for people inthe behavioural theories as being ... anything towards raising the profile of women in management, as the theory was constructed as a male model at a time when women were not visible in paid employment One ofthe off shoots ofthe ... enabling of others to help achieve the goals ofthe organisation Furthermore, the ability to control others is given no prominence in this recent definition of leadership A brief review of early...
... relies on the securities booking system ofthe CGSDTC and the bond trading system ofthe inter-bank lending centre The trading system ofthe national inter-bank lending centre provides pricing information, ... source of financing for enterprises, if their own capital is excluded In summary, the deepening process ofthe financial markets has rendered the dominance ofthe banking sector inthe financial ... in turn contributed to the financial stability not only in Asia but also inthe whole world Roleofthe international financial institutions ( IFIs ) The IFIs have played an active rolein financial...
... adults (39 ) The renewed interest in examining the indications for BCG vaccination inthe United States included consideration ofthe wide range of vaccine efficacies determined by clinical trials ... explore the sources ofthe heterogeneity inthe efficacy ofthe BCG vaccine reported inthe individual studies Using a model that included the geographic latitude ofthe study site and the data ... efficacy of BCG vaccine in HCWs or b) the effects on efficacy ofthe vaccine strain administered Vol 45 / No RR-4 MMWR and the vaccinee’s age at the time of vaccination The protective efficacy of BCG...
... understanding issues facing community banks I THE CURRENT ROLEOF COMMUNITY BANKS The banking system inthe United States has always been unique inthe sense of containing large numbers of small ... were not there, other financial services providers might readily step in to take their place This article examines theroleof community banks inthe U.S economy The first section ofthe article ... While community banks still comprise the vast majority of banks, the question arises whether their roleinthe banking system has declined to the point of insignificance This section shows that...
... through the exchange between subunits of either their N-terminal, or their C-terminal ends [33–35] We found that the behavior with the model membrane ofthe dimer in which the C-terminal ends ... geometry ofthe hinge loop after ligation Also in this case no clashes were detected at Electrostatic interactions and antitumor RNases the dimer interface ofthe models or inthe surroundings ofthe ... Nter are the C-terminal and N-terminal structural regions, respectively, ofthe two A and B monomers ofthe dimeric RNase The black circle between the monomers indicates the mass center ofthe dimer...
... N-linked oligosaccharide side-chains are important for the GABA transport activity 1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into theroleofthe ... misfolding of this protein, resulting in its partial retention inthe ER and its rapid digestion thereafter [16,19] Accordingly, our results indicate that the intracellular trafficking of N-glycosylation ... Aliquots were used for measurement ofthe remaining [3H]GABA and [14C]sucrose The protein concentration inthe supernatant was determined using the bicinchoninic acid protein assay reagent (Pierce, USA)...
... t is thein interaction ofthe results of these asynchronous processes that the process of comprehension is defined 4.1 The processes are independent ofthe knowledge representations defined ... defined than through other methods, because i t enables one to develop a broader perspective ofthe questions within an analysis ofthe hypothesis inthe cont e x t of a characterization ofthe ... activation of a l l meanings of each recognized word in HOPE, the determination ofthe phonetic representation of a recognized word determines the breadth of active competition amon meanings for...
... many of them have been pioneers inthe Latin American microfinance industry As of today, out of 15 Latin American members are active in microfinance These members are involved in different ways in ... unrivalled in scale, and outreach continues to grow in terms ofthe number of microborrowers Institutions providing microfinance in Asia play a critical rolein increasing the access to finance for ... very helpful in bringing microfinance into the spotlight not only in developing countries but also inthe developed world The awareness by policy makers about theroleof microfinance as a major...
... ambiguous the meaning ofthe visual image, the more influence is exerted by the musical score inthe process of interpreting the scene Music can convey the scope of a film, effectively communicating ... meaning through sound (including music), taking into account the director’s – and, therefore, the composer’s – intentions, the narrative content ofthe film, and the overall strategy ofthe director ... the relationship is invertible without changing the perceived meaning (i.e., it is equally valid to say that the music projects the meaning ofthe image or the image projects the meaning of the...
... However, the mechanistic roles of several of these residues are not described well and there is no example of mutational analysis of all of these residues inthe same enzyme To obtain an insight into ... 1), thereby confirming the crucial roleof Asp142 Catalysis in family 18 chitinases (Eur J Biochem 271) 259 In most ChiB structures, Asp142 is clearly defined, being either inthe ÔdownÕ or inthe ... positioned inthe ÔupÕ position rows and shows that inthe presence ofthe substrate, rotation of Asp142 towards Glu144 lowers the pKa ofthe latter by 0.8 pH units The calculated effects ofthe D140N...
... properties ofthe document containing the sentence and properties ofthe sentence itself Regarding the former type, two features come into play: the relevance score ofthe document (from the IR engine) ... evaluating answers to definition questions In HLT/EMNLP 2005 J Lin and D Demner-Fushman 2006a Theroleof knowledge in conceptual retrieval: A study inthe domain of clinical medicine In SIGIR ... the findings of Monz (2003), who made the same observation inthe factoid QA task There are a few caveats to consider when interpreting these results First, the test set of 25 questions is rather...