the physiology of metabolic tissues under normal and disease states
The role of hydrogen sulfide in normal and ischemic heart
Ngày tải lên :
11/09/2015, 09:57
... blood flow into and out of the heart A region of the heart called the sinoatrial (SA) node is capable of producing and discharging an action potential and sending the impulse across the atria to ... as disease of the cardiac muscle and of the vascular system supplying essential substances to heart, brain and other vital organs The most common manifestations of CVD are coronary heart disease, ... lysing the thrombi in the infarct artery The effectiveness of thrombolytic therapy is determined by the timing of the therapeutic intervention The best results are always observed when the thrombolytic...
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Báo cáo y học: "Significance of differential expression of thymidylate synthase in normal and primary tumor tissues from patients with colorectal cancer" ppsx
Ngày tải lên :
10/08/2014, 21:23
... 0.030 and P = 0.029) primary tumor cells Thirty of them (39.49%) have showed higher level of TS in primary tumors than in normal tissues To study the significance of the differential expression of ... (G1 and G2, P = 0.001), but not to the other parameters defined above MSI was also examined in these patients High frequency of MSI was found in 32.89% (25/76) of the patients in this study The ... site, and the number of lymph nodes examined, were analyzed and compared The results showed that higher TS gene expression in primary tumors correlated to earlier stage (stage II, P = 0.018), and...
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DIFFERENTIATION AND CONTRACTILITY OF COLON SMOOTH MUSCLE UNDER NORMAL AND DIABETIC CONDITIONS
Ngày tải lên :
24/08/2014, 12:32
... motility in the colon The muscularis mucosae is located at the border between the mucosal and submucosal layers, and promotes movement of the epithelial mucosa The main functions of the external ... direct the expression of the two isoforms of the 220-kDa MLCK that differ from each other only in the sequence encoded by exon 1* of the 220-kDa MLCK E1* The protein produced from usage of exon ... utilized standard transgenic approaches One of the limitations of this approach is that the site of integration of the transgene and the transgene copy number can greatly affect both the pattern and...
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Understanding cofactor f420 dependent mechanism(s) in the activation of bicycle nitroimidazoles and in the physiology of mycobacterium tuberculosis
Ngày tải lên :
09/09/2015, 10:17
... compromised by the length of the treatment and therefore emergence of resistance issues due to lack of adherence - short and simple regimens that are effective, safe and robust are the need of the hour ... damage at the early stage of disease and is therefore the histological correlate of both protection and pathology (Reece and Kaufmann, 2012) In humans, the granuloma shows high plasticity and these ... is lost upon reduction of the cofactor F420H2 is the active form of the cofactor that is utilized by Ddn (Figure 1.3) The physiological role of both cofactor F420 and the activating enzyme Ddn...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 1
Ngày tải lên :
10/09/2015, 09:08
... fluids and tissues Hence, quantification of a wide range of potential chemical compounds in biological fluids and tissues may lead to proper understanding of the origin and progress of a disease ... cancer in Singapore For the better understanding of the role of xenobiotics in the progression of ovarian cancer, it is necessary to monitor the levels of these xenobiotics and their metabolites in ... by these substances This is followed by a brief literature survey on the micro extraction and quantification techniques and their significance in the disease diagnostics The aim and scope of the...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 2
Ngày tải lên :
10/09/2015, 09:08
... [5-8] Therefore, determining the level of estrogens in these body fluids would be very important for the study of their roles in the carcinogenesis of ovarian and breast cancer The role of estrogen ... of the compounds by the method of external standardization The limits of detection (LODs) for the analytes at a signal-to-noise ratio of under GC-MS selective ion monitoring, ranged between and ... 34 Chapter [13, 14] The relative standard deviations (RSDs) of the determinations (n = 3) of the analytes were between and 11% To assess the performance of µ-SPE, one of the cyst fluid samples...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 3
Ngày tải lên :
10/09/2015, 09:09
... biplot, the observations are the samples and the variables are the chemicals present in those samples In a biplot, the length of the lines approximates the variances of the variables The longer the ... at least any one of the samples This analysis highlights trends of different xenobiotic and their impact on severity of cancer The trends of the chemicals in the two groups of tumor cyst fluid ... data The goodness of the biplot approximation depends on the axes and the points As for the points, the `quality' of the PCA approximation is found from the R program In this case, the quality 0.627...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 4
