the function of protocols
Tài liệu Báo cáo khoa học: Chemical approaches to mapping the function of post-translational modifications ppt
Ngày tải lên :
18/02/2014, 17:20
... [11,12]. The study of these events is
taxing, as the biosynthesis of glycoproteins is not tem-
plate driven. This results in the formation of so-called
‘glycoforms’ [11,12], proteins with the same ... 1957
catalyze enhanced hydrolytic degradation of the target
protein.
More recently, the glycoMTS method has allowed
the synthesis of the first examples of a homogeneous
protein bearing symmetrically ... scaf-
fold. These terms reflect not only the linearity or
convergence of the chemical steps that may lead to a
given synthetic protein, but also the structural strategy
that links the (linear) segments of...
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Báo cáo khoa học: The influence of heterodimer partner ultraspiracle/retinoid X receptor on the function of ecdysone receptor pot
Ngày tải lên :
07/03/2014, 12:20
... amount of RXR pulled down by
EcR in the presence of ligand was maximum in the
case of HsRXR and minimum in the case of the
Hs–LmRXR chimera, and LmRXR was between
these two (Fig. 9). These data ... concentrations of ligands
for the transactivation of genes and functions well
in vivo. The RXR chimeras containing most of
HsRXR and helix 9 and the loops on either side of
helix 9 from HsRXR or mutants of ... been
used in the place of USP in all EcR gene switches
developed to date. One of the major limitations of cur-
rent versions of EcR gene switches is the requirement
of micromolar concentrations of ligand...
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Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
Ngày tải lên :
14/02/2014, 18:20
... posi-
tioned in the connecting loops. Approximately one-
third of all mutations in the BTK gene are missense
and some of these reduce the stability of the protein.
This is exemplified by mutations in the ... identify individuals
with mild disease, thereby providing the missing data.
The phenotype of XLA and the
potential of BTK and ITK inhibitors
The outcome of defective BTK signaling in humans
has ... regarding their potential function, it
was the identification of BTK, as the kinase affected in
XLA [9,10], which immediately made TFKs known to
the wider scientific community. In the same year, the
xid...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
Ngày tải lên :
14/02/2014, 19:20
... [9]. The KIND domain in these
proteins is localized to the N-terminal region, and their
specific functional domains are located in the C-termi-
nal region. The C-lobe of protein kinases mediates the
interaction ... under-
stood, the data obtained in the present study indicate
that the 43 residues (amino acids 702–744 in mice) that
reside in the middle region of the CD act as the
v-KIND binding core. The v-KIND-binding ... between the
Leu residues from v-KIND and MAP2 contributes to
the interaction between the two proteins.
In conclusion, the present study has clarified the
structural and functional importance of the...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf
Ngày tải lên :
16/02/2014, 15:20
... in all of these conditions [22]. In the trau-
matically injured brain, however, the synthesis of MT1
and MT2, as well as the synthesis of GIF, are up-regu-
lated by reactive astrocytes in the vicinity ... loss
in the AD brain. Further investigation of the increased
neurotrophic activity of the AD brain revealed that it
correlated with the loss of a specific neuroinhibitory
factor, rather than the presence ... inhibit neurite outgrowth (as described above).
The functional role of GIF synthesis and secretion
in the brain
Taken together, the regulation of GIF synthesis by
reactive astrocytes, and its subsequent...
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Tài liệu Body Size: The Structure and Function of Aquatic Ecosystems pptx
Ngày tải lên :
17/02/2014, 19:20
... W,is
simply the sum ofthe body mass of all individuals. For organisms ofsimilar size, it
can be estimated by taking the product of the population, N,andthebodymass,
M. Similarly, the store of each ... obvious.
We asked the author(s) of each paper to examine the importance and role of
body size in the systems in which they work. Essentially the book builds from the
level of the individual and ... links
between the processing of energy and elements at the individual level to the
flux, storage and turnover of these elements at the level of ecosystems.
Our second example concerns the role of metabolism...
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Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx
Ngày tải lên :
18/02/2014, 16:20
... dif-
ferent apoptotic stimuli. Thus, the apoptotic volume
decrease may further disarrange the balance between
survival and death signals, thereby promoting execu-
tion of the apoptotic program.
Concluding ... changes trigger signals involved in the regulation
of metabolism, gene expression and the susceptibility
to different kinds of stress [6]. For example, the inhibi-
tion of autophagic proteolysis by ... a functional outcome.
