synthetic aspects and novel molecular architectures

Báo cáo khoa học: Benzo[a]pyrene impairs b-adrenergic stimulation of adipose tissue lipolysis and causes weight gain in mice A novel molecular mechanism of toxicity for a common food pollutant doc

Ngày tải lên : 30/03/2014, 11:20

... Maurice and Erwan Magueur is greatly appreciated This work was supported by grants from the Lorraine Region and Urban Community of Grand Nancy (CUGN) and from the French Ministry of Research and ... monitoring the kinetics of B[a]P and other pollutants in both overweight and obese subjects before and during weight loss would provide useful information The molecular mechanisms directly responsible ... disrupters and enzyme inducers and are associated with breast cancer [12] and impairment of thyroid function [13,14] Because of this, organochlorine insecticides are prohibited in North America and...

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BIOTECHNOLOGY MOLECULAR STUDIES AND NOVEL APPLICATIONS FOR IMPROVED QUALITY OF HUMAN LIFE potx

Ngày tải lên : 28/06/2014, 15:20

... modify A vinelandii and Azomonas agilis, but the problems of segregation and mutant stability remained, despite their nitrogen-fixation 16 Biotechnology - Molecular Studies and Novel Applications ... rapid, trustworthy 36 Biotechnology - Molecular Studies and Novel Applications for Improved Quality of Human Life and simple method of molecular genotyped bacterial and fungoid strains The aptitude ... significant in random effect model We could not check the condition of energy expenditure, and that was one of reasons for explaining about heterogeneity 10 Biotechnology - Molecular Studies and Novel...

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Báo cáo y học: " Ancient, independent evolution and distinct molecular features of the novel human T-lymphotropic virus type 4" pot

Ngày tải lên : 13/08/2014, 05:21

... p30II, and p13II (where I and II denote ORFI and ORFII, respectively), have been identified in the pX region of HTLV-1 and are important in viral infectivity and replication, T-cell activation, and ... confidence intervals for the origin of HTLV-2 as it migrated out of Africa and Asia and into the Americas via the Bering land bridge and 40,000 – 60,000 ya as confidence intervals for the origin of HTLV-1 ... HTLV-2 and PTLV-3 sequences are drawn in red, blue and green respectively The branch leading to HTLV-4(1863LE), STLV-2, and to the divergent MarB43 strain are drawn in magenta, purple, and yellow...

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Báo cáo y học: " Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy" pps

Ngày tải lên : 13/08/2014, 14:20

... antiangiogenic and apoptotic effects on human AI PcBra1 cells from localized prostate cancer and metastatic and androgen-dependent (AD) LNCaP and AI C4-2B, DU145 and PC3 prostate cancer cells in vitro and ... radiosensibilizing and chemosensibilizing effects on diverse human cancer cell types, including leukemia and lymphoma cells, multiple myeloma cells and brain, melanoma and epithelial cancer cells (Figures and ... characterization of the anticarcinogenic properties of curcumin and its novel synthetic analogs and nanotechnology-based formulations as well as the molecular mechanisms at the basis of the observed therapeutic...

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Tài liệu Plug and Play Splitter Architectures Drive Operational Savings doc

Ngày tải lên : 21/12/2013, 07:17

... connectors to both the F1 and the splitter, running the tests, cutting off the connectors, and re-splicing the F1 to the splitter input This process is both time consuming and costly Benefits of ... two splitter configurations available – pigtail -and- play or plug -and- play Although both offer substantial benefits over straight splicing, the plug -and- play has additional advantages For example, ... a plug -and- play splitter design, the connection is made between the F1 and the splitter simply by plugging the splitter in the backplane of the cabinet Page One argument for the pigtail -and- play...

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Tài liệu TRADITIONAL AND NOVEL RISK FACTORS IN ATHEROTHROMBOSIS pptx

Ngày tải lên : 12/02/2014, 16:20

... diabetics The complex and intimate relationship between atherothrombosis and traditional and novel risk factors is discussed in the following chapters of Traditional and Novel Risk Factors in ... differentiation of EPCs and their homing to sites of vascular injury are complex and involve several mediators and receptors, such as P-selectin glycoprotein ligand-1, CXC chemokine, and integrins (Chavakis ... coagulation factors and the risk of myocardial infarction among men: Opposite and synergistic effects of factors XI and XII Blood, Vol.108, No.13, pp.4045-4051 16 Traditional and Novel Risk Factors...

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Traditional and Novel Risk Factors in Atherothrombosis Edited by Efraín Gaxiola pot

Ngày tải lên : 07/03/2014, 20:20

... diabetics The complex and intimate relationship between atherothrombosis and traditional and novel risk factors is discussed in the following chapters of Traditional and Novel Risk Factors in ... differentiation of EPCs and their homing to sites of vascular injury are complex and involve several mediators and receptors, such as P-selectin glycoprotein ligand-1, CXC chemokine, and integrins (Chavakis ... coagulation factors and the risk of myocardial infarction among men: Opposite and synergistic effects of factors XI and XII Blood, Vol.108, No.13, pp.4045-4051 16 Traditional and Novel Risk Factors...

