the role of manned submersibles in sedimentological and faunal investigations on the united kingdom continental shelf

báo cáo hóa học:" The role of tendon microcirculation in Achilles and patellar tendinopathy" doc

Ngày tải lên : 20/06/2014, 01:20

... body of the Achilles tendon, 2–6 cm proximal to the insertion, associated with tenderness and swelling In contrast, insertional tendinopathy of the Achilles tendon might involve various distinct ... or the combination of both [57] Non-invasive topical nitroglycerin in tendinopathy The rationale for the use of topical transdermal nitroglycerin in tendinopathy is based on the following animal ... least part of the pathophysiological process in tendinopathy of the Achilles tendon in its mid-portion area, at the patella tendon and in tendinopathies of the upper extremity such as in tennis...

13
675
0

The role of hydrogen sulfide in normal and ischemic heart

Ngày tải lên : 11/09/2015, 09:57

... abnormality in H2S level is a cause or simply a consequence of these diseases There is also growing interest in understanding the role of H2S in pain appreciation Administration of either NaHS ... intracellular Ca2+ concentration, ultimately determining the strength of contraction This important role explains the convergence of multiple signalling cascades regulating the activity of the L-type ... reticulum and the elevated free intracellular Ca2+ ([Ca2+]i) bind to the myofilament protein troponin C, which then switch on the contractile machinery (Bers, 2002) In addition, activation of PKA...

183
360
0

The role of variety seeking in short and long run revisit intentions in holiday destinations

Ngày tải lên : 08/08/2016, 22:23

... the consideration of temporal issues in the research of revisit intention, and the analysis of specific variety seeking The findings offer new insights into the role of the time perspective in ... and long run, aiming to identify the main differences The most outstanding findings are those concerning the influence of satisfaction and specific variety seeking on short and long run destination ... short and long term revisit intention The influence of brand and corporate image on consumer satisfaction has obtained strong support in the service marketing literature (Andreassen and Lindestad,...

14
556
0

Báo cáo y học: "Functional genomics analysis of low concentration of ethanol in human hepatocellular carcinoma (HepG2) cells. Role of genes involved in transcriptional and translational processes"

Ngày tải lên : 31/10/2012, 15:28

... expression of the ankyrin-repeat oncoprotein (gankyrin) in human hepatocellular carcinoma Gankyrin binds to the cell-cycle regulator CDK4 and the S6b ATPase subunit of the regulatory component of the ... ethanol injection The systemic application or the ingestion of ethanol induces a completely different pattern due to the reported ethanol-induced expression and activation of cytokines and chemokines ... chemokines in monocytes and macrophages (including Kupffer cells) [41, 42], and ethanol-induced mucosal injury in the upper gastrointestinal tract leading to increase in the permeability of the gut...

8
702
0

Báo cáo "The effect of Cu concentration in soil and phosphorous fertilizer on plant growth and Cu uptake by Brassia juncea L. grown on contaminated soils " doc

Ngày tải lên : 14/03/2014, 15:20

... reflected the concentration in soil The contents of Cu in plant increase upon the rates of Cu application, especially at the high rate of Cu above 100 ppm It can be said that the increase of rate of ... combination of phosphate application on heavy metal uptake [1, 4] The main purpose of this research is to investigate the relation between contents of Cu in soil and Cu accumulation in plant, and ... Meanwhile, the rate of biomass decreases only by 53% The results showed that the uptake of Cu by Brassica juncea L plants corresponded to the increasing level of Cu contamination of soil, while the...

5
590
1

Báo cáo y học: "Role of interleukin-7 in degenerative and inflammatory joint diseases" potx

Ngày tải lên : 09/08/2014, 10:23

... pathways In addition to its role in inflammation driven joint destruction, and its potential role in T cell-driven bone loss in the absence of prominent inflammation, direct harmful effects on cartilage ... cell-dependent bone loss [10] By giving a first glimpse of the direct effects of IL-7 on chondrocytes, the study of Long and colleagues contributes to our knowledge on the broad range of IL-7/IL-7R-driven ... & Therapy Vol 10 No van Roon and Lafeber suggest that this will be the case TNFα is a potent inhibitor of cartilage matrix synthesis and an inducer of cartilage degradation (by activation of...

2
331
0

Báo cáo y học: "Role of IL-33 in inflammation and disease" docx

Ngày tải lên : 11/08/2014, 03:20

... that injection of IL-33 into mice induces a profound eosinophilia [3], and has potent effects on this cell type, including induction of superoxide anion and IL-8 production, degranulation and ... ankylosing spondylitis and OA) Recently, the role of IL-33 in bone metabolism and remodeling has been studied with conflicting results Bone structure and metabolism are determined by the formation and ... [49] Furthermore, administration of blocking anti-ST2 antibodies or ST2-Ig fusion protein inhibited Th2 cytokine production in vivo, eosinophilic pulmonary inflammation and airways hyper-responsiveness...

