tam ly hoc xa hoi trong he thong cac khoa hoc
OReilly hadoop the definitive guide 4th edition 2015 3
Ngày tải lên :
13/09/2016, 11:24
... finished promptly I am grateful to my editors, Mike Loukides and Meghan Blanchette, and their colleagues at O’Reilly for their help in the preparation of this book Mike and Meghan have been there ... that there are two parts to the computation—the map and the reduce—and it’s the interface be‐ tween the two where the “mixing” occurs Like HDFS, MapReduce has built-in reliability In a nutshell, ... predefined schema This is the realm of the RDBMS Semi-structured data, on the other hand, is looser, and though there may be a schema, it is often ignored, so it may be used only as a guide to the structure...
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Tài liệu Tips for turning everyday activities into learning activities pptx
Ngày tải lên :
24/02/2014, 18:20
... Count your child’s toes as you bathe her, the buttons as you dress her, and the number of steps as you walk Talk about size and shape Help your child learn the meaning of “big” and “small.” ... day he is born – helps him get ready for success in life and in school When you hold and comfort your baby, you are helping him feel safe so that he can develop the confidence he will need to ... Show how it is done, and then let your child help you set the table, sort laundry, and other simple jobs Praise his efforts even if the result is not perfect This will help your child develop self-confidence...
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DNA, RNA and proteins
Ngày tải lên :
13/03/2014, 16:38
... and attaches them to the growing protein chain 3) When protein production is complete, the ribosome releases the protein chain DNA and Protein Synthesis - Summary DNA and Protein Synthesis Practice ... mutations THE DOG BIT THE CAT DNA and Mutations - Substitution THE DOG BIT THE CAT • Substitution - Replace just one letter: THE DOG BIT THE CAR DNA and Mutations - Deletion THE DOG BIT THE CAT • ... (T): THE DOG BIT HEC AT DNA and Mutations-Insertions THE DOG BIT THE CAT • Insertion - Add just one letter (E): THE DOE GBI TTH ECA T Cells have “proof reading” proteins that constantly check the...
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Turning Many Projects into Few Priorities with TOC pot
Ngày tải lên :
16/03/2014, 01:20
... projects individually without proactively dealing with the interactions between them is not sufficient to assure the attainment of the goals of the organization The system that really needs to be ... philosophy known as the performing the task at hand, while at the same time Theory of Constraints (TOC) to the realm of project protecting the truly critical promises of the project management ... protect the promise of the project [See Exhibit 2] could systematically both provide clear priorities and In the real world, we expect time variation in the minimize the queue, then the devastating...
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Báo cáo khoa học: Translational incorporation of L-3,4-dihydroxyphenylalanine into proteins docx
Ngày tải lên :
16/03/2014, 22:20
... thus, potentially, affect the chemical shifts of the protons in the immediate vicinity of the hydroxyl groups, whereas the chemical-shift changes of protons far from the DOPA side chains are always ... completely, whereas the others are closer to the protein surface and are partially exposed to solvent Whereas DOPA–PpiB remained soluble, DOPA– hCypA was found in the insoluble fraction The greater ... the four proteins (all of which have known structures) were assessed by examination of their solubility following their in vitro synthesis Results Protein synthesis in the presence of DOPA The...
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báo cáo khoa học: "Detection of DNA mismatch repair proteins in fresh human blood lymphocytes - towards a novel method for hereditary non-polyposis colorectal cancer (Lynch syndrome) screening" doc
Ngày tải lên :
10/08/2014, 10:21
... numerator; the larger became the denominator Thus, the smaller the ratio is relative to 1.0, the greater the decrease of the protein in the numerator with respect to the level of protein in the denominator ... and HCT116 cell lysates when the lysates from these cell lines were mixed together in varying proportions (Figure 1C) To detect these MMR proteins and determine their ratio in lymphocytes from fresh ... it is highly reproducible (Table 2) The fact that MLH1 and MSH2 are not readily detected in untreated fresh lymphocytes or monocytes is likely due to the fact that they are not rapidly proliferating...
