structure function and regulation of cardiac gap junctions
Báo cáo khoa học: Protein transport in organelles: The composition, function and regulation of the Tic complex in chloroplast protein import pptx
Ngày tải lên :
07/03/2014, 03:20
... constituent of the Tic motor complex (see below) The present minireview provides a short description of recent advances in the understanding of the channel-, motor- and regulatory components of the ... position and function of the long C-terminal tail on the other hand remains a matter of controversy [10,11,13–15] According to one hypothesis, the hydrophilic Tic110-Ct faces the stroma, where it functions ... plants of the pea ortholog and main Arabidopsis isoform of Tic20, AtTic20-I, similarly exhibit pronounced chloroplast defects, and attic20-I knockouts were albino even in the youngest 1168 parts of...
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Báo cáo khoa học: Structure, expression and regulation of the cannabinoid receptor gene (CB1 ) in Huntington’s disease transgenic mice ppt
Ngày tải lên :
16/03/2014, 18:20
... the primary cause of HD Examination of the regulation of individual mutant huntingtin-affected genes such as CB1 may increase our understanding of at least one abnormal function of mutant huntingtin ... expression of mutant huntingtin and the exact mechanism by which mutant huntingtin alters the function of such factors This work describing the gene structure of CB1 and its pattern of expression ... (C and D) are shown For each series of protection reactions, 10 pg of undigested probe control (P) and a no target control that consists of 400 pg of probe combined with excess yeast RNA and...
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Báo cáo khoa học: Function and regulation of ABCA1 – membrane meso-domain organization and reorganization pptx
Ngày tải lên :
22/03/2014, 15:21
... FEBS 3195 Function and regulation of ABCA1 K Nagao et al ABCA1 whereas direct binding of photoactive cholesterol to ABCA1 could not be detected [74]; however, analysis of the functions of ABCA7 ... Hayden MR (2003) Efflux and atherosclerosis: the clinical and biochemical impact of variations in the ABCA1 gene Arterioscler Thromb Vasc Biol 23, 1322–1332 Function and regulation of ABCA1 Oram JF ... Wang N & Tall AR (2010) Role of HDL, ABCA1, and ABCG1 transporters in cholesterol Function and regulation of ABCA1 100 101 102 103 104 105 106 107 108 109 efflux and immune responses Arterioscler...
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FUNCTION AND REGULATION OF CALCIUM INDEPENDENT PHOSPHOLIPASE a2 IN THE ATTENUATION OF PAIN IN MICE
Ngày tải lên :
09/09/2015, 08:15
... inflammation and cell proliferation regulation (Farooqui, 2009a) In addition, they are involved in blood flow regulation, behavioral control and regulation of immune and neural activities (Chiu and Richardson, ... structures of the oral cavity and face, usually of a diffuse pattern” (Zwemer, 1998) Orofacial pain includes pain disorders that are linked with the hard and soft tissues of the neck, head, face and ... the PAG and descending pain inhibitory pathway xiv List of Tables List of Tables Table 1.1 Differences between somatic and visceral pain 24 Table 1.2 Potencies and elimination profile of amitriptyline,...
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Characterization of the function and regulation of cullin ring e3 ubiquitin ligases
Ngày tải lên :
10/09/2015, 09:04
... other cellular functions in addition to the regulation of CRL function ! xii! List of Figures Figure Title Page Introduction 1.1 Ubiquitination 1.2 Structures and subunit organization of CRL complexes ... that in a crystal structure of the CAND1-Cul1-Rbx1 complex, CAND1 employs a highly sinuous superhelical structure to wrap and fold tightly around the Cul1-Rbx1 complex The CAND1 N-terminus is ... Binding of the CAND1 C-terminus to the Cul1 N-terminus inhibits the binding of the Skp1 adaptor and the substrate-recognition subunit F-box proteins to Cul1 On the other hand, upon binding of the CAND1...
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Molecular function and regulation of the bax associating protein MOAP 1
Ngày tải lên :
14/09/2015, 12:54
... MOLECULAR FUNCTION AND REGULATION OF THE BAX-ASSOCIATING PROTEIN MOAP-1 Fu Nai Yang INSTITUTE OF MOLECULAR AND CELL BIOLOGY NATIONAL UNIVERSITY OF SINGAPORE 2007 MOLECULAR FUNCTION AND REGULATION OF ... i TABLES OF CONTENTS SUMMARY ABBREVIATION LIST OF FIGURES LIST OF TABLES INTRODUCTION 1.1 APOPTOSIS 1.1.1 Definition and morphology of apoptosis 1.1.2 Extrinsic and intrinsic pathways of apoptosis ... 41 1.4.2 Regulation of Bax function 42 1.5 REGULATION OF MITOCHONDIA-DEPENDENT APOPTOSIS BY THE UBIQUITIN-PROTEASOME SYSTEM 47 1.5.1 The ubiquitin-proteasome system 47 1.5.2 Regulation of Bcl-2...
