the role of epigenetics in cancer from molecular function to high throughput assays
Báo cáo Y học: The role of zinc in the methylation of the coenzyme M thiol group in methanol:coenzyme M methyltransferase from Methanosarcina barkeri New insights from X-ray absorption spectroscopy doc
... sulfur ligand in all zinc-containing MtaA proteins [i.e 2.0 (N/O) plus (S)] We interpret these results as indicating the binding of the thiol sulfur of HS-CoM to the zinc atom of MtaA in a way that ... Ala the HS-CoM binding results in sulfur ligation to the active-site zinc XANES spectra of wild-type and mutants As shown in the following, the interpretation of the EXAFS of the mutant enzymes ... ligands increased from to However, this increase could also be due to the binding of a cysteine residue to the active site zinc upon enzymesubstrate complex formation Final proof could come from...
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The Role of Deployments in Competency Development - Experience from Prince Sultan Air Base and Eskan Village in Saudi Arabia potx
... within the preceding 12 months Respondents selected from a list of settings all those settings in which they learned a specific competency or skill They then indicated the single “best” learning ... Specifically, they asked whether officers learn enough during contingency deployments to merit an examination of how to track that learning The research summarized here responds to that query and, in doing ... to learn the majority of the competencies and skills included in the survey, and in many cases viewed it as the “best” place to learn them These results suggest that if the Air Force elects to...
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The role of chitosan in protection of soybean from sudden death syndrome caused by fusarium solani f sp glycines
... due to its role in protecting soybeans against SDS symptom development 3.4 The level of chitinase activity in infected soybean leaves To investigate the level of chitinase activity in infected ... 2004) 2.3 Evaluation of the role of chitosan in protection of soybean from SDS development The use of chitosan as a natural antifungal agent against SDS in soybeans was investigated as described ... was determined for the cleared intercellular Xuid prior to their use in enzyme activity assays Total protein was determined by Coomassie Blue Protein Assay (BioRad, USA) according to the sensitive...
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Báo cáo khoa học: "A Clinical review: Molecular mechanisms underlying the role of antithrombin in sepsis" docx
... videomicroscopy of damage to the small intestine in endotoxinaemia In both of these studies, the effect of antithrombin on the leucocyte– endothelium interaction could be abolished by indomethacin, which ... inhibition Two isoforms of antithrombin circulate in the plasma, namely the α and the β forms, which not differ from each other in their thrombin inhibiting effect, but they differ in their affinity for ... leucocyte adhesion to the endothelium Antithrombin inhibited the tumour necrosis factor (TNF)-α induced increase in E-selectin expression in endothelial cells by inhibiting the interaction of NF-κB with...
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The role of TFF3 in cytotoxic drug resistance of breast cancer
... routine test in breast cancer diagnosis, because of their therapeutic implications The two main approaches of hormone treatment are blocking the binding of hormone to their receptors and inhibiting ... al 2010) The approaches to overcome chemotherapy resistance mainly involve the use of combinations of different classes of drugs in therapy Adjuvant therapy using certain inhibitors to abrogate ... cancer increased three fold in 2006-2010 (NRDO 2012) Increasing effort in breast cancer screening and awareness in the society may have contributed to the increasing incidence in breast cancer Singapore...
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ELUCIDATING THE ROLE OF AUTOPHAGY IN ZEBRAFISH MODELS OF LIVER CANCER
... to maintain the line to study the function of the gene -of- interest Furthermore, fluorescent proteins can be expressed in specific organs in order to study their development over time by placing ... be used to induce autophagy by relieving mTOR-induced inhibition (Rubinsztein et al., 2007) 3-Methyladenine, a potent PI3K inhibitor, can also be used to inhibit autophagy by inhibiting the activity ... there are evidences implicating autophagy induction and inhibition during carcinogenesis; however the exact role of autophagy in carcinogenesis remains to be elucidated With the zebrafish gaining...
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Circuit theory of finance and the role of incentives in financial sector reform
... Creating a stronger investor base amounts to strengthening the circuit by completing the financial market structure of the economy, thus eliminating discontinuities in the transmission of information ... placing money with investment financial institutions in the capital market, and hold the remaining share in noninterest bearing, short-term bank deposits (eq 7) The share of savings going to the ... including those that deal with insider trading SROs can play a significant role in ensuring the smooth functioning of vital links of the circuit The underlying rationale of SROs is to exploit the...
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The role of language in adult education and poverty reduction in Botswan
... English at the expense of the other languages that exist in the country, the adult language program in Botswana maintains the hegemony and the gap between the poor and the rich, the major and minority ... is for the most part the preserve of the few (elites) The choice of which language or dialect to use to teach (medium of instruction) reflects the interests of those elite In countries in which ... the learners to be confident to participate in the discussions and activities of their education and economy This involves the teaching of local languages, Setswana and English By involving the...
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The role of advertising in society
... executives point to the vast array of topics they cover and the investigative reporting they often as evidence of their objectivity It is in their best interest to build a large audience for their publications ... most vital tools in Marketing The appearance and the role of advertising is increasingly higher in the market economy Advertising shows the rapid growth in technology and lifestyle, in people’s ... advertising industry Since the opening policy and law of foreign investment, advertising industry has seen remarkable changes The growth rate of advertising service is the highest in economy, in which...
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Tài liệu THE ROLE OF UNIVERSITIES IN REGIONAL INNOVATION SYSTEMS - A NORDIC PERSPECTIVE pdf
... the Folketing, on the role of the University as the principal shareholder in Cheminova The listing of Cheminova on the Stock Exchange in 1986 and the establishment of the first science park in ... potential of new knowledge might be biggest in the latter case The growth of the minicomputer industry in the Boston region in the 1960s and the internet industry in Silicon Valley in the1 9990s ... functio of the university in addition to teaching and research The new requirements reflect the growing of complexity of society It is increasingly difficult to distinguish between the domains of the...
