the result of differentiation
philips sarah d. women's social activism in the new ukraine. development and the politics of differentiation. bloomington, 2008
... sight of the human face of the NGO sphere, the individuals who populate it, or their stories The problem with existing models of civil society, and with many critiques of these models, is that they ... categories of citizens are weathering these changes Civil Society for Whom? The processes of differentiation outlined here had real effects on the lives and organizing strategies of many of the social ... dispossessed groups of citizens who are struggling to regroup and recoup in the wake of the reordering of state priorities and the withdrawal of social welfare benefits The drama of differentiation...
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Báo cáo Y học: The mitochondrial-lysosomal axis theory of aging Accumulation of damaged mitochondria as a result of imperfect autophagocytosis ppt
... error catastrophe theory and the somatic mutation theory, were based on the idea that aging results from the accumulation of synthetic errors [26,27] Adequate support for these theories, however, ... ACCUMULATION OF LIPOFUSCIN Deposition of lipofuscin pigment within postmitotic cells, one of the most prominent signs of aging, has been known for more than 150 years [28] However, the relation of lipofuscin ... changes in the activity of enzymes of the tricarboxylate cycle and lipid oxidation, and of carnitine content, in muscles of the rat Mech Ageing Dev 19, 191–200 40 Perron, J.T., Tyson, R.L & Sutherland,...
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Báo cáo khoa học: Lack of stabilized microtubules as a result of the absence of major maps in CAD cells does not preclude neurite formation pot
... analyzed to measure the length of the processes The sum of the lengths of all the measured processes was divided by the number of cells Cells with no process were excluded from the analysis At day ... and the use of different antibodies against Tau] confirmed the absence of these proteins Molecular biology techniques showed the presence of the genes corresponding to each MAP and the absence of ... 30% of the complete genes At least these portions of the genes corresponding to each of the MAPs were present in CAD cells (Fig 5A) We consider it most likely that the complete sequences of the...
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Báo cáo y học: "Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling" ppsx
... gain insight into the mechanisms of these drugs on the OA subchondral bone osteoblasts, we further studied the effect of the therapeutic concentration of these drugs, 20 μg/mL, on the major intracellular ... from these studies support the beneficial effect of rhein on both the subchondral bone and the cartilage The mechanisms by which these drugs exert their effect occur through the downregulation of ... levels, by limiting the extent of the type I collagen degradation as well as the resorptive activity of the subchondral bone The role of cathepsin K in the remodelling of this tissue has been well...
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Báo cáo y học: "Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663" docx
... under the control of the RNA Pol III mouse U6 promoter Positive clones were confirmed by sequencing and subcloned into the pHR’ SINcPPT SFFV-WPRE vector under the control of the SFFV promoter The ... it affects HL-60 differentiation requires further study Conclusion Our study is the first investigation of the effect of ATRA on microRNA expression, specifically the ability of ATRA treatment ... induced differentiation [31] Lutherburrow et al reported expression of miR-663 is higher in M1 than M5 AML patients and hypothesized it may potentially be involved in blocking the differentiation of...
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báo cáo khoa học: "Hepatocyte growth factor incorporated chitosan nanoparticles augment the differentiation of stem cell into hepatocytes for the recovery of liver cirrhosis in mice" pptx
... good correlation with the results of biochemical parameters The results of both biochemical and immunohistochemical studies were further confirmed by the expression of mRNAs of Alb, CK18, AFP and ... stability of HGF-CNP to focus further on the localized delivery with the receptor mechanism Acknowledgements The authors are thankful to the Director and the members of the Research Council of CSIR-Central ... HGF-CNP enhanced the process of differentiation Wang et al (2003) showed that hepatic differentiation of HSC could Page of 11 be enhanced by intravenous injection of soluble HGF None of the earlier...
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báo cáo khoa học: "Vulval elephantiasis as a result of tubercular lymphadenitis: two case reports and a review of the literature" pptx
... Page of residents who assisted in the surgery and work up of both of the patients They also contributed to the preparation of the manuscript SSa was the histopathologist who reported on the specimen ... Moreover, both of our cases had a past history of lymph node tuberculosis, with evidence of the puckered scars of healed sinuses in their inguinal regions The etiology in both of our cases was the extensive ... examination of the specimen in both cases showed changes of lymphedema The features were suggestive of non-specific inflammation There was, however, no clear evidence of tuberculosis in the specimens...
