... transfection, the cells were incubated for another 24 h
and then infected by Senda
ă
virus for 2 h. Cells were washed
and preincubated in a Met and Cys-depleted medium for
1 h. Metabolic labeling was performed ... non-
infected and infected cells [13], further supports the
involvement of this protein inthe deadenylation process
of IFN-b mRNA. Interestingly, IFN-b ARE does not
recruit other ARE-binding ... mRNA insta-
bility andthe involvement of the ARE in this process
[10,11]. In addition, another destabilizing sequence was
identified within the coding region of IFN-b mRNA [12,13].
Whereas the independent...
... site.
This hypothesis was further investigated by deter-
mining thein uence on the glycone binding of the
Sfbgly interactions with the aglycone. Thus, the effect
of the alteration of the glycone ... about the role of different resi-
dues of the aglycone-binding site inthe stabilization
of ES
à
and the interdependence between the binding of
aglycone andthe positioning of glycone in subsite ... Furthermore, these data
may be of particular importance in understanding the
physiological role of b-glycosidases andin designing
inhibitors.
In addition, another important issue in understand-
ing the...
... central
DNA-binding domain (DBD) and a C-terminal ligand-
binding domain (LBD) containing activation func-
tion 2 [67–70]. Upon binding androgens, the AR LBD
undergoes conformational changes leading to ... alters interactions between
G-actin andthe RPEL domain. Guettler et al. [57]
showed that the RPEL domain of MRTF-A binds
actin more strongly than the RPEL domain of myocar-
din, and that the RPEL ... the actin-binding
LIM protein (ABLIM) family, ABLIM-2 and -3, as
STARS-interacting proteins. These novel proteins con-
tain four LIM domains and a C-terminal villin head-
piece domain, which mediates...
... characteristics in RA patho-
genesis [1]. FLSs play a key role inthe development of
sustained in ammation and angiogenesis in arthritic
joints [2–4]. Several cytokines and RA factors existing
in the RA ... in less severe disease and reduces cytokine levels
in tissue in vivo [8].
In RA synovium, FLSs express both tumor necrosis
factor-a (TNF-a) and Fas receptors, and their ligands
are detected in ... associated with the exon
junction complex inthe nucleus and remains stably
associated with mRNA inthe cytoplasm [18,19]. A
recent study has found that MLN51 is essential for
the formation of stress...
... inthe brainstem and hypo-
thalamus, and induce neuroendocrine and behavioral
responses. Food intake also activates the brainstem
and hypothalamus, resulting inthe termination of
meals andthe ... distributed within the brain [44]. Expression of
the main receptor for RFRP, GPR147, is broadly dis-
tributed within the brain, including the septal areas,
amygdala, bed nucleus of the stria terminalis, ... hypothalamus. The administra-
tion of RFRP increases Fos expression inthe hypotha-
lamic paraventricular nucleus andin hypothalamic
oxytocin neurons, and facilitates the release of ACTH
and oxytocin into...
... class="bi x0 y0 w1 h1" alt=""
Claremont Colleges
working papers in economics
Claremont Graduate University ã Claremont Institute for Economic
Policy Studies ã Claremont McKenna College • ... Claremont McKenna College • Drucker Graduate
School of Management • Harvey Mudd College • Lowe Institute •
Pitzer College • Pomona College • Scripps College
... elucidate the notion of seeing in terms of the notion of perceiving
things to have such -and- such features, smelling in terms of perceiving things to have
such -and- such other features, and so on. In ... now incapable of bring-
ing any precise testimony, and leaving the object as incomplete and open as it is
indeed, in perceptual experience. Through this opening, indeed, the substantiality
of the ... to us? One can bring together discursively the notion of the number six,
the notion of “side” and that of equality, and link them together in a formula which
is the definition of the cube. But this...
... examining gene expres-
sion (GE) inthe serum and synchronizing GE changes
with the clinical course of events.
Processing of the blood and serum samples w as per-
formed after blood sampling during ... complement and coagulation
cascades, linking downstream to the inflammatory pro-
cess or to B cell receptor signaling.
NAMPT is another indicator for prognosis. It is the
rate-limiting component inthe ... hemostasis
and reflect damage to endothelial megakaryocytes
expressing VWF. Inthe signaling pathway, VWF inter-
acts with integrins inthe extracellular matrix (ECM)
and has functions in t he complement...
... to find out the subject andthemain verb. In this case,
subject andmain verb are together at the beginning of the sentence, but in other case, they
are separated or the writer delays the ... illustration forthe dishonesty in implementing state-owned
projects.
22
understand a direct speech; in contrast, there remain some hints in indirect speech and one
has to know the rules to interpret ... to the first (and occasionally the second) paragraph of an article. It is usually
one information-packed sentence which expands on the story’s main point as introduced in
the headline. The...
... biomass of the
giant reed and maintain the wetland potential is proposed as shown in Fig. 10. In this
method, the above-ground part of the giant reeds that will remain the following year are ...
cropped before the start of the dying down period. Then, after all of the above-ground
part has died down, the whole plants including the roots and rhizomes are cropped
except forthe roots and rhizomes ... rhizomes remaining forthe next year. Thereafter, the giant reeds
grow with the rhizome extension, andthe giant reed community inthe wetland is
regenerated.
Journal of Water and Environment...
... customer-intimate organiza-
tion would respond to certain business situations. My intent was to
tailor specific training language and training situations to bring the
strategic plan andthe training into ... carried inthe jungles of Vietnam
in 1969 is exactly the same pattern as the model featured in the
company’s 2000 catalog. Thelate Bo Randall and later his son Gary
remained true to their purist ... with customers. Putting employees first
means taking care of your people, eliminating the common gripes
and complaints that stand inthe way of them doing a first-class job
for the customer. This...