targeting colon drug delivery by natural products
báo cáo hóa học:" Metabolically stable bradykinin B2 receptor agonists enhance transvascular drug delivery into malignant brain tumors by increasing drug half-life" pot
... transvascular delivery of small chemotherapy drugs across the BBTB of malignant gliomas by increasing the blood half-life of the co-infused drug The selectivity of the increase in drug delivery into ... findings of the published literature suggest that the primary mechanism by which labradimil increases transvascular drug delivery is by temporarily and selectively increasing the transvascular flow ... transvascular delivery of Gd-DTPA into RG-2 glioma tumor tissue We have shown here that metabolically stable bradykinin B2 receptor agonists directly enhance the transvascular delivery of Gd-DTPA by increasing...
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Báo cáo hóa học: " Natural products that reduce rotavirus infectivity identified by a cell-based moderate-throughput screening assay" pot
... and absorption, and the propensity of natural products to act by affecting protein-protein interactions [18] Important for the studies described here, natural products are known to modulate immune ... 7000 6000 5000 4000 3000 2000 1000 Figure products identified in the MTS assay reduce rotavirus infectivity in a dose-dependent manner Natural Natural products identified in the MTS assay reduce ... expression by retinoic acid Up-regulation of STAT1 protein in IFNunresponsive cells J Biol Chem 1996, 271:10508-10514 Koehn FE, Carter GT: The evolving role of natural products in drug discovery...
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Activity based chemical proteomics profiling of natural products and drug like small molecules
... anti-cancer agents.[24] Natural products are biosynthesized or modified by proteins, and as such natural product have to bind them However, the interaction of many bioactive natural products with their ... (colored in blue) after affinity pull-down 16 1.2.4 Application of ABPP for Target ID of Natural Products Natural products, and their derivatives and mimics, have rendered an enormous contribution ... reporter group to natural product structure, many more ABPsbased on natural products have been developed and their target proteins have been identified Examples include microcycins targeting serine/threonine...
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Skin permeation enhancement by terpenes for transdermal drug delivery
... 129 drug delivery candidate products under clinical evaluation, of which 51 are transdermal or dermal systems and 30% of 77 candidate products in preclinical development fall under this drug delivery ... reported to enhance the permeation of various drugs in transdermal drug delivery [24,25] The permeation of drugs through human skin can be evaluated by in vitro methods Franz cells and flow-through ... may increase the skin permeability by interacting with the skin lipid domains 1.1 Human Skin Lipids and Transdermal Drug Delivery Transdermal administration of drug has been exploited extensively...
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Drug Delivery Systems
... for Drug Delivery Systems Drug delivery systems modify the kinetics or the location of the escape of the drug from the medicine Tables 15.1 and 15.2 provide generic reasons for using drug delivery ... a drug delivery system for kinetic control Dissolution of drug is too slow Drug and/or formulation is physically removed from the site of action too rapidly Metabolism or excretion of the drug ... from the delivery system due to the dissolution of the products of degradation The kinetics of degradation and erosion are determined by chemical and physical properties of the drug delivery...
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Biogeochemical Variability of Vietnamese Coastal Waters Influenced by Natural and Anthropogenic Processes
... rainfall is removed as surface and Biogeochemical Variability of Vietnamese Coastal Waters Influenced by Natural and Anthropogenic Processes coasts and have been increasing in frequency over the past ... 2000 (CMESC, 2004) In addition, the Vietnam coastal waters are touched by major Europe-Asia shipping routes and are affected by the heavy traffic In addition, construction of dams for hydroelectric ... 236835 4266 32832 8487 19828 Biogeochemical Variability of Vietnamese Coastal Waters Influenced by Natural and Anthropogenic Processes hydrodynamic conditions This is best seen in the distribution...
