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![Báo cáo khoa học: Benzo[a]pyrene impairs b-adrenergic stimulation of adipose tissue lipolysis and causes weight gain in mice A novel molecular mechanism of toxicity for a common food pollutant doc](https://media.store123doc.com/images/document/14/rc/rp/medium_luUKRIz7Xm.jpg)
Báo cáo khoa học: Benzo[a]pyrene impairs b-adrenergic stimulation of adipose tissue lipolysis and causes weight gain in mice A novel molecular mechanism of toxicity for a common food pollutant doc
Ngày tải lên :
30/03/2014, 11:20
... unknown whether environmental pollutants exert a toxic effect on the adipocyte itself This led us to question whether the pollutant had a negative impact on one of the key functions of the adipocyte, ... subjects living in the New York area [11] These studies unambiguously established that, because of their lipophilicity, environmental pollutants accumulate in the fat of organisms and their concentrations ... increased atherosclerotic lesion size [19] However, little has been documented on the effect of B[a]P on adipocyte function, one of the main sites of storage We therefore decided to address the question...
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BIOTECHNOLOGY MOLECULAR STUDIES AND NOVEL APPLICATIONS FOR IMPROVED QUALITY OF HUMAN LIFE potx
Ngày tải lên :
28/06/2014, 15:20
... Human Life the rational use of essential medicines; the safety of the patients; and the guarantee of certified laboratories On the other hand, the struggle against the resistance to the antimicrobial ... of the sea together with the algae cells, or have been the result of a contamination in the algae culture These mixed populations that are present in the culture and in the sea, show that the ... consequence of the capacity of certain microorganisms (bacteria, virus and parasites) to neutralize the effect of the medicine The resistance can come from the mutation of the microorganism or from the...
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Báo cáo y học: " Ancient, independent evolution and distinct molecular features of the novel human T-lymphotropic virus type 4" pot
Ngày tải lên :
13/08/2014, 05:21
... and HTLV-3 [27] The absence of PDZ suggests that the HTLV-4 Tax may be more phenotypically similar to the HTLV-2 than the HTLV-1 Tax Furthermore, the high amino acid identity of the Tax4 and Tax2 ... either with or without the enforcement of the global clock constraint with the program PAML [72] The PTLV evolutionary rate assuming the global molecular clock model was estimated by using the ... [18-20,23,31,34,35] The distal 21-bp repeat element found in HTLV-1 and HTLV-2 is absent from the HTLV-4(1863LE) genome (Fig 7) Others have shown that deletion of the middle, rather than the distal 21-bp...
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Báo cáo y học: " Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy" pps
Ngày tải lên :
13/08/2014, 14:20
... [143-145] Together, these data support the therapeutic interest of using curcumin or its derivatives, alone or in combination with other dietary substances, to improve the efficacy of the current ... formulations as well as the molecular mechanisms at the basis of the observed therapeutic effects induced by these agents Search strategy Literature search for this article was conducted in the MEDLINE/PubMed ... vitro and in vivo [160-162] Together, these data support the therapeutic interest of using low doses of curcumin or its derivatives in combination therapy with other cytotoxic agents acting on...
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Tài liệu Plug and Play Splitter Architectures Drive Operational Savings doc
Ngày tải lên :
21/12/2013, 07:17
... one or the other readily available increases the time it takes to perform the task and slows down the overall deployment Another issue created by splicing is in the initial turn-up of the cabinet ... less loss and enabled the addition of more splitters as the network grew However, there were also a few downsides to splicing the F1 cables to the splitters The first issue is the amount of time ... how to connect the F1 optical feeder cable inputs to the splitters in the fiber distribution hubs (FDHs) There are several methods for making these connections, but selecting the best technique...
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Tài liệu TRADITIONAL AND NOVEL RISK FACTORS IN ATHEROTHROMBOSIS pptx
Ngày tải lên :
12/02/2014, 16:20
... the cell surface of the activated leukocytes to bind to PECAM-1, allowing them to pass through the endothelial layer into the arterial intima in a process labelled diapedesis (29;36) Within the ... Thus, the thinning of the fibrous cap is though to be a state vulnerable to rupture, the so-called thin-cap fibroatheroma (Kolodgie et al., 2001) However, the thin-cap fibroatheroma is not taken into ... activation and adhesion but the thrombus does not extend into the arterial lumen (12) The thrombus subsequently undergoes organisation, the endothelial layer regenerates and the episode is clinically...
