the feedback instrument does not match the needs of the leader and or the organization
Báo cáo y học: "Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients – a prospective clinical study" ppt
... study the therapeutic effects of systemic infliximab therapy on the synovial expression of other important pro-inflammatory molecules [38,47] Infliximab treatment in another small cohort of patients ... with buffered glycerol Two evaluators (ES and CG), blinded to the order of the sections, performed a semi-quantitative analysis of the expression of HMGB1 Scoring for each section was evaluated using ... before and during therapy with TNF-specific mAb (infliximab) and the levels of synovial expression of HMGB1 protein and mRNA were evaluated Page of (page number not for citation purposes) The...
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Báo cáo y học: "Development of proteoglycan-induced arthritis depends on T cell-supported autoantibody production, but does not involve significant influx of T cells into the joints." potx
... presence in the synovial fluid, it failed to inhibit the development or reduce the severity of PGIA in either the primary or the adoptively transferred form of the disease These results not seem ... administer oral treatment with the S1P receptor modulator FTY720 [20] to the SCID mice during the adoptive transfer of PGIA The principal mechanism of action of FTY720 is the induction of internalization ... Examination of the cellular composition of JDLNs and spleens of SCID mice at the conclusion of the transfer experiments (days 42 to 45) revealed T-cell pools of comparable size in the lymphoid organs of...
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Báo cáo y học: "Prone positioning does not affect cannula function during extracorporeal membrane oxygenation or continuous renal replacement therapy" potx
... jugular and 11 femoral) did not affect the risk of malfunction One internal jugular cannula was repositioned, and one was replaced for poor flow One femoral cannula was replaced for poor flow ... catheters is not related to complication or malfunction rate, thus all sites can be safely used for access The outcome of the present group of patients was poor, with 57% mortality This is not ... Hospital of the University of Pennsylvania There was no financial support for this study The original abstract was a poster presentation at the Society of Critical Care Medicine in San Diego, California,...
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The theory of financial intermediation: An essay on what it does (not) explain
... does and does not explain from both a practical and a theoretical point of view The theory is impressive by the multitude of applications in the financial world of the agency theory and the theory ... of the firm evolved under the paradigm of the agency theory and the transaction costs theory as a theory of economic organization rather than as a theory of entrepreneurship A separate line of ... framework of the agency theory and the theory of asymmetric information The question goes into the heart of the present theory, into the paradigm on which it is based This paradigm is the famous...
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Tài liệu Báo cáo khoa học: Parvalbumin deficiency in fast-twitch muscles leads to increased ‘slow-twitch type’ mitochondria, but does not affect the expression of fiber specific proteins doc
... up-regulation of that order is found for both COX isoforms, as well as for cytochrome c On the other hand, the up-regulation of F1-ATPase b was clearly smaller and comparable to the composition of SOL ... seen in SOL These findings further support the presence of distinct pathways regulating fiber specific isoforms and metabolic enzymes, on the one hand, and mitochondrial biogenesis, on the other Renewed ... RT-PCR RT-PCR Northern blot Northern blot Northern blot strate (1 : 100; Roche) The bands corresponding to particular mRNAs were visualized and quantified by the Molecular Imager using the chemoluminescence...
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Báo cáo khoa học: Trigger factor interacts with the signal peptide of nascent Tat substrates but does not play a critical role in Tat-mediated export pptx
... investigate whether this interaction is functionally relevant for the export of Tat proteins, we monitored the effect of the intracellular TF level on the efficiency and kinetics of SufI export in vivo ... leaves the ribosome via the major ribosomal exit site and that, upon extension of the nascent chain, the SufI signal peptide moves away from L23 and L29 and interacts with TF Furthermore, the combined ... deletion of tig does not affect the export of SufI which proceeds in vivo with the slow kinetics that are characteristic for the Tat translocation process (Fig 4) In contrast, the export of SecB...
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Báo cáo khoa học: Reducing expression of NAD+ synthesizing enzyme NMNAT1 does not affect the rate of Wallerian degeneration ppt
... NMNAT2 and mRNA relative expression is not changed Normalization was performed for each isoform by calculating the ratio between the expression of an individual NMNAT isoform and that of the reference ... during the extraction procedure The absence of compensatory changes in NMNAT2 and NMNAT3 when NMNAT1 is depleted supports the model of non-redundant functions for these isoforms Despite the reduction ... Giacomo Morreale for critically reading the manuscript and Dr Gloria Esposito for helpful advice This work was funded by the BBSRC, the Centre for Molecular Medicine of the University of Cologne...
