the focus of this book
Tài liệu Báo cáo khoa học: The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression ppt
Ngày tải lên :
19/02/2014, 17:20
... platform spread on the b-sheet from b4 to b2 in the 5¢)3¢ direction More often, the nucleotide at the 5¢ end of the central dinucleotide contacts the loops at the bottom of the b-sheet (loop and ... Specificity of this central dinucleotide recognition is provided by other non conserved elements of the RRMs The two most frequently observed elements are the protein side chains at the surface of the ... figures, the RNA is shown in yellow and the protein side chain in green The ribbon of the RRM is shown in grey The N- and C-terminal extensions of the RRM are shown in green and red, respectively This...
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Báo cáo khoa học: Cyclic ADP-ribose requires CD38 to regulate the release of ATP in visceral smooth muscle ppt
Ngày tải lên :
05/03/2014, 23:20
... must, then, be present in this preparation Of particular importance is the finding that exogenous cADPR failed to increase the spontaneous release of ATP in the absence of CD38 In other words, the ... to determine the mechanisms of purine-mediated presynaptic neuromodulation in the bladder The enhancing effect of cADPR on the spontaneous release of ATP is not caused by activation of membrane-bound ... with this notion, the present study demonstrates that exogenous cADPR modulates the spontaneous but not the action potential-evoked release of ATP Therefore, the neuromodulator effects of cADPR...
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Báo cáo khoa học: Unconventional translation initiation of human trypsinogen 4 at a CUG codon with an N-terminal leucine A possible means to regulate gene expression pdf
Ngày tải lên :
07/03/2014, 10:20
... identied leucine as the only N-terminal amino acid of the isolated protein, irrespective of the specicity of the immobilized antibody (Fig 1C) In order to prove the integrity of the isolated protein, ... the longer isoform (Isoform A) and no traces of the shorter isoform (Isoform B) By contrast, the expression of only Isoform B was detected in the cells transfected with the p28LT4 construct (Fig ... in the transfected cells The observed localization of trypsinogen was the same when GFP was fused to the N- or the C-terminal end of the molecule (data not shown) We determined the number of...
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Báo cáo sinh học: "The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans" ppt
Ngày tải lên :
06/08/2014, 18:21
... pathfinding of the epaxial nerve fibers (Figure 5n) The epaxial nerve is formed by axons of motoneurons of the MMC These axons leave the spinal cord together with the neurons of the LMC to form the ventral ... had the AWCOFF phenotype; e911 was the strongest allele among all the nine alleles that we tested For the other unc-76 alleles, the AWCOFF phenotype varied from 6% to 30% Interestingly, the strength ... from the soma and the axonal shaft of the ALM neuron in unc-69(e602) mutant (arrowheads) (g,h) Tracings of representative electron micrographs of sections through the DNC and VNC (g) In the wild...
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Báo cáo y học: " A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells: a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis" doc
Ngày tải lên :
12/08/2014, 15:22
... basis of the rate of accumulation of joint damage over a specific interval of time, and therefore an effect of I50V on severity may have been overlooked The pattern of IL-17 suppression seen in the ... http://arthritis-research.com/content/13/1/R15 Page of the healthy control group genotypes There was a more pronounced suppression of the percentage of IL-17+ cells in the I/I genotype culture, as shown in the top row of Figure 3A, ... were enrolled in the study The average age of the healthy individuals was 40.6 years (range, 21 to 62 years), and this group included 12 females and 14 males The characteristics of the RA patients...
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Báo cáo y học: " The conserved dileucine- and tyrosine-based motifs in MLV and MPMV envelope glycoproteins are both important to regulate a common Env intracellular trafficking" doc
Ngày tải lên :
13/08/2014, 09:20
... Figure of either the dileucine- or the tyrosine-based motifs affect the TGN localization of CD25 chimeras Mutation Mutation of either the dileucine- or the tyrosine-based motifs affect the TGN ... mutagenesis (figure 2B) We then analyzed the effects of these mutations on the intracellular localization of the resulting mutated chimeras Mutation of the tyrosine 23 to serine in either MLV and MPMV ... CTs governed this peculiar trafficking The dileucine-based motif is implicated in the sorting of the chimeras at the level of the TGN, whereas the tyrosine-based motif is required in the retrograde...
