... take into account these two distinct cellular types Imatinib is a tyrosine kinase inhibitor that specifically binds the ATP pocket of Bcr-Abl tyrosine kinase, inhibiting the activity ofthe kinase ... well defined in terms ofthe oncogenes involved Imatinib induces a high rate of remissions when given in a clinical context, but when Imatinib is discontinued the disease returns to a clinical ... generation of altered cellular behavior because of an altered protein network secondary to the introduction of a new oncogene protein or the removal of a tumor suppressor protein In either case, definite...
... for mechanisms of PI resistance inthe CAPAN-1 (BRCA2 null) cell line by treating the cells with the drug and identifying the genetic alterations in resistant clones Fascinatingly, the resistance ... within BRCA2 that removed the original germline frameshift mutation, restoring the coding sequence to the correct frame with an in- frame fusion that, while still missing parts ofthe protein, ... Interestingly, autophagy continued to occur even when the drug was removed after the initial treatment, thereby decreasing side effects One ofthe looming unresolved issues in targeted therapeutics...
... survivors are within the psychological domain; fear ofthe cancer spreading, concerns regarding the worries of those close to them, uncertainty about thefuture [26] , and existential issues [23] ... QoL, have been introduced in clinical trials on a large scale, in addition to measures of morbidity and mortality A simple search on ‘quality of life’ on Medline at the beginning of 2009 gives ... Qualitative methods of inquiry provide an in- depth insight into the lived experience of people However, predominantly standardized QoL-questionnaires are being applied A distinct number of reliable and...
... to various facets of human resource constraints including inadequate number of personnel being involved inthe supply chain, staff being inadequately trained and staff being inadequately remunerated ... heads ofthe facilities providing ART services inthe four countries were the key informants at the program level The survey looked at the types of HIV/AIDS services provided, the existence of guidelines ... management Inappropriate prescribing • Inadequate training • Insufficient number of prescribers • Training on appropriate prescribing • Training more prescribers • Review prescribing laws and...
... {128-bit strings} {128-bit strings with 64 1s} Figure 2: Two-part representations of a 128-bit string As the length ofthe model increases, the size ofthe set including the target string decreases ... representations ofthe 128 binary string 101010 · · · 10 In this representation, the model is defined in English language text that defines a set, and the log2 ofthe number of elements inthe defined set is the ... an instantaneous code approaching the entropy inthe limit ofin nite message length when the distribution is known Inthe absence of knowledge ofthe model, one way to proceed is to measure the...
... rupting the continuity of a treatment course without compromising the result The principle implied by this intriguing example merits further study Pharmacokintetic based studies in lapatinib therapy ... even with the additional costs of HER2/new testing Low dose, prolonged infusion gemcitabine The encouraging response of phase I-II trials of low dose gemcitabine in prolonged infusion inthe treatment ... to support research • To determine the key barriers to pharmaceutical companies in investing in LMCs research and provide a strategy to overcome those barriers -Investment in creating infrastructure...
... cause In breast cancer patients it has been reported that the severity of dermatomyositis follows the clinical course ofthe malignancy [4] The severity of this patient's symptoms and the level of ... visceral disease Biopsy ofthe axillary lymph node confirmed the diagnosis of an oestrogen receptor (ER) positive invasive carcinoma of mammary type Mammography and ultrasound ofthe breasts were unremarkable ... http://www.wjso.com/content/6/1/132 Competing interests The authors declare that they have no competing interests Authors' contributions KLC and AH treated the patient and conceived the idea JW performed the literature...
... reliability ofthe scales The scales have been included inthe paper in their entirety to expedite further testing ofthe instruments by other researchers These preliminary findings indicate that the ... of treatment on future' These items were retained because the values did not indicate high levels of redundancy and given the pilot stage oftheresearch warrant further testing Inthe case of ... radiation therapy [2,12,13] and the findings ofthe qualitative interviews that the researchers conducted with patients and health professionals The theoretical model of Information Seeking Behaviour...
... PSK were involved in clinical management ofthe patient and interpretation of data; KES was responsible ofthe interpretation of pathology; HDS was supervisor of clinical management ofthe patient ... was responsible ofthe acquisition of data, drafting the manuscrips; KHJ was responsible ofthe clinical management ofthe patient, scientific revision, discussion and editing ofthe manuscript; ... K, Fojo T: Oxaliplatin, tetraplatin, cisplatin, and carboplatin: spectrum of activity in drugresistant cell lines and inthe cell lines ofthe National Cancer Institute’s Anticancer Drug Screen...