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Coronary Artery Disease – New Insights and Novel Approaches Edited by Angelo Squeri pdf

Ngày tải lên : 08/03/2014, 00:20

... Autoimmune and Atherosclerosis Jun-Jun Wang 49 Chapter ICAM-1: Contribution to Vascular Inflammation and Early Atherosclerosis 65 Sabine I Wolf and Charlotte Lawson Chapter Molecular and Cellular Aspects ... secreted and bound to the hepatocyte Gene Polymorphism and Coronary Heart Disease surface and readily released by heparin It is homologous to LPL and pancreatic lipase and hydrolyzes TGs and phospholipids ... sphingomyelin phosphodiesterase 1, Gene Polymorphism and Coronary Heart Disease 23 and glucocerebrosidase Molecular variation in ABCAI and Apo AI and partly lecithin cholesteryl acyl transferase...

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Báo cáo Y học: Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules pptx

Ngày tải lên : 08/03/2014, 09:20

... from the a1 and a5 helices of both subunits Synthetic peptides corresponding to the respective sequences (93–107 and 167– 187) were found to strongly inhibit the 3¢-processing and strand-transfer ... bind substrate and exclude water Protein–protein interactions in the dimer include interactions between the catalytic triad residues (D25-G27), I50 and G51 at the tip of the ﬂaps, and the antiparallel ... by the four termini in the dimer (residues 1–5 and 95–99) Additional interactions include a complex salt bridge between D29 and R87 of one subunit and R8 of the other subunit Thermodynamic analyses...

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Báo cáo khoa học: "Formal aspects and parsing issues of dependency theory Vincenzo Lombardo and Leonardo Lesmo" potx

Ngày tải lên : 17/03/2014, 07:20

... in both the u and the % components of the d-quads Both IX and vindices are null (0), and T-stack is empty ([]) The body consists of an external loop on the sets Si (0 < i < n) and an inner loop ... Given the constraints I and II, there is a one-to-one correspondence between the u-indices and the u-triples o f the d-quads Given that a dependency rule constrains one head and its direct dependents ... W ) and two integers g and v is a word object of the grammar Given a grammar G, the set of word objects of G is Wx(G)={ ~tXv/ IX, v_>0, xe W u {e} } A pair consisting of a category X (e C) and...

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Báo cáo khoa học: Investigation of leucine-rich repeat kinase 2 Enzymological properties and novel assays pptx

Ngày tải lên : 23/03/2014, 06:20

... implicated in PD, and understanding its properties and functions will aid in our understanding of disease pathology and progression Experimental procedures Chemicals and reagents All compounds and proteins ... and C-terminus of Roc (COR) regions and a kinase domain Mutations linked to PD are found throughout the protein, including the kinase domain (G2019S and I2020T), the Roc– COR domain (R1441C and ... thank Marie Uphoff and Jeanne Dudek for expert molecular biology assistance V S Anand, K Lipinski, P Pungaliya, E L Brown, W Stochaj, W Duan, K Kelleher, P H Reinhart, W D Hirst and S P Braithwaite...

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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx

Ngày tải lên : 23/03/2014, 07:20

... apoptosis and transcription Hippi Also, expression of the mitochondrial-coded genes ND1 and ND4, the nuclear genome-coded mitochondrial genes SDHA and SDHB and the antiapoptotic genes BCL-2 and survivin ... protein (AP) complex AP2A1 and AP2A2, clathrin heavy chain (CLH1), and clathrin heavy chain (CLH2), clathrin light chain A (CLTA), and clathrin light chain B (CLTB), and N-methyl-d-aspartate receptor ... caspase-1, caspase-9 ⁄ HIP-1 & HIPPI mediated apoptosis and transcription caspase-6, and caspase-3 Cleavage of Bid and release of cytochrome c and apoptosis-inducing factors from the mitochondria...

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Goethe and the Molecular Aesthetic ppt

Ngày tải lên : 23/03/2014, 13:20

... components of macromolecules and how they are put together, molecular structures are still created artifacts In an article on what molecular structures and not really signify, Luisi and Thomas (1990) warn ... internalize and mentally manipulate such images if it is to make sense of them There are still many diﬃcult mental processes required for understanding This is particularly true for understanding macromolecular ... maps, and such views are used, but these lack the coherence and clarity of the more metaphorical forms Today as we struggle with diﬃcult issues in molecular biology, as we try to understand molecules,...

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Erectile Dysfunction – Disease-Associated Mechanisms and Novel Insights into Therapy Edited by Kenia Pedrosa Nunes potx

Ngày tải lên : 23/03/2014, 17:20

... is both autonomic (sympathetic and parasympathetic) and somatic (sensory and motor) From the neurons in the spinal cord and peripheral ganglia, the sympathetic and parasympathetic nerves merge ... 16 Erectile Dysfunction – Disease-Associated Mechanisms and Novel Insights into Therapy Conclusion The molecular and clinical understanding of ED continues to gain ground at a particularly fast ... Pedrosa Nunes and R Clinton Webb Chapter Erectile Dysfunction Etiological Factors 23 Rafaela Rosalba de Mendonça, Fernando Korkes and João Paulo Zambon Chapter Erectile Dysfunction and Quality...