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Báo cáo khoa học: Lack of stabilized microtubules as a result of the absence of major maps in CAD cells does not preclude neurite formation pot
... for the elongation of neurites and the maintenance of neuronal architecture [3], and the stabilization of microtubules is considered to be essential for neurons to maintain their asymmetry and ... 30% of the complete genes At least these portions of the genes corresponding to each of the MAPs were present in CAD cells (Fig 5A) We consider it most likely that the complete sequences of the ... by an abnormal layering of brain cortex, led to the discovery of these two proteins, which are lacking or mutated in patients [46] Although they are not major MAPs of neurons (based on their quantity...
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Báo cáo khoa học: Disruption of the gene encoding 3b-hydroxysterol D14-reductase (Tm7sf2) in mice does not impair cholesterol biosynthesis pdf
... shows the size of the exons and introns and the sequence of the exon–intron junctions All 5¢ donor and 3¢ acceptor splice sites conformed to the consensus Table Exon–intron organization of mouse ... in these mice The evaluation of C14SR and LBR expression and the determination of their enzymatic activity in the liver of wild-type and Tm7sf2() ⁄ )) mice reinforce the hypothesis that LBR and ... genomic and the cDNA sequences revealed that the exon–intron organization of the mouse Tm7sf2 gene is highly similar to the homologous human gene [1] The gene spans kb and consists of 10 exons and...
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Báo cáo khoa học: The complex of the insect LDL receptor homolog, lipophorin receptor, LpR, and its lipoprotein ligand does not dissociate under endosomal conditions pot
... of ligand recycling by LpR, this implies that for the stability of the complex, the ligand-binding domain is sufficient, but for proper targeting of LpR to the ERC, the combination of the ligand-binding ... Construction of expression vectors encoding lipoprotein receptor cDNA The cloning of the expression vectors was performed according to standard laboratory procedures and according to the protocols ... incubations did not affect the size or the morphology of the cells, and thereby the amount of fluorescence The population with low fluorescence intensity was excluded from the analysis by defining...
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This factsheet is not exhaustive and does not bind the Court pot
... services and to take, in the light of their results, an informed decision as to whether or not to seek an abortion Given that Polish domestic law allowed for abortion in cases of foetal malformation, ... constitutional right to an abortion where there is a real and substantial risk to the life of the mother One of the applicants, in remission from a rare form of cancer and unaware that she was pregnant, ... the courts or the medical services available in Ireland The Court noted the uncertainty surrounding the process of establishing whether a woman’s pregnancy posed a risk to her life and that the...
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Information Management Resource Kit Module on Management of Electronic DocumentsUNIT 5. DATABASE MANAGEMENT SYSTEMS LESSON 6. TEXTUAL DATABASES AND CDS/ISIS BASICSNOTE Please note that this PDF version does not have the interactive features offered th doc
... features They can personalize the system in order to match your organization s needs But not all the adaptations can be made, and not all involve the same amount of work To better understand these ... databases and can be tailored for different applications • The system manages: - the structure of textual databases, - text-oriented formatting, - fast and powerful retrieval, and - the usage of different ... like/ / or , each word in a field By using the formatting language, they can format terms in the inverted file Defining searches For example: In a database there are records from Senegal and Burkina...
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Báo cáo sinh học: " Insertion of the human sodium iodide symporter to facilitate deep tissue imaging does not alter oncolytic or replication capability of a novel vaccinia virus" pptx
... monitoring of therapy is needed for human studies The tracking of viral delivery could give clinicians the ability to correlate efficacy and therapy and monitor potential viral toxicity Furthermore, ... at the end of the article large 192-kb genome enables a large amount of foreign DNA to be incorporated without reducing the replication efficiency of the virus, which has been shown not to be the ... a more sensitive and specific diagnostic technique to detect tumor origin and, more importantly, presence of metastases may be possible [3] Here, we report on the construction and testing of...
