the investigation of gene regulation and variation in human cancers and other diseases

Báo cáo y học: " Advances in the genetics and epigenetics of gene regulation and human disease" pps

Ngày tải lên : 14/08/2014, 17:22

... involved in cell-cycle control and cell-size regulation in Drosophila Using flow cytometry, Björklund and colleagues analyzed the RNAi-induced loss -of- function of 70% of the genes in Drosophila, including ... understanding key regulatory mechanisms of human gene expression Outi Hallikas (University of Helsinki, Finland) aimed to determine the binding specificities of transcription factors that are involved ... Biology 2006, reviews reports The annual Human Genome Meeting of 2006 was an inspiring meeting, updating us on the latest knowledge in human genomics The power of combining high-throughput experimental...

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RESEARCH ON THE CHANGE OF 2-AP AND OTHER VOLATILE COMPOUNDS IN PROCESSING BUN FROM RICE

Ngày tải lên : 28/08/2013, 16:28

... of OM 6162 exposed the peak 2-AP at the Rt 9.678 minute 734 Research on the Change of 2-AP and Other Volatile Compounds in Processing Bun from Rice 3.4 Investigating the changes of 2-AP and other ... 3°C/min then from115°C to 220°C at 30°C/min and finally maintained at 220◦C for The detector port was maintained at 2500C Concentration of 2-AP in samples s is identified and quantified in the ... rate of 1.9 ml/min at 250C The injection was performed in splitless mode first (5 for SPME and for SDE), then in split mode to the end of the cycle (38.5 for SPME and 70 for SDE) After warming the...

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Credit Growth and the Effectiveness of Reserve Requirements and Other Macroprudential Instruments in Latin America pdf

Ngày tải lên : 06/03/2014, 04:21

... deposit and lending interest rates These findings, more generally support the use of RRs as a policy instrument in an inflation-targeting regime in terms of their effectiveness in reinforcing monetary ... Considerations The effects of RRs on the cost and availability of credit is determined by the banking system’s market structure, the degree of financial development, and the design of RRs themselves.14 The ... complementary and recent discussion of the motives and use of RRs across the world 4 partly reflects the sectoral and targeted nature of many of these other macroprudential instruments and also their...

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BÁO CÁO "RESEARCH ON THE CHANGE OF 2-AP AND OTHER VOLATILE COMPOUNDS IN PROCESSING BUN FROM RICE" doc

Ngày tải lên : 19/03/2014, 16:20

... of OM 6162 exposed the peak 2-AP at the Rt 9.678 minute 734 Research on the Change of 2-AP and Other Volatile Compounds in Processing Bun from Rice 3.4 Investigating the changes of 2-AP and other ... 3°C/min then from115°C to 220°C at 30°C/min and finally maintained at 220◦C for The detector port was maintained at 2500C Concentration of 2-AP in samples s is identified and quantified in the ... rate of 1.9 ml/min at 250C The injection was performed in splitless mode first (5 for SPME and for SDE), then in split mode to the end of the cycle (38.5 for SPME and 70 for SDE) After warming the...

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Báo cáo y học: "The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes" ppsx

Ngày tải lên : 09/08/2014, 01:23

... rate-limiting step in the de novo synthesis of pyrimidines [7,8] The inhibition of DHODH activity by A77 1726 might explain part of its mechanism of action in suppressing inflammation Indeed, many ... production in fibroblasts and chondrocytes Two types of inhibitors were tested: genistein, a broad range tyrosine kinase inhibitor; and PP1, a more specific inhibitor of the src family of tyrosine kinases, ... Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: I IL-1 receptor antagonist inhibits IL-1-induced cytokine synthesis and blocks the binding of IL-1 to its type II receptor on human...

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Báo cáo y học: "The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanase" docx

Ngày tải lên : 09/08/2014, 06:23

... reducing the synthesis of LTB4 and IL-1β by the OA synovium [6] These findings are in strong support of the in situ role played by LTB4 in the structural changes that occur in OA The progression of the ... focuses on the in situ effect of licofelone on the gene expression and protein synthesis of the major collagenolytic enzymes (MMP-13 and cathepsin K) and aggrecandegrading proteases (ADAMTS-4 and ADAMTS-5) ... found between the 5-LOX cell score and both safranin-O staining and the Mankin score Therefore, the downregulating effects of licofelone on the level of mRNA expression/protein synthesis of 5-LOX...

