... present for the last four residues at
the C-terminus. The stereochemistry ofthe model has
been assessed using the program procheck [23]. Ninety
per cent ofthe residues fall in the most favoured
regions ... metal-
bound hydroxyl group onto the substrate, as observed
in other members ofthe amidohydrolase superfamily
[24,25]. However, as no structureof complexes with
either the substrate, product or inhibitors ... building using the program o [42].
Approximately 7% ofthe randomly chosen reflections
were excluded from refinement ofthestructure and
used for the free R-factor calculation [43]. The pro-
gram...
... X-ray
irradiation [59]. Therefore, we believe that the structure
reported in this paper is also that ofthe glycerol
dehydrataseÆcob(II)alamin complex. The dihedral angle of
the northern and southern least-squares ... twofold axis around the center of
Fig. 3A. Thestructureof an abc heterotrimer unit is shown
in Fig. 3B. The central region ofthe a subunit constitutes
the (b/a)
8
barrel, the so-called TIM (triosephosphate
isomerase) ... A
˚
resolution by the molecular replacement method. The
schematic view ofthe overall structure is shown in Fig. 3A.
Theenzymeexistsasadimeroftheabc heterotrimer. There
is a noncrystallographic twofold axis...
... three-dimensional
crystal structureof Anx(Gh1) from cotton emphasizes the
high conservation ofthe unique annexin fold even among
the members ofthe plant subfamily of annexin proteins. The
fold is comprised ofthe ... either distorted or the access of a
cation to the site is blocked by the p resence of a side chain
of a b asic residue. I n case ofthe IIAB s ite (Fig. 2), the
acidic re sidue a cting a s the ... residue in the present structure is s omehow halfway
between the loop-in and the loop-out position ofthe bell
pepper annexin.
Fig. 1. The three-dimensional structureof Anx(Gh1). (A) The fold of Anx(Gh1)...
... express ε
AB
R
A43B
in the form curl/π
(2)
+ E
(2)
.
5. Strategy ofthe proof ofthe Asymptotics Theorem
In this section we describe the main ideas in the proof ofthe Asymptotics
Theorem.
(1) Section ... given a detailed proof ofthe theorem by relying heav-
ily on a result, which we have called the Asymptotics Theorem, concerning
the geometric properties ofthe causal structureof appropriately ... I
+
0
is the future domain ofthe origin
on Σ
0
.
Remark 9.3. The proof of Corollary 9.2 requires an extension argument.
The estimates ofthe Asymptotics Theorem, which are uniform with respect
to the...
... best
IM:Type full time
IM:Title the godfather
Other the, in, that Other the, in, that Other the, in, that
Table 3: Label sets and their respective query segment examples for the intent class Movie, Job ... goal of
this work is to identify the semantic labels of IMs,
i.e., the attribute names they implicitly refer to. We
use A
c
to denote the set of IM semantic labels for
the intent class c.
Other
Additionally, ... se-
mantic understanding of noun phrase queries. As-
suming that the intent class c ∈ C of a query is
known, we cast the problem of extracting the se-
mantic structureofthe query into a joint...
... The
difference between rmsd of monomeric and dimeric species
is due to the indetermination ofthe reciprocal orientation of
the two subunits. The average total penalty for the REM
family ofthe ... was used to back calculate the NOESY
cross-peaks from the calculated structure to assess the
quality ofthe structure.
The final family was made up of 30 structures with the
lowest target function. ... NMR
solution structure [26,27] as well as the crystal structure [28]
of the reduced form were re ported. Also the b ackbone
mobility ofthe monomeric state was investigated and
compared with that of the...
... tertiary structure.
For the two dimeric models of LPL (the closed and open
forms, Fig. 1), the active dimeric form of LPL in particular
was based on the cocrystallized structures ofthe complexes
of ... on the
crystal structures ofthe human, porcine, and horse PLs
(Fig. 1). A frontal view illustrates the overall saddle shape of
the dimeric structure and the key heparin-binding residues
in the ... modeling ofthe dimeric structureof LPL. Two dimeric model structures of LPL were constructed using
INSIGHT II
version 2000 on
a Silicon Graphics workstation. The model structureofthe closed...