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Tài liệu Báo cáo khoa học: Membrane targeting and pore formation by the type III secretion system translocon pdf
... Membrane targeting and pore formation by the T3SS P.-J Matteı et al ¨ des Sciences du Vivant (DSV), CEA P.J.M was supported by a PhD fellowship from the Rhone-Alpes ˆ region and T.I was supported by ... translocation by Yersinia pseudotuberculosis expressing FEBS Journal 278 (2011) 414–426 ª 2010 The Authors Journal compilation ª 2010 FEBS 423 Membrane targeting and pore formation by the T3SS ... translocators of Shigella (IpaB), Salmonella (SipB), P aeruginosa (PopB), Yersinia Membrane targeting and pore formation by the T3SS (YopB) and pathogenic Escherichia spp (EspD) all carry two predicted...
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Tài liệu Báo cáo khoa học: Efficient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription (STAT) 3 hairpin decoy oligodeoxynucleotide – interference with interferon-c-STAT1-mediated killing pdf
... breast, head and neck, lung and colon cancers [8], is considered to be a marker of poor prognosis The role played by STAT3 in malignant cell growth is mediated in part by the up-regulation of the ... that SW480 cells were efficiently killed by the hpST3dODN SW480 cells were also efficiently killed by IFN-c treatment, and this action was counteracted by hpST3dODN, which reduced transcriptional ... DNA-binding motif Specific inhibition of STAT3 by DNA-binding targeting may require an improved consensus sequence that would be recognized principally by STAT3 As noted above, an NF-jB decoy ODN...
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Tài liệu Báo cáo khoa học: Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? docx
... other multidrug transporters, contains more than one drug binding site In addition, the binding sites are linked by both negative and positive heterotropic allostery In a departure from the drug ... B (2002) Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter Modulation of substrate specificity by a point mutation J Biol Chem ... obtained for ABCC1 Thus, the eukaryotic multidrug transporters are thought to mediate drug translocation through a ‘power stroke’ which is obtained by the binding of nucleotide The focus of the...
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Tài liệu Báo cáo khóa học: Inactivation of copper-containing amine oxidases by turnover products doc
... spectrophotometrically by incubating LCAO (4.0–6.0 lM) at 37 °C or 25 °C, with 1.0 mM substrate in a spectrophotometer cuvette closed by a Teflon stopper The oxygen was consumed by most substrates ... species was always present at same concentration, as shown by the measured amounts of H2O2, by the initial intensity of the radical spectrum and by the bleached 500 nm band Which of the two equilibrium ... oxidation by H2O2 was the ratedetermining step, slower than the back-reaction with aldehyde At difference from the 350 nm band formed by Co- and Ni-AGAO, the LCAO band was not affected by the admission...
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Transdermal and Topical Drug Delivery Principles and Practice doc
... percutaneous drug delivery In: Guy RH, Hadgraft J, eds Transdermal Drug Delivery, 2nd ed Marcel Dekker, New York, 2003; 305–326 50 Kondo S, Yamanaka C, Sugimoto I Enhancement of transdermal delivery by ... the relative solubility of the drug in the components of the delivery system and in the SC.9 However, in some situations, drug delivery may also be controlled by the formulation, as is the case ... the focus of this chapter as they enhance drug delivery by active methods or by disrupting the skin.21 Passive penetration enhancement can be achieved by: 26 Chapter Passive Skin Permeation Enhancement...
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Bioactive marine natural products
... Natural Products (edited by P J Scheuer), Academic Press, N.Y 1981, 4, p 54 Higa, T In: Marine Natural Products (edited by P J Scheuer), Academic Press, N.Y 1981, 4, p 93 Goto, T In: Marine Natural ... 4, p Withus, N In: Marine Natural Products (edited by P J Scheuer), Academic Press, N.Y 1981, 4, p 54 Fattorusso, E.; Piateli, M In: Marine Natural Products (edited by P J Scheuer), Academic ... 2002, 19, Erickson, K L In: Marine Natural Products (edited by P J Scheuer), Academic Press, N.Y 1983, 5, p 131 Moore, R E In: Marine Natural Products (edited by P J Scheuer), Academic Press, N.Y...
