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Báo cáo khoa học: The crystal structure of NlpI A prokaryotic tetratricopeptide repeat protein with a globular fold potx
Ngày tải lên :
07/03/2014, 16:20
... Monomer of NlpI, showing the rolled-up array of helices with the C-terminus folding within the curvature of the N-terminus Helix numbers are in brackets Note that ‘A’ helices locate to the globular ... motifs and the rest of the protein, showing how the TPR participates in the overall fold Until now, many of the TPR-containing regions of proteins have behaved as separate domains: they fold and ... to the diagonal (helix A interacting with helix B), then parallel to the diagonal (helix A interacting with helix A¢ of the next repeat), and finally returning to the diagonal (helix B interacting...
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Tài liệu Đề tài " The causal structure of microlocalized rough Einstein metrics " pptx
Ngày tải lên :
16/02/2014, 05:20
... fundamental for the proof of Theorem 2.5 In Section we obtain some crucial properties of the components of the Riemann curvature tensor Rαβγδ The remaining sections are occupied with the proof of the Asymptotics ... the development of bilinear techniques for the Einstein equations; see the discussion in the introduction to [Kl-Ro1] We denote by Rαβ the Ricci curvature of g In wave coordinates the Einstein ... step in the derivation of the decay estimates needed in the first paper Introduction This is the second in a series of three papers in which we initiate the study of very rough solutions of the Einstein...
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Tài liệu Báo cáo khoa học: The crystal structure of human a-amino-b-carboxymuconatee-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis ppt
Ngày tải lên :
18/02/2014, 06:20
... located in the proximity of the zinc ion and with the hydroxymethylene group pointing toward Pro295 DHAP interacts with the catalytically essential Zn2+ through mediation of the metal-coordinating ... C-terminus The stereochemistry of the model has been assessed using the program procheck [23] Ninety per cent of the residues fall in the most favoured regions of the Ramachandran plot, with Asn148 ... centre and the ligand binding site The hACMSD active site is located in a crevice on the protein surface at the C-terminal opening of the b-barrel (Fig 2), with a Zn2+ ion occupying the metal...
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Tài liệu Báo cáo khoa học: "Understanding the Semantic Structure of Noun Phrase Queries" pptx
Ngày tải lên :
20/02/2014, 04:20
... example, there are two constraints implied in the query “alice in wonderland 2010 cast”: (1) the Title of the movie is “alice in wonderland”; and (2) the Year of the movie is “2010” Interestingly, the ... observed in the training data We can also generalize this type of features from words to n-grams In other words, instead of inspecting the word identity at the current position, we inspect the n-gram ... intent class The first type of lexicon is an IH lexicon comprised of a list of attribute names for the intent class, e.g., “box of ce” and “review” for the intent class Movie One easy way of composing...
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Tài liệu Báo cáo khoa học: The solution structure of reduced dimeric copper zinc superoxide dismutase doc
Ngày tải lên :
21/02/2014, 03:20
... a single subunit and in 22 000 steps for the dimeric form The dimeric nature of the protein was taken into account by connecting the amino acid sequence of the two subunits with a chain of linkers ... 2.1 a REM indicates the energy minimized family of 30 structures, is the energy minimized mean structure obtained from the coordinates of the individual REM structures b The number of experimental ... clustered in a few regions of the protein: at the interface between the two subunits (mainly in loop IV and b 8), in the odd loops and at the corresponding end of the b barrel, and in the even...
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Tài liệu Báo cáo khoa học: The crystal structure of coenzyme B12-dependent glycerol dehydratase in complex with cobalamin and propane-1,2-diol pptx
Ngày tải lên :
21/02/2014, 03:20
... cobalamins (2.9–5.1°) [9,10] Figure 4C indicates the comparison of the position of the a-acetamide side chain of pyrrole ring A of the corrin ring in the glycerol dehydratase-bound cobalamin (Fig ... upon protein staining The ratio of the upper protein band to the lower one was estimated to be approximately by densitometric scanning Activity staining of the enzyme indicated that the upper ... amino acid than aD in the N-terminal and by three than bD in the C-terminal, respectively In the final structure, all residues of the a chain (Met1–Glu555), all but N-terminal 10 residues of the...
