... costs of premature mortality in this analysis, the overall view ofthe authors, in the interests of conservatism, is that the evidence on premature death is not strong enough to include at this ... due to the musculoskeletal disease in a given year, then 50% ofthe cost of musculoskeletal diseases can be attributed to chronic pain. Repeating this calculation for the other causes of chronic ... value on the informal care provided. ã Opportunity cost isthe value of lost wages forgone by the carer. ã Replacement valuation isthe cost of buying a similar amount of services from the...
... the core ofthe examination of any interference in the exercise of freedom of opinion is therefore a balancing of interests in which the Court takes account ofthe significance of freedom of ... or the economic well-being ofthe country, for the prevention of disorder or crime, for the protection of health of morals or for the protection ofthe rights and freedoms of others. Furthermore, ... the basis ofthe Helsinki Final Act ofthe Conference on Security and Co-operation in Europe, the OSCE has assumed the tasks of identifying the potential for the outbreak of conflicts and of...
... to the pronounced sequence heterogeneity foundat this position (see below). The southern boundary of the active site cleft of DESC1 is formed by the 145autolysis loop. The backbone of this ... compounds. The following analysis ofthe active site pockets and the key residues is based on the structurally solvedmembers ofthe TTSP subfamilies. Within the indi-vidual subfamilies these residues ... the pocket), Ser214–Gly219 (the entrance frame), Lys224–Tyr228 (the back ofthe pocket) and the disulfide bridgeCys191–Cys220 (the front ofthe pocket) (Fig. 4A). The backbones of these segments form...
... residuesP336 and Y338 of ClfA. One ofthe objectives of thisstudy was to determine the mechanism of Fg bindingby the A domain of FnBPB.Located distal to the A domains of FnBPA andFnBPB are ... achieved by the expression ofthe ligand-bindingsite in the A domain of FnBPB.DiscussionAn important factor in bacterial pathogenesis is the ability ofthe invading organism to colonize host tis-sue. ... objective of this project was to determine whether the A domain of FnBPB binds Fg by the same mecha-nism as the A domain of ClfA. A three-dimensionalmolecular model ofthe N2N3 domains of FnBPBbased...
... &DePaoli-Roach AA (1996) High complexity in the expression ofthe BÂ subunit of protein phospha-tase 2A0. Evidence for the existence of at least sevennovel isoforms. J Biol Chem 271, 2578–2588.9 ... the luciferase reporter assay system, using a glomax luminome-ter (Promega). Luciferase activities were normalized on the basis ofthe b-galactosidase activity ofthe cotransfectedvector. All ... regulates the expression of Ppp2r5c, which is a regulatory subunit of PP2A. These results support the potential benefits of association between Nrl and Ppp2r5c as its target geneduring retinogenesis....
... classical and patristic authors. Lucian, the witty writer ofthe firsthalf ofthe second century, makes the subject of one of his satires the pupil of a disciple of Apollonius, of one of those who ... purification ofthe many cults ofthe Empire and to the instruction of the ministers and priests of its religions. With the exception ofthe Christ no more interesting personageappears upon the stage of ... out ofthe fears ofthe citieson the left shores ofthe Hellespont. These cities had suffered severely from shocks of earthquake, and in theirpanic placed large sums of money in the hands of these...
... techni-cal assistance to the Ministry of Economy. The prime minister at that time, Egor Gaidar, supported this decision. The establishment of HSE under the jurisdiction ofthe Ministry of Economy ... science.Setting for HSE The rootsof this situation start in the intellectual history ofthe Soviet Union. In the beginning ofthe 20th century (and even in the first A New Research University: The Higher ... rate meant the recognition ofthe high status ofthe young university. In the early 1990s, however, this rate did not address the issue of HSE financing, as government funding ofthe entire...
... This white paper has had significant impact in the U.S. and other countries. Its most significant conclusions include: (1) There is no evidence ofthe existence of unique hazards, either in the ... nature as those that might arise from other ways of altering the genome of an organism, such as conventional breeding…While there may be limitations to the application ofthe substantial equivalence ... safety assessments. They are assumed to be safe because they are similar to other varieties or because they have been safely consumed elsewhere in the world. On the other hand, products derived...
... dueregard to the risks. It then describes the marketresponses to the deteriorating conditions and the response ofthe authorities to the crisis. The sec-ond part discusses how the structure ... Run. The paper byAlistair Milne and Geoffrey Wood in this issue of the Review details many ofthe developmentsin the Northern Rock bank run, so the discussionhere is brief. Northern Rock had adopted ... second approach is to identify the mort-gages by borrower characteristics: The Board of Governors ofthe Federal Reserve System, the Office ofthe Comptroller ofthe Currency, the Federal Deposit...
... segment is distinguished. All remaining edges are called lateral or side segments. A sequence of segments is called an axis if:ã the rst segment in the sequence originates at the root ofthe treeor ... and the rule b → a means that the letter b is to bereplaced by a. The rewriting process starts from a distinguished stringcalled the axiom. Assume that it consists of a single letter b.Inthefirst ... ordered. The axis originating at the root of the entire plant has order zero. An axis originating as a lateral segment of an n-order parent axis has order n+1. The order of a branch is equalto the...
... middle part of England, euen vnto Humber. To the archbishop of Yorke allthe north parts of Britaine from the riuer of Humber vnto the furthest partes of Scotland. And to the archbishop of Caerleon ... manie of the enimies, neither restored the goods to them ofthe countrie from whome the enimies had bereft the same, noryet sent anie part therof to the emperours, but kept the whole to his owne ... weapons, and the force of themby whom they had so often béene put to flight. In manie legions (saith he) the number is small of them thatwin the battell. Their glorie therefore should be the more,...
... with the end ofthe eight of Cerdicus king ofthe Westsaxons, that is, the 527 of Christ, and 78 after the comming of the Saxons. In the 13 yéere ofthe reigne of Cerdicus, he with his sonne Kenrike, ... Horsus the brother of Hengist, after a long combat betwixt them two, either of them slue other:but the Britains obteined the field (as saith the British [Sidenote: The Ile of Tenet.] historie.) The ... there is none more perillous, so is it ofall other the least in continuance: this is prooued byhistoricall obseruation through the course of this historie.* * * * *Ceolric reigneth ouer the...
... men.[Sidenote: The end ofthe Danish rulers.] In this Hardicnute ceased the rule ofthe Danes within this land, with the persecution which they had executed against the English nation, for the space of 250 ... crowned of Athelnotus archbishop of Canturburie, in the yere of our Lord 1041, in the first yéere ofthe emperour Henrie the third, in the 9 yeere of Henrie the first of that name king of France, ... Controuersie for the crowne.] sonne of king Cnute, to succéed in his fathers roome, hauingearle Leofrike, and diuerse other ofthe noble men ofthe north parts on their side. But other of the Englishmen,...
... on fire there. This, then, is exactly the same kind of vapour as we have in the middle ofthe candle; and that you may be sure this isthe case, let You see, then, these two great distinctions; ... by the combustion ofthe phosphorus. Here, again, are two substances. This is chlorate of potassa, and this other sulphuret of antimony. I shall mix these together a little, and then they ... tongues of flame that I refer to. You have the air creeping in over the edge ofthe dish forming these tongues. Why? Because, through the force ofthe current and the irregularity ofthe action of...