Ngày tải lên :
10/09/2015, 09:09
... contaminants because of their extensive use and persistence Furthermore, they are distributed globally via the atmosphere, oceans, and other pathways, PCBs released in one part of the world have contaminated ... probable that the dilution reduced the extent of interferences by the protein (clogging on the membrane) and the low viscosity of the matrix that allowed more efficient extraction Standard safety ... for a group congener with the same number of chlorine atoms This is the first research work of its kind to be carried out and the method showed good linearity of the standard calibration solutions...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 5
Ngày tải lên :
10/09/2015, 09:09
... environmental exposure [1-3] The number of elements of interest has increased in the recent decade, not only the trace metals but the heavy metals as well The study of the role of the trace elements has ... out in studying the role of trace elements in the development or inhibition of cancer To understand the cause for metal induced tumors, it is important to understand the mechanism of metal carcinogenicity ... fluid specimens and to understand the effects of altered homeostasis of these elements in the etiology of ovarian cancer Almost all the elements identified were found to be elevated in the malignant...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 6
Ngày tải lên :
10/09/2015, 09:09
... Approximately µL of organic solvent was withdrawn into the GC syringe and the needle of the syringe was inserted into hollow fibre to about 0.2 cm of the tip of the syringe needle was covered by it The hollow ... that of human the prediction of rate of accumulation of estrogens in zebrafish can reveal the effects of xenobiotic estrogens on humans [12] There is a direct correlation between the rate of bioaccumulation ... a mL vial The organic solvent in the GC syringe was released into the channel of the hollow fibre after which the stir bar in the aqueous phase was activated and at the same time, the stopwatch...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 7
Ngày tải lên :
10/09/2015, 09:09
... after the discovery of the first angiogenesis inhibitor and the purification of the first angiogenesis protein in the mid 1980s that resulted in the widespread acceptance of the concept The discovery ... biomarker and cancer therapeutic drug[20] However, as of today, there is no known crystal structure of the protein available Therefore, in an attempt to further comprehend the molecular factors of the ... molecular mass of polypeptides The speed of migration is dependent on the size of the ‘pores’ in the gel mesh which is in turn determined by the percentage of acrylamide present in the gel The polyacrylamide...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 8
Ngày tải lên :
10/09/2015, 09:09
... terms of concentration levels of compounds which give some clear insights of the influence of xenobiotics in the disease progression 3) The complete profile of environmental organic, inorganic and ... Since the aim of the study was to explore the biologically important tumor fluids and tissues, the choice of analytes should be pertinent to the tumor, such as 164 Chapter carcinogens and EDCs ... cost and biological nature Inclusion of more samples would enhance the reliability of the results 2) The association of chemical levels on the disease progress is greatly influenced by the characteristics...
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A study on improving the performance of control charts under non normal distributions
Ngày tải lên :
26/09/2015, 10:34
... mean, µ j and the mean of the log of the ˆ original observations, µ j (LT ) { } ˆ ▪ Given the K values of M j , estimate the median, the mean and the mean of the log of the distribution of the sample-median ... Repeat these same calculations for the distributions of the sample-mean and the sample mean -of -the- log ▪ Based on procedures for fitting the distribution and the given sample estimates, find the ... observations and R is the average of the ranges The values of A2, D3 and D4 are taken from standard tables (see, e.g., Grant and Leavenworth, 1986 and Montgomery, 2001) 35 Chapter Investigation of the...
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Physiology Of A Marine Beggiatoa Strain And The Accompanying Organism Pseudovibrio Sp. – A Facultatively Oligotrophic Bacterium
Ngày tải lên :
21/12/2016, 10:51
... influence the turnover of nutrients in the oceans The first part of this thesis (Chapter 2) addresses the physiology and mat formation processes of the large sulfide-oxidizers belonging to the genus ... 93% of the carbon demand of the bacteria and to 100% of the nitrogen demand (Fuhrman, 1987; Jørgensen, 1987; Stanley et al., 1987; Keil and Kirchman, 1999; Cherrier and Bauer, 2004) Attached and ... filaments moved below the oxygen-sulfide interface without the presence of nitrate and aggregated in anoxic parts of the culture tube Therefore, the aim of the first part of this thesis (Chapter 2)...