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Báo cáo khoa học: Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase pptx
Ngày tải lên :
28/03/2014, 23:20
... Kd of 500 nm In the presence of ANP, ECD dimerization was strongly enhanced (Kd 10 nm) [18] Crystal structures of the ECD with and without ANP We have determined the crystal structures of ... natriuretic and diuretic regulation [52] Similar tubular synthesis and urinary excretion of CNP has also been reported [61] In addition to urodilatin, ANP and other natriuretic peptides of cardiac ... determination of the native structures in the absence of crystal contacts and in solution conditions closer to those of the native environment The three-dimensional reconstructions of the apo-ECD dimer and...
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STRUCTURE AND REGULATION OF YEAST GLYCOGEN SYNTHASE
Ngày tải lên :
24/08/2014, 12:49
... the crystal and thus its contribution to the structure factor and the phase angle The structure factor of a isomorphous derivative (FPH) is related to the sum of the structure factor of the protein ... Pathway for the biosynthesis and degradation of glycogen Figure Regulation of glycogen metabolism in skeletal muscle Figure Transcriptional and enzymatic regulation of glycogen metabolism in ... INTRODUCTION A Glycogen Structure of glycogen Glycogen, a branched polymer of glucose serves as one of the major repositories of carbon and energy in eukaryotes The linear polymerization of glycogen is...
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A study on structure, function and diachronic evolution of chinese extended middle construction
Ngày tải lên :
09/09/2015, 17:57
... STUDY ON STRUCTURE, FUNCTION AND DIACHRONIC EVOLUTION OF CHINESE EXTENDED MIDDLE CONSTRUCTION 蔡淑美 CAI SHU MEI (Ph D, NUS) 新加坡国立大学中文系 博士学位论文 A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... relations and syntactic features have prompted many scholars debating its particularity and intrinsic properties This study explores the structure, function, and historical developments of this ... descriptive and illustrative context where Chinese extended middle construction emerges and put forwards that this construction is a double-topic nested structure The issue of how its form and meaning/function...
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Tài liệu Báo cáo khoa học: miRNAs and regulation of cell signaling pptx
Ngày tải lên :
14/02/2014, 19:20
... global, and yet specific, insights into the function and evolution of a broad layer of post-transcriptional control These comprehensive analyses will yield many additional examples of functionally ... Scientific Fund of the Ministry of Education, Science and Culture of Japan (G.T.); the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation ... of miR-221 and miR-222 in PC12 cells, and that this induction is dependent on sustained activation of the ERK1 ⁄ pathway [20] Furthermore, the induction of miR-34a depends on the activation of...
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Tài liệu Global Change and the Function and Distribution of Wetlands ppt
Ngày tải lên :
18/02/2014, 20:20
... (18% of the total land area) if we assume that at least 50% of the area currently classified as ice (Greenland and Antarctica) and tundra would become wetland and the current wetland area of 12.8 ... change because of the resistance of pollens and spores to decay, and their ubiquity and abundance (Traverse 2008) Wetlands are excellent sources of pollen and spores and like macrofossils, palynomorph ... study of wetland fossils and deposits to understand the potential effects of future climate change on wetlands We review the methods and assumptions associated with the use of plant macro- and...
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Tài liệu Báo cáo khoa học: Relationships between structure, function and stability for pyridoxal 5¢-phosphate-dependent starch phosphorylase from Corynebacterium callunaeas revealed by reversible cofactor dissociation studies doc
Ngày tải lên :
19/02/2014, 16:20
... the presence of mM potassium phosphate and potassium sulphate Reconstitutions with PLP of apo-Cc StP and mutants thereof, and characterization of the wild-type holo-enzyme Incubation of apo-CcStP ... pathway of thermal denaturation of CcStP [17] and contribute to an improved understanding of the effect of phosphate binding on the dimer stability of CcStP The evidence presented here and summarized ... to a better understanding of the dimerization process per se and the role of interprotomeric contacts to generate a functional enzyme The utilization of a phosphorylase devoid of the complex regulatory...
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Tài liệu Báo cáo Y học: Characterization and regulation of yeast Ca2+-dependent phosphatidylethanolamine-phospholipase D activity docx
Ngày tải lên :
22/02/2014, 07:20
... response Identification of the gene encoding PtdEtn-PLD is an obvious key to progress in understanding the structure, mechanism of action, localization, regulation and function of this intriguing ... promoter region of INO1 and other genes that are part of the INO1 regulon [45] As regulation of phospholipid biosynthesis and degradation are likely to be coordinated, it was of interest to examine ... both wild-type and spo14D cells Future identification of the PtdEtn-PLD gene and analysis of its promoter region will allow examination of its transcriptional regulation by inositol and the possible...
