tests in addition to physical examination are useful tools in the assessment of patients with craniofacial microsomia
Báo cáo y học: "Pro/con clinical debate: Are steroids useful in the management of patients with septic shock" ppt
... Con: steroids are not useful in the management of septic shock Katherine G Craig and Keith R Walley The debate surrounding the use of corticosteroids in septic patients has continued for over ... of steroids in this clinically improving patient without another indication We must be cautious in our enthusiasm to try new therapies as history provides many examples of promising small clinical ... groups [8] There is ongoing debate in the literature as to the usefulness of this corticotropin stimulation test in so-called ‘relative adrenal insufficient’ patients, although it may be of prognostic...
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Báo cáo y học: "Assessment of radiographic progression in the spines of patients with ankylosing spondylitis treated with adalimumab for up to 2 years" ppt
... effect of adalimumab on the reduction of signs and symptoms and to assess the inhibition of progression of structural damage in the spine as measured by the mean change in the modified Stoke AS Spine ... performed the blinded reading of the radiographs RL was an investigator for the OASIS study and was the adjudicator for the radiographic reads DvdH was the principal investigator of the OASIS ... is the principal investigator who assisted in designing the ATLAS study WPM is the principal investigator and assisted in designing the Canadian M03-606 study RW and HK assisted in designing the...
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Báo cáo y học: "B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin" pdf
... necrosis factor (TNF) receptor-associated factor-binding motif of B cell-activating factor belonging to the TNF family (BAFF) receptor mediates induction of the noncanonical NF-kappaB signaling pathway ... can bind and respond to all forms of BLyS [4,8,13] BLyS and APRIL are overexpressed in the sera of patients with a wide variety of autoimmune disorders, including systemic lupus erythematosus ... heterotrimers levels in healthy donors compared with the mean values of each ligand in patients with SLE or RA, with the possible exception of elevated APRIL levels in patients with RA (Table 1) The mean...
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Báo cáo y học: "Pro/con clinical debate: Antibiotics are important in the management of patients with pancreatitis with evidence of pancreatic necrosis" ppt
... used intravenous and enteral antibiotics (including amphotericin) to achieve decontamination of the gastrointestinal tract for the purpose of possibly decreasing bacterial inoculation of the necrotic ... there is no definitive, level one, data supporting the use of intravenous antibiotics in the treatment of patients with severe pancreatitis, even in the setting of pancreatic necrosis The few prospective ... Pooling of the data from these 183 patients by Bosscha and colleagues in a meta-analysis resulted in a group of 95 patients treated with prophylactic antibiotics and 88 patients without [5] These...
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Báo cáo y học: " Pro/Con Debate: Does recombinant factor VIIa have a role to play in the treatment of patients with acute nontraumatic hemorrhage" ppt
... Recombinant activated factor VIIa in an unselected series of cases with upper gastrointestinal bleeding Thromb Res 2005, Epub ahead of print 18 Rizoli SB, Chughtai T: The emerging role of recombinant ... multicenter survey of off-label use of rFVIIa in American academic hospitals [16], which reported that only 52% of the patients stopped bleeding within hours of rFVIIa administration and 9% suffered ... lack of evidence There are no reports of rFVIIa use in diffuse gastric erosions, with the arguable exception of a sketchy report [17] In other gastrointestinal bleeds, there are two RCTs (discussed...
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Báo cáo y học: "Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities"
... phenobarbital, and lamotrigine The triad of hypersensitivity includes fever, rash and internal organ involvement with onset of symptoms within to weeks of exposure The frequency of the syndrome is estimated ... following the post-dialysis dose There is a case report in which lithium levels were maintained in the therapeutic range by intraperitoneal administration of lithium during continuous peritoneal ... pointes Unlikely Risk of liver injury in conjunction with lipid-lowering agents; risk of bleeding complications in conjunction with antiplatelet agents, warfarin, niacin Induction of CYP3A4 increases...