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Design of Biomembrane-Mimicking Substrates of Tunable Viscosity to Regulate Cellular Mechanoresponse
Ngày tải lên :
24/08/2014, 13:45
... temperature, μ is the viscosity of the lipid membrane, μ’ is the viscosity of the surrounding fluid (i.e water), the thickness of the membrane, is is Euler’s constant, and a is the radius of the cylinder ... Since this time, 22 interest in the lateral structure of membranes and the way they regulate the activity of constituent membrane proteins has prompted the design of cell mimetic surfaces [48] The ... preparation of more complex, asymmetric, solid-supported bilayers The disadvantage of this method is that is that the reconstitution of membrane proteins can be difficult The combination of these techniques,...
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Advanced control strategies for automatic drug delivery to regulate anesthesia during surgery
Ngày tải lên :
14/09/2015, 08:25
... anesthetics Inhaled anesthetics are used by many anesthesiologists for the maintenance of anesthesia while the intravenous anesthetics are used at the start of the surgical procedure as they ... compared to most other drugs used for the rapid intravenous induction of anesthesia This is one of the most important advantages of propofol compared to other intravenous anesthetic drugs Inhalation ... performance with the performance of other control structures The second objective of this study is to develop and evaluate the MPC control structure to find the best infusion rates of the anesthetic and...
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Báo cáo khoa học: Mitochondria regulate platelet metamorphosis induced by opsonized zymosan A – activation and long-term commitment to cell death docx
Ngày tải lên :
16/03/2014, 04:20
... molecule CD47 are shown in the upper panels Numbers represent the percentage of highly positive platelets In the lower panels, dot plots of the physical parameters of the platelet population (one ... points The numbers in the boxed areas represent the percentages of cells with hyperpolarized mitochondria The percentages of cells with depolarized mitochondria are shown below the dashed line The ... On this basis, we can also hypothesize that, in some immunopathological instances, the increased number of platelets could be due to a defective death of these cells (although PS-positive) rather...
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Báo cáo khoa học: Mitochondria regulate platelet metamorphosis induced by opsonized zymosan A – activation and long-term commitment to cell death potx
Ngày tải lên :
16/03/2014, 04:20
... positioning of the general acid residue, GH22 enzymes differ from the others in this group in that they act by a mechanism with anomeric retention [11] Asp40 of CsnN174 is found inside another element of ... enhanced by the addition of the azide ion The effect of the azide concentration on the reaction rate, shown in Fig 4B, clearly demonstrates that the rate enhancement depends upon the azide concentration ... refers to the distance of the first residue from the N-terminus of the mature protein (Csn-N174; chitosanase from B circulans MH-K1) or of the precursor protein as stored in GenBank (other chitosanases)...
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Báo cáo khoa học: Cas utilizes Nck2 to activate Cdc42 and regulate cell polarization during cell migration in response to wound healing docx
Ngày tải lên :
23/03/2014, 03:20
... phosphorylation of Cas [8] PP2 treatment delayed the protrusion of cells toward the wound and disrupted reorientation of the Golgi in the direction of migration, which is consistent with the findings of previous ... on the leading edge Fifty cells on the wound edge in each of three independent experiments were evaluated for the localization of Cdc42 The percentage of these cells with Cdc42 localized on the ... whereas more than 50% of the CasWt cells at the wound edge contained Cdc42 localized on the leading edge, < 10% of the CasKo cells at the wound edge showed localization of Cdc42 on the leading edge...
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Báo cáo khoa học: Transcription factor specificity protein 1 (SP1) and activating protein 2a (AP-2a) regulate expression of human KCTD10 gene by binding to proximal region of promoter pot
Ngày tải lên :
30/03/2014, 02:20
... containing this 271 bp of the 3¢-end showed only a 8.7% increase These results suggested that the functional promoter region was located in the 271 bp region of the 3¢-end (from )241 to +30) Further ... the start the codon of human KCTD10 and 5¢ cDNA end of UBE3B (Fig 1B) The transcription start site (TSS) of KCTD10 was determined by primer extension assay An antisense primer on the 3¢-end of ... maintain the hypomethylation of CpG islands [13,14], and interacts with some components of the basal transcription complex [15,16]; therefore it plays a critical role in the assembly of the transcription...
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báo cáo sinh học:" Narrowing the gap between eye care needs and service provision: a model to dynamically regulate the flow of personnel through a multiple entry and exit training programme" pdf
Ngày tải lên :
18/06/2014, 17:20
... Within reason, these additional modules can be learnt some time after the completion of the original set of modules In the case of eye care, this permits the definition of a new role of non-physician ... played out over time in order to show the effects of a range of assumptions and estimates This type of modelling is a synthesis of a large number of small units of activity and how each relates to ... illustrative example, this simulation uses only the four stages of optometry training At the end of the first year, graduates can either enter the workforce as refractionists, move onto Stage of training...