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Báo cáo y học: "Evaluation of the Prevalence of Concomitant Idiopathic Cyclic Edema and Cellulit"
Ngày tải lên :
25/10/2012, 10:51
... idea of the high prevalence of edema in the more advanced grades of cellulite The lack of specific clinical and laboratory studies hinders research on cyclic edema and the dissemination of information ... routinely made in the diagnosis of cellulite, in obesity and in other evident causes of clinical edema The diagnosis of idiopathic cyclic edema was clinical based on the clinical history and fluid retention ... legs at the end of the day Participants were asked to weigh themselves using the same weighing scales at around a.m and p.m for three consecutive days They were requested to use the same clothes...
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Báo cáo y học: "Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities"
Ngày tải lên :
25/10/2012, 10:51
... [42] Renal disease The prevalence of chronic kidney disease in the adult population of the United States is 11% (19.2 million people) [64], and as death rates from heart disease, cancer and pneumonia ... from renal disease are on the rise [65] As more of our patients develop renal disease, psychiatrists must be aware of the effects of psychotropics on the kidneys, as well the effects of decreased ... across other populations [38,39] The effects of lamotrigine and topiramate on serum cholesterol and triglyceride levels have been reported in small studies and case reports [16,38] Neither of these...
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Báo cáo y học: "Godoy & Godoy technique in the treatment of lymphedema for under-privileged populations."
Ngày tải lên :
26/10/2012, 09:39
... factors such as, for example, the weight and the fitness of the patient and the duration of exercises Compression mechanism One of the most important weapons in the treatment of lymphedema is compression ... specialized professionals and the specific materials used are limitations in the treatment Alternatives were sought to simplify and reduce the cost both of the material and the use of this mechanism The ... on the vessels; the authors suggest the use of the term ‘myolymphokinetic therapy’ when these activities or exercises result in a volumetric reduction of the limb These exercises are specific and...
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The role of language in adult education and poverty reduction in Botswan
Ngày tải lên :
05/11/2012, 16:27
... improve the quality of life of the poor and rural people adult education programs should include as one of its components the observation and imitation of the artisans and other skilled persons in the ... maintains the hegemony and the gap between the poor and the rich, the major and minority groups In order to redress poverty the adult education program needs to be aware of the social functions of language ... for the betterment of their conditions It could mobilize the so called minorities to oppose their status and challenge the hegemony of the majority communities in Botswana 31 In most parts of the...
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153 The role of marketing activities to bankcard and actual state of Ngân hàng nông nghiệp và phát triển nông thôn (AgriBank) cards
Ngày tải lên :
03/04/2013, 12:13
... transaction to the acquire and is reimbursed the amount of the sales ticket by the acquirer (4) - The acquirer then summits the ticket to the issuer for payment, via the ICO interchange and settlement ... maintaining the flow of funds and information between issuing and acquiring members The exchange of financial information is called clearing The exchange of the actual funds for the transaction and the ... accumulation of 12 months The growth of total profit showed that the Department has continuously made an effort to diversify the variety of services to meet and satisfy better customers’ needs and demands...
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494 The role of marketing activities to bankcard and actual state of Ngân hàng nông nghiệp và phát triển nông thôn (AgriBank) cards
Ngày tải lên :
08/04/2013, 17:01
... “bộ” “trọn gói” theo nguyên tắc giá gói nhỏ tổng số tiền mua hàng theo phương thức riêng rẽ Định giá theo nguyên tắc địa lý: cách thức mà doanhnghiệp định giá bán sản phẩm theo nguyên tắc địa ... sản phẩm Bề rộng chủng loại sản phẩm phân giải số lượng mặt hàng thành phần theo tiêu thức định ví dụ theo kích cỡ, theo công suất… Bề rộng chủng loại sản phẩm mục tiêu công ty định phần Những ... trường theo giác độ khác Theo quan điểm Marketing thị trường bao gồm tất khách hàng tiềm ẩn có nhu cầu mong muốn cụ thể sẵn sàng có khả tham gia vào trao đổi để thoả mãn nhu cầu Như vậy, theo khái...
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