the dual direction of analogy in hippocratic thought and the meteorological tradition frédéric le blay
Báo cáo y học: " Dual role of TRBP in HIV replication and RNA interference: viral diversion of a cellular pathway or evasion from antiviral immunity?" potx
... Reports and the Journal of Virology establish another link through a doublestranded (ds) cellular RNA binding protein, TRBP TRBP binds Dicer and is part of the RNA-induced silencing complex (RISC), ... are in fact generated by Dicer cleavage after TRBP binding to the 5' or the 3' TAR structure of the incoming virus A large amount of TAR RNA in the cell inhibits PKR [29], and this may also be the ... immunoprecipitation and in vitro interaction Haase et al., show that the interaction is independent from RNA and that the complex cofractionates with the miRNA miR-17 By using a two-hybrid assay, they map the interaction...
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Báo cáo khoa học: Dual role of Nbs1 in the ataxia telangiectasia mutateddependent DNA damage response ppt
... similar to the ATM-binding domain of Nbs1 are also found in ATRIP and Ku80 and are required for the interaction of these proteins with the ATM-related kinase, ATR, and the catalytic subunit of DNA-dependent ... formation of MRN foci in cells exposed to IR, led to the hypothesis that the MRN complex functions in the sensing of DNA strand breakage and in the activation of the ATM-dependent DNA damage signaling ... domain in its NH2-terminal region, as well as an Mre11-binding domain and an ATM-binding domain in its COOHterminal region (Fig 1) FHA and BRCT domains are often present in eukaryotic nuclear...
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aging of the genome the dual role of dna in life and death mar 2007
... amino acids for a mismatch at the third position of each triplet With the evolutionary synthesis and the new understanding of its underlying molecular principles, the pursuit of the origin and ... understanding of the processes that give and maintain human life At the dawn of modern biology two major, often intertwined, branches of knowledgegathering sprung from the same source: the invention ... being inherited together, whereas the farther away they are from each other, the more chance of their INTRODUCTION being separated by the process of crossing over The Morgan is now the unit of...
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The Project Gutenberg EBook of Evolution in Modern Thought, by Ernst Haeckel and J. Arthur Thomson ppt
... an unrivalled British doggedness made real—visions of the web of life, of the fountain of change within the organism, of the struggle for existence and its winnowing, and of the spreading genealogical ... Kant, Lessing, Herder, and Schelling "They alone were upon the main track of modern thought It is evident that they were groping in the dark for a working theory of the Evolution of life, and it ... very intricate, and the evolution of the evolution-idea is bound up with the whole progress of the world Thus in order to interpret Darwin's clear formulation of the idea of organic evolution and...
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The role of language in adult education and poverty reduction in Botswan
... dominates and the vast majority of people are left out In an education system where English dominates the majority of learners get little benefit from schooling, either in terms of acquiring the necessary ... people and use them to mobilize the poor and minorities who are struggling for the betterment of their conditions It could mobilize the so called minorities to oppose their status and challenge the ... Botswana maintains the hegemony and the gap between the poor and the rich, the major and minority groups In order to redress poverty the adult education program needs to be aware of the social...
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Tài liệu Faultlines of Conflict in Central Asia and the South Caucasus - Implications for the U.S. Army docx
... nuclear threats in the future: • Deterrence of nuclear attacks by threat of nuclear retaliation may continue to be the best option against the standard nuclear threats of the past • Other kinds ... for the future and in implementing that strategy Among the range of options, a contemporary nuclear strategy that retains the traditional threat of nuclear retaliation in hopes of deterring serious ... nuclear strategies Drawing on classical writings on nuclear strategy and the U.S experience during the Cold War as well as subsequent work—both by RAND and others—on the changes in the wake of the...