12
517
0

Báo cáo y học: " Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts" pdf

Ngày tải lên : 13/08/2014, 20:22

... risk of severe infections and a combination of genetic variants in sequential molecules of the LPS-sensor consisting of TLR4 and its adaptor TIRAP/Mal The presence of TLR4 mutations in combination ... affecting the capability to sense invading microorganisms, but rather the appropriate initiation and modulation of the innate immune response These findings are supported by the fact that following ... frequent one being the Asp299Gly/Thr399Ile variation There have been conflicting reports on the influence of this SNP on severity of infections or outcome in prospective trials [11] Two SNPs within the...

11
429
0

Role of bcl 2 in metabolic and redox regulation via its effects on cytochrome c oxidase and mitochondrial functions in tumor cells

Ngày tải lên : 14/09/2015, 08:42

... binding and inhibition of anti-apoptotic Bcl-2 proteins or the direct activation of Bax and Bak They also exhibit varying specificities in their binding to other Bcl-2 family members (Willis and ... where the mitochondria play a central role in the induction of apoptosis The intrinsic pathway usually involves the translocation of cleaved Bid to the mitochondria, which in turn drives the activation ... involvement of Bcl-2, Tom20 and COX Vb in facilitating the translocation of COX Vb into the inner mitochondria compartment True to this, the data of this thesis provides the initial and defining lead...

78
267
0

Evaluation of loop mediated isothermal DNA aplification (LAMP) detection of salmonella spp in foods and listeria monocytogenes on environmental surfaces

Ngày tải lên : 30/09/2015, 10:11

... vehicle of transmission for pathogens to grow and make consumers sick Hence, monitoring of contamination in the food is crucial Advances in detection methods of pathogens in foods and environmental ... Validation on the naturally contaminated food matrices was conducted as well The second study was the detection of L monocytogenes on environmental surfaces at inoculum levels: 100, 101 and 102 ... highly likely that the interior of fruits could be contaminated through improper handling via cutting on cutting board and knife as it had been in contact with the external surface of the fruit 12...

82
415
0

Tài liệu The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States: A Joint Statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices docx

Ngày tải lên : 15/02/2014, 13:20

... vaccination These developments have prompted a re-evaluation of the role of BCG vaccination in the prevention and control of TB in the United States CDC, the Advisory Council for the Elimination ... re-evaluation of the role of BCG vaccination in the prevention and control of TB This updated report is being issued by CDC, the Advisory Committee for the Elimination of Tuberculosis, and the Advisory ... demonstrated in persons who had been vaccinated as adolescents or adults (39 ) The renewed interest in examining the indications for BCG vaccination in the United States included consideration of...

27
1.3K
3

Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafﬁcking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efﬁcient GABA-uptake activity of the GABA transporter pptx

Ngày tải lên : 19/02/2014, 17:20

... 1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into the role of the terminal structures of the N-glycans of GAT1, N-glycosylation processing of NNN was inhibited ... N-glycosylation, but not the terminal trimming of N-glycans is involved in the regulation of the stability and trafﬁcking of GAT1 It has been reported that a variety of molecular chaperones and folding ... DND, DGN and DDN contain only one N-glycosylation site, deﬁciency of terminal trimming of their N-oligosaccharides strongly affected their GABAuptake activity These indicate that the terminal structure...

14
654
0

Enterprise Adjustment and the Role of Bank Credit in Russia: Evidence from a 420 Firm''''s Qualitative Survey pdf

Ngày tải lên : 06/03/2014, 08:20

... judgement; on the other hand, they give indications on their expectations as regard the evolution of the economic environment as well as their intended behaviour over the next six or twelve months ... declare their 'intentions' with regard to the evolution of their level of bank debt, during the next period Finally, in section 6, we identify the determinants of the actual, ex post distribution of ... firm along axis f1 and f2- which are continuous and orthogonal, by construction, and incorporate a large fraction of the information present in the data set Moreover, as already underlined, the...

30
635
0

Báo cáo khóa học: Mutational and computational analysis of the role of conserved residues in the active site of a family 18 chitinase docx

Ngày tải lên : 07/03/2014, 14:20

... departure, and formation of the oxazolinium ion intermediate; (C) Hydrolysis of the oxazolinium ion intermediate Copyright National Academy of Sciences, USA questioned on the basis of studies of chitinase ... protons at the pH where the enzyme is most active The basic arm of the pH-activity proﬁle must be determined by the loss of one or both of these protons Comparison of rows 1, and with rows and in ... substrate-binding has drastic effects on the pKa of Glu144, raising it by 3.8 to 5.4 units, depending on the position of Asp142 and the calculation used Interestingly, the calculations also suggest...