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in the crosshairs famous assassinations and attempts from julius caesar to john lennon
Ngày tải lên :
03/07/2014, 16:10
... heart the wisdom of the adage that opined that if you want to kill a dog, you don’t cut off its tail, you cut off its head—and the Southerners were horrified After the failure of the raid, the ... broke off Thomas’s brains spilled out onto the floor of the cathedral, and the knights finished the job by spreading the archbishop’s hacked-out brain matter all over the marble floor By this ... knife wounds, the combined effect of which were fatal Caesar died on the floor of the Senate in front of the statue of Pompey JUDICIAL OUTCOME: Cassius and Brutus spoke to the Senate the day after...
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Báo cáo y học: "CCR2 and CXCR4 regulate peripheral blood monocyte pharmacodynamics and link to efficacy in experimental autoimmune encephalomyelitis." ppsx
Ngày tải lên :
11/08/2014, 08:22
... 4B) Thus, the in vivo effects of MK0812 align well with the predicted potency based on the in vitro characterization of the compound In the course of this experiment, we noted that the circulating ... curve (AUC) of the disease scores over the course of the experiment (Figure 7A and 7B, respectively) At the termination of the study, we assessed the number of CD11b+Ly6Chi monocytes in the peripheral ... question Irrespective of the contribution of monocytes to the effect of MK0812 in this model, our data support the utility of monitoring monocyte numbers and CCR2 ligands in the peripheral blood...
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báo cáo khoa học: " Can NGOs regulate medicines markets? Social enterprise in wholesaling, and access to essential medicines" pdf
Ngày tải lên :
11/08/2014, 14:21
... interviewed, two non-profit and one for-profit firm did their own repeated inspections of manufacturing sites One used only suppliers they had approved themselves At the time of the research, the WHO had ... is, a non-profit enterprise]’ Page of 13 Furthermore, the stated ‘social mission’ of the forprofit firms is a tool of effective competition in this market All these firms stated that it attracts ... enterprise, since the cultural and behavioural feedback between firms is very direct, allowing the weight of the nonprofit traders to influence the strategy of commercial firms in the direction of social...
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Báo cáo y học: "Suicide attempts and related factors in patients admitted to a general hospital: a ten-year crosssectional study (1997-2007)" pot
Ngày tải lên :
11/08/2014, 15:22
... function, and that the variance of the dependent variable is a known function Page of 10 of its expectation The parameters of the model are then estimated subsequent to the specification of the intracluster ... population, rather the sub-set of patients who are admitted to hospital Nonetheless, given the magnitude of the problem in this sub-set of patients, we feel that it is relevant to be able to define the ... study, then the measure of effect may be weakened; i.e biased towards the null hypothesis of no association This produces a systematically higher exposure rate among the comparison group, an therefore...
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Báo cáo khoa học: "Prevalence of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum in questing Ixodes ricinus ticks in relation to the density of wild cervids" pptx
Ngày tải lên :
12/08/2014, 18:22
... destruction by the complement system of a particular host species are lysed early in the midgut of the feeding tick and are thereby eliminated by the host [10] These findings have led to the hypothesis ... in Great Britain in the absence of other reservoir hosts which suggests that I trianguliceps is a competent vector The aim of the present study was to compare the prevalence of B burgdorferi s.l ... over to prevent tick infection and lyse the spirochetes early in the midgut of the feeding tick, and are thereby eliminated by the host [10] Low levels of B burgdorferi s.l in ticks werre found...
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Báo cáo y học: " Tetraspanins regulate cell-to-cell transmission of HIV-1" pot
Ngày tải lên :
12/08/2014, 23:21
... potential role of this tetraspanin in HIV-1 budding, it appears now more likely that this treatment, which results in the clustering not only of CD9 but also of other tetraspanins and of all the viral ... etc) These results are in line with findings of the Marsh group, who reported that knockdown of CD63 in macrophages did not alter the efficiency of viral release, regardless of whether the knockdown ... knockdown of CD81, but not the ablation of the other tetraspanins, enhanced cell-to-cell transmission of HIV-1 (Fig 5B) However, since this effect was not paralleled by a significant increase in the...
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