the nusa tenggara uplands indonesia multiple site lessons in conflict management
Báo cáo y học: "Clinical review: SARS – lessons in disaster management" potx
... maintaining infection control measures), and serve as a way to train treatment teams at different hospital sites Indeed, internet-based technology proved invaluable during the SARS outbreak in ... prevent other infected individuals from falling through the cracks From the critical care point of view, it is important that there is a feedback loop from these surveillance teams to the critical ... [11,14] The SARS outbreak and the ongoing risk for other emerging infections emphasize the importance of having some basic stock [14], and creating a list of potential suppliers who could rapidly increase...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
... constitutive or inducible hemoprotein isoforms [281], exhibiting insignicant sequence identity with P450s in the heme-binding region [282], but bearing a C-terminal avoprotein fragment in the single polypeptide ... & Mayer, B (1994) The pteridine binding site of brain nitric oxide synthase Tetrahydrobiopterin binding kinetics, specicity, and allosteric interaction with the substrate domain J Biol Chem 269, ... iron-peroxo intermediate [11] The sum of these ndings points at the involvement of more than one active oxidant in the diverse types of P450-catalyzed substrate processing [1215] The goal of the present...
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Tài liệu Báo cáo Y học: Structural determinants of the half-life and cleavage site preference in the autolytic inactivation of chymotrypsin pdf
... cleavage site preference is unable to digest D-chymotrypsinogen at sites other than the activation site Furthermore, the trypsinogen propeptide in the chimera proved to be more efficient in protecting ... D-chymotrypsin and trypsin Interestingly, despite the presence of four potential chymotrypsin cleavage sites in its surface loop regions (the interdomain loop does not contain such sites), this ... predominate over heterolysis in the initiation of the physiological inactivation of these enzymes Consistent with this notion is the fact that the interdomain loop autolytic sites are conserved in...
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Báo cáo khoa học: CD91 interacts with mannan-binding lectin (MBL) through the MBL-associated serine protease-binding site doc
... strongly reduced binding (Fig 7B), providing further support to the hypothesis that, as previously reported for calreticulin [28], CD91 binds at or in the vicinity of the MASP-binding site of MBL Discussion ... lectins The interaction site of the CD91 molecule on MBL ⁄ L-ficolin seemed to be in close proximity to the MASP-association site because inhibition was observed with the MASPs and reduced binding ... L-ficolin is a lectin with specificity for N-acetylated and neutral carbohydrates [8] It is synthesized in the liver and, like the other ficolins, has the potential of initiating the MBL ⁄ lectin complement...
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The Art of Being Unreasonable: Lessons in Unconventional Thinking
... about putting the needs of children first—no matter what the special interests say Over the past decade, Eli has been instrumental in helping us undertake major reforms, including launching the NYC ... invaluable, and I appreciate his careful skill in refining the stories and lessons contained in these pages Thank you to Karen Denne, my chief communications officer, for her exemplary coordination ... to contribute their insights to these pages I am indebted to them for their continuing commitment to our work There are many more members of our foundation team, too many to list individually...
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Báo cáo khoa học: Low U1 snRNP dependence at the NF1 exon 29 donor splice site doc
... New site New site New site New site New site New site New site Site broken Site broken New site New site New site New site New site Site broken New site Site broken New site Site broken Site ... New site Site broken New site New site Site broken Site broken Site broken Site broken Site broken Site broken New site Site broken New site New site New site Site broken Site broken New site Site ... Nde1 site in their 5¢-ends, and they were used to clone the product into a modified version of the a-globin-fibronectin extra type III homology B or extra domain B (EDB) minigene, in which the alternatively...