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Tài liệu Báo cáo Y học: Molecular modeling of the dimeric structure of human lipoprotein lipase and functional studies of the carboxyl-terminal domain docx
Ngày tải lên :
21/02/2014, 15:20
... the catalytic site in the N-terminal domain of one subunit and the substrate recognition site in the C-terminal domain of the other face each other, thereby bringing together the substrate-binding ... illustrates the overall saddle shape of the dimeric structure and the key heparin-binding residues in the N-terminal domain held coordinately by the two subunits on the top of the hollow (Fig 1A) The ... the C-terminal domain may constitute heparin binding-site residues that coordinate with heparin-binding residues in the N-terminal domain The cluster of hydrophobic residues may function in substrate...
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Báo cáo khoa học: Crystal structure of salt-tolerant glutaminase from Micrococcus luteus K-3 in the presence and absence of its product L-glutamate and its activator Tris pdf
Ngày tải lên :
06/03/2014, 09:22
... [10] was used as an initial phasing model for the N structure The G and TG structures were solved using the N structure as a search model, and the TG structure was used in phasing of the T structure ... Although the R and free R values of the four structures were in the range of the values of the published structures, those of the N and G structures were slightly poor [38,39] For the N structure, the ... Ser227 interact with Tris Tris binding in the TG structure seems to be coupled to the protein local structure in the region encompassing aa 222-228, which is distinct from the corresponding structures...
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Publicly Funded Agricultural Research and the Changing Structure of U.S. Agriculture doc
Ngày tải lên :
06/03/2014, 15:20
... president of the National Academy of Engineering The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions ... from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine The members of the committee responsible for the report were chosen for their ... Engineering in providing services to the government, the public, and the scientific and engineering communities The Council is administered jointly by both Academies and the Institute of Medicine...
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Báo cáo khoa học: "Understanding the thematic structure of the Qur’an: an exploratory multivariate approach" pdf
Ngày tải lên :
08/03/2014, 04:22
... significant finding of the proposed methodology The scaling of the ‘Allah’ variable dominates all the other variables To gain resolution for the others, ‘Allah’ was eliminated from the lexical ... elements contains the mean of the frequencies for the corresponding data matrix column: sj = (∑ i =1 n ) Fi , j / n where j is the index to the jth element of s, i indexes the rows of the data matrix ... analysis” 10 3.3 Interpretation Given that the lengths of the vertical lines in the above tree represent relative distance between subclusters, interpretation of the tree in terms of the constituency...
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Báo cáo khoa học: Molecular mass of macromolecules and subunits and the quaternary structure of hemoglobin from the microcrustacean Daphnia magna ppt
Ngày tải lên :
16/03/2014, 13:20
... Germany) was used ¨ according to the manufacturer’s protocol Glycoprotein staining was followed by total protein staining using the fluorescence stain RuBPs, synthesized according to [63], and staining ... I–III) reflect the deviation of individual measuring points from the calculated fit, indicating the quality of the fit and the calculated molecular mass mp, measuring point; mc, meniscus with N-glycosidase ... second peak in case of pale D magna (Fig 3A) was heterogeneously composed (polydispersity), as indicated by the inclination of individual measuring points The molecular mass of these proteins (Hb...
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The Economic Structure of Intellectual Property Law pot
Ngày tải lên :
16/03/2014, 15:20
... for the original In the case of books and other printed matter, the copier may not be able to match the quality of paper or binding of the original or the crispness of the printing, and there ... determine the number and character of expressive works created and then examine the modes of exploitation of the created works These are the building blocks of the formal model developed in the next ... number of factors, besides the head start noted in the preceding section, would limit the effect of copying in preventing the creator of an original work from recouping the cost of creating it,...
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Báo cáo khoa học: Methods to monitor the quaternary structure of G protein-coupled receptors doc
Ngày tải lên :
16/03/2014, 22:20
... of the partners is not promoted by the bivalent nature of the antibodies In studies assessing the effect of ligand-binding on the quaternary structure of the receptors, the possibility that the ... could inhibit binding to the receptor also needs to be controlled Finally, the presence of an antibody between the fluorophores and the proteins of interest, increases the uncertainty concerning the ... reflect the higher concentration of G protein provided in the membranes by the : GPCR : G protein stoichiometry of the fusion proteins allowing the G protein fused to one receptor to interact with the...
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Báo cáo khoa học: "Parsing the Internal Structure of Words: A New Paradigm for Chinese Word Segmentation" doc
Ngày tải lên :
17/03/2014, 00:20
... segmentation and POS tagging In Proceedings of the Joint Conference of the 47th Annual Meeting of the ACL and the 4th International Joint Conference on Natural Language Process- ing of the AFNLP, pages ... we split the words with internal structures into their components, comparison with other systems should be viewed with that in mind Based on these discussions, we divide the labels of all constituents ... denote the set of lexicalized phrase structures in T by C, the set of lexicalized word structures by W, and the set of unknown flat words by F, then the joint probability Pr(T, S) according to our...
