the major regulator of hi phi and nai in cardiomyocytes and an important promoter of cardiac hypertrophy
Báo cáo y học: "bEstrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly" docx
Ngày tải lên :
14/08/2014, 08:21
... Hardman and Ashcroft R80.2 findings have clear implications for our understanding of ageassociated cellular changes in the context of wound healing, and are highly relevant with respect to many other ... regulated in uterus and prostate, it has not previously been shown to be estrogen regulated in skin Again, this novel finding may be important in light of the role of arginase in modulating the balance ... were significantly changed in the same direction between human and mouse (Figure 5a) The remaining genes (PTPRO and SPRR1A) were also significantly changed in both human and mouse but in opposite...
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Báo cáo y học: "Quantifying the major mechanisms of recent gene duplications in the human and mouse genomes: a novel strategy to estimate gene duplication rates" docx
Ngày tải lên :
14/08/2014, 08:20
... ensure annotation quality and obtained 22,598 human genes and 24,064 mouse genes Of these, 8,312 in human and 8,105 in mouse are single-copy genes, and the remaining are clustered by Ensembl into ... that for the entire genome We hope that the results of this study will further our understanding of the mechanisms of gene duplication in mammals Pan and Zhang R158.3 comment of the human genome ... About 94% of the human gene pairs and 91% of the mouse gene pairs in the NEW gene set have Ks ≤ 0.25, which confirms the recent duplications of these genes The majority of the gene pairs in the NEW...
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Báo cáo y học: "A hidden reservoir of integrative elements is the major source of recently acquired foreign genes and ORFans in archaeal and bacterial genomes" pdf
Ngày tải lên :
14/08/2014, 21:20
... explain the origin of the majority of ORFans in the majority of prokaryotes and consequently, other, not necessarily exclusive, mechanisms are likely to better explain the origin of the increasing ... of likely virus origin 875 (25.1% of all ORFans inside CAGs) Number of ORFans in CAGs of likely plasmid origin 680 (19.5% of all ORFans inside CAGs) Number of ORFans in CAGs of likely virus and ... 5a, red) and 4% as of plasmid/viral origin (CAGs with equal probabilities of being of plasmid and viral origin; Figure 5a, yellow) Nevertheless, the origin of an important proportion of newly...
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Báo cáo y học: "Proteinase-3 as the major autoantigen of c-ANCA is strongly expressed in lung tissue of patients with Wegener’s granulomatosis" pptx
Ngày tải lên :
09/08/2014, 03:24
... [10] One of the unresolved issues is the inability to explain the nonrandom, selected organ injury that defines the WG vasculitis and the concurrent, seemingly random, nature of injury within ‘targeted’ ... be induced by cytokines in human endothelial cells [13,14] The lung is the organ most frequently involved in WG, and in some cases it is the only organ affected [15] Given the potential importance ... We found this kind of distribution of PR-3 mRNA expressing cells at sites of inflammatory infiltration, granulomas and vasculitis At the We found the PR-3 protein in only few cells in normal...
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báo cáo khoa học: "On the genetic determinism of muscular hypertrophy in the Belgian White and Blue cattle breed" pptx
Ngày tải lên :
09/08/2014, 22:23
... phenotype The calves from the sires De and Na were dissected between 1972 and 1978 and the calves from the sires Te and Ch between 1979 and 1984 The calves were reared in the constant environment of an ... Considering figure 1, the cut-off point is lying between 16 and Bimodality 17 kg The mean, the standard deviation and the test of normality of the component distributions are given in table where they ... were estimated through the fitting to the data of a monogenic model Regarding their degree of muscling, the breeds used in this cross the Friesian (D) and the Belgian White and Blue (DM) —...
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the major sources of secondary data
Ngày tải lên :
11/06/2015, 13:00
... education achieved • type of dwelling lived in • number of people living in the household • level of income etc These data can be used to build a profile as broad as the Australian population ... levels and body mass) and health status The Census: These special areas of interest aside, the ABS also conduct the National Population Census every five years (the last one was done in 1996) The ... The Major Sources of Secondary Data: Australian Bureau of Statistics The Census Other Sources Australian Bureau of Statistics The ABS collects data on a wide range of subjects from the...
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The major parts of diesel engines
Ngày tải lên :
14/05/2016, 20:49
... d cylinder covers • • • • • • The design of a cylinder cover depends upon such factors as: the size of the valves, The size of fuel injection valve, the size of cylinder, and the shape of the ... 2.3.3 Crankshaft a Acting force and materials: The crankshafts are subjected to bending and torsional action during engine operation and These alternately changing forces exert complex and ... machanism The fundamental roles the driving mechanism plays are: To control the process of charging fresh air into the cylinder, Discharging the combustion products out of the cylinder and...
