... properties of the document containing the sentence and properties of the sentence itself. Regarding the former type,two features come into play: the relevance score of the document (from the IR engine) ... in the case of Indri. These results are consistent with the findings of Monz (2003), who made the sameobservation inthe factoid QA task.There are a few caveats to consider when in- terpreting ... Association for Computational Linguistics The RoleofInformation Retrieval in Answering Complex QuestionsJimmy LinCollege ofInformation StudiesDepartment of Computer ScienceInstitute for Advanced...
... of GSK3 (using Li or SB-415286)appears to be sufficient for inducing activation of GS in muscle and fat cells, and that inhibition ofthe kinasepotentiates insulin action in muscle of insulin-resistant ... increases in glucose uptake and glycogen synthesisallowing for more effective ÔchannellingÕ of glucose intoglycogen in response to insulin. However, one of the potential difficulties in interpreting ... phosphatidylinositol3-kinase, p70, S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement ofthe mammaliantarget of rapamycin (mTOR) pathway in the L-leucine-inducedup-regulation...
... phenylalanine was thereforemutated to Ala, Leu, Trp or Tyr. These mutations may in uence the shape and volume ofthe acyl binding pocket and thereby alter the binding mode and affinity of the enzyme ... PAA and derivatives thereof, while maintaining the hydrophobicity ofthe binding site.To test the effect ofthe mutations on the specificity forphenylacetylated substrates, the steady-state kinetic ... kcatrepresents the rate of acylation and Kmequals the binding constant of the substrate to the free enzyme. The results then indicateÓ FEBS 2002 Roleof active-site phenylalanines in penicillin acylase...
... underscoring the importance of introducing fixed effects into the present count regressions. Then again, in the case that determinants interrelate with the number of bank failures—meaning that the strict ... restructuring ofthe industryor they mark the occurrence of a more profound instability in financial intermediation.Furthermore, variables designating e.g. the duration of a crisis are uninformative ... out insolvent depository institutions the sharp increase in bankruptcies of banks at the end ofthe 1980s was followed by an equally dramatic decrease at the beginning ofthe 1990s.Table 4 of the...
... create signiịcant changes in the genetic makeup of plants and animals due to the random recombination and sorting of thousands of genes. As a result of intervention by people, the hybrid seed corn ... throughout the world bears little resem-blance to teosinte, the original ancestor of corn. The newer techniques involv-ing genetic engineering, on the other hand, allow for the transfer of a fewgenes ... for thefood supply chain to segregate and identity preserve grain destined for ingredient manufacture. However, sev-eral countries have adopted labeling guidelines for foods containing ingre-dients...
... Measurementsare often based on private informationandthe application of standards involves judgment.Corporate insiders can use the resulting discretion in reporting to convey information about the firm’s ... rule of law, and corruption index). SIZE is the book value of total assets at the end ofthe fiscal year (in EUR thousands). We use the natural log ofthe size variable inthe analysis. Financial ... the public firm indicator in some ofthe analyses but without changing the tenor of the results. The Importance of Reporting Incentives:Earnings Management in European Private and Public Firms*David...
... binding properties The affinity of wild-type and mutant forms for the cofactor was measured to evaluate the impact of the mutations on the structure ofthe PLP binding site.Because PLP binding ... interacts with the phosphate moiety of PLP; E57Â is crucial inthe binding ofthe l-serinehydroxyl group [15] andinthe catalysis ofthe hydrox-ymethyltransferase reaction [16]; and Y65Â interactswith ... toexplain the increase ofthe dissociation constant of the monomer–dimer equilibrium determined by the muta-tions. The results obtained inthe present study alsoshow that the monomeric form of the...
... implicated in retraction of the PilA4-comprising DNA translocator transporting the DNA through the periplasmic space. Binding ofthe DNA to the DNA-binding proteinComEA on the surface ofthe inner ... mutations in either pilW or pilQsignificantly affect the location ofthe other protein inthe outer membrane.Furthermore, no PilA4 was present inthe outer membranes of thesemutants. From these findings, ... localization of the PilMNOWQ and PilA4 competence proteins and on the effect of mutations in distinct competence proteinson the subcellular localization of other proteins. Takentogether, the data...
... studies within inthe border of Vietnam but also in some other places inthe world to have better supporting sources. Using the mentioned informationand knowledge, there is a theoretical ... defined as the continuing commitment by business to contribute to economic development while improving the quality of life ofthe workforce and their families as well as ofthe community and ... the business. After finding the common point ofthe concept, he synthesized and introduced the concept of business ethics as follows: “Business ethics is all the rules, standards, ethics or...
... likelythat the increased rate of 13C label incorporation into the C6position of glycogen inthe ADM group is indicative of activated 6-phosphofructo-1-kinase, which can lead toincreased13C labeling ... concentrations. There-fore, an understanding ofthe regulation of these fluxes canprovide important insights into the mechanisms and poten-tial treatment of diabetes. The rates of glycolysis and gluconeogenesis ... C1, the C6 and C2–C5 signals were measured simultaneously for the first time in vivo, which provide the basis for the estimation of direct and indirect synthesis of glycogen inthe liver. The...
... Russell Investments // Roleof bank loans in a rising rate environment / p 7 Bank loans in rising interest rate environments In the past 20 years (since 1992), there have been three periods of significant ... surprise. The duration ofthe Credit Suisse Leveraged Loan Index is significantly lower than durations inthe traditional fixed income asset classes, reflecting the prevalence of floating rate instruments ... price movements. The default rate is the default rate of a bank loan portfolio (historically, 2%–3%), andthe recovery rate is the amount of principal recovered inthe event of default (historically,...
... that the interactions inthe tetramerinterface are weaker than those inthe dimer interface(Fig. 1A); thus, the Kdvalue ofthe wild-type mayreflect the dissociation between the A and D or B and ... As the crystal structure of human m-NAD-ME in complex with fumarate hasbeen determined, the binding network of fumarate in the enzyme has become clear. Inthe fumarate-bindingpocket, two arginyl ... for the quantitation of microgram quantities of protein,utilizing the principle of protein-dye binding. AnalBiochem 72, 248–254.38 Segel IH (1993) Enzyme Kinetics: Behavior and Analysisof...
... [16–18].Interestingly, the sum of ATP and UTP was two-foldhigher than that of CTP and GTP, andthe ratio of dATP and dTTP to dCTP and dGTP was also 2 : 1[16,17]. This fact is in accordance with the ... after 3 min and thendeclined, while the formation of [3H]ATP was increasedlinearly with time within the first 15 min. After 30 min, the reaction reached equilibrium (Fig. 4A). Furtherexperiments ... substrate in a totalvolume of 20 lL. The reaction was initiated by the addition the enzyme (100 ngặreaction)1for the determination of NTP synthesis rates and 0.51 ngặreaction)1for the deter-mination...