the nature of strength enhancement and weakening by
Báo cáo khoa học: Netropsin interactions in the minor groove of d(GGCCAATTGG) studied by a combination of resolution enhancement and ab initio calculations pot
... evaluating the interaction energies and hydrogen positions of the end fragment and the bases of base pair T8-A25 and base G9 (Table 2, Fig. 4).For the bases of the A25-T8 base pair, the interac-tion ... complex. The NH amide atoms of the drug in particular form H-bonds with thymine O2 and adenine N3 atoms in the AATT-rich sequence of the decamer. Part of the spine of hydration is substituted by the ... Waals’interactions between the drug and the floor and walls of the minor groove [21,22]. Electrostatic interactionsbetween the negatively charged minor groove and the positively charged end groups of the drug...
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Báo cáo khoa học: Monitoring the prevention of amyloid fibril formation by a-crystallin Temperature dependence and the nature of the aggregating species pdf
... decreased by 0.0167 gÆcm)3, from the start of the experiment. By the end of the measurement, the thickness had increased by 0.342 nm, the mass hadincreased by 0.10 ngÆmm)2 and the density ... channel 3, the mass increased by 0.02 ngÆmm)2 and the density decreased by 0.0072 gÆcm)3. After 2.5 h, the thickness increased by 0.212 nm, the mass increased by 0.05 ngÆmm)2 and the density ... during the entire experiment (Fig. 5), i.e. the thickness of the layer decreased by 0.014 nm, the layerdensity decreased by only 0.0086 gÆcm)3, and the massdecreased by 0.03 ngÆmm)2. The process...
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Báo cáo y học: "The association of meat intake and the risk of type 2 diabetes may be modified by body weight"
... assessment of dietary intake, physical activity, and measurement of anthropometrics and other lifestyle factors. Protocols for the SWHS were approved by the Institutional Review Boards of all ... followed by a question on the amount consumed in lians (50g/lian) per unit of time. A lian is the unit of weight in China equivalent to 50 g. The reproducibility and validity of the FFQ was ... of type 2 DM in four prospective studies [3;5-7]. The available data on the association between meat intake and the risk of type 2 DM are limited to four health professionals cohorts and the...
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Tài liệu Báo cáo khoa học: Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3 pdf
... indicate the 5¢-ter-minus of 33 clones isolated after 5¢-RACE. (B)Primer extension analysis of fgl2 mRNA. The left side of the figure is the sequence ladderusing the same primer and the pM166 ... indicates the nucleotide thatis matched to the band present in the primerextension reaction on the right. The sequence of the primer is 5¢-CCTCCACCGCTCGGCAGGCAGCGAGGACGG-3¢. The laneson the right ... theseprobes. All the lanes have labelled probes. The adding of extracts and cold probe are indicated in the top of the panel. Supershift, ss-Sp1 and ss-Sp3, were shown in presence of anti-Sp1 and anti-Sp3...
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Open Cultures and The Nature of Networks doc
... made audible the resonances between the blast of Dada at the end of WWI in Zurich and Berlin, the gust of the Situationists on the Rive Gauche in Paris in the 1960s, and the explosion of Punk Rock ... reduce the imbalances of power between the developer and the user, and between the rich and the comparatively poor. However, what the effects of this leveling of the playing field will be on other ... supporters of FOSS.For the time being, the low costs which increase its accessibility are offset by the still rather high barrier of technical expertise necessary to make use of the much of the software....
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Báo cáo khoa học: Versatile regulation of multisite protein phosphorylation by the order of phosphate processing and protein–protein interactions pptx
... the shape of the response curve isstrongly affected by the two groups of parameters thatdetermine the protein–protein interactions: the concen-trations of the enzymes relative to the target ... to kinase or phospha-tase; the respective concentrations of the target will bedenoted by Xn,0, Xn,K and Xn,P, respectively. They aredetermined by the rates of the reversible enzyme–targetassociations ... for the kinase and phosphatase. Moreover, Eqn (3) shows that the phos-phorylation can be directly inhibited by the phosphatase (and dephosphorylation by the kinase) due to competi-tion of the...