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Báo cáo y học: "Early onset pauciarticular arthritis is the major risk factor for naproxen-induced pseudoporphyria in juvenile idiopathic arthritis" pdf
Ngày tải lên :
09/08/2014, 10:20
... predominantly of Scandinavian ancestry, and so fair skin is more likely to be present in these children In addition, they are generally young, making early age another confounder 10 11 12 Further ... within year, and one within each of 2, and years (Figure 4) Of children with PP, 21% continued to develop new skin lesions after discontinuation of naproxen therapy; clinical features continued ... in accordance with the principles of the revised declaration of Helsinki and has been approved by the ethics committee of the University of Würzburg All patients were examined for clinical manifestations...
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NVESTIGATING THE MOLECULAR MECHANISM OF PHOSPHOLAMBAN REGULATION OF THE Ca2+-PUMP OF CARDIAC SARCOPLASMIC RETICULUM
Ngày tải lên :
24/08/2014, 11:06
... mutants to V89C-SERCA2a in the presence and absence of 40 µM TG B, TG inhibition of PLB cross-linking Upper panel shows immunoblots and Lower panel show the plot of TG inhibition of PLB cross-linking ... enter the cell Then, through the process known as Ca2+ induced Ca2+ release, the “activator” Ca2+ triggers the opening of the Ca2+ release channels/ryanodine receptors in the membrane of the SR, and ... (or calmodulin kinase II (CaMKII), see below) reverses PLB inhibition of SERCA2a, increasing the apparent Ca2+ affinity of the enzyme and increasing the rate of Ca2+ uptake into the SR (2, 3)...
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Characterization of plasma myosin heavy chain in zebrafish as an important factor for ompa mediated anti phagocytic function
Ngày tải lên :
03/10/2015, 20:32
... diagnosis, the change of the concentration of MHC in human serum and plasma is an important factor to examine the muscle injury and myosin-related diseases 12 1.3 The role of Outer membrane protein A ... the wide type E coli K1 can inhibit the phosphorylation of NF-κB thereby prevents the translocation of NF-κB to the nucleus The mechanism of inhibiting the proinflammatory response can help the ... are involved in recognition of different phage protein as well as involving in conjugation and in binding of a phage and a bacteriocin (Morona et al, 1984) 1.3.3 The role of OmpA in virulence The...
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The major factors affecting speaking skill of first year english major students at vinh university and some suggested solutions tions improve their communicative competence
Ngày tải lên :
18/12/2013, 21:45
... for further study are also mentioned in this chapter of the thesis The study ends with the “References” which lists all the materials and sources of the information used in the study and the “Appendix” ... in the forms of the texts while coherence deals ith the meaning of the texts Canale also states four ways to achieve coherence, they are: repetition of meaning, progression of meaning, relevance ... newspaper while my mother is interested in cooking” Parallel structure is a useful mean to create meaning relevance in the text Non contradiction is avoiding the conflict in the meaning of the text The...
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Teaching speaking skill to non english major students of pre intermediate level at the people’s police academy some suggested techniques and activities
Ngày tải lên :
06/02/2014, 14:40
... teaching in general and the changes in English language teaching in particular are not the changes in the way we teach These are the changes in the aims of language teaching and learning In the ... communication involves four macro inter-related skills: listening, speaking, reading and writing The teaching and learning of a foreign language is, in fact, the teaching and learning of the linguistic ... teachers and students at the PPA encountered in teaching and learning speaking skill The last chapter – Findings and Recommendations – consists of author’s findings of the difficulties of the teaching...
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Báo cáo khoa học: The 3¢-UTR of the mRNA coding for the major protein kinase C substrate MARCKS contains a novel CU-rich element interacting with the mRNA stabilizing factors HuD and HuR ppt
Ngày tải lên :
08/03/2014, 08:20
... overexpression of HuD (lane 4) and HuR (lane 6) (upper panel) Staining of the gel with ethidium bromide revealed equal loading of the gel and integrity of the RNA (lower panel) The positions of the 28S and ... StuI and HindIII, and the luc-fragment was cloned into pcDNA3 (Invitrogen, Karlsruhe, Germany) via a filled -in EcoRI site and a HindIII site downstream of the CMV promoter, resulting in the plasmid ... (PCC7-Mz1) Ethidium bromide staining shows equal loading of the gel and integrity of the RNA (lower panel) The positions of 18S and 28S rRNA are indicated (B) Western blot analysis with the affinity-purified...