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Báo cáo y học: "Acute small bowel obstruction as a result of a Meckel''''s diverticulum encircling the terminal ileum: A case report" pdf
... with dilatation of the small bowel proximal and collapse of the large bowel distal to the stricture (Fig 2) However the aetiology of the stricture, and therefore the cause of the small bowel ... divided at the base using a linear stapler (TLC55, Ethicon) to release the obstruction Care was taken not to compromise the lumen of the ileum The tip of the diverticulum was then dissected off the ... to the other cases previously reported in the literature, where an internal hernial orifice was created by the Meckel's as the result of adhesions or bands between an inflammatory end of the...
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Báo cáo y học: "HIV-1 and recombinant gp120 affect the survival and differentiation of human vessel wall-derived mesenchymal stem cells" pot
... and endothelial cells To study the effects of HIV-1 on the differentiation of these cells, the interaction of HIV-1 and recombinant gp120 on MSC differentiation to adipogenic and endothelial ... express the CD4 mRNA in the absence of detectable amounts of CD4 protein on the cell membrane by flow cytometry analysis However, the presence of CD4 protein below the sensitivity limit of the technique ... and the promotion and development of atherosclerosis lesions due to impaired MSC repair control of endothelial and vessel structure On the other hand, HIV and gp120 induce the differentiation of...
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Báo cáo y học: "Theoretical analysis of the mechanisms of a gender differentiation in the propensity for orthostatic intolerance after spaceflight" docx
... mass in the lower extremities Examining the theoretical consistency of the hypothesis in the context of the current considered mechanism for OI induction suggests that a change in the COG of the ... important test of this hypothesis Appendix Steps in the simulation Man Load the executable form of the model Turn the daily planner option under the “clock” icon to off Run the model under the “Go” ... earth when they were force to assume an upright posture in the simulations Results The results of the simulations studies are displayed as graphical outputs in figures 1, The utility of the model...
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Báo cáo y học: "New genes in the evolution of the neural crest differentiation program" pot
... focused on the ontogenetic and phylogenetic origin of the tissue from the dorsal area of the ancestral chordate neural tube Along these lines, the rewiring of the genes involved in the neural ... 'precursors' offers a satisfactory answer to the evolutionary origin of the neural crest, it fails to account for the acquisition of fundamental properties of this tissue These include the pluripotency of ... Ndeu is the cumulative number of 'new genes' at the level of deuterostomes, Ncho is the cumulative number of novel genes at the level of chordates, and Nver is the cumulative number of 'new genes'...
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THE ROLE OF SWI/SNF IN REGULATING SMOOTH MUSCLE DIFFERENTIATION
... consisted of Exemplar G, was separated from the other classes based off of the positive region of PC2 and the positive region (not shown) of PC3 The positive region of PC2 consisted of the trailing ... understanding of the groupings of the data as well as the areas of the spectra that provide the most variation The AHC dendrogram of the eleven exemplars is shown in Figure 2.2 The dendrogram ... separated from the other classes based on the negative regions of PC1 and PC2 The negative region of PC1 exhibited differences along the leading edges of the spectral curves of the exemplars Differences...
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THE ROLE OF SWI/SNF IN REGULATING SMOOTH MUSCLE DIFFERENTIATION
... by reintroduction of Brg1 into the SW13 cells (Figure 7B) These results are consistent with the results obtained from the DN-Brg1 3T3 cell lines To verify that the inability of MRTFA to induce ... characterized by the expression of smooth muscle α-actin in the absence of other smooth muscle-specific proteins The precursor SMCs further differentiate into mature contractile SMCs characterized by their ... endoderm differentiation in that small intestine mesoderm grafted onto colon endoderm results in the development of a small intestinal-like epithelium rather than the normal colonic epithelium...