... overlapping with the Mg-ATP binding site of MEK1 and MEK2 [19] Binding ofthe inhibitor induces a conformational change in unphosphorylated MEK1/2 that locks the kinase into a close catalytically inactive ... inhibition of Raf signaling contributes to the clinical activity ofthe drug is not clear Future clinical trials of more selective Raf inhibitors will help determine Page of 11 whether blocking ... rationale for the clinical development of drugs targeting the ERK1/2 MAP kinase pathway in cancer, the effectiveness of this approach in cancer therapy remains to be validated The first and only inhibitor...
... was determined using the molybdenum-H2SO4 method (Schinttger et al., 1959) Protein was determined according to the method of Lowry et al (1951) using a standard of bovine serum albumin Nucleic ... polymer obtained using a Bio-Gel P-100 column As compared with the intact polymer (Fig 1A), the peak ofthe absorbance at 280 nm showing protein fell against that of saccharide Components ofthe pronase-digested ... observed Figure shows the effect ofthe concentration ofthe polymer on the flocculation of kaolin clay When the polymer concentration was changed from zero to 12.5 ppm, the extent of flocculation...
... Warm-up: The teacher asks students (in pairs) to think of "hotel words" such as lobby or front desk and write them on the blackboard The teacher then goes over each word explaining any difficult points ... we will have difficulty in continuing to grow professionally Lessons Need a Routine or Framework There is a fine line between in communicative methodology between giving students too much responsibility ... crucial that we maintain awareness of our "style" of teaching It often helps to observe a colleague's class or have a trusted colleague observe your own You may find some useful insights into your own...
... adjective Of or pertaining to the end of a century, especially the nineteenth century, and its climate of sophisticated world-weariness and self-doubt From French fin de siècle, literally, the end ofthe ... finished applying the second coat of paint to the patch ofthe wall where once the artwork stood, my then preschool-age daughter delivered her expert opinion:“This doesn’t look much gooder.” The ability ... American Writing on the Wall One ofthe few “bad” things I did and got punished for as a small child was writing on the wall—more precisely, drawing on the wall Thinking of Lascaux, Altamira...
... answers inthe face of overwhelming complexity.” The Sciences In a perfect union the man and woman are like a strung bow Who is to say whether the string bends the bow, or the bow tightens the string? ... alone can break the duopoly ofthe Williams sisters in this year’s championships.” —Guardian (London) Two Sides ofthe Same Coin In Mandarin the words buy and sell are the same inthe spoken language, ... is one ofthe plumbers Mr Underhill makes his living watching homo emptor the king and queen of retail, otherwise known as the shopper: you and me One of his findings: ‘Men are buying their own...
... in meaning: they meanings, both concrete and abstract of linguistic communication will differ in respect of their grammatical meaning.” There are always two elements involved in this sense: the ... at the beginning ofthe study, a large numbers can be classified into meanings based on the criteria of different of English learners have a lot of difficulties when they acquire the manners of ... hearing without the knowledge ofthe new words by compiling page upon page of vocabulary lists with the speaker translation in their mother- tongue Or when they make a sentence in Meaning 4: informs...
... includes reason ofthe study, aims ofthe study, scope ofthe study, method ofthe study, design ofthe study Part II, DEVELOPMENT is the main part oftheresearch paper and it is divided into chapters: ... originally in one language into an equivalent text in a different language retaining, as far as possible, the content ofthe message and the formal features and functional roles ofthe original ... be the case” _Tudor, cited in Duff (1989: 5)_ Although these definitions are different in expression, they share common features about finding the closest equivalence in meaning by the choice of...
... parts, in which the second, naturally, is the most important part Part I is the INTRODUCTION in which reason ofthe study, aims ofthe study, scope ofthe study, method ofthe study, design ofthe ... reproduces the matter without the manner, or the content with out ofthe form ofthe original The advantage of this type of translation is that the text in TL sounds more natural On the contrary, the ... meaning in vague Therefore, systematism is seen as one ofthe most important features of terminology There is the difference in viewpoints ofthe characteristics of terminology among terminologists...
... which, inthe process of applying, indicate the word “Độ bộ” in Vietnamese In addition, let‟s consider the term “Westerly wind” The term is the combination of two words, so we can divide it into the ... translation is the interpreting ofthe meaning and the subsequent production of two texts One other definition is made by the translator: “Translation can be generally defined as the action of interpretation ... when putting and comparing the meaning inthe thinking of English and Vietnamese We can clearly see that it is grammatically correct and the equivalence inthe way to explain about the weather‟s...
... at the top ofthe page / of + N 24 at the end ofthe road at the corner ofthe street inthe corner ofthe room at the front / at the back of a building, hall, group of people Inthe front / the ... (Manchester) in (the ocean) on (the beach) in (the desert) in (the mountains) at (the post office) on (MK Street) on / at (the corner) in (the street) on (the island) in (the west) at (the top of) on (the ... coat behind inthe office (the office is considered as a building) • There’s a good film at the cinema (the cinema as a public place for seeing films) • It was very cold inthe cinema (the cinema...