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Báo cáo y học: " Induction of multiple matrix metalloproteinases in human dermal and synovial fibroblasts by Staphylococcus aureus: implications in the pathogenesis of septic arthritis and other soft tissue infections" pdf

Ngày tải lên : 09/08/2014, 08:23

... and osteomyelitis in murine models of these diseases We therefore tested the ability of cell lysates and culture supernatants obtained from these mutants and their isogenic parent strain to induce ... complication of RA The risk is highest in severe, longstanding, seropositive disease The clinical presentation of joint infection is frequently atypical, and in 25% of cases, the infection is ... against infection Inhibition of its activity could therefore be anticipated to augment the risk of infection in patients with RA The reasons for the predominance of S aureus in SA and the mechanisms...

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Báo cáo y học: "Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases'''' pps

Ngày tải lên : 12/08/2014, 15:22

... Structure of spleen tyrosine kinase (Syk) protein Syk includes two tandem SH2 domains and a tyrosine kinase domain Interdomain A is between the two SH2 domains, and interdomain B is between the tyrosine ... downstream of Syk in ITAM-mediated activation [63] These studies have generated a rationale for the use of Syk inhibitors in the treatment of crystal-induced arthritis and other autoinﬂammatory diseases ... macrophages, and osteoclasts As all of these cells are involved in the instigation and establishment of tissue pathology in autoimmune allergic and autoinﬂammatory diseases, Syk inhibition has gained...

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Báo cáo y học: " Alterations in the expression of DEAD-box and other RNA binding proteins during HIV-1 replication" potx

Ngày tải lên : 13/08/2014, 13:20

... genes and genes encoding other RNA binding factors may indicate that such gene products are involved in other aspects of HIV replication These aspects of HIV replication could involve activities in ... show that several other RNA binding proteins are differentially regulated during HIV-1 replication, suggesting that there may be a general involvement of these classes of genes in the HIV replication ... of RNA In addition, genes encoding other proteins involved in nucleic acidprotein interactions were also upregulated, such as members of the SWI/SNF family of ATP-dependent chromatin remodeling...

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The role of nitric oxide and other gaseous mediators in cardiovascular disease models; emphasis on septic shock

Ngày tải lên : 14/09/2015, 14:16

... both the heterogeneity of the clinical situations involved and the extreme complexity of the host response to overwhelming infection As such, the need to assess which animal model of inducing ... by the host in the course of severe sepsis and septic shock 2.3 Evidence for the involvement of NO in sepsis and septic shock 2.3.1 In vivo overproduction of NO in sepsis The strength of the ... an increase in the plasma NOx levels At and hr after continuous i.v infusion of LPS in the pig, iNOS mRNA in the liver had a diffuse appearance (Pastor et al., 2000), with the expression of the...

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The effect of vitamine E and bta carotence on the incidence of lung cancer and other cancers in male smokers

Ngày tải lên : 23/05/2016, 10:05

... The New England Journal of Medicine Downloaded from nejm.org on January 6, 2013 For personal use only No other uses without permission Copyright © 1994 ... Massachusetts Medical Society All rights reserved The New England Journal of Medicine Downloaded from nejm.org on January 6, 2013 For personal use only No other uses without permission Copyright © 1994 ... Massachusetts Medical Society All rights reserved The New England Journal of Medicine Downloaded from nejm.org on January 6, 2013 For personal use only No other uses without permission Copyright © 1994...

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Tài liệu "Promoting healthy diets and physical activity: a European dimension for the prevention of overweight, obesity and chronic diseases" doc

Ngày tải lên : 14/02/2014, 13:20

... process and consensus-building exercise The Global Strategy underlines the importance of achieving a balanced diet reducing the consumption of fats, free sugars and salt, of increasing the intake of ... 7-11 The rates of the increase in childhood overweight and obesity vary, with England and Poland showing the steepest increases49 12 EN As relatively few risk factors cause the majority of the ... Transport and urban planning policies can ensure that walking, cycling and other forms of exercise are easy and safe, and address non-motorised modes of transportation The provision of safe cycling and...

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CAN AESTHETIC THEORIES OF ART BE RESCUED FROM THE PROBLEM OF AVANT-GARDE AND OTHER NON-PERCEPTUAL ARTWORKS? – AN EXPLORATION OF NON-PERCEPTUAL AESTHETIC PROPERTIES pdf

Ngày tải lên : 30/03/2014, 16:20

... avant-garde artworks in the domain of the aesthetic Since the era of Duchamp’s Fountain, avant-garde artworks have developed to the point of once again challenging the aesthetic theory of art Counterexamples ... aesthetic to incorporate avant-garde artworks However, part of the art domain remains outside of that of the aesthetic Artworks in this area remain counterexamples to the aesthetic theory of ... into the aesthetic theory of art The third solution invokes the idea of non-perceptual aesthetic properties and takes the following form: it accepts (R) and (X) but denies (S).7 Shelley’s main...