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Báo cáo khoa học: Gain of structure and IgE epitopes by eukaryotic expression of the major Timothy grass pollen allergen, Phl p 1 pdf
Ngày tải lên :
16/03/2014, 18:20
... for enhanced secretion of the recombinant protein into the culture supernatant and a C-terminal His6-tag The pBacPAK8 construct was confirmed by DNA sequencing and cotransfected with the linearized ... Allergy Clin Immunol 94, 689– 698 17 Suphioglu C & Singh MB (1995) Cloning, sequencing and expression in Escherichia coli of Pha a and four isoforms of Pha a 5, the major allergens from canary grass ... supernatants and cell pellets were analyzed by SDS ⁄ PAGE and immunoblotting with a rabbit anti-Phl p antiserum and a monoclonal anti-hexahistidine antibody Rabbit antirPhl p Igs were detected with an...
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Báo cáo khoa học: The pivotal regulator GlnB of Escherichia coli is engaged in subtle and context-dependent control potx
Ngày tải lên :
23/03/2014, 04:21
... Scanning of the autoradiograms and the determination of intensity of the PII* and PII*UMP bands were as described above Some gels did not result in a complete separation of the uridylylated and ... intensity of the GlnB band was quantied as the sum of the concentrations of GlnB and GlnK and was denoted by PII* Note that PII* includes the modied forms of GlnB and GlnK as well, i.e GlnBUMP and ... and the biosynthesis of glutamine, glutamate, aspartate, asparagine, l-alanine, and d-alanine In Escherichia coli and Salmonella Cellular and Molecular Biology (Neidhardt FC, Curtiss R III, Ingraham...
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Báo cáo khoa học: A strategy for the generation of specific human antibodies by directed evolution and phage display An example of a single-chain antibody fragment that neutralizes a major component of scorpion venom docx
Ngày tải lên :
23/03/2014, 13:20
... of these changes occurred at framework of the heavy chain (Asp74Asn) and of the light chain Two of the changes (Thr152Ile and Ser197Gly) occurred at frameworks and 3, respectively, and the third ... (Val101Phe) of the heavy chain might also be important for binding to the toxin The change of Val to Phe may result in a better interaction in terms of an increased contact area Changes at CDRs and in ... closest germ line, diversity and joining segments for the VH domain of clone C1 were IGHV3-30*18, IGHD2-21*01 and IGHJ2*01, respectively For the VL domain, the germ line and the joining segments...
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Báo cáo khoa học: The N-glycans of yellow jacket venom hyaluronidases and the protein sequence of its major isoform in Vespula vulgaris pdf
Ngày tải lên :
23/03/2014, 15:20
... sera containing antiglycan immunoglobulin can bind to a variety of plant and insect glycoproteins and even to human proteins unrelated to any allergen in the peptide part when the glycan has been ... N-glycans of the 43 kDa band and of whole venom The major glycan species found by MALDI-TOF MS had masses indicating them to consist of two GlcNAc, either two or three mannose residues and two ... those of free glycans horizontally, and that of the mother ion tilted From the loss of two fucose, of three mannose and, finally, of two GlcNAc residues, the composition of the glycan moiety of this...
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Báo cáo y học: "The opposite effects of fluvoxamine and sertraline in the treatment of psychotic major depression: a case report" potx
Ngày tải lên :
08/08/2014, 23:21
... the dopaminergic system by the inhibition of dopamine transporter may be involved in the mechanism of unwanted effects (deterioration of psychosis) of sertarline in this case, although further study ... pieces of evidence suggest that sigma-1 receptors play a role in the pathophysiology of major depression and in the active mechanisms of some antidepressants [16-20] The inhibition constants (Ki) of ... the clinical and rating evaluations during the follow-up periods KH conceived of the study and participated in its study and coordination All authors read and approved the final manuscript Author...
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Báo cáo y học: "Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice" doc
Ngày tải lên :
09/08/2014, 01:24
... from the nose, trachea, and larynx, and the degree of pathologic changes was correlated with clinical scores The inflammatory infiltrates consisted of neutrophils, lymphocytes, and eosinophils In ... infiltrations of macrophages and lymphocytes In addition, a subgroup of patients with RP produces an antibody response to matrilin-1, and serum antibodies from these patients inhibit the binding of anti-matrilin-1-specific ... important at the induction of MIRP In order to define the infiltrating inflammatory cells in the acute and chronic phases of murine MIRP, we stained tissue sections dissected from cartilage of...
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Báo cáo khoa học: "The combined effect of erythropoietin and granulocyte macrophage colony stimulating factor on liver regeneration after major hepatectomy in rats" pot
Ngày tải lên :
09/08/2014, 03:21
... for 12 hr before the procedure and the same care continued in the postoperative period Care and handling was in accordance with the National and European guidelines laboratory animal care Eighty ... that they have no competing interests Authors' contributions VI, LE and SV conceived of the study, and participated in its design and coordination and helped to draft the manuscript NC, TA and ... role of autologous transfusion inducing endogenous EPO production Finally, the mechanisms involved in the inhibition of EPO by GM-CSF are the focus of our current research Competing interests The...
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