... divergence of Sco proteins in prokaryotes is apparent from the analysis of their genomes, Determinants ofthe elusive functionsof Sco proteins some of which contain genes coding for Sco proteins ... determining the aggregation state of these proteinsThe data therefore support the hypothesis that this N-terminal region is important for modulating the aggregation state oftheproteins In ... diffuses across the outer membrane into the IMS through Determinants ofthe elusive functionsof Sco proteins either porin or the TOM complex; however, the highly impermeable nature ofthe inner membrane...
... Production ofthe antibiotics is the primary factor in the competitive fitness of P aureofaciens in the rhizosphere and the relationships between it, the plant, and the fungal pathogens The antibiotic, ... University of Wisconsin isolated ultraviolet-induced mutants of Demerec’s strain One of these, Wis Q-176, which produced 550 mg/ml, is the parent of most ofthe strains used in industry today The further ... intermediates ofthe shikimic acid pathway, the tricarboxylic acid cycle, and from amino acids The regulation ofthe biosynthesis of secondary metabolites is similar to that ofthe primary processes,...
... N-glycans located on either the b-propeller of a5 [55] or the I-like domain of b1 or b3 [68] contribute to the regulation of integrin function Therefore, we speculate that modification of particular sites, ... Downregulation ofthe alpha-Gal epitope expression in N-glycans of swine endothelial cells by transfection with the N-acetylglucosaminyltransferase III gene Modulation ofthe biosynthesis of terminal ... inhibition of GnT-V might be useful in the treatment of malignancies by interfering with the metastatic process Fut8 Fut8 catalyzes the transfer of a fucose residue from GDP-fucose to position on the...
... above the relevant lanes, and the absence of any added protein is indicated by ()) The position ofthe free RNA and ofthe loading slots is indicated to the right of each gel A B abolished by the ... is shared by the MNAB protein encoded by the other member ofthe mammalian Rc3h gene family, Rc3h2 Stress granule localization is likely to be critical for the function of these proteins, because ... series of GFP fusions with the various motifs of Roquin, and by selectively deleting domains from the full-length protein, we determined that the ROQ domain in the N-terminus ofthe protein is the...
... conformations in the structures ofthe isolated b¢ domain and full-length proteins In the crystal structure ofthe b¢x fragment of human PDI, the C-terminal part ofthe x-linker turns back to contact the ... Specifically, the side chains of Leu343 and Trp347, which are part ofthe linker between the b¢ and a¢ domains, are inserted into the PDI family ofproteins hydrophobic cavity ofthe b¢ domain The binding ... Representation ofthe full-length ERp57 structure with the region recognized as the x-linker colored in red (B) The N-terminal part ofthe x-linker folds against the b¢ domain in the structures ofthe ERp57...
... females The percentage indicates the GSI ofthe females M (B) indicates the expression pattern of MIH-B in the same tissues in males (N ¼ 5) The lower panel is the northern blot analysis of MeMIH-B ... on the reproductive function of MeMIH-B has been attempted, as there is a lack of a good bioassay system for the neuropeptide The recent cloning and characterization ofthe gene encoding the ... drops of 20%, 71% and 23% ofthe overall MeVg1 transcript level were recorded (Fig 6A) Unlike in the hepatopancreas, the reduction of MeVg1 expression in ovaries of these female was small after the...
... impact the outcome ofthe struggle for monomers between several types of fibril due to modulation of their nucleation and exponential growth rates [23] Interestingly, another class ofproteins ... the way to the beginning ofthe experiment [23] (Fig 2C), which means that the observed lag time depends inversely on the growth rate of fibrils, as well as the nucleation rate A compilation of ... fibrils The key to the properties of amyloid assemblies lies in the regularity and repetitiveness of their underlying molecular architecture of intermolecular b-strands stacked perpendicular to the...
... as DFMO retards the growth ofthe pancreas [101], but does not inhibit the secretory function ofthe exocrine part ofthe organ [102] The cellular functionsofthe polyamines in the pancreas were ... SSAT The apparent synergism between the polymorphism ofthe ODC gene and the use of aspirin was proposed to be a combined result of an inhibition of polyamine biosynthesis and an activation of their ... A further function ofthe polyamines, specific to spermidine, is the formation of hypusine, an integral component ofthe eIF5A [10] As the latter factor is essential for the proliferation of mammalian...
... angle between the direction ofthe magnetic field H and the direction ofthe magnetization M ofthe bar magnet [11] The product pl is the magnetization M ofthe bar [13] The work done by the torque ... under the influence of an applied uniaxial tensile load The plot is elongated in the direction of magnetic anisotropy which in the case ofthe 0.03% deformation is also the direction ofthe applied ... minimum at the same time Formation of a certain magnetic domain configuration is the outcome ofthe sum ofthe five basic energies being minimized, although the energies themselves may not be at their...
