... at the bottom of his list of interesting things to I was taught in medical school that all babies are born withthe need for mutual gazing because it isthe key to developing the mother-infant ... formation the hippocampus is also larger inthe female brain, as isthe brain circuitry for language and observing emotions in others This means that women are, on average, better at expressing ... at Harvard and the University of California, San Francisco, my thinking has been in uenced by Bruce Ames, Cori Bargmann, Regina Casper, Francis Crick, Mary Dallman, Herb Goldings, Deborah Grady,...
... silicon atom is removed from the surface bilayer in this area and is transferred inthe island, the height ofthe island will be 4.8 nm for cone-shaped islands with an aspect ratio of 0.3 The estimated ... scattering ofthe island height for islands grown in one experimental run was within 10%, and the height of islands increased gradually whenthe duration increased [7] Fig shows STM data forthe islands ... in Fig The scattering ofthe island height in one experimental run increased with increasing tunneling current The increase ofthe scattering coincided withthe appearance of fluctuations of the...
... DNA-binding domain in an active conformation RLjunRP is an 40 kDa protein that forms an 80-kDa protein–DNA adduct To assess approximate molecular mass ofthe factors interacting withthe )148 to )124 ... acrylamide) and analysed by autoradiography changes of · binding buffer over a period of 30 and autoradiographed Affinity purification ofthe factor(s) interacting withthe )148 to )124 region of ... Phosphatase-treated nuclear extracts were assayed for their DNA-binding capacity in standard EMSA UV crosslinking of DNA–protein adduct The EMSA reaction was carried out using ng labelled Jun)25 and...
... and a significant tumor growth inhibition in animals, indicating that the DTA-H19 construct has a high therapeutic potential and isa very promising candidate for ovarian cancer therapy in humans ... delivered by a non-viral vector Non-viral vectors appear promising due to their potential to overcome the main disadvantage of adenoviral vectors, causing immune responses directed against adenovirus ... cycles (98°C for 15 sec, 58°C for 30 sec, and 72°C for 40 sec and finally 72°C for min) The integrity ofthe cDNA was assayed by RTPCR analysis using the histone variant, H3.3 or GAPDH as positive...
... using the RNA STAT-60TM Total RNA/mRNA isolation reagent, according tothe manufacture’s instructions The RNA was treated by RNAse-free DNAse I to eliminate any contaminating DNA Total cDNA was ... activation was reported as a major mechanism forthe IGF2 overexpression ina variety of tumors including bladder carcinoma, hepatocellular carcinoma, breast cancer, ovarian cancer and prostate ... bladder was determined by ImagePro Plus software Another healthy mice were used as control The total tumor area of each bladder was determined and the mean ofthe total areas was calculated for...
... These data indicate a need for an improved approach to GERD management inthe primary care setting, tailoring treatment on an individual basis in order to lessen the impact ofthe disease This ... interpretation and manuscript preparation Data analysis was provided by AstraZeneca All authors read and approved the final submission 13 14 Additional material 15 Additional file Extra-esophageal ... RDQ allowed for an evaluation ofthe frequency and intensity of GERD symptoms, the GIS providing complimentary information in terms ofthe use of additional medication for GERD symptoms and the...
... Acknowledgements Assistance with data forthe sample frame was provided by the World Food Programme (Gulu Office) and the International Organisation for Migration (Gulu Office) This work was supported by the ... pre-testing to check for errors or problems The data collectors were all fluent in Luo and English A final forward and back-translation was then produced and a final review conducted by the study team ... tests All statistical analysis was performed using STATA version 9.2 (Stata Corporation, College Park, Texas, USA) and adjusted forthe clustered design Results The total number of completed individual...
... (5’TGACTAAGCAGGACTATGCCTTCC-3’ and 5’-CAACGAGCCACATATGCGGATTAC-3’); IL-1β, (5’-TCATGGGATGATAACCTGCT-3’ and 5’-CCCATACTTTAGGAA- GACACGGAT-3’); IFN-α, (5’-ACCTCCTCTGACCCAGGAAG -3’ and 5’-GGCTCTCCAGACTTCTGCTC-3’); ... (5’-CCCTATGGAGATGACGGAGA-3’ and 5’-CTGTCTGCTGGTGGAGTTGA-3’); IFN-γ, (5’-ACTGGCAAAAGGATGGTGAC-3’ and 5’-TGAGCTCATTGAATGCTT GG-3’); IL-10, (5’-GCCAAGCCTTATCGGAAATGATCC-3’ and 5’-AGACACCTTGGTCTTGGAGCTT-3’); ... 3Ad and e) GFAP staining showed markedly increased number of activated astrocytes inthe white matter ofthe spinal cords of these mice (Fig 3Af) Next, we examined the spinal cords of TMEV-infected...
... cannot be demonstrated The tourism industry has begun to embrace performance management practices For example, inthe handbook Standard CVB Performance Reporting, the Destination Marketing Association ... renewal deliberations relating to HTA’s major contractors The Hawaiʻi Tourism Authority replied that it isinthe process of developing an operational plan to address the audit’s findings and ... propose to mandate certain health insurance benefits Such bills cannot be enacted unless they are referred tothe Office ofthe Auditor for an assessment ofthe social and financial impact ofthe proposed...