This minireview summarizes recent progress in the understanding of how
osmosensing and osmosignaling integrate into the overall context of growth
factor signaling and the...
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Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf
Ngày tải lên :
18/02/2014, 16:20
... interruption of the geometry
of the recognition helix for either Antp or the TTF-1
HD, the anomalous amide exchange pattern and the
NOE connectivity data of the C-terminal portion of
helix III ... respec-
tively. The proximity to one of the intercepts between
the theoretical and fitting curves reflects the relative
contribution of each component Lorentzian function
to the specific spectral density of ... conflict with the
global interpretation of the data. With the exclusion of
the N-terminal octapeptidyl and C-terminal nonapept-
idyl fragments of Glu17, Leu34 and Lys46, the average
of the {
1
H}–
15
N...
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Tài liệu Global Change and the Function and Distribution of Wetlands ppt
Ngày tải lên :
18/02/2014, 20:20
... greater than the rate of decomposition.
Therefore, the nature of the accumulated organic matter can then be used as a proxy
to represent the composition of the former wetland communities at the site. ... Stratigraphic Commission, the beginning of the Pleistocene now
coincides with the base of the Quaternary ( Gibbard et al. 2009 ) . The Holocene
begins at the end of the Pleistocene (Walker et ... environmental
information at the regional, rather than at the local scale. Nevertheless, the spatial
resolution of the pollen fl ora is strongly in fl uenced by the size and nature of the
depositional setting...
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Tài liệu Báo cáo khoa học: Expression and function of Noxo1c, an alternative splicing form of the NADPH oxidase organizer 1 doc
Ngày tải lên :
19/02/2014, 06:20
... in
regulation of Nox3, the role of the PX domain in Nox3
activity remains unknown.
In the process of cloning of human Noxo1, some
spliced transcripts of the NOXO1 gene have been
identified [15,17–19]. They ... between the pair of primers
(Fig. 2A). The lengths of the PCR products of Noxo1b
and Noxo1c were 225 and 240 bp, respectively. To
delineate the difference in the two products, we subjec-
ted the ... activity of the PX
domains of Noxo1b and Noxo1c
The membrane localization of Noxo1b is mediated in
part by binding of the PX domain to membrane phos-
pholipids [19]. Less association of Noxo1c with the
membrane...
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Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc
Ngày tải lên :
19/02/2014, 12:20
... studies. The high
selectivity of the a-conotoxins, together with the possibility
of obtaining detailed information on their three dimen-
sional structures and the relative ease of synthesis, makes
them ... identified in a
cloning approach making use of the high conservation of
the 3¢ untranslated region and the intron preceding the
sequence of the a-prepropeptide [39]. The peptide was
characterized on oocyte-expressed ... and the deter-
mination of their precise subunit composition and
physiological function( s). Compared to the muscle
nAChR, relatively little is known about the function and
composition of the...
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Tài liệu Báo cáo khoa học: Cold survival in freeze-intolerant insects The structure and function of b-helical antifreeze proteins pdf
Ngày tải lên :
19/02/2014, 16:20
... attributed to the lack of
a hydrophobic core typically found in globular proteins.
Instead, there is a rung of disulphides down the middle of
the protein. The addition of dithiothreitol destroys the TH
activity ... activity.
Examination of the crystal structure of sbwAFP did not
Fig. 6. Bound water molecules extend the ice-binding face of insect
AFPs. The position of the water oxygen atoms along the TXT f ace
found in any of ... determine the handedness of the proteins, or
may prevent the unfolding of the protein at cold temper-
atures.
The b-helix as an AFP structural motif?
The sbwAFP and TmAFP structures represent the first
AFPs...
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THE EFFECTS OF MEGAMERGERS ON EFFICIENCY AND PRICES: EVIDENCE FROM A BANK PROFIT FUNCTION docx
Ngày tải lên :
06/03/2014, 08:21
... to
change
the
size
of their asset portfolio because of the size of their markets and/or because of regulatory restrictions on
their
expansion.
In this
event,
the efficiency of smaller firms ... data
set.
IV. The Profit Efficiency Effects of
Megamer~ers
The Level of Profit
Efficiency.
We begin discussing the results with some information on the
levels of profit efficiency of merging and ...
‘
standard profit efficiency model in equations
(1)
and
parameters of the
model.
The level of profit efficiency
the ratio of predicted profits to maximum or optimal profits on
the frontier...
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