... deflected The greater intensity increased the number of photon-particles, but not the amount of momentum carried by each On the other hand, changing the color ofthe light did change the angle ... demonstrated using the simplest particles of which our universe is built, the photon and the electron, the basic units of light and matter Measuring the spin of an electron, or the polarization of a photon—scratching ... opposite directions, measuring where one of them is also tells us where the other is Measuring one ofthe electrons also knocks the other one off its guide wave! The technical term for such a relationship...
... van den Berg-Huysmans AA, Huisman MV: Embolus location affects the sensitivity of a rapid quantitative D-dimer assay in the diagnosis of pulmonary embolism Am J Respir Crit Care Med 2002, 165:345-348 ... reliability ofthe confusion assessment method for the intensive care unit (CAM- ICU) JAMA 2001, 286:2703-2710 Tsuchiya, M, Asada A, Kasahara E, Sato EF, Shindo M, Inoue M: Antioxidant protection of propofol ... therapy in infants with acute bronchiolitis Pediatrics 2002, 109:68-73 Abid O, Sun Q, Sugimoto K, Mercan D, Vincent JL: Predictive value of microalbuminuria in medical ICU patients: results of...
... 7:9 ment of food allergy The prevalence ofthe transgenic protein in food and its resistance to processing and cooking may affect the amount of protein ingested, and the resistance ofthe protein ... 8-mer only Number 1of matching pairs ofproteins from the FARRP allergen database that meet the indicated identity criterion Figure Number of matching pairs ofproteins from the FARRP allergen ... database that meet the indicated identity criterion Inset shows a further breakdown in the number of pairs meeting only the 8-mer criteria where the amino acid length of both proteins in the pair is...
... relationships with other mercantile men in distant places for their own 10 TheMany Panics of 1837 profits The particular urban geographies of three ofthe most important cities in the trade ofthe 1830s ... traces the evolution of this event into competing versions ofthe Panic of 1837 that all lost sight ofthe experience of panic But this tale of panic’s disappearance is the end and not the beginning ... Center, the Center for History and Economics at Harvard University, the University of Georgia, the Culture ofthe Market Network at the University of Oxford, the University of Liverpool, the University...
... uncertainty ofthe constant A, however, the absolute positions ofthe energy barriers can be determined from xβ To compare the topography ofthe energy landscape ofthe dissociation of Cldn1/Cldn1 ... contact force of 200 pN and contact time of ms were used,
... contact force of 200 pN and contact time of ms were used, b25% ofthe force–distance curves showed bond rupture events On the basis of Poisson statistics,25 the low frequency of these de-adhesion ... dissociation of bounded complex The geometry ofthe conceptual energy landscape for the dissociation pathway can be constructed based on these kinetic parameters The geometric locations of their bound ... difference ofthe outer barrier The effect of different activation energy barriers on the dynamic properties of Cldn2/Cldn2 and C2E1/ C2E1 complexes is best illustrated in the comparison of their...
... dissociation of bounded complex These kinetic parameters can be further used to construct the geometry ofthe conceptual energy landscape for the dissociation pathway To compare the topography ofthe ... magnitude ofthe rupture events and the apparent loading rate (defined as the slope ofthe retrace curve prior to the rupture event multiplied by the reproach velocity) using MATLAB version 7.1 (The ... slope ofthe curve just before rupture multiplied by the reproach velocity (Vr , expressed in nm/s) defines the loading rate (rf, expressed in pN/s) The height ofthe rupture event defines the...
... better – the best Far – farther – the farthest - further – the furthest Bad – worse – the worst Eating a lot of vegetables is better for our healt Uranus is the farthest planet from the Sun in the ... Descriptive Giving the theoretical background ofthe adjectives and the syntactic functionsofthe adjectives in the two languages c) Comparison Comparing the syntactic functionsof adjectives in ... with the function of verbless caluse supplements the description ofthe tree About xli “pale and fearful” at the beginning ofthe sentence illustrates the serious situation ofthe survivors The...
... demonstrated that these caveolae functioned in the uptake and hydrolysis of cholesteryl ester from HDL The involvement of SR-B1 in this uptake was indicated by the inhibition ofthe uptake by the SR-BI ... classes of caveolae are hidden in the partly separated peaks of caveolae defined herein Our findings nevertheless clearly demonstrate the segregation of different functions in different caveolae in the ... contamination ofthe plasma membrane fraction may be the source ofthe small amounts of TGN38, but it is unlikely that the closed VHD-caveolae fraction is Golgi ⁄ microsomal membrane, for the following...
... in vitro wound healing Ratios ofthe percentage of fluorescent cells in the wound area to the percentage of fluorescent cells in nonwound regions ofthe monolayer on the same extracellular matrix ... constructs The extent of increased apoptosis among DP9-expressing cells was similar to the extent ofthe adhesion deficit This concordance of apoptosis and adhesion suggests that one may cause the other ... the RGD motif Interestingly, even without STS treatment there were increases of about 20–25% in the percentages of apoptotic cells in the cell subpopulations that were overexpressing any of the...