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Báo cáo khoa học: The crystal structure of annexin Gh1 from Gossypium hirsutum reveals an unusual S3 cluster Implications for cellulose synthase complex formation and oxidative stress response potx
Ngày tải lên :
17/03/2014, 03:20
... reflects the characteristic fourfold repeat, there is variation in the loops harbouring the endonexin sequence The motif is conserved only in the first domain, occurs with quite some variations in the ... clear that the plant protein is not able to bind metal cations in the conformation found in the crystal structure Neither the first nor the other domains are able to coordinate cations in these regions, ... of Anx(Gh1) with the structures of Anx24(Ca32) and AnxA5 reveals that the cotton annexin, in contrast to the bell pepper protein, provides canonical calcium binding sites in the first domain The...
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Báo cáo khoa học: "TENSE TREES AS THE "FINE STRUCTURE" OF DISCOURSE" ppt
Ngày tải lên :
17/03/2014, 08:20
... embedding links to the roots of embedded tense trees There are two kinds of these embedding links, both illustrated in Figure One kind, indicated by dashed lines, is created by subordinating constructions ... asserted in the course of deindexing using the rules shown later As a preliminary example, consider the following passage and a tense tree annotated with episodes derived from it by our deindexing ... - t i m e ell, in view of examples involving a longer preceding event, such as " J o h n painted a picture He was pleased with the result." The processing of the (indexical) LF of a new utterance...
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Báo cáo Y học: The solution structure of gomesin, an antimicrobial cysteine-rich peptide from the spider pptx
Ngày tải lên :
17/03/2014, 23:20
... and one lysine) in the primary structure of the peptide Structure evaluation The three-dimensional structure of gomesin was determined using the standard simulated annealing protocol of DYANA AND ... Arg10 but, in these cases, the extremity of their side chain is rather floppy In contrast, the side chains of Arg16 and Arg18 at the Table Structural statistics of the 20 models of gomesin Ramachandran ... pH was adjusted to 3.5 with microlitre increments of HCl N For experiments in heavy water, 90% of the volume of the previous sample was lyophilized and then dissolved in 99.99% D2O The remaining...
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Báo cáo khoa học: "TEMPORAL REASONING IN NATURAL LANGUAGE UNDERSTANDING: THE TEMPORAL STRUCTURE OF THE NARRATIVE" docx
Ngày tải lên :
18/03/2014, 02:20
... their mother to fix the tail v-~hveof the windmilL b In the great expanse of the prairie where they lived, the high tower of the windmill was the only real landmark (Worline, 1956:1) Given the conceptual ... required Inferential work le relatively transparent The event of John's entering the o n c e results in the state of his being in the ofrice: this le part of the lexical meaning of enter The temporal ... it, the children set off walking The temporal focus, Indicated by the past perfect tense, is in the middle of the wallri~g event; the time scale of the entire sequence is within a day or two The...
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Báo cáo khoa học: The crystal structure of a xyloglucan-specific endo-b-1,4glucanase from Geotrichum sp. M128 xyloglucanase reveals a key amino acid residue for substrate specificity potx
Ngày tải lên :
23/03/2014, 05:22
... to the exo-loop of OXG-RCBH The coordinates and structure factors have been deposited in the Protein Data Bank (PDB) (accession code 3A0F) The structure of XEG was compared with those of other ... using HKL2000 [16] and the ccp4 pro- gram suite [17] The structure of XEG was solved by means of the molecular replacement method, using the AMORE program [18] in the ccp4 package The coordinates ... of residues in the substrate binding cleft Experimental procedures Purification of XEG The gene encoding the mature region of XEG [7] was subcloned into pET14-b (Novagen, Madison, WI, USA) using...
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Báo cáo khoa học: The crystal structure of human WD40 repeat-containing peptidylprolyl isomerase (PPWD1) pdf
Ngày tải lên :
23/03/2014, 07:20
... SNW domain-containing protein (SKIP), and CypH binds to the small ribonucleoprotein Prp4 [18,31–33] Interestingly, in both of these cases, the interaction with spliceosomal components was found ... referenced in the text Green boxes highlight the conserved positions in the active site of CypA [2]; blue boxes outline the positions of the spliceosomal binding site on CypH [32]; pink boxes outline the ... Binding, but not isomerization, of the N-terminal peptide of PPWD1 A synthetic peptide corresponding to the seven residues seen in the crystal structure (QAEGPKR) was added to the PPWD1 protein...
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