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THE FACTORS AFFECTING THE USE OF ELDERLY CARE AND THE NEED FOR RESOURCES BY 2030 IN FINLAND pot
... 0Simulations30 The growth in operating costs is of the same order of magnitude as the rise in the number of care personnel. The € 508 million operating cost of the domicileelderly care in the year ... services they need either from the keeperSimulations26 The actual coverage of the domicile services at target year depends on the number of elderly living home, their dependency and the expected ... usage and shifts in it. In most of the cases the distribution isnot monotone, therefore we have smoothened the distributions by linear discretemodels. An example of smoothing the distribution of...
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Changing Nature Of Financial Intermediation And The Financial Crisis Of 2007-09 pptx
... held by banks with the assets of securitization pools and those held by institutions that fund themselves mainly by issuing securities. By the end of the second quarter of 2007 (just before the ... 2007). The fluctuations of credit in the context of secured lending expose the fallacy of the lump of liquidity in the financial system. The language of liquidity suggests a stock of available ... The increased importance of the market-based banking system has been mirrored by the growth (and subsequent collapse) of the broker-dealer sector of the economy, the sector that includes the...
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Báo cáo khoa học: A region within the C-terminal domain of Ure2p is shown to interact with the molecular chaperone Ssa1p by the use of cross-linkers and mass spectrometry doc
... observed in the presence of ATP.No change in the mobility of the Ure2p–Ssa1p com-plexes was detected in the presence of ATP. The stoichiometry of Ure2p and Ssa1p within the 120 and 160 kDa ... built from the X-ray structure of the C-terminal domain of Ure2p and integrates the finding that the N-terminal domain of Ure2p is flexible. An enlargement of the region of Ure2p involved in the interaction ... (MH+exp) and the calculated mass difference (p.p.m.) with the theoretical monoisotopic mass of the identified peptide are given. The presence of the modified peptides in the Ure2p, Ssa1p and Ure2p–Ssa1p...
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The Duration of Bank Retail Interest Rates BY Ben R. Craig and Valeriya Dinger ppt
... of deviating from and optimal price (which is a function of the costs and the demand function faced by the firm) and the costs of adjusting the price. Under the assumption of a state-dependent ... advantage of an extraordinarily rich dataset, we extend the scope of this strand of the literature by exploring the effects of 4 Hofmann and Mizen (2004) and De Graeve et al. (2007) relax the ... extend the analysis to study the determinants of the hazard of changing the retail rates. The exploration of these determinants contains, on the one hand, information on the effect of observed...
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Báo cáo khoa học: A strategy for the generation of specific human antibodies by directed evolution and phage display An example of a single-chain antibody fragment that neutralizes a major component of scorpion venom docx
... of these changes occurred at frame-work 3 of the heavy chain (Asp74Asn) and 3 of the lightchain. Two of the changes (Thr152Ile and Ser197Gly)occurred at frameworks 1 and 3, respectively, and ... for the selection of human antibodies through the creation of large repertoires in vitro [10]. This process beginswith the cloning and expression of cDNAs encoding the variable regions of the ... venomobtained by electric stimulation of scorpions of the speciesCentruroides noxius Hoffmann. The venom was purified by Sephadex G-50 gel filtration and cation-exchange chroma-tography [37]. The other...
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wonderful life - the burgess shale and the nature of history
... specimensreveal the crucial point of connection between the head appendages and the shield itself. (The end of the appendage opposite to the point of attachmentwith the body the distal, or farthest, ... position of the eyes and nozzle, the full sequence of lateral lobes, and the gills lying above the lobes. The gut runs as a straighttube down the middle of the body. Figure 3.25 is a side view and revealsseveral ... source of evidence retains achemical signature of organic activity. Of the two common isotopes of carbon,^12C and ^13C, photosynthesis differentially uses the lighter ^12C and therefore raises the...
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