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Tài liệu Báo cáo Y học: A Raman optical activity study of rheomorphism in caseins, synucleins and tau New insight into the structure and behaviour of natively unfolded proteins pot
... Six isoforms of tau protein, ranging from 352 to 441 amino acids in length, are expressed in the adult human brain [54] They fall into two classes, depending on the number of microtubule-binding ... full-length a-synuclein [11] Shaking may lead to the shearing of a-synuclein assemblies, which then function as seeds, resulting in a marked acceleration of ®lament formation On the other hand, ... due to b strand These data suggest that, as in the caseins and synucleins, the major conformational element present in the wild-type Ó FEBS 2002 Rheomorphism in caseins, synucleins and tau (Eur...
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NOTES ON THE ROLE OF EDUCATION IN PRODUCTION FUNCTIONS AND GROWTH ACCOUNTING pot
... of lack of relevant data They used the education of the total labor force in a state for the measurement of the quality of the labor force of individual industries within the same state But the ... attainment; on the quality of his education (quality of the school facilities); and other knowledge he gained from his educational training or otherwise, in and outside of the school These are interrelated ... data.' At the simplest level, the issue of the quality of labor is the issue of the measurement of labor input in constant prices and a question of correct aggregation It is standard national-income...
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Doctor of Philosophy in Mathematics Linear and Non-linear Operators, and The Distribution of Zeros of Entire Functions
... order of the sum of two functions is not greater than the larger of the orders of the two summands, and if the orders of the summands and of the sum are all equal, then 21 the type of the sum ... greater than the larger of the types of the two summands In addition, if one of the two functions is of larger growth than the other, then the sum has the same order and type as the function of larger ... all the zeros of g(z) lie in (−1, 0), then the zeros of h(z) also lie in K (iii) If the zeros of f (z) lie in (−a, a) and the zeros of g(z) lie in (−b, 0) (or in (0, b)), where a, b > 0, then the...
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Beyond Bias and Barriers: Fulfilling the Potential of Women in Academic Science and Engineering docx
... Engineering in providing services to the government, the public, and the scientific and engineering communities The Council is administered jointly by both Academies and the Institute of Medicine ... Engineering, or the Institute of Medicine, and many of whom have dedicated great thought and action to the advancement of women in science and engineering The committee’s recommendations—if implemented ... presidents, and provosts should provide clear leadership in changing the culture and structure of their institutions to recruit, retain, and promote women—including minority women—into faculty and leadership...
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Báo cáo khóa học: The proteasome inhibitor, MG132, promotes the reprogramming of translation in C2C12 myoblasts and facilitates the association of hsp25 with the eIF4F complex pptx
... reorganization of the actin filament system, playing a role in the migration of endothelial cells and in recovery of cells from wounding [40] In a variety of cells, in addition to the induction of hsp25 and ... [55,56] and the biochemical data presented in Fig Treatment of cells with MG132 (Fig 8A, middle panel) reduced the general level of costaining of these proteins while promoting distinct areas of intense ... fragment of eIF4G (M-FAG [48,49,52]); containing the eIF4E binding site and central domain of eIF4G (lane vs lane 1), less with the N-terminal domain of eIF4G (N-FAG; lane 3), and not to the C-terminal...
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Báo cáo sinh học: " Roles of adjuvant and route of vaccination in antibody response and protection engendered by a synthetic matrix protein 2-based influenza A virus vaccine in the mouse" pdf
... (containing 2000 TCID50 of X31) to the nares, dispensing ~half of the inoculum per nare This challenge results in a sublethal infection that is initially confined to the nasal epithelium and then ... determined by the level of virus replication in the lung but not the nose The contrasting finding by Tompkins et al [9] that T cells contributed to protection against lethal IAV challenge in mice ... possible also that the G2a isotype provides a smaller advantage over other isotypes in inhibition of a descending infection by X31 virus – the endpoint used for the data in table – than in reduction...