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Báo cáo y học: "A 64-week, multicenter, open-label study of aripiprazole effectiveness in the management of patients with schizophrenia or schizoaffective disorder in a general psychiatric outpatient setting" pptx
... judged by the investigator to complicate the evaluation of the study treatment were also excluded, as were those having participated in another study or taken the investigation drug within month ... representative of all patient types encountered in real-world settings Furthermore, the findings reported here should also be interpreted within the context of the open-label study design Additional ... that occurred in ≥5% of subjects are shown in Table The most frequently reported AEs (occurring in ≥10% of subjects) during the entire study were headache, auditory hallucinations and insomnia Most...
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Báo cáo y học: "Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis" potx
... highest score of bone marrow infiltation in the histopathological assessment Some of the patients had inflammatory lesions in other parts of the spine, as indicated in Table Page of (page number ... reported the first systematic histological study of zygapophyseal joints in patients with AS [10] In the present study, we first examined whether inflammation in the spine of patients with AS, ... al In patients with AS, spinal MRI is being used to assess spinal inflammation as an indicator of disease activity Lesions of active inflammation are depicted as areas of increased signal intensity...
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báo cáo khoa học: " Connectedness of healthcare professionals involved in the treatment of patients with Parkinson’s disease: a social networks study" pot
... finding should be interpreted in the context of the newly established network One of the aims of ParkinsonNet is to better integrate primary care professionals in the treatment of patients with ... each other was defined in the questionnaire as ‘knowing the face, having talked to each with other, or having heard of. ’ Having professional contact was defined in the questionnaire as ‘having ... (define by in/ outgoing connections), here defined as the sum of the lengths of the shortest geodesic paths from an individual to others The measure is standardized by norming against the minimum...
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Báo cáo y học: "Improvement in symptoms and signs in the forefoot of patients with rheumatoid arthritis treated with anti-TNF therapy" ppsx
... beneficial in monitoring the progression of active inflammation in rheumatoid arthritis [13] and in the monitoring of biologic therapy [14-16] The aim of this study was to evaluate by means of US, the ... required to confirm that this is sustained The findings further indicate that the use of US imaging of the foot would be more beneficial than clinical examination alone in the refinement of diagnosis ... recorded To reduce recall bias, all investigators (CJE, SB, CJB, KD and MS) were blinded to each other's results and all were blinded to their own baseline assessment of the individual patient being...
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Báo cáo y học: " Pro/con clinical debate: The use of prone positioning in the management of patients with acute respiratory distress syndrome" potx
... that they are withholding effective life-saving therapy from a patient with ARDS by deciding not to put the patient in the prone position Clinicians who choose ventilation in the prone position are ... common in the group whose position was varied than in the group that remained continuously supine Con: prone positioning is not useful in the management of ARDS patients Gordon Rubenfeld Imagine the ... some therapy, any therapy, to a patient in imminent danger of dying [16] As is often the case in critical care, a therapy that looks great from a basic science standpoint does not appear to save...
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Báo cáo y học: "CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease" potx
... also cytokine production, indicating a potential role for regulatory T cells to influence the inflammatory processes in the joint These features were apparent in the vast majority of the patients ... providing a possible way for the immune cells of the joint to avoid being regulated In addition, low levels of IL-2 in the joint could influence the function of the regulatory T cells [32] Further ... between the different diseases Also, a relative increase of this population in the joint in comparison with R342 the circulation was observed in all patient groups These are interesting findings with...
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Báo cáo y học: "A novel approach to measure the contribution of matrix metalloproteinase in the overall net proteolytic activity present in synovial fluids of patients with arthritis" pptx
... When testing the activity using SF of patients with RA, we found that while the percentage of inhibition of the NPA in the presence of inhibitor III rarely exceeded 10–15%, the level of inhibition ... represents an interesting tool to test the potential of new protease inhibitors for the treatment of arthritis 10 11 12 Competing interests The authors declare that they have no competing interests ... simply the presence of proteases, in patients during the course of their disease and under the influence of treatment This may represent a sine qua non to achieve clinical success in the development...
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Tài liệu Báo cáo khoa học: Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients pdf
... cytokines, including IL-1b, TNF-a and IFN-c (B) Chemokines expressed in the joint recruit leukocytes into the joints In addition to functioning in cell trafficking, several chemokines have other biological ... concentrations of several chemokines Chemokines in the joints of patients Table Chemokines and chemokine receptors expressed in the joint of RA patients Systemic name CC chemokines CCL2 CCL3 ... Iwamoto et al Chemokines in the joints of patients CXC chemokines C and CX3C chemokines Interleukin-8 ⁄ CXCL8 (a ligand of CXCR1 and CXCR2) was the first chemokine identified to be involved in leukocyte...
