the cannabinoid receptors and their interactions with synthetic cannabinoid agonists and antagonists
báo cáo khoa học: " Dissecting grain yield pathways and their interactions with grain dry matter content by a two-step correlation approach with maize seedling transcriptome" pps
... 190 of the 200 genes showing the strongest correlation with PY in the estimation set were among the set of the 200 genes with the strongest correlation in the complete data set For HY the average ... conducted the statistical analysis, interpreted the results and wrote the paper; AT grew the plants, performed all microarray hybridizations and helped to write the paper; TAS gathered and analyzed the ... to the set of the trait associated genes in the 100 estimation sets The genes were arranged according to this frequency and the sequence of the first 200 genes was compared to the sequence of the...
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apoptotic b cells their interactions with macrophages and modulation by rituximab
... inflammation The aim of the current study was to begin to unravel the possibility of this hypothesis The role of apoptotic B cells and their immunomodulatory capacity was focused on, with the following ... in the reduction of tissue damage Another theory, put forward by Silverman and Boyle in 2008, is the ‘B cell roadblock hypothesis’ [107] This theory attributes the clinical efficacy of RTX to the ... enhancing their killing ability and further mediating the removal of microbes [23] The uptake and destruction of pathogens by M1 macrophages results in the production of danger signals, such as the...
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Surface functionalized substrates and their interactions with biomolecules and cells
... immobilization The change can be attributed to the diffusion of solutes to the active sites within the matrix, the interactions of the enzyme with the matrix, and partitioning of components between the ... believed to be the most representative and has also been confirmed by Waltman and Bargon (1986) with their theoretical studies (Figure 2.2) According to their proposal, the reaction begins with electron ... involves the investigation of the effect of gases used to activate the polymer surface on the degree of grafting of AAc and glycidyl methacrylate monomer Their work further developed the grafted...
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Báo cáo Y học: Domain V of m-calpain shows the potential to form an oblique-orientated a-helix, which may modulate the enzyme’s activity via interactions with anionic lipid potx
... USA), and, for each sample, absorbance spectra were produced (Fig 5) These spectra were analysed, and, for those with strong absorption bands, the band parameters (peak position, band width, and ... fitting was then applied within the original spectra after the subtraction of baselines resulting from neighbouring bands Similar to the deconvolution technique, the bandshapes of the single components ... residues, and, for each sequence under investigation (Table 1), the window with the highest hydrophobic moment was identified (Table 1) For these windows, the mean hydrophobic moment, ÆlHæ, and the...
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Tài liệu The Acquisition of Drugs and Biologics for Chemical and Biological Warfare Defense - Department of Defense Interactions with the Food and Drug Administration doc
... the National Defense Research Institute The latter is a federally funded research and development center sponsored by OSD, the Joint Staff, the unified commands, and the defense agencies in the ... fragmented within the department and between the government and private contractors DoD acquisition personnel and DoD contractors often lack the technical and managerial expertise and experience ... involvement in the acquisition of CBW drugs and vaccines have many other claims on their time Typically, the acquisition of pharmaceuticals is secondary for them; they have limited knowledge of and experience...
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Tài liệu Báo cáo khoa học: Post-translational modifications of the linker histone variants and their association with cell mechanisms docx
... associated with X-chromosome inactivation will always have their CpG islands methylated Histone modifications The N-terminal tails of the core histones extend beyond the nuclesomes and can have their ... compensate Third, there are differences in the localization of the H1 variants within the nucleus, and there are variations in their relative amounts between different cell types [28] Fourth, the H1 variants ... cell types The affinity of the various types seems to depend on their C-terminal tails H1.1 and H1.2, with the shortest C-terminal tails, a low density of positively charged residues, and the lowest...
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Báo cáo khoa học: The bI/bIII-tubulin isoforms and their complexes with antimitotic agents pptx
... conformation (the superposition between the modeled and the experimental structure of the ligand had an RMSD of 0.91) and all the known interactions between the protein and the ligand were reproduced ... the ligands with other residues in the M-loop In particular, paclitaxel interacts through hydrogen bonds with Ser277, Gln282 and Arg284 in the case of the bI isoform and only with Arg278 in the ... involving C3 and C7 hydroxyl groups and lateral chains of Arg278 and Gln282, respectively; and (ii) p–p interactions between the thiazole ring and His229 In E3, the ligand is farther away from the M-loop...