... plan “intended to guide all stakeholders in working together to attain the state’s vision fora Hawai‘i that isthe best place to live, work and visit.” Adopted in 2004, the Hawai‘i Tourism Strategic ... to manage program planning and marketing strategies for leisure tourism forthe North American market (United States and Canada) and corporate meetings and incentives domestically and internationally ... and the NFL The major contractors, the Hawai‘i Visitors and Convention Bureau (HVCB), Hawai‘i Tourism Japan (HTJ), SMG forthe marketing and operations ofthe Hawai‘i Convention Center, and the...
... performance measures in their plans for activities related to tourism promotions Tourism agencies in Montana, Florida, Texas, and Louisiana use a range of performance measures to establish baseline ... Its Major Marketing Contractors The Hawai‘i Tourism Authority’s failure to establish clear objectives and accountfor its own activities extends to its major contractors Here again, the authority’s ... That It Was Designed To Replace For example, some of these measures provide benchmarks and indicators forthe impact of advertising campaigns Results may be shown as a campaign’s influence in the...
... Attorney General and incorporated in all the major contracts under review In addition, waiving these contractual provisions has diminished the authority’s ability toaccountforthe contractor’s ... objective data that are useful to demonstrate the effectiveness ofa contractor The 360-degree evaluation is an adaptation ofa human resource performance appraisal tool to gather feedback from various ... 2: The Hawai‘i Tourism Authority Practices an Approach to Tourism Promotion That It Was Designed To Replace variables inthe marketplace that affect a consumer’s behavior to purchase a vacation...
... before and during an event include sending a delegation toa mainland conference in order to build attendance fora Hawai‘i event the following year In one case, SMG spent $8,000 to send Hawaiian ... ignored those documents as they pursued an annual budgetary approach to planning and spending Inother words, by choosing to map out their strategy and appropriate funds on a year -to- year basis, ... HTA officials have returned tothe approach to tourism promotion that the authority was created to replace This is trial version www.adultpdf.com Chapter 2: The Hawai‘i Tourism Authority Practices...
... This is trial version www.adultpdf.com This is trial version www.adultpdf.com This is trial version www.adultpdf.com This is trial version www.adultpdf.com This is trial version www.adultpdf.com ... version www.adultpdf.com This is trial version www.adultpdf.com This is trial version www.adultpdf.com This is trial version www.adultpdf.com This is trial version www.adultpdf.com ...
... consideration and intention to travel to Hawaiʻi as the most controllable and measurable performance metrics” and contracted witha leading international research company to track the impact and ... opinions and subjective evaluations for an accounting of taxpayer funds Finally, the use of performance measures is not limited to broad, agencylevel activities Measures are useful for planning for and ... brand marketer as suggested inthe response The authority has a dual role as lead agency forthe development ofthe state-wide Hawai‘i Tourism Strategic Plan and that of an active partner in...
... numeric rating scale ranging from (indicating no pain) to 10 (indicating pain as bad as you can imagine) Higher scores indicate greater pain severity Based on previous analyses, scores ofto are considered ... important forthe evaluation of FM treatments and priority setting in health care, for example by providing input data forthe evaluation of medical resource utilization, costs and quality of ... preparing meals, doing laundry, climbing stairs, shopping, yard work, driving a car, visiting friends, washing dishes, vacuuming, making beds, and walking several blocks) was evaluated using the...
... diagnostic material Other disadvantages of FNAC are lack of material for an accurate typing of lymphoma due to lack of tissue for immunohistochemistry [5] Low grade lymphomas are difficult to diagnose ... lymphoma incidence in Wales witha ratio of 1:4 [1] Table 1: Anatomical location of lymphomatous lymph nodes (n = 62) Anatomical location Number of cases Cervical Inguinal Axillary Intra-abdominal ... splenectomy was believed to debulk the disease mass and offer a more precise target for radiotherapy The advent of computed tomography brought about the demise of staging laparotomies and splenectomy is...
... activated by increases in [Ca2+]i and is also known to phosphorylate GABAAR [22] Kao et al [21] suggested that injuryinduced increases in glutamate activated NMDA receptors, increasing [Ca2+]i and subsequently ... greatest change forthe greatest number of subunits (24 h) was chosen for pharmacological manipulation The NMDA receptor antagonist MK-801, the L-type VGCC antagonist diltiazem, orthe GABAAR agonist ... receptors toa more developmental state This is an intriguing possibility since GABA activity can be excitatory during development [45] Excitatory GABAergic signaling has already been proposed as...
... inconclusive using ultrasonography when postoperative impingement is suspected because of inflammatory changes inthe subacromial space because of surgery The introduction of rotator cuff MITEK anchors ... started complaining of pain on abduction This was initially treated with analgesics but whenthe patient did not settle the shoulder was examined using ultrasound This showed inflammatory changes ... competing interests Consent Written informed consent was obtained from the patient for publication of this case report and accompanying images A copy ofthe written consent is available for review...