the role of nmr spectroscopy in understanding how proteins fold
báo cáo hóa học: " Understanding the role of discriminative instruments in HRQoL research: can Ferguson''''s Delta help?" docx
... addressed in the Hankins' paper, and there is no explanation for how the use of Ferguson's Delta would enhance interpretability Although the use of Ferguson's Delta may someday improve our understanding ... look forward to seeing relevant demonstration of the usefulness of this novel psychometric method in HRQOL research that fully encompasses the intent of the taxonomy, integrates the relevant properties ... Journal of clinical epidemiology 1992, 45(12):1353-1355 The second property of a discriminative instrument is a cross sectional relationship with a theoretical criterion or prediction, and again, in...
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báo cáo hóa học: " Discrimination and reliability: equal partners? Understanding the role of discriminative instruments in HRQoL research: can Ferguson''''s Delta help? A response" pptx
... Delta then indexes the degree to which the instrument makes valid discriminations Wyrwich suggests that the results of another study [6], in which the dichotomous scoring method of the GHQ-12 was ... 'Understanding the Role of Discriminative Instruments in HRQoL Research: Can Ferguson's Delta Help?' to which the answer is a definitive yes, subject to the constraints previously discussed Finally, ... establish the consistency with which discriminations are made Both Norman and Wyrwich raise the interesting issue of what constitutes a meaningful discrimination, and whether Delta is an index of such...
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Báo cáo y học: "Towards a better understanding of the role of psychological variables in arthritis outcome research" potx
... critically reading the manuscript and Dr Wojciechowski, clinical psychologist, for the interesting discussion Competing interests The author declares that they have no competing interests Published: ... understanding of, and insight into, health outcomes Identification of a core set of psychological variables from the increasingly large number on offer, and consensus on the instruments used to measure them, ... emerging from the manuscript of Brionez and colleagues is how to deal with the role of psychological variables in self-reported outcomes in ankylosing spondylitis and likely in rheumatology in...
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The role of leadership theory in raising the profile of women in management
... raising the profile of women in management However, during this period of research, there was an emerging recognition of the importance of a concern for people in the behavioural theories as being ... of the skills and attributes of women in management or leadership roles Contemporary theories The beginning of the gender difference theories marked a shift in the leadership literature, as the ... enabling of others to help achieve the goals of the organisation Furthermore, the ability to control others is given no prominence in this recent definition of leadership A brief review of early...
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Globalization: the Role of Institution Building in the Financial Sector _ The Case Study of China
... relies on the securities booking system of the CGSDTC and the bond trading system of the inter-bank lending centre The trading system of the national inter-bank lending centre provides pricing information, ... source of financing for enterprises, if their own capital is excluded In summary, the deepening process of the financial markets has rendered the dominance of the banking sector in the financial ... in turn contributed to the financial stability not only in Asia but also in the whole world Role of the international financial institutions ( IFIs ) The IFIs have played an active role in financial...
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Tài liệu The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States: A Joint Statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices docx
... adults (39 ) The renewed interest in examining the indications for BCG vaccination in the United States included consideration of the wide range of vaccine efficacies determined by clinical trials ... explore the sources of the heterogeneity in the efficacy of the BCG vaccine reported in the individual studies Using a model that included the geographic latitude of the study site and the data ... efficacy of BCG vaccine in HCWs or b) the effects on efficacy of the vaccine strain administered Vol 45 / No RR-4 MMWR and the vaccinee’s age at the time of vaccination The protective efficacy of BCG...
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Tài liệu The Role of Community Banks in the U.S. Economy pdf
... understanding issues facing community banks I THE CURRENT ROLE OF COMMUNITY BANKS The banking system in the United States has always been unique in the sense of containing large numbers of small ... community banks still comprise the vast majority of banks, the question arises whether their role in the banking system has declined to the point of insignificance This section shows that community banks ... were not there, other financial services providers might readily step in to take their place This article examines the role of community banks in the U.S economy The first section of the article...
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Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx
... through the exchange between subunits of either their N-terminal, or their C-terminal ends [33–35] We found that the behavior with the model membrane of the dimer in which the C-terminal ends ... geometry of the hinge loop after ligation Also in this case no clashes were detected at Electrostatic interactions and antitumor RNases the dimer interface of the models or in the surroundings of the ... region, and (b) their cytotoxic action This finding strongly suggests that the electrostatic surface potential of a defined 3D district of these proteins has a role in determining their cytotoxic...
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Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx
... assist the folding of newly synthesized proteins in the ER If N-glycosylation is inhibited, some glycoproteins fail to fold or assemble efficiently, resulting in a prolonged retention in the ER ... N-linked oligosaccharide side-chains are important for the GABA transport activity 1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into the role of the ... a misfolding of this protein, resulting in its partial retention in the ER and its rapid digestion thereafter [16,19] Accordingly, our results indicate that the intracellular trafficking of N-glycosylation...
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Tài liệu Báo cáo khoa học: "From HOPE en I''''ESPERANCE On the Role of Computational Neurolinguistics in Cross-Language Studies " pptx
... form the basis of the discussion I t is the in interaction of the results of these asynchronous processes that the process of comprehension is defined 4.1 The processes are independent of the ... results Because of the parallel activation of a l l meanings of each recognized word in HOPE, the determination of the phonetic representation of a recognized word determines the breadth of active ... questions in pointing out the value of applying a C methodology to crossN l i n g u i s t i c study Because of the import of articles in language processing, as b r i e f l y mentioned, how they are...