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Tài liệu Báo cáo Y học: Presence and regulation of the endocannabinoid system in human dendritic cells potx
Ngày tải lên :
22/02/2014, 07:20
... macrophages and lymphocytes are able to produce a higher amount of anandamide and/ or 2-AG [21,23–26] IgE-dependent stimulation of RBL-2H3 cells also leads to the formation of anandamide and of its ... Purification and quantification of endocannabinoids The extraction, purification and quantification of anandamide, 2-AG and PalEtn from immature and mature dendritic cells requires a set of different ... immune cell function, some of which (e.g modulation of cytokine release from macrophages and inhibition of lymphocyte proliferation) resemble those of THC, while some others (e.g stimulation of hematopoietic...
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Báo cáo khoa học: Sequences downstream of the transcription initiation site are important for proper initiation and regulation of mouse ribonucleotide reductase R2 gene transcription ppt
Ngày tải lên :
08/03/2014, 02:20
... numbers represent the intensity of each band normalized to the band in lane The lower numbers represent the intensity of the bands in lanes and normalized to the band in lane In order to map the position ... TATA-box-deficient promoters Genes Dev 10, 711–724 15 Thelander, M & Thelander, L (1989) Molecular cloning and expression of the functional gene encoding the M2 subunit of mouse ribonucleotide reductase: a new ... with high concentrations (50 lM) of polyamide (Fig 1C) Importance of the R2 TATA-box and TBP binding to the R2 promoter We next studied the importance of TBP and the R2 TATA-box in an in vitro...
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Báo cáo khoa học: Characterization and regulation of a bacterial sugar phosphatase of the haloalkanoate dehalogenase ppt
Ngày tải lên :
14/03/2014, 23:20
... number of phosphate containing substrates, and it has a high specificity for nucleotide monophosphates and, in particular, UMP and GMP The structure of NagD has been determined and the occurrence of ... family of NagDlike phosphatases to be characterized at the level of gene regulation Results and Discussion The araL gene in the context of the B subtilis genome and in silico analysis of AraL ... Fig Overproduction and purification of recombinant AraL-His6 (A) Analysis of the soluble (S) and insoluble (P) protein fraction (20 lg of total protein) of induced cultures of E coli Bl21(DE3)...
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Characteristics and Regulation of Exempt Institutions and the Implications of Removing the Exemptions pptx
Ngày tải lên :
15/03/2014, 09:20
... corporation Office of the Comptroller of the Currency Office of Thrift Supervision savings and loans Securities and Exchange Commission Summary of Deposits Department of the Treasury This is a work of ... availability and allocation of credit, the stability of the financial system and the economy, and the safe and sound operations of such institutions To determine the number of certain types of financial ... other hand, accounted for about percent of credit card loans, but they accounted for less than percent of construction and land development loans and almost none of any other type of loan Grandfathered...
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Viruses STRUCTURE, CLASSIFICATION AND PHYSIOLOGY OF VIRUSES
Ngày tải lên :
15/03/2014, 13:08
... things (herpes and HIV in humans, for example) Viruses are found everywhere Viruses consist of a core of nucleic acid, either DNA or RNA, and a protective coat of protein molecules and sometimes ... Viruses The Boundary of Life At the boundary of life, between the macromolecules (which are not alive) and the prokaryotic cells (which are), lie the viruses and bacteriophages (phages) ... sometimes lipids In isolation, viruses and bacteriophages show none of the expected signs of life They not respond to stimuli, they not grow, they not any of the things we normally associate with...
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Consultative Document Strengthening Oversight and Regulation of Shadow Banking docx
Ngày tải lên :
16/03/2014, 08:20
... Weighted-average • Outstanding amount of function 23 • Outstanding amount of off-balance sheet exposures by instruments (compared to capital) • Outstanding amount of off-balance sheet exposures ... underlying economic functions rather than legal forms and structures, and offer a standard set of options to address the shadow banking risks arising from each underlying economic function 3.1 Overarching ... economic function and risks of these new innovative structures The ways in which each of the economic functions gives rise to shadow banking concerns are described below in detail Examples of possible...
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Báo cáo khoa học: Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1 pot
Ngày tải lên :
17/03/2014, 09:20
... elevation of NADH/NAD+ and acetyl-CoA/CoA ratios The rise in these ratios is sensed by the rapid and reversible E3 and E2 reactions which act to increase the proportion of the lipoyl groups of E2 and ... Surface residues of the L2 domain of E2 that are required for activating PDK3 and PDP1 Panels A and B show opposing sides of space-filled models of the human L2 domain The position of Lys173 (lipoylated ... lysine) is at the top of the structures; unstructured regions that are not part of the connecting linker regions are shown at the N- and C-termini at the bottom of the structures Lys173 must...
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