the role of e cadherin catenin complex in prostate cancer progression
Báo cáo khoa học: "In vitro studies on the modification of low-dose hyper-radiosensitivity in prostate cancer cells by incubation with genistein and estradiol" pot
... with the better tolerable genistein in irradiated PC cell lines in vitro Other mechanisms for genistein action besides the ER mediated effects have been reported It has been shown that genistein ... and estradiol dependent from the genetic background of the investigated cell line Furthermore, the effects of both tested compounds on survival were ER and p53 independent Since genistein and estradiol ... effects in both cell lines were comparable, neither ER- nor p53-expression seemed to play a role in the linked signalling Nevertheless both compounds targeted the same molecular switch To identify...
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Báo cáo y học: "The role of pleiotrophin and β-catenin in fetal lung development" doc
... repeated branching morphogenesis and prominent interactions between mesenchyme and epithelium In the embryonic kidney, PTN is present in the basement membrane surrounding the developing ureteric ... during the early stages of bone development However, the effect is diminished with advanced age and the generated bones are more brittle compared to the wild type [48] Kidney development involves ... through the regulation of mesenchymal cells Deletion of β -catenin in the embryonic mesenchyme leads to shortened trachea, decreased branching, and reduced peripheral mesenchyme [100] However, the sub-epithelial...
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The Role of Genetically Modified Organisms (GMOs) in Beverage Production
... material The Þrst method involves enzyme-linked immunosorbent assays (ELISAs), which are based on the detection of proteins coded for by the genes inserted into GM crops These tests require minimal ... conÞdence in the safety of GM foods Because GM crops have been readily adopted in the U.S., availability of non-GM crops has been limited, and these ingredients are more expensive Even when efforts ... a result of intervention by people, the hybrid seed corn currently grown throughout the world bears little resemblance to teosinte, the original ancestor of corn The newer techniques involving...
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Tài liệu Báo cáo khoa học: Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc-dependent Erk signaling docx
... mouse NCAM were generated by the stable transfection of the pSuper retro vector (OligoEngine, Seattle, WA, USA) containing the respective sequences These cell lines were kindly provided by F Lehembre ... of E- cadherin function induces uPA S Kleiner et al the invasive phenotype could be achieved by ectopic expression of E- cadherin [3,5] While E- cadherin expression is maintained in most differentiated ... progression, the understanding of these underlying intracellular events is of importance In the present study, we explored the signaling pathway linking disruption of E- cadherin- dependent cell–cell...
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The Role of Small and Large Businesses in Economic Development doc
... self-employment is their primary source of income Clearly, many entrepreneurs start their businesses as self-employed people They acquire new employees as their businesses expand Mainly because these establishments ... Perhaps the greatest generator of interest in entrepreneurship and small business is the widely held belief that small businesses in the United States create most new jobs The evidence suggests ... measure net employment changes as total employment in a size class at the end of the year less total employment in the size class at the beginning of the year The numbers presented in this section...
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Báo cáo khoa học: The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase pptx
... strands of the coding region of the mutated genes were sequenced The only differences with respect to wild-type nucleotide sequence were those that were intended Enzyme expression was performed using ... of the inter-domain segment and the other helix lines the boundary between the major domain and the N-terminus (Fig 1) Therefore, the formation of the third cluster may represent a key event of ... constant of the serine hydroxymethyltransferase reaction d Kinetic parameters of the L-threo-3-phenylserine cleavage reaction which is expected to be mostly in the monomeric state Therefore, the similar...
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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf
... Whilst there is considerable evidence implicating GSK3 in the regulation of glycogen metabolism there are conflicting reports in the literature as to whether the kinase also participates in the hormonal ... three separate experiments Alternatively cells following insulin treatment were assayed for 2-deoxyglucose uptake Values are the mean ± SEM for three experiments carried out in triplicate, asterisks ... uridine diphospho-[6-3H]-Dglucose into glycogen and expressed as a ratio of the activity in the absence divided by that in the presence of glucose-6-phosphate Values are the mean ± SEM for three...
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The Role of Gestures and Facial Cues in Second Language Listening Comprehension pptx
... between gestures and facial cues seeking the most informative cue according to the content of the lecture The results of the questionnaire revealed that the majority of those who reported they ... speaker’s gestures would have helped comprehension (AV-face) Seeing the speaker’s gestures helped comprehension (AV-gesture-face) Seeing the speaker’s face helped comprehension (AV-gesture-face) ... was in the form of words and phrases in an outline rather than full sentences to be read She did not need to make frequent reference to the outline because of her knowledge of the topic The transcript...
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Bringing the Hidden Giants to the Footlight: the Role of Savings and Retail Banks in Increasing the Level of Access to Financial Services docx
... an even lower amount in fees is required to keep this account active In other countries and in Latin America and Asia, the figures also remain well below the average requirement of the banking ... remittances into the financial system and intermediating the flow of the resources, savings banks contribute to leveraging the positive impact of these transfers In several savings banks, efforts have been ... Conclusion Despite their longstanding commitment and their tremendous efforts in the field of access to finance, savings banks still seem to be the invisible players in the arena It is clear however that...
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Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism docx
... mechanism can lead to increases in labeling of glycogen C6 even in the presence of decreased activity of the indirect pathway, provided that the increase in glycolytic flux exceeded the decreased ... attributed to the fact that in contrast to the previous work, in the present study mice were fasted for 8–12 h before the NMR experiments were begun Together, these results demonstrate that increased ... in the C6 relative to the C1 position When the changes in glycogen C1 and C6 are linear with time, the differentials in the middle part of Eqn (7) can be replaced by the differences in label incorporation...