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Báo cáo y học: "Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins" doc
Ngày tải lên :
14/08/2014, 16:21
... that the heptad repeat domains in all four subunits of the S cerevisiae NDC80 complex associate to form an extended stalk that is linked to two globular heads [32,33] Whether the stalk is simply ... than the extent of conservation among syntenic CENs in different organisms (Figure 1c) Together, these data strongly imply that all organisms with CDEI-II-III point CENs arose from a relatively ... using the highly conserved reference proteins αtubulin, the signal recognition particle subunit SRP54 and PCNA) they were found to cluster closely together (Figure 1f) While recognizing the possibility...
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Turning Data into Information
Ngày tải lên :
03/10/2013, 00:20
... Run the program When the Switchboard form appears, click Aggregate Functions When the Aggregates form appears, use the fields to the right of the Compute label to generate the aggregate For example, ... the contents of the column This code makes that distinction Run the program When the Switchboard form appears, click Aggregate Functions When the Aggregates form appears, use the fields to the ... from the Aggregate Function field (the one just to the right of the Compute label), and choose Child.Population2009 from the Column Name field (the one in parentheses) Then click Compute The response...
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Tài liệu Báo cáo khoa học: DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 proteins in a target site-dependent manner pptx
Ngày tải lên :
19/02/2014, 05:20
... in the other, thus offering not only the highest total number of reactive motifs among the p53DBSs tested, but also the highest number of sites known to be modified most frequently (i.e the GG ... ability of the particular p53 target site to accommodate the cisplatin IACs The higher the probability of formation of the cisplatin IACs within the p53DBSs due to the occurrence of the GG, AG ... cis-platination was connected with the abundance of the highly reactive GG motifs rather than with the location of the AG doublet within the CWWG tetranucleotide On the other hand, our preliminary results...
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Tài liệu Báo cáo khoa học: Differentiation stage-dependent preferred uptake of basolateral (systemic) glutamine into Caco-2 cells results in its accumulation in proteins with a role in cell–cell interaction pptx
Ngày tải lên :
20/02/2014, 01:20
... apical or the basolateral side Higher glutamine concentrations in the medium resulted in higher glutamine uptake by the cells (Fig 1A) Uptake of apically and basolaterally administered glutamine ... Caco-2 cells We further investigated whether the supplied glutamine was incorporated into proteins and whether this was dependent on the delivery site We examined this using our newly developed method ... know whether glutamine taken up by the cells from the apical or basolateral side enters a common metabolic pool The purpose of this study was to investigate the relevance of the route of glutamine...
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Tài liệu Báo cáo Y học: A Raman optical activity study of rheomorphism in caseins, synucleins and tau New insight into the structure and behaviour of natively unfolded proteins pot
Ngày tải lên :
21/02/2014, 15:20
... high pH and poly(L-lysine) at low pH [18,19] Accordingly, the ROA spectra of disordered poly(Llysine) and poly(L-glutamic acid) are reproduced in Fig to facilitate comparison with the protein ROA ... dominates the ROA spectra of disordered poly(L-glutamic acid) at pH 12.6 and poly(L-lysine) at pH 3.0 (Fig 1) As these disordered polypeptides are thought to contain substantial amounts of the PPII helical ... largely on the PPII helical conformation There may also be some b strand in some of the proteins, especially b- and j-casein judging by the wellde®ned negative ROA bands in these proteins in the...
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Báo cáo khoa học: Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria doc
Ngày tải lên :
07/03/2014, 00:20
... assembly that involve formation of the catalytic core The remaining nDNA-encoded subunits are thought to be added during the last steps of assembly; however, this part of the assembly pathway is the ... mitochondria when the assembly of the Cox6a ortholog, Cox10p was analyzed, thus indicating that the assembly profile for this subunit is evolutionarily conserved In comparison to complex IV, the LSI ... supercomplex forms The consequence of these differences is that further analysis of the biogenesis of the mammalian enzyme is required Assembly of nDNA-encoded complex IV subunits Of the five nDNA-encoded...