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IDENTIFICATION OF A MINIMAL CIS-ELEMENT AND COGNATE TRANS-FACTORS REQUIRED FOR THE REGULATION OF RAC2 GENE EXPRESSION DURING K562 CELL DIFFERENTIATION
... in the melting of the DNA TFIIH has kinase and helicase activity The kinase activity of this factor is required for the phosphorylation of the C-terminus domain (CTD) of Pol II that consists of ... regulation of genes Genomic DNA is the ultimate template of our heredity In spite of the completion of the human genome project, many challenges remain in understanding the regulation of genetic ... in the promoter-specific activation of genes Histone acetyltransferases are the group of enzymes that catalyze the transfer of an acetyl moiety from acetyl coenzyme A to the ε-NH3+ groups of the...
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The role of CD8 t cells in the differentiation of TNF iNOS producing dendritic cells and TH1 responses
... _ 1.1 Immunity The sick and the dying were tended by the pitying care of those who had recovered, because they knew the course of the disease and were themselves free from apprehensions ... interaction also resulted in the production of a cytokine milieu that promoted the differentiation of monocytes into TNF/iNOS-producing (Tip) DCs These Tip-DCs expressed high levels of MHC class ... et al., 2002) These observations are due to the association of the p40 subunit with the p19 subunit which forms IL-23 (Oppmann et al., 2000) IL-23 promotes the differentiation of Th17 cells (Park...
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Development of sphingosine kinase (SPHK) inhibitors and the role of sphingolipids in adult stem cell proliferation and differentiation 2
... of Human SPHK Inhibitors components in the samples, which are then separated in the TLC plate The plate was run in the chamber until the solvent front reached 2cm from the top of the plate, then ... was stated in the beginning of this chapter, one of the motivations for synthesizing new inhibitors for SPHK was the present lack of specific inhibitors Therefore, the newly synthetic compounds ... Evaluation of the Synthetic Human SPHK Inhibitors 2.1.2.1 Compound Function on Exogenous SPHK Activity After the six analogues of sphingosine were synthesized, the inhibitory function of them on...
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Development of sphingosine kinase (SPHK) inhibitors and the role of sphingolipids in adult stem cell proliferation and differentiation 3
... to the large variations The only comparable results were from 1μM of CP6 at the 14 days culture, and 5μM of CP6 at the 14 and 28 days of culture, where in the cell cultured in the presence of ... days of culture, the cells grown in the presence of either 1μM of DMS, 0.5μM of CP6, 1μM of CP6, or 5μM of CP6, showed more lipid droplets staining than that from the cells cultured without the ... osteogenic differentiation in the presence of 1μM of DMS cultured for 14 or 28 days, or in the presence of 0.5μM of CP6 for 28 days, or 1μM of CP6 for 14 or 28 days, or with 5μM of CP6 for 14 days, there...
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Development of sphingosine kinase (SPHK) inhibitors and the role of sphingolipids in adult stem cell proliferation and differentiation 4
... 2002) In the cells, NF-κB forms a complex with iκB, and the phosphorylation of iκBα would cause the release and the activation of NF-κB The activated NF-κB can then translocate into the nucleus ... medium without any other supplements, most of the cells showed to be elongated, and the cell-cell adhesion and the cells attachment to the culture flask looked different with the ones cultured ... triplicate samples were counted The percentages of the expressed cell surface markers in the cells are summarized in Table 4.1, and plots of receptor expression of the last passage cells cultured...
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Development of sphingosine kinase (SPHK) inhibitors and the role of sphingolipids in adult stem cell proliferation and differentiation 5
... concentrations of CP6 (≤0.5μM), or any other of the compounds generated in this study, affect human MSCs differentiation in the mixture of both osteogenic differentiation media and adipogenic differentiation ... to inhibit the osteogenic differentiation in most of the experiments Interestingly, in human BM- and AD- MSCs adipogenic differentiation, DMS and CP6 showed to promote the adipogenic differentiation ... little studies on their expansion being reported in the literature The benefit of using this type of MSC is quite obvious, as the cells are extracted from “unwanted” fat Also, the 156 Chapter Conclusion...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25