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Báo cáo khoa học: Angiotensin-converting enzyme inhibition studies by natural leech inhibitors by capillary electrophoresis and competition assay doc
... bradykin, implicating natural inhibitors [10] In this context, research of natural ACE inhibitors [11,12] seems to be a promising way for discovering novel pharmaceutical drugs to treat cardiovascular ... control Only the Ó FEBS 2004 ACE inhibition studies by natural leech inhibitors (Eur J Biochem 271) 2103 activity that could be inhibited by captopril was regarded as ACE activity To find out ... angiotensin I (30 mM) by ACE in presence of different amounts of IPEP (10–20 mM) (A) and comparison of LORF inhibition and IPEP inhibition (B) Ó FEBS 2004 ACE inhibition studies by natural leech inhibitors...
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Chemical Aspects of Drug Delivery Systems pptx
... for Drug Delivery and Targeting P York The Use of Bioadhesive Polymers as a Means of Improving Drug Delivery Slobodanka Tamburic and Duncan Q.M Craig Some Novel Aspects of Transdermal Drug Delivery ... control drug release will clearly continue to provide major challenges for pharmaceutical scientists working in drug delivery and targeting New Materials and Systems for Drug Delivery and Targeting ... stability Chemical Aspects of Drug Delivery Systems Table Routes of administration and general classification of drug delivery systems ROUTES OF ADMINISTRATION DRUG DELIVERY CLASS ORAL SOLIDS (e.g...
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Learning Organic Chemistry Through Natural Products pdf
... at present divide natural organic chemical research and the inspiration for Ifis products into various structural categories -There- provided by nature Thus, the chemisfry of natural fore, when ... and illustrate and highlight important guiding prin- by creating If ingeniously in the laboratory using ciples of the subject This can be done by removing tools of her own Thissynthesis Is an integral ... unfortunate since half a dozen molecule need to be established as they enable us carefully chosen natural products can take a stu- to understand the biological activity An organic denffo every nook...
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electrochemotherapy, electrogenetherapy and transdermal drug delivery
... delivered: drug versus genes In vivo EP requires techniques for the delivery of the drug/ gene to the tissue site, and techniques for the delivery of the field The delivery of the field is done by a ... old drug [Review] Gen Pharmacol 27, 745–748 Gehl, J., Skovsgaard, T., and Mir, L (1998) Enhancement of cytoxicity by electropermeabilization: An improved method for screening drugs Anticancer Drugs ... transfer and drug delivery into the cells In electrochemotherapy, for instance, the optimization of the electroporative channeling of the cytotoxic drugs into the tissue cells may be refined by using...
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THE CHEMISTRY OF DRUG DELIVERY SYSTEMS (hoá học các hệ dẫn truyền thuốc)
... Generalities of drug delivery Liposomes as drug delivery systems Polymers and polymeric systems for drug delivery Dendrimers for drug delivery GENERALITIES OF DRUG DELIVERY DRUG DELIVERY SYSTEM ... Targeted drug delivery systems: deliver drug to a desired body location, organ, tissue, specific cells… Controlled-release drug delivery systems: preprogramed drug release By the route of delivery: ... multiple doses of a conventional drug delivery system B: ideal drug concentration profile PRODRUG What is a prodrug? Prodrug is an inactive precursor of a drug Prodrug reconversion occurs in the...
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synthetic applications of 1,3 dipolar cycloaddition chemistry toward heterocycles and natural products
... entirely new aspect of the current reference work In recent years, numerous natural and unnatural products have been prepared by synthetic routes that have a 1,3-dipolar cycloaddition as a crucial ... SYNTHETIC APPLICATIONS OF 1,3-DIPOLAR CYCLOADDITION CHEMISTRY TOWARD HETEROCYCLES AND NATURAL PRODUCTS Edited by Albert Padwa Department of Chemistry Emory University William H Pearson Department ... Synthetic Applications of 1,3-Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products Edited by Albert Padwa and William H Pearson Copyright # 2002 John Wiley & Sons, Inc ISBN:...
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