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Báo cáo khoa học: Transcription termination at the mouse mitochondrial H-strand promoter distal site requires an A/T rich sequence motif and sequence specific DNA binding proteins pptx
Ngày tải lên :
08/03/2014, 08:20
... used for preparing the mt extract The RNA polymerase activity from the mt lysate was enriched by successive chromatography on heparin agarose and DNA–Sephacel columns [24] The polymerase activity ... protein bound to the H and L-strands of the probe Some of the discrepancies between the South-western and UV cross-link analyses as well as the failure to obtain the sequence of the poly(vinylidine ... the M KCl eluted fraction contained only the 45-kDa species Further, the 45-kDa species in both the 0.5 M and 1.0 M KCl eluted fractions resolve as doublets Currently it remains unknown if these...
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Báo cáo khoa học: Drosophila proteins involved in metabolism of uracil-DNA possess different types of nuclear localization signals pdf
Ngày tải lên :
15/03/2014, 11:20
... test whether the nuclear import of UDE requires any or both of the predicted signals, various C-terminally truncated UDE species were linked to the N-terminus of the YFP reporter (Fig 1) In the ... potential of the predicted UDE NLS1 and NLS2 sequences To determine whether either of the two predicted NLS sequences possess strong nuclear targeting potential on their own, the PEKRKQE (NLS1) ... of the two NLS segments The close overlap is indicated by the observation that the two colors (green and turquoise) overlap considerably, and it is mostly the green color that is seen as the dUTPase...
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Báo cáo khoa học: 3¢- to 5¢ DNA unwinding by TIP49b proteins docx
Ngày tải lên :
15/03/2014, 11:20
... microscopy analysis (Fig 1B) of these fractions confirmed that they differ in their oligomeric state: fraction was found to be mostly hexamers (Fig 1B, left), whereas fraction mostly contained ... (black arrowheads) suitable for further biochemical analysis The major contamination detected by LC-MS ⁄ MS was a 67 kDa GLMS_ECOLI protein (Fig 1C, grey arrowhead) We did not detect contamination ... monomers (filled circles) or hexamers (open circles) The inset shows the corresponding TLC for monomers (mono) and hexamers (hex) as a function of time (t) (C) ATP hydrolysis as a function of ssDNA...
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The future of internal audit is now Increasing relevance by turning risk into results pot
Ngày tải lên :
15/03/2014, 23:20
... Use analytics as part of a comprehensive program throughout the audit life cycle rather than on an ad hoc basis Embedding data analytics into the audit plan can help internal audit guide the risk ... down the hall toward her office, her smile disappeared and her brow furrowed slightly She had achieved her goal Now what? She could shift her focus to give greater attention to the annual audit plan, ... truly gauge the health of the organization,” said Mr Dixon He needed to know more than whether a control was passing or failing He needed to understand how big a risk a failing control was, whether...
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Báo cáo khoa học: DNA mediated disassembly of hRad51 and hRad52 proteins and recruitment of hRad51 to ssDNA by hRad52 pot
Ngày tải lên :
16/03/2014, 14:20
... highly salt sensitive and in the present assay conditions with 20 mm KCl, the protein remains highly aggregated The addition of ssDNA rendered the protein into forms that not only entered into the ... conclusion was further strengthened when the protein aggregation was tested as a function of Mg2+ In the same assay, Mg2+ titration rendered hRad52 highly soluble, whereas hRad51 was highly insoluble ... of the latter, thereby implying that hRad52 plays a role in the recruitment of hRad51 to ssDNA The results described in this study help us to understand the transitions associated with the oligomeric...
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