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Tài liệu Improving health, connecting people: the role of ICTs in the health sector of developing countries ppt
... save from to 10% of their household income from gaining better prices for the sale of goods or from refraining from unnecessary trips to the urban areas The income that Village Phone Operators ... critical in ensuring the effective use of ICTs in the health sector Programme designs should consider the role of the intermediary at the same time as, if not before, the role of the technology The ... understanding and the evidence base about the use of ICTs in the health sector are: • How to evaluate the impact of the use of ICTs on health? • What can be done to strengthen the role of and build the capacity...
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Tài liệu The Role of Nutrition in Maintaining Health in the Nation’s Elderly: Evaluating Coverage of Nutrition Services for the Medicare Population ppt
... president of the National Academy of Engineering The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions ... by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of ... appropriate professions in the examination of policy matters pertaining to the health of the public The Institute acts under the responsibility given to the National Academy of Sciences by its congressional...
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Tài liệu Egypt''''s Water Warriors : Water Pollution in Egypt and the Role of NGOs in Reaching Integrated Management ppt
... compliance to the natural protectorate law and the decision of the Prime Minister regulating to activities inside the protectorates in addition to the inefficiency of the biological treatment project of ... Azeem was one of a few Media reported the progress in increasing interest.[19],[20] .to investigate the amount and seriousness of pollution caused by factories dumping their waste in the Egyptian ... properties of groundwater in Saint Katherine, South Sinai, Egypt and exploring the diversity, occurrence and distribution of fungal taxa in groundwater in South Sainai, samples of groundwater from...
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Tài liệu Báo cáo khoa học: The role of antioxidants in the cytotoxicity of chemotherapeutic drugs pptx
... of intra-endosomal vesicles contained within MVBs, thereby releasing the nucleocapsid into the lumen of these vesicles Then, the capsid uses these intra-endosomal vesicles as a Trojan horse to ... of the recombination intermediates that lead to cell death We are also investigating the role of the MMR system in the cytotoxicity of 5-fluorouracil (FU), which has been reported to kill MMR-proficient ... In addition, production of the cytokines interferon c, interleukin-6 and interleukin-2 is clearly different in wild type and in Ung-deficient mice Thus, Ung-proteins have important functions in...
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Tài liệu Investigating the Role of Poultry in Livelihoods and the Impact of Avian Flu on Livelihoods Outcomes in Africa docx
... affected the poultry sectors The countries also differ in various other factors, including the size and structure of the poultry sector, reliance of the poor on poultry, and the levels of diversification ... income, thereby providing a more accurate measure of the impact of the disease If one looked only at the impact of HPAI on the income from poultry without accounting for its role in the whole income ... variables, including livelihoods indicators such as livestock income and wealth According to this method of matching, the two groups—which include the treatment group of households representing the...
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Tài liệu Báo cáo khoa học: "The Role Of Focussing in Interpretation of Pronouns " pdf
... of Computer Science TR-70, Rutgers University, New Brunswick,N.J Reinhart, T;mya [1976] The Syntactic Domain of Anaphora unpublished Ph.D dissertation, Department of Foreign Literature and LinBuistics,M.I.T ... Conceptual Memory: A Theory and Compufer Program for Processing Ihe Meaning Content of Natural Language Utterances Stanford Artificial Intelligence Lab Memo AIM-233 Sidner, Candace L [1979] To, 'ards a ... Thmr7 of Definite Anaphora Comprehension in £nglish Discour~ unpublished Ph.D disseration, Electrical Engineering and Computer Science, M.I.T Webber, Bonnie Lynn [1978] A Formal Approc~k to Discourse...
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Tài liệu Báo cáo khoa học: "The Role of Initiative in Tutorial Dialogue" pdf
... overview of the evidence in favor of Socratic tutoring as well as describing an opposing viewpoint supporting a tutoring style referred to as didactic Here, rather than drawing out the answer from the ... ADs have closer to an equal sharing of initiative — the expert had initiative for 60% of the turns in finance ADs and 51% of the turns in software ADs This is because in the ADs, the novice must ... initiative as TODs In the TODs, the expert would issue a series of commands in order to get the novice to perform a procedure In the Socratic dialogues, the tutor was issuing a series of questions in order...
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TMJ Disorders and Orofacial Pain The Role of Dentistry in a Multidisciplinary Diagnostic Approach pptx
... sections of the developing joint space (yellow) of a right temporomandibular joint In the center of the picture is the condyle (1); to the right of it lies the coronoid process (2) To the left behind ... fibrocartilaginous joint surface (thin arrows) of the condyle of a 58-year-old individual In spite of the intact joint surface on the condyle, the pars posterior (1) of the disk is flattened and the functional ... created during sectioning, and through it can be seen the upper surface of the condyle (arrow) upon the shape of the fossa, the inclination of the protuberance, and the shape of the condyle In the 1970s...
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NOTES ON THE ROLE OF EDUCATION IN PRODUCTION FUNCTIONS AND GROWTH ACCOUNTING pot
... of lack of relevant data They used the education of the total labor force in a state for the measurement of the quality of the labor force of individual industries within the same state But the ... number of men and e1 the proportion of the workers in the lth category of labor services, one may write the index of the total labor input in the form: L = —+—+ H N — Thus, to eliminate errors of ... x4 is the logarithm of the ith input per unit of output, P, is the logarithm of the "real" price of the jth input, mi's are the respective price = 0), v5 is the share of the jth factor in total...
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