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Báo cáo khoa học: Crystal structure of RNase A tandem enzymes and their interaction with the cytosolic ribonuclease inhibitor potx
... constrain the ability of the RNase A entities to adopt the same orientation in the crystal as monomeric RNase A On the other hand, the decreased activity of the RATEs as compared with RNase A ([16] and ... relaxed in solution, thereby enabling RI binding to both the N-terminal and the C-terminal RNase A entities The distance between the C-terminus of the first and the N-terminus of the ˚ second RNase ... possible without steric clashes, the distance between the C-terminus of the RNase A in the first complex and the N-terminus of the RNase A in the second 334 ˚ complex is about A, i.e less than the...
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The Global Technology Revolution - Bio-Nano-Materials Trends and Their Synergies with Information Technology by 2015 pot
... and decisions must be addressed as the world’s population comes to grips with the potential effects these trends may have on their cultures and their lives The most significant issues may be ... agencies, and the unified commands The NIC provides mid-term and long-term strategic thinking and intelligence estimates for the Director of Central Intelligence and key policymakers as they pursue ... factors In many cases, the significance of these technologies appears to depend on the synergies afforded by their combined advances as well as on their interaction with the so-called information...
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báo cáo hóa học: " Microglia use multiple mechanisms to mediate interactions with vitronectin; non-essential roles for the highly-expressed avb3 and avb5 integrins" pptx
... activation and phagocytic processes in other cell types [24,25] The purpose of the current study was to investigate the contributions of the avb3 and avb5 integrins to this process, and test our hypothesis ... As the avb3 and avb5 integrins have well-defined roles in activation and phagocytic processes in other cell types, the purpose of the current study was to investigate the contribution of these ... [10,23], the purpose of the current study was to investigate the contribution of these two integrins in microglial activation, and thereby test our hypothesis that absence of both avb3 and avb5...
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Báo cáo y học: "Cartilage markers and their association with cartilage loss on magnetic resonance imaging in knee osteoarthritis: the Boston Osteoarthritis Knee Study" doc
... of the study, participated in its design and coordination, and drafted the manuscript JL and ML carried out the statistical analyses JD carried out the assays AG and DG read and interpreted the ... and skyline views) and if on any of these views they had a definite osteophyte in the symptomatic knee (either tibiofemoral or patellofemoral), they were eligible for the study In addition, they ... MN, RP, DE, and DF participated in the design of the study All authors read and approved the final manuscript 14 15 16 Acknowledgements The authors thank the participants and staff of the Boston...
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Báo cáo y học: "Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis" pdf
... endocannabinoids and thus are commonly termed 'entourage' compounds due to their ability to modulate the endocannabinoid system [20,21] The endocannabinoids and PEA are synthesised on demand, and ... protein and RNA and the endocannabinoids AEA and 2-AG are present in the synovia of patients with end-stage OA and RA The presence of increased levels of AEA and 2-AG in the synovial fluid of OA and ... investigate the role of the cannabinoid receptors in mediating the effects of HU210 on phosphorylation of ERK1, ERK2, and p38 MAPK, the potential ability of the CB1 and CB2 receptor antagonists...
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báo cáo khoa học: "Endemic microorganisms of a Drosophila simulans strain and their relationships with the non-mendelian transmission of a character" ppt
... was poured on the eggs laid by wild-type females coming from S mothers Another ml was added, the following day, into the same tube on the larvae in the first instar The phenotype of the emerging ... for the pathogenic microorganisms in the SimES strain, and secondly, the results of the measures of some fitness parameters of the SimES strain free of these pathogenic microorganisms Finally, these ... infected with N kingi A disharmony in the cycles of the parasite and the host was induced by lowering the breeding temperature from 25 °C to 17 °C After a few generations, the test for the presence...
