... near the flexible C terminus of SNase.
Changes inthe fluorescence intensity of W140 reflect
a change inthe surrounding hydrophobic environment
of the tryptophan and thus indicate a change in the
overall ... (E75G)
lower than that ofthe wild-type protein, suggesting
that Glu residues at positions 75 and 129 play key
roles in maintaining the native structure ofthe protein.
Furthermore, two mutants, ... exists in these mutants (Fig. 1).
Thermal analysis of protein unfolding
Thermal denaturation determined by DSC was used to
measure the stability ofthe mutant proteins. Based on
the measurements of...
... presence of
ionizing radiation [12], and inthe present study, in the
absence and the presence of cisplatin. In addition, we
showed that Pph3p directly or indirectly binds to
cH2AX, indicating that ... hypersensitivity to the antitumour drug
cisplatin, indicating that all three proteins may oper-
ate as a functional unit in vivo, playing a rolein the
cisplatin response [9]. Cisplatin interferes with ... Substitution of
the H2AX Ser129 by Ala restored the ability of the
pph3D strain to turn off checkpoint signalling in a
timely manner and re-enter the cell cycle after DNA
repair ofthe double-strand...
... the failure ofthe bank
would undermine the financial stability ofthe economy. Only then would the FDIC be
entitled to protect all the liabilities ofthe bank against loss. Further, enacting ... maximize profits at the point where the marginal cost of raising
funds equals the marginal benefit from using those funds. Deposit insurance affects the
analysis by shifting the marginal cost ... that the government safety
net removed the oversight roleofthe market in assessing the risk of banking institutions.
The moral hazard created by the safety net enables banks to increase the...
... BMP-2, the yin and yang of mineralization:
Contrast of effect of 24 hours of treatment with FGF-2 or BMP-
2 on fold increase in abundance of mineralization-related gene
expression. Mineralizing ... reduce the relative
abundance of a majority ofthe mineralizing-associated
genes.ThedramaticreductionofIGF-1byFGF-2sug-
gests a role for IGF-1 in minera lization, this is i n agree-
ment with findings ... visualized the mineralizing
cells with 2% Alizarin Red. After rinsing in distilled
water and air drying the samples, we mounted the cov-
erslips on microscope slides using Fluoromount and
examined...
... reduce the relative
abundance of a majority ofthe mineralizing-associated
genes.ThedramaticreductionofIGF-1byFGF-2sug-
gests a role for IGF-1 in minera lization, this is i n agree-
ment with findings ... to
heal the defect. The increase in cell replication in a miner-
alizing cell likely represents a de-differentiation from th e
mineralizing phase to the growing phase, and increases
expression of ... BMP-2, the yin and yang of mineralization:
Contrast of effect of 24 hours of treatment with FGF-2 or BMP-
2 on fold increase in abundance of mineralization-related gene
expression. Mineralizing...
... be part of a risk group. In addition,
the combination of these two LEs seems to be usual. In
fact,notonlytheLCUssumscoredeterminetheeffect,
it’s the undesirab ility of thes e LEs what makes respon-
dents ... measures of LEs in order to take into
account also their effect in previous HRQoL.
Conclusions
The experience of LEs did impact the HRQoL of adoles-
cents and youths in this sample, although the effect ... method in order to address the multiple
testing problem. The decision rule is to reject the
null hypothesis when the adjusted p-value is les s than
a = 0.05[39].
To investigate the first aim of the...
... nearby, these are the main source of
medicine inthe hamlet. A diverse array of
medicinal plants is gathered year round, and
most households also used medicinal plants to
purify daily drinking ... sources of income. The roles of
NTFPs in Que seemed less important than those
in Tha Lang, although cash income from
NTFPs in Que was much higher. The reason for
this was the better access to the ...
analysis running SPSS software presents that
the 29 remaining households can be divided
into four clusters. The indicators in clusters
show that all of these households seem to
follow the extensive...
...
overlooked in mountain spruce forests inthe Tatra
Mountains and, possibly in other mountain areas in
Europe too. Inthe study area, the bark beetle acts as
a vector of at least four species of uropodine ...
from 0.064 inthe valley Bielovodská dolina to 0,108
in Tomanova dolina and 0.145 in Velická dolina, giv-
ing the value of 0.103 for the study area as a whole.
The rarefaction curve ofthe pooled ... 261
5.8% inthe valley Velická dolina (N = 695), 17.6% (N
= 2,204) in Tomanova dolina and 24.6% (N = 403) in
Bielovodská dolina.
Of the 3,302 individuals of H. cunicularius sampled
in the study...
... to determine the usefulness of ther-
apies against mast cells, it is important to know the degree
to which mast cells are involved in IR injury of other skel-
etal muscle fibre types. In this ... variation in the
period of ischaemia, the muscle temperature during
ischaemia and the period of reperfusion allowed for man-
ifestation ofthe reperfusion injury. Idstrom [12] utilised a
period of 2, ... IR injury than the slow/fast-
and fast-twitch muscles. Data from other studies are diffi-
cult to compare because ofthe wide variety of IR models
in use. In particular, there is a great deal of...
... Effects of active immunization of sheep against an amino
terminal peptide ofthe inhibin αC subunit on intrafollicular
levels of activin A, inhibin A and follistatin. Journal of Endocrinol-
ogy ... Our findings suggest that Akt is
important in mediating the effects of FSH on inhibin-A,
activin-A, oestradiol and progesterone secretion and also
important in mediating IGF-I stimulated inhibin-A,
activin-A, ... assess the
equal transfer ofthe proteins from the gel to the mem-
brane. TBS-Tween was used to destain the membrane,
which was then blocked in 5% Marvel in TBS-Tween for
1–2 h. The blocking solution...
... capital
profitability is declining. The internalization of information within the same institution may thus
enhance intra-circuit and inter-circuit stability by reducing the incentive to overfinancing.
The ... placing money with
investment financial institutions inthe capital market, and hold the remaining share in non-
interest bearing, short-term bank deposits (eq. 7). The share of savings going ... Banks thus increase lending to the point where the marginal revenue from lending equals
the marginal default risk. The amount lent determines the amount of inputs that firms can
purchase inthe factor...