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Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf
... and thereby alter the binding mode and affinity of the enzyme for PAA and derivatives thereof, while maintaining the hydrophobicity of the binding site To test the effect of the mutations on the ... around the ester bond in the acyl-enzyme complex and thereby in uence the relative rates of reaction of the acyl-enzyme with different deacylating nucleophiles, leading to changes in the Vs/Vh ... that the yields obtained in synthesis correlate well with the steady state kinetic parameters of the enzymes for acylation and deacylation that were determined in independent experiments (Tables...
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The role of floating-rate bank loans in institutional portfolios pdf
... Those factors, particularly with leveraged vehicles, have greatly diminished since then At the same time, the market participants have evolved considerably in the last several years Therefore, ... date at the beginning of the document The opinions expressed in this material are not necessarily those held by Russell Investments, its affiliates or subsidiaries While all material is deemed ... returns not increase with rising rates) The credit spread is the market-determined spread paid to the investor for taking on the credit risk (historically the normal range has been 3%–8%, depending...
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Báo cáo khoa học: The role of residues R97 and Y331 in modulating the pH optimum of an insect b-glycosidase of family 1 pdf
... pKa of E1 87 remained the same, but the pKa of E3 99 clearly increased Actually, the substitution of R97 by methionine or lysine resulted in the same increment in the pKa of E3 99 (Table 2) Therefore, ... mM triethanolamine buffer pH 8.0 and retained proteins were eluted using a gradient of NaCl prepared in the same initial buffer The presence of the recombinant Sfbgly50 was detected as above and ... of the decrease in kcat may result from destabilization of the ES complex, because the tyrosine residue is thought to interact with the oxygen of the glycone ring in that complex [10,12] Nevertheless,...
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Báo cáo khoa học: The role of Ureaplasma nucleoside monophosphate kinases in the synthesis of nucleoside triphosphates potx
... The aim of the present study was to define the role of Ureaplasma NMPKs in the synthesis of nucleoside triphosphates Four Ureaplasma NMPKs were cloned, expressed and the recombinant enzymes were ... kinases, i .e adenylate kinase, thymidylate kinase, cytidylate kinase, and uridylate kinase, were cloned and expressed in E coli The recombinant enzymes were affinity purified and their role in dNTP ... while the formation of [3H]ATP was increased linearly with time within the first 15 After 30 min, the reaction reached equilibrium (Fig 4A) Further experiments were designed to study the extent of...
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báo cáo hóa học: " The role of cumulative physical work load in symptomatic knee osteoarthritis – a case-control study in Germany" potx
... squatting, differentiating between two different Kneeling and squatting, differentiating between two different modes of squatting *In German: „Fersensitz" Interviewers were intensively trained in ... defined procedure, any other variables were categorized in tertiles based on the distribution of the exposed control subjects If less than 20% of the control subjects were nonexposed, the reference ... In deep knee flexion, peak stresses were over 80% larger than peak stresses in walking; peak stresses in deep knee flexion reached the damage limits of cartilage According to the results of this...
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Báo cáo khoa học: " The role of marine salt and surfactants in the decline of Tyrrhenian coastal vegetation in Italy" ppt
... doses of ABS (1st experiment), even in the presence of salt, are mainly attributable to the surfactant, and there is no correlation between the degree of leaf damage and the Cl levels in the leaves ... order to measure chlorides in the P pinea needles, the needles were rinsed before testing for about in deionized water The chloride extraction was performed according to the method described ... physical, etc) The ratio that is most probably the closest to the original ratio in the aerosol is that recorded in the rainwater gathered near the coastline, ie the one closest to the source Here the...
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báo cáo khoa học: "The role of 18F-FDG-PET/CT in the preoperative staging and posttherapy follow up of gastriccancer:Comparison with spiral CT" docx
... Inc.,Chicago,Illinois,USA) Then the concordance and discordance between these two imaging modalities were investigated by checking the reliability As most of the patients included were in the restaging group, ... the routine procedure But especially in the detecion of the response in the primary tumor, these changes may not always be realized accurately [7] When it comes to the detection of the solid ... early metabolic response to therapy before anatomic response became evident As demostrated in these cases, we concluded that PET/CT has an important role in determining the early metabolic response...
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Báo cáo y học: "The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models" pps
... seems of crucial importance in osteoclastogenesis and the bone erosion process RANKL and the decoy receptor osteoprotegerin [61] are important Schematic overview of the mechanism of interleukin-17 ... Interrelation between IL-17 and IL-1/TNF Overexpression of IL-17 in the mouse knee joint of CIIimmunized mice resulted in elevated levels of IL-1β protein in the synovium [41] Intriguingly, blocking of IL-1α/β ... destructive process IL-17 therefore seems to be a significant target for the treatment of cartilage destruction in T cell-mediated arthritis Role of IL-17 in bone erosion In addition to the role of...
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Báo cáo y học: "The role of tumor necrosis factor-alpha in systemic lupus erythematosus" pdf
... anti-inflammatory effects of infliximab may have prevented damage despite the presence of potentially pathogenic antibodies Nevertheless, we have observed one episode of deep vein thrombosis in temporal ... after TNF blockade was stopped None of the patients experienced a lupus flare, and serum complement levels remained stable [62,67] Nevertheless, the induced antibodies to dsDNA were of high affinity, ... least in part, the increase in anti-histone and anti-chromatin antibodies preceded the anti-dsDNA increase All of these antibodies were only transiently elevated and fell back to baseline levels...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25