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Báo cáo khoa học: "Distribution of trkA in cerebral cortex and diencephalon of the mongolian gerbil after birth" docx
... essential in determining NGF biological activity [15], we have measured levels of trkA-IR to examine the availability of endogenous NGF in two areas of the mongolian gerbil brain Cholinergic neurons in ... analysis of trkA showed the presence of trkA-IR in the granule layer as well as in the molecular layer of the dentate gyrus This result suggests that trkA IR is localized mainly in axonal terminals ... but there was a much lower level of trkA-positive reaction at P6 and P9 (A and B) Positive reactions increased after ages (C~H) There was lower level of expression in the DG region than in the...
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Báo cáo lâm nghiệp: "Frost resistance of seeds in Mediterranean oaks and the role of litter in the thermal protection of acorns" docx
... create a leaf litter cover which protected acorns during winter The insulating role of leaf litter along a winter season in a Q faginea stand in the Zaragoza province was monitored to check its insulation ... been considered the starting point of the exotherms as suggested in several studies [10, 12] Some freezing and exotherm profiles are shown in Figure It is remarkable the presence of an apparent ... description of these species [2, 4] Frost resistance and leaf litter in Quercus acorns The role of leaf litter as an insulating material appears now as an important element in improving the microhabitat...
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Báo cáo y học: " Health status and lifestyle factors as predictors of depression in middle-aged and elderly Japanese adults: a seven-year follow-up of the Komo-Ise cohort study" doc
... Results Table shows the characteristics and the social network variables for the subjects included in the analysis and the number cases of depression in 2000 by sex For men, the prevalence of depression ... those with a BMI of >25 Table shows the lifestyle variables for the subjects in the analysis and the number of associated cases of depression in 2000 For men, the prevalence of depression was ... years living in the village of Komochi and the downtown area of the city of Isesaki who were identified based on the municipal resident registration file in 1993 Page of 10 Baseline survey: In Komochi,...
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Báo cáo khoa học: "Influence of organic versus inorganic dietary selenium supplementation on the concentration of selenium in colostrum, milk and blood of beef cows" pptx
... Pehrson B: Organic selenium for supplementation on farm animal diets: it's influence on the selenium status of the animals and on the dietary selenium intake of man In Re-defining Mineral Nutrition ... mg/kg, vitamin A 1000000 I.U./kg, vitamin D 100000 I.U./kg, vitamin E 1000 mg/ kg) The Se status was determined at the beginning of the study by analyzing whole blood of 20 randomly selected cows ... calf nursings using a sterile tube The samples for Se analysis were frozen at -18°C, and analyzed at the end of the study Laboratory analyses The concentrations of Se in whole blood, milk, and feed...
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Báo cáo y học: " A multi-center, randomized, double-blind, parallel, placebo-controlled trial to evaluate the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for the treatment of fever in critically ill and non-critically ill adults" pdf
... stratification The randomization block size was four The randomization block size was not revealed during the course of the study to assist in maintaining the blind The study was double-blind with ... by using the linear-log trapezoidal rule: linear trapezoidal rule up to time to maximum concentration, and then a log trapezoidal rule for the remainder of the curve, where the last measurable ... For secondary endpoints, 21 of 30 (70%) of subjects in the 200 mg IV ibuprofen group, and 19 of 31 (61%) of subjects in the 100 mg IV ibuprofen group, compared to of 28 (32%) of the placebo group...
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Báo cáo y học: " Updating the evidence for the role of corticosteroids in severe sepsis and septic shock: a Bayesian meta-analytic perspective" pot
... completed origin Cooperative 1963 Study Group [32] Study Table Final study cohort Yes Double- Yes blind Double- No blind Double- NA blind Double- Yes blind Double- Yes blind Double- Yes blind ... attenuated the negative slope of the line In the risk difference metric, the intersection of the (meta)regression line with the line of null effect (’cross-over’ point) occurred for age at 62 years and ... representation of the effect The vertical straight line denotes null effect (odds ratio (OR) = 1) The individual points denote the OR for each study and the lines on either side the 95% Bayesian credible intervals...
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