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Báo cáo y học: "Getting out and about in older adults: the nature of daily trips and their association with objectively assessed physical activity" doc
... have found for trips and their modes and purposes with physical activity and with participant characteristics help improve our understanding of the importance of “getting out and about” behaviour ... supplied with and briefed on how to complete the daily trips log The daily trips log was used to record details of the days and times when the Actigraph was worn and any trips made away from the home ... age, and BMI was achieved The age and gender of the sample differed minimally from the patient lists from which they were selected The differences in proportions between pooled practice lists and...
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bowlin et al - 2014 - the effects of auditor rotation, professional skepticism, and interactions with managers on audit quality
... assess the likelihood that they will be injured within the next year can easily conjure mental support for this risk As a result, they evaluate the subjective likelihood of injury in their minds and ... know in the near-term (and may never know) the private financial reporting choices of their clients, and managers not know with certainty the auditor’s strategy (Kennedy, Kleinmuntz, and Peecher ... assigned to their roles, their computer screens display a brief review of a portion of their earlier instructions that are unique to their roles In particular, managers are reminded of the outcome...
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A study on the use of listening test-taking strategies and their relationship with students' performance at Que Vo I Upper Secondary School in Bacninh
... the treatment they received The students tried to link what they read about the topic with the clues they found in the test questions and formed a picture of the talk Because the handout on the ... students (without revealing these students‘ names) who perform the best and share their strategy use with the whole class The purpose of these actions is to raise student awareness of their strategy ... the words they learned with the words they heard This implies that students may use the same strategy but for a different purpose, and also differ in the way they use it Therefore, to close the...
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A study on the use of listening test-taking strategies and their relationship with students' performance at Que Vo I Upper Secondary School in Bac ninh
... contents List of charts and tables Part one: Introduction……………………………………………………… Rationale…………………………………………………………………… The aims of the study…………………………………………………… Scope of the study………………………………………………………… ... in Relation to Task Performance and Strategy Use Chapter two: Methodology………………………………………………… II.1 .The setting of the study………………………………………………… II.1.1.Overview of the new “Tiếng Anh 12” textbook………………………… ... skill in the textbook………………………………….… II.1.1.2.1 Stages of teaching listening ……………………… II.1.1.2.2 Listening skills, tasks and activities……………………… v II.1.2 .The context of teaching and learning...
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A study on the use of listening test-taking strategies and their relationship with students' performance at Que Vo I Upper Secondary School in Bacninh
... what make them anxious and fail in listening tasks or listening tests is the strategies they use Therefore, my minor thesis here studies the use of listening test-taking strategies and their relationship ... during, and after a test, then further investigated any correlation with listening test performances, and finally a student report was used to examine how HLP and LLP students adjusted their strategy ... proficiency and they are experienced and armed with most listening strategies Therefore, students of grade 12 were chosen Research questions In order to achieve the aims mentioned in the section two, the...
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The study of interactions of transmembrane receptors and intracellular signaling proteins in live cells by fluorescence correlation and cross correlation spectroscopy
... interact with each other before ligand binding In the former situation the receptors exist as monomers on the cytoplasmic membrane, and ligand binding induces two receptors to interact with each other ... in the interactions between Cdc42 and effectors with different binding domains The ErbB receptors locate on the cell surface, and Cdc42 and effectors distribute in the cytoplasm of the cell Therefore, ... this thesis: the physiological functions of ErbB receptors and Cdc42 together with its effectors, and their related topics that were studied by using FCS/SW-FCCS Chapter introduces the theory...
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HCV functional genomic protein interactions with NS3 and their role in viral replication
... unwinding the extensive RNA secondary structures in the HCV genome for the synthesis of the complementary strand and the translation of viral products The intrinsic NTPase activity of the helicase ... orientation The full-length and truncated helicases were tested for interaction with one another using the yeast twohybrid assay The minimal region interacted well with the helicase domain and with ... M288T and T266A) and Dr Tan Yee Joo for useful discussion and help with using the FPLC machine The presence of wonderful lab members in the CAVR group, both past and present, has made my stay in the...
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- the essence of object oriented programming with java and uml pdf
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- patterns of hippocampal neuronal loss axon reorganization in the dentate gyrus in mice with type 1 type 2 neuronal loss and their comparison with the control mice
Tìm thêm: xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008