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Traditional and Novel Risk Factors in Atherothrombosis Edited by Efraín Gaxiola pot
Ngày tải lên :
07/03/2014, 20:20
... the cell surface of the activated leukocytes to bind to PECAM-1, allowing them to pass through the endothelial layer into the arterial intima in a process labelled diapedesis (29;36) Within the ... Thus, the thinning of the fibrous cap is though to be a state vulnerable to rupture, the so-called thin-cap fibroatheroma (Kolodgie et al., 2001) However, the thin-cap fibroatheroma is not taken into ... activation and adhesion but the thrombus does not extend into the arterial lumen (12) The thrombus subsequently undergoes organisation, the endothelial layer regenerates and the episode is clinically...
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Coronary Artery Disease – New Insights and Novel Approaches Edited by Angelo Squeri pdf
Ngày tải lên :
08/03/2014, 00:20
... encircles the muscle to supply blood to the lateral side and back of the heart, and the left anterior descending artery, which supplies the blood to the front of the left side of the heart The right ... water from the kidney tubules into the blood This in turn increases the fluid volume in the body and therefore the blood pressure Increased RAAS activity leads to high blood pressure, and therefore ... domain is then released from the endoplasmic reticulum membrane and transported into the nucleus, where it binds to specific nucleotide sequences in the promoters of the LDLR and other genes...
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Báo cáo Y học: Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules pptx
Ngày tải lên :
08/03/2014, 09:20
... modification of their amino-acid composition and the addition of a hydrophobic moiety, such aminocaproyl or palmitoyl, to the N-terminus of the peptide [20] The development of these Ômore potentÕ ... plasmid (that contains the selection module kPR-lacZ-tet and directs the production of the cI-PR fusion protein), cI-PR represses the transcription of the reporter genes and the transformants show ... heterodimer is the structural asymmetry which exists between the p66 and p51 subunits despite the fact that they are products of the same gene and exhibit identical amino-acid sequences for the first...
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Báo cáo khoa học: "Formal aspects and parsing issues of dependency theory Vincenzo Lombardo and Leonardo Lesmo" potx
Ngày tải lên :
17/03/2014, 07:20
... from the grammar The selection is carried out by matching the head of the rules with the words of the sentence The second step follows Earley's phases on the dependency rules, together with the ... follow the events; the separator symbol I helps to keep trace of the sets in the stack; finally, we have left in plain text the d-quad sequence of the dotted rules; the other components of the items ... constraint on the order of consumption of the u-triples Following Earley's style, the general idea is to move the dot rightward, while predicting the dependents of the head of the rule The dot can...
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Báo cáo khoa học: Investigation of leucine-rich repeat kinase 2 Enzymological properties and novel assays pptx
Ngày tải lên :
23/03/2014, 06:20
... the protein and not just to the presence of an extra phosphorylation site The mutation also affects the apparent Km of ATP, indicating that it modifies the active site of the enzyme to alter the ... appearing on the autoradiograms was at the size of the LRRK2 protein (204 kDa), indicating that none of the other minor contaminant bands seen on Coomassie-stained gels (Fig 1A) are other active ... D1994A there is significant, although low, incorporation of 32P into LRRK2 as compared to reactions in the presence of the D1994A kinase-dead LRRK2, or in the absence of enzyme (Fig 2B) These findings...
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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx
Ngày tải lên :
23/03/2014, 07:20
... implicated in HD These processes may not be independent of each other Detailed descriptions of these processes are beyond the scope of this review In the present review, we specifically focus on the role ... (484–489) and other domains are taken from the published literature and mentioned in the text The positions of the amino acids are not to scale 4272 FEBS Journal 275 (2008) 4271–4279 ª 2008 The Authors ... of them wH16-Hi It is not clear how HIPPI, being a cytoplasmic protein, enters into the nucleus and interacts with the putative promoter sequences and eventually increases the expression of the...
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Goethe and the Molecular Aesthetic ppt
Ngày tải lên :
23/03/2014, 13:20
... argue that Goethe’s archetypes are mental constructs, they are loathe to admit the same for the structures they create Both are the result of the processing of data by the mind, both are therefore ... relative to the question comes the interpretation and evaluation of the data: does it support the original hypothesis? Then it is back to testing, to further investigating the validity of the results ... establishment for the same reason that Goethe’s view was For both Goethe and McClintock, the affective is allowed to mix with the objective and this is anathema to the dominant view of the scientific...
