... investigated the effects
of genetic manipulation of BACE1 on the processing ofthe APP family of
proteins. BACE1 expression regulated the levels and species of full-length
APLP1, APP and APLP2, of their ... APP and APLP1 [13].
There is also considerable evidence that the APP
family of proteins have a role in cell–cell and cell–
matrix adhesion, and that they can form both cis and
trans homodimers and ... which recognizes the
N-terminus of APP, the polyclonal antiserum C8, which
recognizes the C-terminus of APP, and the polyclonal
antiserum D2-II, which recognizes the ectodomain of
APLP2 (Calbiochem,...
... evaluation ofthe material, which is
based on an analysis ofthe teaching material, and the requirements ofthe course. Therefore
document analysis of this study was the analysis ofthe course ... criteria the course is based. The third step is to determine the
objective analysis, that is, to evaluate whether the existing materials realize the criteria set in
the subjective analysis. The ... introduction, development, and conclusion.
The introduction provides the rationale, the aims, the significance, the scope, and design of
the thesis.
The development consists of three chapters:
Chapter...
... in the river
branches is very complicated. The main factors that determine this process are river
discharges, local rainfall and runoff, the tides and the depth of bars in the sea in front of ... in discharge between
wet season and dry season. In the 5 months ofthe wet season, from May to
October, the river discharges 2/3 the total annual flow. The rest amount of river
flow is distributed ... in the MD is necessary to discuss in all its aspects. Although the amount of water on
the delta is large if compared others regions on the world, but the capacity of clean water
supply is finite...
... the return on the mortgage portfolio lies be-
tween the claim ofthe senior tranche and the sum ofthe claims ofthe senior and mezzanine
tranches, the holders ofthe mezzanine tranche get the ... the sum ofthe claims ofthe senior and
mezzanine tranches, the claim ofthe mezzanine tranche is also paid off. The holders ofthe final
tranche, usually referred to as the equity tranche, receive ... losses ofthe US savings and loans industry. Yet,
the effects ofthe burst ofthe stock market bubble and ofthe S&L crisis on the global financial
system were rather more limited; in the...
... though they strongly felt it was the
authorities‟ role to improve the water quality in the Ganga, not the
2
The aim of this study is to investigate (i) whether and how much
the Indian public ... plants (STPs), and (ii) whether the public‟s aggregated
willingness to pay (WTP) to this end is sufficient to offset the costs of
improvements in the capacity and technology ofthe STP. The ...
Employment and Growth
C. Rangarajan
* Monograph 3/2006
The Importance of Being Earnest about Fiscal Responsibility
C. Rangarajan and Duvvuri Subbarao
* Monograph 4/2007
The Reserve Bank and The...
... egg is a girl.
In the span of just thirty-eight weeks, we would see this girl grow
from a group of cells that could fit on the head of a pin to an infant
who weighs an average of seven and ... about the girl they left behind,” this isthe stage
they are usually referring to. This isthe quiet period before the full-
volume rock ’n’ roll of puberty. It’s the time when a girl is devoted ...
sustaining mist of life; energizing; father and mother of testos
-
terone and estrogen, nicknamed the mother hormone,” the Zeus
and Hera of hormones; robustly present in youth, wanes to nothing...
... What isthe meaning ofthe
noise around us, ofthe trampling of people's feet, ofthe rustling ofthe bow, the
quiver, and the lance? Let us rise up and inquire. Behold! the inhabitants ... in the one case there is little, in the
other no conflict or resistance at all. It is otherwise with a slave; he is human, and can
disobey—can even resist. This feeling always rankles in his ... within the shores of a little island.
Most ofthe islands of a continent, and many of these of considerable population and
extent, were filled with them. And the continent itself, to which these...
... the quantum representations and simply write
ρ
k
= ρ
n,d
k
throughout the rest ofthe paper.
Our key idea in the proof of Theorem 1 isthe use ofthe endomorphism
bundle End(V
k
) and the construction ... initiated the program of using ofthe theory of
Toeplitz operators on the moduli spaces in the study of TQFT’s. The main
insight behind the program isthe relation among these Toeplitz operators and
Hitchin’s ... in the quantum level k. Here we have
presented the initial application of this program, namely the establishment of
the asymptotic faithfulness property for the quantum representations of the
mapping...
... insertion.
Membrane potential is required for the insertion
of KdpD-N
To test whether the translocation ofthe periplasmic loops
requires the pmf, the location ofthe loops was analysed in
the presence of ... to the outside ofthe cells either in the
absence or presence of sodium azide (Fig. 1A, lower panel).
Translocation ofthe second periplasmic loop of KdpD was
followed by the generation ofthe ... lower panels) shows the
Fig. 1. The translocation ofthe second periplasmic loop of KdpD is
independent of SecA, SecE and YidC, but is sensitive to the membrane
potential. (A) Protease mapping of...
... Tyr25 and Ly26 (all of them
belonging to the first helix); Asn51 and Cys54 (at the
N-cap ofthe second helix); Ala64 and Ala65 (in the
b-turn between the second and third helices); and Thr72
and ... (in the
type II b-turn); Leu67 and Met71 (in the second helix);
and Gly78 and Gly81 (at the C terminus ofthe protein).
For the different regions, the first a-helix presented a
mean of 0.73 (range ... distributed
throughout the 3D structure ofthe protein, and most
of them are large (Fig. 4); the exception is Tyr25, with
an R
ex
value of 0.5, which indicates that the dynamics
of its
15
N backbone nuclei is not...
... but characteristic conformational changes are
introduced into the active-centre loop. They lead to a dis-
placement ofthe ring system of His15 and a distortion of the
N-terminus ofthe first helix, ... orientation, is arranged almost parallel to
the a-helices and the b-sheet ofthe protein. As the
1
H
N
-
15
N
bond vectors in the a-helices are therefore almost parallel to
the z-axis, their size is mainly ... During
the transport p rocess, the phosphoryl group of phos-
phoenolpyruvate is transferred first to enzyme I (EI) and
then to His15 of HPr. The phosphoryl group is transiently
bound to the N
d1
atom...
... the progress of physical science, the rapid
advance in the knowledge of electricity and magnetism, and the rise ofthe science of biology were profoundly
altering the whole outlook ofthe existing ... company. For the French-Canadian Roman Catholics, Franklin did the best he {98}
could; he read to them the creed ofthe Church of England in French. In the leisure part ofthe day a bundle of
London ... sheet
of open water, ofthe very colour ofthe ocean itself, buoyed up their hopes ofthe discovery ofthe Western
Passage. Davis turned his ships to the south, coasting the shore. Here and there...