10
651
0

Báo cáo khoa học: Kinetic and crystallographic analyses of the catalytic domain of chitinase from Pyrococcus furiosus – the role of conserved residues in the active site pdf

Ngày tải lên : 15/03/2014, 11:20

... residues contribute to the binding of the substrate by hydrogen bonding and ⁄ or hydrophobic interactions Using the ligplot program [31], we investigated the speciﬁc interactions between enzymes and ... p-nitrophenol at a concentration range covering those of the substrates used in the kinetic experiments The production of p-nitrophenol was linear with time for the incubation period, and < 5% of the available ... substrate The results of the kinetic analyses conﬁrmed that the Glu526 residue has a proton-donating function like other family 18 chitinases Asp524 was considered to act to restrain the side-chain of...

13
514
0

Báo cáo khoa học: Alternative initiation of transcription of the humanpresenilin 1gene in SH-SY5Y and SK-N-SH cells The role of Ets factors in the regulation ofpresenilin 1 pptx

Ngày tải lên : 16/03/2014, 18:20

... point mutations on the eﬃciency of transcription initiation and 23 the position of the start site(s) (A) Eﬀect of point mutations in Ets and Sp1 motifs on PS1 promoter activity The positions of ... using the concentration of protein in the extract as an internal standard The activity of ()119/+178) PS1CAT in the presence of the empty vector was taken as 100% The values represented in the ... (d) and Sp1 (h) motifs in the )119/+178 region of the PS1 promoter are indicated The positions relative to the +1 site of point mutations (X) eliminating Ets or Sp1 consensus in each motif are indicated...

10
492
0

Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx

Ngày tải lên : 18/03/2014, 01:20

... the carboxyl group of the a-aminoadipoyl- side-chain of penicillin N (1), with arginines 74 and 75 apparently playing a less important role in side-chain binding Taken together, the results of ... 10–12), consistent with loss of penicillin binding Arginines 306 and 307 Fig Proposed binding mode for penicillin N to the iron(II)-2-oxoglutarate complex of DAOCS, showing possible involvement of ... mutant binding to the enzyme (arginines 160, 162 and 266), as demonstrated by the lack of stimulation of 2-oxoglutarate conversion and the almost complete absence of any deacetoxycephem product Other...

5
462
0

Báo cáo Y học: Role of histidine 42 in ascorbate peroxidase Kinetic analysis of the H42A and H42E variants pptx

Ngày tải lên : 18/03/2014, 01:20

... determined above The maximum concentration of the intermediate under these conditions was 91% of the initial enzyme concentration Under these experimental conditions and in contrast with rAPX, there ... isosbestic point for the conversion of ferric H42A into Compound I, indicating that there are more than two absorbing species in solution and therefore consistent with the formation of an intermediate ... obtained in the absence of exogenous imidazoles Formation of Compound I again showed saturation kinetics (Fig 6), and a nonlinear least-squares ﬁt of the data to Eqn (7) in the presence of imidazole...

11
469
0

Báo cáo khoa học: Mechanisms of obesity and related pathologies: Role of apolipoprotein E in the development of obesity potx

Ngày tải lên : 29/03/2014, 22:21

... intolerance Fat cells Fig Model for the role of ApoE in the development of diet-induced obesity in mice Dietary lipids are packaged into chylomicrons in the intestine and then secreted into the ... ApoE3 isoform are taken up more avidly by adipose tissue than the lipoproteins containing mouse ApoE There has been much discussion in the medical community concerning the role of in ammation in obesity ... variety of spontaneous and induced tumors [44] The Ay mutation is the result of a 170 bp deletion that removes all but the promoter and noncoding ﬁrst exon of the Raly gene, which lies in the same...

9
655
0

Báo cáo khoa học: The role of residue Thr249 in modulating the catalytic efﬁciency and substrate speciﬁcity of catechol-2,3-dioxygenase from Pseudomonas stutzeri OX1 ppt

Ngày tải lên : 30/03/2014, 10:20

... possible if the conformation of the active site changes with respect to the one observed in the crystal structure of C2,3O upon binding of the dimethylcatechols Since the CH atoms at position of the ... independently of the orientation of the substrate in the binding site Thus, the regioselectivity of cleavage would be mainly controlled by the reactivity of the substrate This could explain the ... progressive increase as the volume of subsite 3¢ increases (Fig 4A) In contrast, the Km values on 3,5-DMC and 3,6-DMC decrease with the increase of the volume of subsite 3¢ Assuming that the kinetics of...

14
411
0