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báo cáo hóa học:" Insertion of the human sodium iodide symporter to facilitate deep tissue imaging does not alter oncolytic or replication capability of a novel vaccinia virus" potx
... monitoring of therapy is needed for human studies The tracking of viral delivery could give clinicians the ability to correlate efficacy and therapy and monitor potential viral toxicity Furthermore, ... at the end of the article large 192-kb genome enables a large amount of foreign DNA to be incorporated without reducing the replication efficiency of the virus, which has been shown not to be the ... a more sensitive and specific diagnostic technique to detect tumor origin and, more importantly, presence of metastases may be possible [3] Here, we report on the construction and testing of...
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Báo cáo hóa học: " ‚Die DFG-Broschüre ‚Grüne Gentechnik‘ genügt ihrem eigenen Anspruch nicht‘ The booklet “Genetically modified crops“, published from the German Research Foundation, does not meet the given claim" pot
... Kucharik, C.J., Monfreda, C and Ramunkutty, N (2010): Mind the gap: how climate and agricultural management explain the ‘yield gap’ of croplands around the world? Global Ecology and Biogeography, DOI ... via the rhizoshere Journal of Plant Diseases and Protection, Special issue 15 FAO The State of the World`s plant genetic resources Rome, 1997 16 ISAAA-Briefs No 41 – 2009, Global Status of Commercialized ... pollution by antibiotics and antibiotic resistance genes can alter the environmental microbiota Nevertheless, we ignore whether part of these alterations might remain over the long term Whereas...
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The world does not progress, it merely changes. ppt
... the world as it is today It is a hundred years since Tennyson dreamt of The Parliament of Man, the Federation of the World” It is still only a dream Mankind has not had the wisdom to learn the ... ago these things were unknown Had not the world progressed far beyond the wildest dreams possible to our ancestors? No doubt all this, and more, is true But this does not disprove this saying The ... economic and political system impossible Modern nations are still on much the same low level as their barbarian predecessors in their relations with one another Fearing and distrusting one another, they...
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Báo cáo khoa học: " Exposure to genistein does not adversely affect the reproductive system in adult male mice adapted to a soy-based commercial diet" potx
... time, duration, and dose of exposure to genistein and/ or use of animal species and strains Meanwhile, data for the exposure to genistein at adult stage is very limited The objective of the present ... Co Seoul, Korea) The real-time of continuous image processing and data acquisition over extended periods was recorded For each slide, the tracks of sperm in 10 fields were recorded for approximately ... out in the thermal cycler using a protocol of initial denaturing step at 95oC for 10 min; then 35 cycles at 95oC for (denaturing), at 55oC for (annearing), and at 72oC for 1.5 (extension); and a...
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Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx
... for VEGF, less than pg/ml for sVEGFR-1, and less than ng/ml for sVCAM-1 Materials and methods The onset of the disease was defined as the time at which skin involvement occurred The laboratory ... days before hospitalisation The baseline evaluation was performed on the morning of admission after hour of rest at room temperature The duration of the wash-out period is long enough for calcium-channel ... women and men), with a mean age of 57 ± 12 years and a mean disease duration of ± 4.5 years (21 patients had a disease duration of less than years) The clinical and laboratory data for these...
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Báo cáo y học: "Disruption of the thrombospondin-2 gene alters the lamellar morphology but does not permit vascularization of the adult mouse lumbar disc" pdf
... disruption of the TSP-2 gene with respect to the morphology and cellularity of the annulus, the presence of vascular beds within the disc, and vascularity of the soft tissue margin of the disc ... may therefore not participate in regression of neonatal vessels in the disc Morphology of the annulus in the TSP-2-null mouse Although there was no difference in the number of disc cells in the ... to understand the transition from the well-vascularized status of the fetal and young discs to the avascular state of the adult human or small mammalian disc Page of (page number not for citation...
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Báo cáo khoa hoc:" The CTGF -945GC polymorphism is not associated with plasma CTGF and does not predict nephropathy or outcome in type 1 diabetes" pptx
... (interquartile range), or N (%) The study was performed according to the principles of the Declaration of Helsinki and approved by the ethical committee of Copenhagen County All patients gave informed consent ... presence of renal and cardiovascular endpoints was compared with genotype There were no Table Distribution of genotype and allele frequencies for the CTGF promoter polymorphism at -945 Genotype ... Apparently, the association of the CTGF -945GC SNP with disease is not the same in all patient groups and categories, as has been noted in previous studies that could not always confirm the originally...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose