... activation of cytokines and chemokines in monocytes and macrophages (including Kupffer cells) [41, 42], and ethanol-induced mucosal injury inthe upper gastrointestinal tract leading to increase inthe ... NM_014393 ▲ 1.52 regulation of transcription protein binding double-stranded RNA binding DNA binding ▼ 5.02 protein binding NM_001149 NM_004242 ▲- increased ▼- decreased Validation of microarray results ... of ethanol (100 mM) induced the expression of genes involved inthe metabolism of ethanol [16] In addition, the metabolism of ethanol 33 results in an increased production of toxic metabolites...
... the better model in out ofthe 26 countries inthe output equation, in 12 out of 26 countries inthein ation equation and in out ofthe 12 countries inthe long run interest rates equation The ... been done in analysing the effect ofcredit on in ation, short term and long run interest rates inthe economy, nor in quantifying the importance ofcreditinthe macroeconomy, both of which we ... lower order TheRoleofCreditin Country Specific Models The theoretical literature on theroleofcredit (see details inthe literature review) has highlighted the importance ofcreditin real economic...
... raising the profile of women in management However, during this period of research, there was an emerging recognition ofthe importance of a concern for people inthe behavioural theories as being ... more typical of male behaviours Of interest is the inclusion of ‘‘control’’ as a significant feature ofthe transactional style, common in definition of leadership inthe 1990s In contrast, women ... valued At the time these theories were achieving prominence, the numbers of women were also beginning to rise dramatically in management roles One significant finding that has arisen from the transactional...
... source of financing for enterprises, if their own capital is excluded In summary, the deepening processofthe financial markets has rendered the dominance ofthe banking sector inthe financial ... price The trade of inter-bank bond market relies on the securities booking system ofthe CGSDTC and the bond trading system ofthe inter-bank lending centre The trading system ofthe national inter-bank ... deepening ofthe financial markets, enterprises more often resort to banks for credits As theroleof government in providing financing gradually faded out, the 15 inter-mediation function of the...
... adults (39 ) The renewed interest in examining the indications for BCG vaccination inthe United States included consideration ofthe wide range of vaccine efficacies determined by clinical trials ... explore the sources ofthe heterogeneity inthe efficacy ofthe BCG vaccine reported inthe individual studies Using a model that included the geographic latitude ofthe study site and the data ... efficacy of BCG vaccine in HCWs or b) the effects on efficacy ofthe vaccine strain administered Vol 45 / No RR-4 MMWR and the vaccinee’s age at the time of vaccination The protective efficacy of BCG...
... understanding issues facing community banks I THE CURRENT ROLEOF COMMUNITY BANKS The banking system inthe United States has always been unique inthe sense of containing large numbers of small ... were not there, other financial services providers might readily step in to take their place This article examines theroleof community banks inthe U.S economy The first section ofthe article ... While community banks still comprise the vast majority of banks, the question arises whether their roleinthe banking system has declined to the point of insignificance This section shows that...
... Hoepner,2008) There is scope to improve the sustainability ofthe desalination processTheprocess results inthe discharge of a concentrated brine into the receiving waters Temperature and salinity ... Figure 19 inthe timing and intensity of rainfall, or the period of time without rain, as well as affecting the quality of water in rivers and lakes through changes inthe timing and volume of peak ... cost-effective way of assessing health risks; • the identification of all risk points along the chain of events from the origin ofthe wastewater to the consumption ofthe produce (e.g the farm-to-fork...
... or without hematoxylin staining In hypoxia experiments, 3T3-L1 cells were maintained in a hypoxia chamber (Invivo 400; Ruskinn Inc., Cincinnati, OH, USA) constantly maintained at 1% O2 Culture ... relevant roleof miR-27 inthe regulation of adipose tissue functions in vivo, we examined the expression of miR-27 inthe genetically obese ob ⁄ ob mice The 2352 expression levels of both miR-27a ... IDM (10 lgÆmL)1 insulin, lm dexamethasone, and 0.5 mm IDM) Cells were then maintained in DMEM containing 10% fetal bovine serum and lgÆmL)1insulin The medium was replaced every other day Mature...
... through the exchange between subunits of either their N-terminal, or their C-terminal ends [33–35] We found that the behavior with the model membrane ofthe dimer in which the C-terminal ends ... geometry ofthe hinge loop after ligation Also in this case no clashes were detected at Electrostatic interactions and antitumor RNases the dimer interface ofthe models or inthe surroundings ofthe ... Nter are the C-terminal and N-terminal structural regions, respectively, ofthe two A and B monomers ofthe dimeric RNase The black circle between the monomers indicates the mass center ofthe dimer...
... N-linked oligosaccharide side-chains are important for the GABA transport activity 1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into theroleofthe ... terminal structures ofthe N-glycans of GAT1, N-glycosylation processing of NNN was inhibited by 1-deoxymannojirimycin (dMM) Inhibition by dMM leads to the formation of NNN molecules containing ... misfolding of this protein, resulting in its partial retention inthe ER and its rapid digestion thereafter [16,19] Accordingly, our results indicate that the intracellular trafficking of N-glycosylation...