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Báo cáo khoa học: The changing patterns of covalent active site occupancy during catalysis on a modular polyketide synthase multienzyme revealed by ion-trap mass spectrometry pptx
... that inhibits the condensation step therefore deserves consideration The missing ingredient, NADPH, would be expected to bind to the KR domain, not to either of the domains involved in the condensation ... degrees in accordance with evidence that the ACP of one chain interacts with the KS of the opposite chain In the resulting quaternary structure, each ACP domain can access the appropriate KS domain ... conditions The mass spectrum for the fraction containing the TE domain and the key ACP-TE domain is shown in Fig 5B Only one peak was observed for the TE domain, with a mass corresponding to the unloaded...
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The South African Index of Multiple Deprivation for Children potx
... concentrated in the most deprived part of the distribution The municipalities in the remaining five provinces are concentrated in the middle of the distribution The Northern Cape lies towards the least ... concentrated in a fairly broad range in the most deprived part of the distribution The municipalities in the remaining five provinces are concentrated in the middle of the distribution The Northern ... part of the distribution, but in a fairly broad range The municipalities in the remaining five provinces are concentrated in the middle of the distribution The Northern Cape lies towards the least...
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Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf
... Tyr These mutations may in uence the shape and volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme for PAA and derivatives thereof, while maintaining the ... that the binding of both the substrate NIPAB and the product PAA are significantly altered by mutating the phenylalanines in the active site suggesting that hydrophobic interactions between the ... located in the substrate binding pocket Few examples exist in which the ratio between hydrolysis and aminolysis was changed by changing the catalytic nucleophile By replacing the activesite serine in...
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Báo cáo Y học: Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors potx
... here) increased the binding of eIF4E to eIF4G In their case, however, binding of eIF4E to 4E-BP1 was decreased, which is more in line with the expected reciprocal effects on the binding of these ... R.M (1996) Both rapamycinsensitive and -insensitive pathways are involved in the phosphorylation of the initiation factor 4E binding protein (4E-BP1) in response to insulin in rat epididymal fat ... shown), seemingly ruling out a role for this protein in the inhibitory effects of all three stresses on protein synthesis in these cells Heat shock has been reported to inhibit eIF2B activity in vitro...
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Báo cáo khoa học: Aegyptin displays high-affinity for the von Willebrand factor binding site (RGQOGVMGF) in collagen and inhibits carotid thrombus formation in vivo ppt
... Aegyptin binds with high affinity to the vWF binding site in collagen, independently of hydroxyproline In an attempt to identify the binding sites involved in collagen interaction with aegyptin, ... that aegyptin binding to the vWF binding site in collagen sterically interferes with collagen binding to integrin a2b1 as these sites are in close spatial proximity [40] Alternatively, multiple ... ischemic stroke without increasing the risk of intracranial hemorrhage [43] Altogether, targeting the vWF-binding domain, in addition to GPVI and integrin a2b1 binding sites in collagen appears to...
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Báo cáo khoa học: The catalytic significance of the proposed active site residues in Plasmodium falciparum histoaspartic protease ppt
... a medium in the catalytic reaction The position of Lys78 is anchored with an interaction between the main chain oxygen of Ala216 and the e-amine of Lys78 In H34A mutant (Fig 6B), the interaction ... in vivo The differences in cleavage site likely reflect the differences in specificity between HAP and the acidic convertase protein Interestingly, D214A did not exhibit such processing The ability ... ultimately breaking the peptide bond and returning the active site to its original state Inhibition assays showed that HAP, H34A and S37A were effectively inhibited by the serine protease inhibitor...
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Civilising the uplands: development of rubber plantations in remote areas of Lao PDR doc
... setting the aim of stabilising shifting cultivation by 2005 and eliminating it by 2010 At the beginning of this year, the Ministry of Agriculture and Forestry just provided the Ministerial Instruction ... Saykham 2009 Sustainable development in the plantation industry in Laos: an examination of the role of the Ministry of Planning and Investment Manitoba: International Institute for Sustainable Development ... promoted in the context of China’s ‘go out strategies’ The programme provides both financial and non-financial supports for Chinese investment in several sectors, including agribusiness, made in Myanmar...
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BIODIVERSITY CONSERVATION in COSTA RICA Learning the Lessons in a Seasonal Dry Forest pptx
... drift and rates of inbreeding increase within the remaining fragments? In the following sections we first examine theoretical expectations of the effects of fragmentation on the frankie chap 03 ... rivers empty into Lake Nicaragua and the San Juan River, which in turn reach the Caribbean Sea, and in the other, the rivers empty directly into the Caribbean The Guanacaste Mountain Range (Cordillera ... Along with the continental northwest, the peninsula encloses the Gulf of Nicoya, one of the most important ecosystems in the country (chapter 10) The coastal hills and mountains determine the watershed...
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Báo cáo khoa học: Differential binding of factor XII and activated factor XII to soluble and immobilized fibronectin – localization of the Hep-1/Fib-1 binding site for activated factor XII pdf
... heparin The Hep-1-binding site is a low-affinity binding site, and the Hep-2-binding site is a high-affinity binding site [21–23] If FXIIa bound to the C-terminal high-affinity Hep-2-binding site, ... cryptic site in FN Such a binding site has been shown to be also responsible for the interaction of FN with fibrinogen and fibrin [27] Hence, fibrinogen and fibrin inhibited the binding of FXIIa The binding ... the C-terminal Fib-2binding site The binding site in FXIIa is unknown, but lack of inhibition of the binding of FXIIa to FN by sulfatides and the surface-binding peptide of FXII strongly indicates...
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lessons in grid computing the system is a mirror
... greeting other insomniacs or offering help to the janitorial crew This was his standard condition when Linwood visited in the evenings, whereas, on the weekends, Linwood came to New Dachau in the ... Lessons in Grid Computing: The System Is a Mirror Stuart Robbins Lessons in Grid Computing Additional praise for Lessons in Grid Computing: The System Is a Mirror “I really like the storytelling ... role in business should manage the relationships between people rather than the individuals themselves I think how they behave as individuals is less of an issue to the business than how they...
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An empirical analysis of the relationship between audit committee multiple directorships and financial reporting quality
... Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited without ... permission Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited without ... permission Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited without...
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báo cáo hóa học: " Prevalence of multiple chronic conditions in the United States'''' Medicare population" pot
... payments increase in a more linear way as the number of chronic conditions increase Discussion As expected, based on earlier findings in the literature, prevalence of the six chronic conditions included ... conditions in older adults, 2) they are commonly targeted in disease management programs in the U.S [6], and 3) "presence" indicators were available in CCW datasets and could easily be used to define the ... research The twenty-one predefined condition indicator variables are coded within the CCW and disseminated to researchers as variables in the Chronic Condition Summary File Algorithms involving Medicare...
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báo cáo hóa học: " Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis" ppt
... described in the mitochondria, located on the inner membrane of these organelles where they play a crucial role in the maintenance of mitochondrial homeostasis and the proton gradient involved in the ... observed, corresponding to the acute inflammatory phase of the disease [62] Interestingly, we did not observe any changes in the number of infiltrating lymphocytes in the spinal cord of diazoxide-treated ... lymphocytic infiltration into the spinal cord during EAE To determine whether diazoxide treatment affected T and B lymphocyte infiltration into the spinal cord of EAE mice, immunoflorescence using anti-CD3...
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báo cáo hóa học:" Can the surgical checklist reduce the risk of wrong site surgery in orthopaedics? - can the checklist help? Supporting evidence from analysis of a national patient incident reporting system" pptx
... clinicians of the usefulness of the data they contribute should in due course further increase the frequency and quality of reporting Yet, it is increasingly likely that mandatory reporting offers the ... post-operative management These questions are a final check They are intended to be usually a redundant step in the process identifying the few occasions when all other processes have failed to ensure the ... of verification in the operating theatre and of a verification checklist, incorrect marking or consent, preparation of the wrong side, incorrect draping, patient answering to the wrong name [26]...
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