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Erectile Dysfunction – Disease-Associated Mechanisms and Novel Insights into Therapy Edited by Kenia Pedrosa Nunes potx
Ngày tải lên :
23/03/2014, 17:20
... On the other hand, dilation of the penile arteries is the first event in the development of erection Its consequence is the increase of blood flow and pressure into the lacunar space Then, the ... (sympathetic and parasympathetic) and somatic (sensory and motor) From the neurons in the spinal cord and peripheral ganglia, the sympathetic and parasympathetic nerves merge to form the cavernous nerves, ... publication of which they are the author, and to make other personal use of the work Any republication, referencing or personal use of the work must explicitly identify the original source As...
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NUTRITIONAL ASPECTS and CLINICAL MANAGEMENT of CHRONIC DISORDERS and DISEASES doc
Ngày tải lên :
28/03/2014, 22:20
... Convincing the patient, including young children, and caretakers of the rationale for the proposed approach is essential The authors here, as authors of other chapters, deal with the question ... relaxing the arm and measuring the arm circumference midway between the olecranon and the tip of the acromion.34 A nomogram can then be utilized to calculate muscle circumference43 and the result ... increasing the fat-to-carbohydrate ratio in the diet, is needed in bronchopulmonary dysplasia, and the authors discuss monitoring the patient to ensure reasonable weight gain over the long term The...
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Báo cáo khoa học: Mechanistic aspects and redox properties of hyperthermophilic L-proline dehydrogenase from Pyrococcus furiosus related to dimethylglycine dehydrogenase⁄oxidase potx
Ngày tải lên :
30/03/2014, 08:20
... sequence similarity with the gene encoding DMGO We show that these genes encode a new member of the hyperthermophilic class of PRODHs that couples the oxidation of l-proline to the reduction of a noncovalently ... further exchanged into 100 mm potassium phosphate buffer (pH 7.5) This treatment releases the ATP and FMN cofactors from the protein, but leaves the FAD-bound form This is a convenient form of the ... 787 identical to that of the authentic FAD standard The m ⁄ z peak at 825 represents the K+ adduct of released FAD cofactor The m ⁄ z peaks of 348 and 458 represent the [M + H]+ ion of both AMP...
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Báo cáo khoa học: Structural aspects and biological properties of the cathelicidin PMAP-36 pot
Ngày tải lên :
30/03/2014, 20:20
... at the proform level of the cathelicidin [21], and this structure is likely to persist in the mature peptide Indeed, it may explain the different activity spectra and potencies observed for the ... report on the use of chemically synthesized dimeric and monomeric peptides to probe the effect of these structural factors on the biological antimicrobial and hemolytic activity of both the hydrophobic ... cathelicidins such as SMAP-29, BMAP-27 and BMAP-28 The amidated form would further increase the charge of the dimer to +28 (see Table 1) Here we further investigated the expression of this protein and performed...
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Imaging of the Breast – Technical Aspects and Clinical Implication Edited by Laszlo Tabar pptx
Ngày tải lên :
30/03/2014, 22:20
... 2003) Finally, the risk of local recurrence is dependent on the age of the patient at the time of the diagnosis (Mann et al., 2008) Even with additional booster radiation therapy, these patients ... breast cancer were published in the 1990s Based on these studies initiated in the Netherlands, the United Kingdom, the United States, Canada, Italy, and Germany, the American Cancer Society (ACS) ... curves, the probability of malignancy should be estimated The maximum diameter of suspicious lesions should be provided, together with their location within the breast and their relationship with the...
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Báo cáo khoa học: Glycation and glycoxidation of low-density lipoproteins by glucose and low-molecular mass aldehydes Formation of modified and oxidized particles pot
Ngày tải lên :
31/03/2014, 01:20
... indicate the first time point at which the data becomes statistically different when compared with the t ¼ value surface of the LDL) In these experiments, the order of preincubation had no impact on the ... the MG system With GA the loss of these two amino acids occured too rapidly to determine an order of reaction Loss of Arg occurred prior to either of these other amino acids as evidenced by the ... initial time point there was a significant decrease in the measurable level of Trp in the presence of 100 mM MG (P < 0.001) while there was no statistical difference between any of the other conditions...
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