... t is thein interaction ofthe results of these asynchronous processes that theprocessof comprehension is defined 4.1 The processes are independent ofthe knowledge representations defined ... the state oftheprocessThe most important aspect ofthe control is that a l l ofthe serial order computations can occur simultaneously and affect any information that has been defined inthe ... "normal" processing The major difference inthe control in H P OE is that the control process can be "lesioned" by modifying parameter settings relative to t h e i r "normal" settings to define hypothesized...
... ambiguous the meaning ofthe visual image, the more influence is exerted by the musical score intheprocessof interpreting the scene Music can convey the scope of a film, effectively communicating ... meaning through sound (including music), taking into account the director’s – and, therefore, the composer’s – intentions, the narrative content ofthe film, and the overall strategy ofthe director ... the relationship is invertible without changing the perceived meaning (i.e., it is equally valid to say that the music projects the meaning ofthe image or the image projects the meaning of the...
... However, the mechanistic roles of several of these residues are not described well and there is no example of mutational analysis of all of these residues inthe same enzyme To obtain an insight into ... 1), thereby confirming the crucial roleof Asp142 Catalysis in family 18 chitinases (Eur J Biochem 271) 259 In most ChiB structures, Asp142 is clearly defined, being either inthe ÔdownÕ or inthe ... positioned inthe ÔupÕ position rows and shows that inthe presence ofthe substrate, rotation of Asp142 towards Glu144 lowers the pKa ofthe latter by 0.8 pH units The calculated effects ofthe D140N...
... properties ofthe document containing the sentence and properties ofthe sentence itself Regarding the former type, two features come into play: the relevance score ofthe document (from the IR engine) ... evaluating answers to definition questions In HLT/EMNLP 2005 J Lin and D Demner-Fushman 2006a Theroleof knowledge in conceptual retrieval: A study inthe domain of clinical medicine In SIGIR ... the findings of Monz (2003), who made the same observation inthe factoid QA task There are a few caveats to consider when interpreting these results First, the test set of 25 questions is rather...
... whereas the slope ofthe slow semi-inactivation process was rather similar to the slope ofthe curve found when the medium did not contain AdoMet, with an estimated halflife of 10.5 Theroleofthe ... are located inthe central domain of each subunit, inthe interface between the two dimers comprising the tetrameric structure [29] This domain contains five cysteine residues, two of them (Cys35 ... forming a disulfide bond which may be necessary for the tetrameric state ofthe enzyme In addition, Cys69 is involved inthe correct folding ofthe monomer, supporting the establishment of the...
... additional schooling, the estimated schooling effect could include both the impacts of schooling and the fact that those continuing in school could earn more inthe absence of schooling.2 For the most ... income levels mainly though speeding up technological progress, rather than shifting the level ofthe production function or increasing the impact of an additional year of schooling In sum, the ... student in a school in Ghana or Peru would gain the same amount of knowledge in any year of schooling as the average student in a school in Finland or Korea? Still, using the quantitative measure of...
... trees The largest plant height was obtained using linings of stone and marble During the first year ofthe study, when the lining served only as mulch due to lack of rainfall, an increase of 33.3 ... crop yields in rainfed areas, even inthe more marginal rainfed environments The continued application of conventional breeding and the recent developments in non-conventional breeding offer considerable ... level ofinvestment Water harvesting activities occur near the location where the rain falls, therefore the storing of river water in large reservoirs and groundwater mining are generally not included...
... as Points of Access into the Financial System TheRoleof African Post Offices in Payments TheRoleof Post Offices in International Remittances TheRoleof Post Offices inSavingsTheRoleof ... Services TheRoleof Post Offices in International Remittances TheRoleof Post Offices inSavingsTheRoleof Post Offices inCredit 5—Conclusion 16 17 17 17 18 19 20 21 21 21 Worldwide Landscape of ... agreed between the ministries of finance, the IMF, and World Bank Inthe recent past in Africa, no distinction was made ofthe roles ofthe post as the mail provider, as owner ofthe post office network,...
... the lower levels of net worth further reduce the ability of banks to attract loanable funds As a result, aggregate investment continues to fall, bottoming out inthe fourth period following the ... rates only increase by 50 basis points, and the increase in inflation is 50 basis points less than inthe baseline case A banking sector that remains well-capitalized can thus reduce the length ... lending Figure illustrates the sequence of events that unfold in each period 2.2 Final good production Final Good Assembly Competitive firms produce the final good by combining a continuum of intermediate...
... number of amino acid residues contribute to the binding ofthe substrate by hydrogen bonding and ⁄ or hydrophobic interactions Using the ligplot program [31], we investigated the specific interactions ... important rolein ‘cycling’ the pKa of catalytic Glu during catalysis [24,38] The mutation ofthe D1 residue to Asn (D140N) in SmChiB caused a 500-fold decrease in activity [39] On the other hand, in ... almost identical, but the D524A mutation resulted in a remarkable change inthe conformation ofthe Glu526 side-chain The 2Fobs ) Fcalc electron density ofthe Glu526 side-chain inthe D524A–substrate...