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Enterprise Adjustment and the Role of Bank Credit in Russia: Evidence from a 420 Firm''''s Qualitative Survey pdf
... evolution of the same type of variables; their judgement on their actual and future behavior, including the type of constraints they face Some sets of answers are strongly cardinal, as for the current ... access-to-input for the worst in this sub-pool Conversely, the overbearing influence of the financial constraints in the lower half is statistically associated with a rather low occurrence of real ... where indebted enterprises represent a much larger proportion of the total than in the other half of the pool Table 6C shows that the demand for credit is here only inertial The results of the...
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BEYOND MICROCREDIT: THE ROLE OF SAVINGS BANKS IN MICROFINANCE potx
... many of them have been pioneers in the Latin American microfinance industry As of today, out of 15 Latin American members are active in microfinance These members are involved in different ways in ... unrivalled in scale, and outreach continues to grow in terms of the number of microborrowers Institutions providing microfinance in Asia play a critical role in increasing the access to finance for ... very helpful in bringing microfinance into the spotlight not only in developing countries but also in the developed world The awareness by policy makers about the role of microfinance as a major...
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THE ROLE OF MUSIC COMMUNICATION IN CINEMA potx
... ambiguous the meaning of the visual image, the more influence is exerted by the musical score in the process of interpreting the scene Music can convey the scope of a film, effectively communicating ... meaning through sound (including music), taking into account the director’s – and, therefore, the composer’s – intentions, the narrative content of the film, and the overall strategy of the director ... the relationship is invertible without changing the perceived meaning (i.e., it is equally valid to say that the music projects the meaning of the image or the image projects the meaning of the...
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Báo cáo khóa học: Mutational and computational analysis of the role of conserved residues in the active site of a family 18 chitinase docx
... [20,26–31] However, the mechanistic roles of several of these residues are not described well and there is no example of mutational analysis of all of these residues in the same enzyme To obtain an insight ... positioned in the ÔupÕ position rows and shows that in the presence of the substrate, rotation of Asp142 towards Glu144 lowers the pKa of the latter by 0.8 pH units The calculated effects of the D140N ... enzyme in the preceding run Some of the pH profiles differed strongly from the wildtype profile, however, the profiles for the amide and corresponding alanine mutants were similar in all cases Together...
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Báo cáo khoa học: "The Role of Information Retrieval in Answering Complex Questions" ppt
... properties of the document containing the sentence and properties of the sentence itself Regarding the former type, two features come into play: the relevance score of the document (from the IR engine) ... evaluating answers to definition questions In HLT/EMNLP 2005 J Lin and D Demner-Fushman 2006a The role of knowledge in conceptual retrieval: A study in the domain of clinical medicine In SIGIR ... the findings of Monz (2003), who made the same observation in the factoid QA task There are a few caveats to consider when interpreting these results First, the test set of 25 questions is rather...
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The Role of Education Quality in Economic Growth* pdf
... additional schooling, the estimated schooling effect could include both the impacts of schooling and the fact that those continuing in school could earn more in the absence of schooling.2 For the most ... income levels mainly though speeding up technological progress, rather than shifting the level of the production function or increasing the impact of an additional year of schooling In sum, the ... student in a school in Ghana or Peru would gain the same amount of knowledge in any year of schooling as the average student in a school in Finland or Korea? Still, using the quantitative measure of...
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The Role of Rainfed Agriculture in the Future of Global Food Production doc
... trees The largest plant height was obtained using linings of stone and marble During the first year of the study, when the lining served only as mulch due to lack of rainfall, an increase of 33.3 ... crop yields in rainfed areas, even in the more marginal rainfed environments The continued application of conventional breeding and the recent developments in non-conventional breeding offer considerable ... showed an increase of farmers’ income of 23 percent for wheat in the 1:1 ratio plots, and a decrease in income variation of 19 percent The income of barley farmers was different, however, with the...
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The Role of Postal Networks in Expanding Access to Financial Services docx
... as Points of Access into the Financial System The Role of African Post Offices in Payments The Role of Post Offices in International Remittances The Role of Post Offices in Savings The Role of ... agreed between the ministries of finance, the IMF, and World Bank In the recent past in Africa, no distinction was made of the roles of the post as the mail provider, as owner of the post office network, ... Services The Role of Post Offices in International Remittances The Role of Post Offices in Savings The Role of Post Offices in Credit 5—Conclusion 16 17 17 17 18 19 20 21 21 21 Worldwide Landscape of...
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The Role of Bank Capital in the Propagation of Shocks potx
... for the role of bank capital in the transmission of shocks In the model, investors provide the bulk of loanable funds but not monitor firms receiving loans: this activity is fulfilled by banks However, ... lending Figure illustrates the sequence of events that unfold in each period 2.2 Final good production Final Good Assembly Competitive firms produce the final good by combining a continuum of intermediate ... after the onset of the shock, reaching a low point in the fourth period, at −0.45% below steady-state Overall, Figure shows that the various propagation mechanisms present in the model, in which the...
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Báo cáo khoa học: Kinetic and crystallographic analyses of the catalytic domain of chitinase from Pyrococcus furiosus – the role of conserved residues in the active site pdf
... important role in ‘cycling’ the pKa of catalytic Glu during catalysis [24,38] The mutation of the D1 residue to Asn (D140N) in SmChiB caused a 500 -fold decrease in activity [39] On the other hand, in ... substrate show that a number of amino acid residues contribute to the binding of the substrate by hydrogen bonding and ⁄ or hydrophobic interactions Using the ligplot program [31], we investigated the ... almost identical, but the D524A mutation resulted in a remarkable change in the conformation of the Glu526 side-chain The 2Fobs ) Fcalc electron density of the Glu526 side-chain in the D524A–substrate...
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