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NUTRITIONAL ASPECTS and CLINICAL MANAGEMENT of CHRONIC DISORDERS and DISEASES doc

Ngày tải lên : 28/03/2014, 22:20

... Health and Disease, John J.B Anderson and Sanford C Garner Edited by Ira Wolinsky Published Titles Practical Handbook of Nutrition in Clinical Practice, Donald F Kirby and Stanley J Dudrick Handbook ... Nutrition and AIDS: Effects and Treatments, Ronald R Watson Nutrition Care for HIV-Positive Persons: A Manual for Individuals and Their Caregivers, Saroj M Bahl and James F Hickson, Jr Calcium and ... NUTRITIONAL ASPECTS and CLINICAL MANAGEMENT of CHRONIC DISORDERS and DISEASES CRC SERIES IN MODERN NUTRITION Edited by Ira Wolinsky and James F Hickson, Jr Published Titles Manganese in Health and Disease,...

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Báo cáo khoa học: Mechanistic aspects and redox properties of hyperthermophilic L-proline dehydrogenase from Pyrococcus furiosus related to dimethylglycine dehydrogenase⁄oxidase potx

Ngày tải lên : 30/03/2014, 08:20

... pH, and analysis of the data by ﬁtting to Eqn (4) (see Experimental procedures) gave macroscopic pKa values of 6.8 ± 0.1 and 9.9 ± 0.1 (H225A), 6.8 ± 0.1 and 9.4 ± 0.2 (H225Q), and 6.0 ± 0.1 and ... of 30.8 ± 1.1 mm and 212.3 ± 17.0 mm for l-proline and l-pipecolic acid, respectively The corresponding apparent kcat values were 18.1 ± 0.2 s)1 and 0.4 ± 0.02 s)1 for l-proline and l-pipecolic ... His225, Tyr259 and Gly270, identiﬁed from the crystal structure, align with conserved residues in both dimethylglycine dehydrogenase and PRODHb, and are highlighted with bold type and shading Additional...

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Báo cáo khoa học: Structural aspects and biological properties of the cathelicidin PMAP-36 pot

Ngày tải lên : 30/03/2014, 20:20

... biological antimicrobial and hemolytic activity of both the hydrophobic C-terminal domain and dimerization in PMAP-36 Results and discussion A cDNA sequence encoding a novel cathelicidin of 166 ... monomeric and dimeric peptides towards several Gram-positive and Gram-negative bacteria and two fungi, in terms of the minimum inhibitory concentration (MIC) Both forms exert a potent and broad-spectrum ... isolated native dodecapeptide [22] and the synthetic monomeric b-hairpin version reported subsequently [23] CAP11 was isolated from guinea pig as a homodimer, and successively shown to be a cathelicidin...

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Imaging of the Breast – Technical Aspects and Clinical Implication Edited by Laszlo Tabar pptx

Ngày tải lên : 30/03/2014, 22:20

... Electrical Impedance Mammography 159 Marina Korotkova and Alexander Karpov Chapter The Role of Molecular Imaging Technologies in Breast Cancer Diagnosis and Management 179 Anne Rosenberg, Douglas Arthur ... benign and malignant breast lesions was primarily based on their differences in T1 and T2 relaxations times (Rausch et al., 2006) Due to the large overlap in T1 and T2 relaxation times in benign and ... patterns can be divided in linear, ductal, segmental, and regional enhancement (Figures and 6) 14 Imaging of the Breast – Technical Aspects and Clinical Implication Fig Proper terminology (according...

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Báo cáo khoa học: Glycation and glycoxidation of low-density lipoproteins by glucose and low-molecular mass aldehydes Formation of modiﬁed and oxidized particles pot

Ngày tải lên : 31/03/2014, 01:20

... artefactual oxidation during such sample handling and analysis [23,24] Samples (80 lL) were removed from the LDL incubations and 0.1 vol each of 20 mM EDTA and 0.2 mM BHT and 670 lL borate buffer (pH > ... 205 and 234 nm and a RF-10AXL ﬂuorescence detector (for TOH; kex 290 nm and kem Ó FEBS 2003 3574 H M Knott et al (Eur J Biochem 270) 330 nm) Metabolites were quantiﬁed by comparison with standards ... incubations and loaded onto precast 1% (w/v) agarose gels Native and acetylated LDL (Ac-LDL, prepared as described previously [25]) were loaded as negative and positive controls, respectively, and the...

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Báo cáo khoa học: "ON REPRESENTING GOVERNED PREPOSITIONS AND HANDLING "INCORRECT" AND NOVEL PREPOSITIONS" ppt

Ngày tải lên : 31/03/2014, 18:20

... knowledge representation and processing strategies take into account the semantic basis of prepositional case marking, and thus facilitate handling non-standard and novel use of prepositions ... non-standard prepositions to mark arguments We presented a classification of these errors and described our algorithm for handling some of these error types The importance of handling such non-standard ... negative and GOAL is substituted for a standard SOURCE, or vice versa Semantic for lexical substitutions are allowed if (iii) the non-standard preposition is a nonprivative sister of the standard...

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