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báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pptx

Ngày tải lên : 20/06/2014, 04:20

... BMP-2 maintained the mineralizing RNA profile of igf-1, alp, and bmp-2 and significantly increased expression of other genes associated with mineralization like col1a1, fn, ilgf-1, noggin and oc ... FGF-2 and BMP-2, the yin and yang of mineralization: Contrast of effect of 24 hours of treatment with FGF-2 or BMP2 on fold increase in abundance of mineralization-related gene expression Mineralizing ... of growth, angiogenic and chemotactic genes and depresses expression of mineralization-related genes, these figures not tell us the relative abundance of the genes In Table 2, we determined the...

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báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pdf

Ngày tải lên : 20/06/2014, 07:20

... BMP-2 maintained the mineralizing RNA profile of igf-1, alp, and bmp-2 and significantly increased expression of other genes associated with mineralization like col1a1, fn, ilgf-1, noggin and oc ... FGF-2 and BMP-2, the yin and yang of mineralization: Contrast of effect of 24 hours of treatment with FGF-2 or BMP2 on fold increase in abundance of mineralization-related gene expression Mineralizing ... of growth, angiogenic and chemotactic genes and depresses expression of mineralization-related genes, these figures not tell us the relative abundance of the genes In Table 2, we determined the...

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Báo cáo khoa hoc:" A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population" doc

Ngày tải lên : 11/08/2014, 08:20

... more), father or mother's height, father or mother's birth weight (obtained from subjects' mothers), father's BMI, mother's pre-pregnancy BMI, mother's age, father's age, father's fasting triglyceride ... CSH1.01 genotype and fathers' fasting insulin There was no association between father's D1/T or D2/T genotype and fasting insulin (Table 1) The P values for fathers' fasting insulin were little ... assess the role of CSH1.01 variation in measures of fetal and postnatal growth and adult insulin resistance, as measured by fasting insulin concentrations and Homeostasis Model Assessment of Insulin...

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Báo cáo y học: "Comment on and reply to "Analysis of variation of amplitudes in cell cycle gene expression" by Liu, Gaido and Wolfinger: On the analysis of gene expression during the normal, eukaryotic, cell cycle" docx

Ngày tải lên : 13/08/2014, 23:20

... doubling time, and in some cells the peak was at hours, others 10 hours, and other 11 hours, the amplitude would be reduced based on the distribution and frequency of the peak of expression in ... trying to explain differences between different experiments in terms of variation in the phase angles of peaking of gene expression in different individual cells Thus, given a particular variation ... It is of interest to look at the basic data in Table of Liu, Gaido and Wolfinger [1] In Table they present results on the gene expression amplitudes in two different experiments In Table they...

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Báo cáo y học: " Horizontal gene transfer and the evolution of transcriptional regulation in Escherichia col" ppt

Ngày tải lên : 14/08/2014, 08:20

... evolve more slowly than other regulators, both in terms of gene gain and gene loss and in their amino acid sequence Co-transfer of neighbor regulators with regulated genes In contrast to global ... horizontal transfer events using a combination of the gene phylogeny and the pattern of gene presence and gene absence If a strongly supported clade in the gene tree was present in disparate genomes, ... duplications within the E coli lineage For the duplicated TFs, we examined whether they regulate the same genes as their duplicates For the HGT regulators, we examined whether they were co-transferred...

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The role of NF kb and histone deacetylase in gene regulation

Ngày tải lên : 14/09/2015, 08:45

... be linking TRAF6 and IKK, are transformining growth β activated kinase (TAK1), TAK1-binding protein (TAB1) and TAK1-binding protein (TAB2) (Wang et al., 2001) The TAK1, TAB1 and TAB2 protein complex ... PP2A, PP2B (Calcineurin) and PP2C These protein phosphatases have been implicated in the negative regulation of the NF-κB signaling pathway The serine/threonine family of protein phosphastase ... cancerous cells In the case of the IL-1 and TNF cytokine, interaction of these cytokines to their respective receptors on the cancer cell activates downstream signaling components of the NF-κB pathway,...

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Tài liệu Báo cáo khoa học: Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3 pdf

Ngày tải lên : 20/02/2014, 11:20

... indicate the bands that are interacting with these probes All the lanes have labelled probes The adding of extracts and cold probe are indicated in the top of the panel Supershift, ss-Sp1 and ss-Sp3, ... facilitate the further recruitment and binding of other positive trans-regulators, such as Oct-1, Ets-1, and Stat3-like protein (Fig 5) In other systems Sp1 has been shown to physically interact and ... is implicated in the constitutive expression of fgl2 to the induced transcription of fgl2 in response to MHV-3 We examined whether a mutation of the PRD would abolish the induction of fgl2 by MHV-3...

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