... secure the services of eminent members of appropriate professions in the examination
of policy matters pertaining to the health ofthe public. The Institute acts under the
responsibility given to the ... president ofthe National Academy of Sciences.
The National Academy of Engineering was established in 1964, under the charter of the
National Academy of Sciences, as a parallel organization of outstanding ... 20418
NOTICE: The project that is the subject of this report was approved by the
Governing Board ofthe National Research Council, whose members are drawn
from the councils ofthe National Academy of Sciences,...
... ª 2004 FEBS
the full-length HOP, they act to facilitate the assembly
of multichaperone regulatory complexes. The struc-
tural independence of these TPR domains, and the
presence of independent ... First, the only structures of
natural TPRs in the PDB (13 TPR-containing coordi-
nate sets) consist of nonglobular, extended arrays of
helices [9,10,13–21]. Second, the majority of these
(11 structures) ... region of NlpI. These constitute the most
distant interactions between elements of primary
structure, and include a hydrogen bond between the
backbone carbonyl of Asn263 and the backbone amide
of...
... another than to any other profile in the data set.
The profiles of G can be summarized by a vector s
whose dimensionality is that ofthe data, and each
of whose elements contains the mean of ... significant finding ofthe proposed
methodology.
The scaling ofthe ‘Allah’ variable dominates
all the other variables. To gain resolution for the
others, ‘Allah’ was eliminated from the lexical ... supportive ofthe
thematic structureof each group. Suras of group C
are more abundant in the use of narratives and
addressing Mohamed to provide evidence of his
message to people. Suras of group...
... orientation.
Accordingly, the present data on the molecular mass
of the native Hb complex as well as the Hb subunits
are inconsistent. In addition, there are only two hypo-
thetical models concerning thestructureof ... [2,4,8,11,12,42] offers the chance to relate
the structure and function of this interesting molecule.
The present study has contributed to this approach:
(a) the determination ofthe molecular mass of the
native ... identified on the basis of their
mass spectra, their retention times and characteristic ratio
of the a- and b-anomers.
Analysis of phosphorylation
For the detection of possible phosphorylation, Hb of red
D....
... for the
original. In the case of books and other printed matter, the copier may not be
able to match the quality of paper or binding ofthe original or the crispness
of the printing, and there ... restricting the use ofthe property, and if so this is as much a cost of
the property right as the cost ofthe fence is. Suppose the owner of a shop-
ping center does charge for the use of his parking ... ownership of the
supplies of a particular good, and of all the easily substitutable alternatives for
it, to enable the owners to control the prices ofthe property they own. Nei-
ther the withholding,...
... both by the orientation ofthe energy transfer
partners and by the distance between them [28]. The
fact that the efficiency of transfer varies with the
6th-power ofthe distance between the fluorophores
presents ... in 50% ofthe maximal
efficacy (R
0
). As indicated by the Fo
¨
rster equation, the efficiency of
transfer varies inversely with the 6th-power ofthe distance. The
extreme steepness ofthe relationship ... assessing
the effect of ligand-binding on the quaternary structure
ofthe receptors, the possibility that the antibodies
could inhibit binding to the receptor also needs to
be controlled. Finally, the...
... Proceedings ofthe Joint Conference of the
47th Annual Meeting ofthe ACL and the 4th Interna-
tional Joint Conference on Natural Language Process-
1413
Proceedings ofthe 49th Annual Meeting ofthe ... with
very complex structures.
By (3)–(5), the generation of word structures is
exactly the same as that of ordinary phrase struc-
tures. Hence the probabilities of these words can be
defined in the ... parse tree T , if we
denote the set of lexicalized phrase structures in T
by C, the set of lexicalized word structures by W,
and the set of unknown flat words by F, then the
joint probability Pr(T,...
... among E, R and S, but rather by successively
taking account ofthe meanings ofthe nested
pres, futr
and
perf
operators in the LF ofthe sentence. As it
happens, each of those operators implicitly ... tree nodes. The traver-
sal of trees and the addition of new tokens is simply and
fully determined by the logical forms ofthe sentences
being interpreted.
The major advantage of tense trees ... (indexical) LF of a new utter-
ance always begins with the root node ofthe current
tense tree (structure) in focus. The processing ofthe
top-level operator immediately pushes a token for the
surface...