... very steep rates, exceeding the rate of all the other nine industries This continued through the advent of the Internet in the nineties andthe gradual opening up of the 42 market As Telstra went ... already been imposed in the model, the last concavity condition must then be tested empirically The theory of cost and production also requires that the second order condition of the Hessian matrix ... to measure the extent of factor substitution by calculating the price elasticities of substitutionThe own and cross price elasticities can be derived from the AES estimates through the relationship:...
... apoptosis as the underlying mechanism for the cytotoxicity observed in the setting of transient B19 NS1 expression (34) We therefore examined whether the reduced cell loss observed in the PathI substitution- ... replication, and packaging These multi-domain proteins have a conserved architecture: the N-terminus encodes for the DNA binding and endonuclease domains (30, 45); the central region contains the conserved ... mock, NS1, PathT and PathI in the SubG1 phase of the cell cycle The data represents at least two independent experiments with bars demonstrating the standard deviation between the individual runs...
... between the helicase catalytic domain of HPV-18 E1andthe viral E2 protein [51]; a dimer of BPV E1 DNA binding domains [52]; andthe BPV E1 DNA binding domain bound to origin DNA [53] These structures ... of the BPV E1 protein Positional phosphate map and functional domains of the BPV E1 protein The 605 amino acid protein is represented on the lower horizontal line The position of each of the ... analysis of theE1 tryptic digest Tandem2 Tandem mass spectrometric analysis of theE1 tryptic digest A Base peak ion chromatogram obtained by HPLC/ESIqTOF MS and MS/MS analysis of theE1 tryptic...
... between the helicase catalytic domain of HPV-18 E1andthe viral E2 protein [51]; a dimer of BPV E1 DNA binding domains [52]; andthe BPV E1 DNA binding domain bound to origin DNA [53] These structures ... of the BPV E1 protein Positional phosphate map and functional domains of the BPV E1 protein The 605 amino acid protein is represented on the lower horizontal line The position of each of the ... analysis of theE1 tryptic digest Tandem2 Tandem mass spectrometric analysis of theE1 tryptic digest A Base peak ion chromatogram obtained by HPLC/ESIqTOF MS and MS/MS analysis of theE1 tryptic...
... of hnRNP E1andE2 alters HIV-1 gene expression Depletion of hnRNP E1andE2 alters HIV-1 gene expression 293 cells were transfected with siRNAs to hnRNP E1( E1(3) or E1( 16)), hnRNP E2 (E2) or a ... SDS-PAGE The arrow indicates the excised band Western blot against hnRNP E2; ESS or mutant thereof are as shown (C) Comparison of hnRNP E1and hnRNP E2 Boxed is the sequence generated from the excised ... acted on HIV-1 ESS3 Two of the factors identified, were hnRNP E1and hnRNP E2and in this paper, we investigate the effects of overexpression and depletion of hnRNP E1andE2 on HIV-1 gene expression...
... Chapter 1.1 Tandem conjugate addition -elimination (CA-E) reactionsTheSN2 reaction (1) andthe tandem conjugate addition -elimination reaction (2) which yields SN2 type product are ... yield theSN2 type product Tandem CA-E reaction is fundamentally different from SN2 reaction in that the two reactions proceed via different mechanisms The substrates of tandem CA-E reactions ... which are not essential to theSN2 reaction To the best of our knowledge, the tandem CA-E reaction is not widely studied There are few reported examples of tandem CA-E reactions, especially asymmetric...
... elimination of the promoter would give rise to theSN2 type product In contrast, the formation of theSN2 type product would be via the direct nucleophilic substitution on the carbon adjacent to the leaving ... onto the amino group to afford the CPS promoters containing same R1 group Considering the efficiency, the first route (Scheme 2.5) was the preferred synthetic pathway and it was used for the synthesis ... the selectivity However, the tandem CA-E reactions were generally slow at low temperatures Therefore, we attempted several other conditions to reduce the reaction time and while maintaining the...
... 48 a TheSN2 :SN2 ratio was obtained approximately 5:1 by H NMR analysis bIsolated yield of both SN2 type andSN2 type products cDetermined by chiral HPLC analysis We have also tested the tandem ... product spots remained a challenge The side product was assigned as SN2 type product by 1H NMR analysis However, the reason for the formation of theSN2 type product in the reaction of linear MBH allylic ... tandem CA-E reaction was that the yield was typically low, often in the range of 30-60% andthe ratio of SN2 to SN2 type products can vary from ratios of 5:1 to 2:1 When the aryl group contains no...
... reaction involves the conjugate addition of a nucleophile to generate an enolate, the attack of the enolate onto the aldehyde and subsequent elimination to generate the product However, the effects ... (entries and 6) andthe methylenediphenyl group (entry 7) The enantioselective improvements by these changes were marginal These results showed that the configuration of the chiral center of the methyl-benzyl ... (entries and 6) did not influence the effectiveness of the imidazolines However, we observed that by increasing the size of the C1-substituent, the rate of reaction was slower The use of the chiral-methylnaphthyl...
... of iodine until the iodine disappeared and then distilled off Other distilled solvents such as CH3CN, ethyl acetate and CHCl3 were 79 Chapter stored under N2 All other reagents and solvents are ... 1.5 eq.) was then added andthe reaction mixture was refluxed (85oC oil bath) and monitored by TLC Upon completion, the solvent was removed under reduced pressure andthe crude product was purified ... anhydrous THF (0.5 mL) andthe reaction flask was cooled to -78oC The hexane solution of nBuLi (1.6 M, 0.15 mL, 0.24 mmol, equiv.) was then added and stirred for 30 at -78oC The mixture of CA-E...