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Coaching Standardized Patients For Use in the Assessment of Clinical Competence pot
... standardized patients just as there is an art to working with real patients in the field of medicine In our work with standardized patients, the methodology for training unites with the art of coaching—which ... using in the CCACC I am grateful to them and to all the SP educators in the CCACC for their dedication to the quality of our coaching and for their ongoing creative ideas that are contributing ... throughout their training and during all of the administrations of the clinical skills examination Otherwise, no one can be certain how accurate the numbers are in the data that were collected Therefore,...
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THE PERFORMANCE OF CREDIT RATING SYSTEMS IN THE ASSESSMENT OF COLLATERAL USED IN EUROSYSTEM MONETARY POLICY OPERATIONS pot
... building the rating model using in- sample” data then the degrees of freedom of the χ distribution are k-2 In the context of this paper, we use the HSLS statistic as backtesting tool on “out of ... quantiles of the standard normal distribution The quality of the approximation depends on the values of the parameters N Y,, the number of rated entities with the same rating grade at the beginning of ... (strictly) below the monitoring level, then the rating source is in the green zone and is in line with the benchmark If the observed default frequency is above (or equal to) the monitoring level and...
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Báo cáo khoa học: Role of gangliosides in the association of ErbB2 with lipid rafts in mammary epithelial HC11 cells docx
... specifically interact with the purified recombinant extracellular domain of EGFR [22] and that this tyrosine kinase receptor contains a structural domain with targeting information for lipid domains [23] ... ester-induced disruption of the CD4–Lck complex occurs within a detergent-resistant microdomain of the plasma membrane Involvement of the translocation of activated protein kinase C isoforms ... no staining was observed in cells labeled with anti-GM3 serum (Fig 1B) The lack of immunolabeling demonstrates the effect of [D]-PDMP on the depletion of gangliosides and the specificity of the...
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Risk Factors Affecting the Development of Tuberculosis Infection and Disease in Household Contacts of Patients with Pulmonary Tuberculosis pptx
... home In addition, in our study the number of male patients was higher in the index cases, but the number of female patients was higher in contacts determined active disease In our opinion, the ... Radiological Extent The extension of lesions in the chest radiograph of the index case was divided into two groups The lesions were defined as follows: Moderate degree lesion; total diameter of the cavities ... the reason of this findings were that female contacts considered their health important, the majority of them have a lot of time because of not working In this study the frequency of TB in household...
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Báo cáo y học: "Quantitative expression of osteopontin in nasal mucosa of patients with allergic rhinitis: effects of pollen exposure and nasal glucocorticoid treatment" pdf
... endothelial cells In most cells, the most prominent staining was observed in the nuclei The most intense staining was observed in epithelial and endothelial cells, but also in the subepithelial ... for the non-parametric statistical analysis of the percentage of positive staining in tissues A Mann Whitney test was used to compare the controls with the patient groups and to compare the changes ... used at the same concentration as the primary antibody Representative pictures were recorded prior to destaining the slides of hematoxylin with 1% HCl in 70% ethanol The hematoxylin destained samples...
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Báo cáo y học: "An analysis of correlations among four outcome scales employed in clinical trials of patients with major depressive disorder" pdf
... 37.5 to 375 75, 150 to 225, 300 to 375 150 to 375 IR: 75 to 150; ER: 75 to 150 75 to 225 75 to 225 150 to 375 75 to 225 75 to 200 75 to 225 25, 50 to 75, 150 to 200 100 to 200 75, 150, 200 100 to ... effects with a variety of antidepressants, including tricyclic antidepressants, selective serotonin reuptake inhibitors, and serotonin-norepinephrine reuptake inhibitors [5,6] The trials in this ... sensitivity of the Montgomery-sberg Depression Rating Scale, the Hamilton Depression Rating Scale and the Clinical Global Impressions Rating Scale in antidepressant clinical trials Int Clin Psychopharmacol...
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