... model They look at the effects of taxes both in the steady state and during the transition to the steady state They find that both consumption and factor income taxes lower the growth rate and for ... are high, the ranking of the taxes is: the labor income tax, the capital income tax andthe consumption tax This is different from the results in Stokey and Rebelo (1995) They argue that the elasticity ... Functions and Economic Growth Scandinavian Journal of Economics 102(1), 41-56 Klump, R and Grandville, O., 2000 Economic growth andthe elasticity of substitution: Two theorems and some suggestions,The...
... phase to the other and enhance the reactivity In the middle to late 1960s, Starks, Makosza and Brandstorm discovered and built the foundation of phase transfer reactions. 4,5 Based on their own ... 1.1) The catalyst could distribute in both organic and aqueous layers, and exchanged the anions in the aqueous phase and took them back to the organic phase Without the phosphosium salt as the ... substrates, the yields were good Two catalytic systems were studied, and each of them had their advantages and disadvantages At the last of this work, suggestions to further improvement were proposed and...
... presented in the thesis and give some suggestions for further studies The References and Appendix are provided at the end of the thesis PART II: DEVELOPMENT CHAPTER 1: THEORETICAL BACKGROUND 1.1 The Nature ... ambiguity caused by ellipsis andsubstitution In this thesis, the author discusses different definitions of ambiguity, ellipsis andsubstitutionand their types first Then, the survey is implemented ... (N), Epithet (E), Classifier(C), and Quantifier (Q) The Deictic is normally a determiner, the Numerative a numeral or other quantifier, the Epithet is an adjective andthe Classifier a noun, the...
... (3) where B2θ is the full width half maximum (rad), λ the wavelength of the X-ray, θ the angle between the incident and diffracted beams (degree) and d the particle size of the sample (nm) (in ... according to the following relation and is shown in Table1 Dx = 8M (2) N A a Where, M is molecular weight of the particular ferrite, NA is the Avogadro’s number and a3 is the volume of the cubic ... weights of all the atoms in the unit cell, V is volume of the unit cell and N is the Avogadro’s number Since each primitive unit cell of the spinel structure contains molecules, the X-ray density,...
... Control and Prevention The role of BCG vaccine in the prevention and control of tuberculosis in the United States: a joint statement by the Advisory Council for theElimination of Tuberculosis andthe ... Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States A Joint Statement by the Advisory Council for theElimination of Tuberculosis andthe Advisory Committee ... children and adults who are infected with human immunodeficiency virus because of the potential adverse reactions associated with the use of the vaccine in these persons In the United States, the...
... dehydration, together with acidification and dilution of the samples, stopped thereactions This finding allowed the acquisition of spectra in the automatic mode, once all the samples had been taken and placed ... diminished the Tm by °C andthe DGU by 3.5 kJÆmol)1, whereas substitution of methionine with leucine at position 23 diminished the midpoint of the thermal denaturation curve (Tm) by °C andthe free ... phosphate of the substrate [32] The closer positioning of the N-terminus to the main protein body is essential for the activity and, together with the 87–104 disulfide bridge, contributes to the high...
... conducive to the expansion of credit without due regard to the risks It then describes the market responses to the deteriorating conditions andthe response of the authorities to the crisis The second ... for these products, thereby introducing further uncertainty about the reliability of their ratings Conduits and SIVs had funded their purchases of CDOs and other securitized assets by issuing their ... were due The result of the dislocation in the capital and money markets would lead to the Northern Rock bank run in the United Kingdom andthe threat of bankruptcy for Bear Stearns in the United...
... on the bioenergetics of the formyl-methanofuran dehydrogenase and heterodisulfide reductase reactions, forcing the organisms to control the Na+ and H+ translocation numbers in the respective reactions ... Methanothermobacter thermautotrophicus PhD Thesis, University of Nijmegen, Nijmegen, the Netherlands Butsch, B.M & Bachofen, R (1984) The membrane potential in whole cells of Methanobacterium thermoautotrophicum ... in time andthe rates depended on the pH2 applied After incubation, cells were analyzed for the contents of methanofuran, formyl-methanofuran, Dw, and for intra- and extracellular pH and sodium...
... oriented towards the same direction and are relatively close The Oe1 and Oe2 atoms of Glu20 are 3.726 ˚ and 1.983 A, respectively, from the imine He proton and ˚ 3.644 and 5.121 A from the proximal ... regions of Ramachandran plot (Table and Fig S2) According to the PROCHECK-NMR [37] program, the average of the 40 models andthe mean minimized structure of the synthetic analogue [D-Phe12, Aib15]CRH, ... further support the continuous C-terminal helix structure Monitoring the Phe12 fi D-Phe and Leu15 fi Aib substitutionThe NOE pattern of the CRH analogue involving HN, Ha and Hb protons of D-Phe12,...
... in the Health Products and Foods Branch to replace the Therapeutic Products Programme: the Therapeutic Products Directorate (TPD); the Biologics and Genetic Therapies Directorate (BGTD); andthe ... – the industry, on the one hand, andthe consumer’s health movement, on the other, with government showing favour to both camps, depending on the political climate of the day Women in both the ... consultation with the women’s health community and include the principle of the right to be warned and informed expands regional reporting centres and adequately funds these as the front lines of the reporting...