structure function and its possible role in the pathogenesis of myotonic dystrophy type 1
Báo cáo y học: "Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration" ppt
... with age, sex, and spine level in 600 autopsy specimens Spine 19 88, 13 :17 3 -17 8 Roughley PJ, Alini M, Antoniou J: The role of proteoglycans in aging, degeneration and repair of the intervertebral ... (average: p16INK4a, 1, 893 copies /10 0 ng of cDNA; MMP -13 , 9,386 copies /10 0 ng of cDNA; ADAMTS 5, 21, 220 copies /10 0 ng of cDNA) Correlation of p16INK4A and matrix-degrading enzyme gene expression The ... has been used in a number of studies to indicate the presence of senescent cells [14 ,27,37], including in the IVD [12 ,13 ] Like Roberts and colleagues [12 ] and Gruber and colleagues [13 ], we have...
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Báo cáo y học: " Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists" pot
... (reviewed in [23]) involves its interaction with receptors consisting of a heterodimer of high-affinity IL-4Rα and either the common γ chain or the IL -13 receptor α chain Binding of IL-4 results in the ... thus, it serves as an anti-inflammatory agent that can counter the effects of IL-4 in asthma Respiratory Research 10 11 12 13 14 15 16 17 18 19 20 21 Vol No Steinke and Borish Pawankar R, Okuda ... high-affinity α chain (IL-4Rα) and a second chain that can be either the common γ chain or the α chain of the IL -13 receptor (IL -13 Rα) [23] The common γ chain is found in multiple cytokine receptors...
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Tài liệu Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen pdf
... Journal 277 (2 010 ) 315 8– 317 5 ª 2 010 The Authors Journal compilation ª 2 010 FEBS C Roghi et al 10 11 12 13 14 15 16 17 18 19 20 activation Evidence that MT1-MMP (MMP -14 ) and gelatinase A (MMP-2) ... confirming the important role of the LLY573 motif in the interaction between the protease and GRASP55 Interestingly, mutation of the LLY573 motif led to the detection of pro-MT1-MMP in the immunoprecipitate, ... important role in the formation of the MT1-MMP–furin complex; therefore, 316 8 disruption of the interaction between GRASP55 and furin should perturb the activation of pro-MT1-MMP and reduce MT1-MMP...
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Báo cáo y học: "Bench-to-bedside review: Functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis" ppsx
... recognition in the innate immune system These include the serum complement [11 ], C-reactive protein (CRP) [10 ], mannose binding lectin [9], LPS-binding protein (LBP), and soluble CD14 [12 ] The cell ... walls off the injured site and contains the inevitable microbial contamination that occurs following a breach in the integument of this marine animal The basic elements of clotting and inflammation ... tethered to the amino-terminus of its extracellular domain Thrombin cleaves the amino-terminus of the PAR, allowing the internal ligand to autoactivate the receptor There are four known PARs in human...
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Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx
... · 10 10 1. 0 · 10 10 28 21. 11 8.0 · 10 10 7.6 · 10 9 2953.4 nsd – – nsd – – 6 .1 · 10 8 1. 4 · 10 8 5760. 01 1.8 · 10 8 1. 1 · 10 8 13 065.2 nsd – – kcal/mole of injectant dichroweb online software [29,30] There ... D160– D164 10 Turk V & Bode W (19 91) The cystatins: protein inhibitors of cysteine proteinases FEBS Lett 285, 213 – 219 11 Turk V, Turk B & Turk D (20 01) Lysosomal cysteine proteinases: facts and ... protein binding are the product of the measured Cu-stefin interaction and 4.0 · 10 5 m )1 for pH or 2.9 · 10 3 m )1 for pH (K1 of CuGly2) As an independent method to confirm copper binding to the protein,...
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Báo cáo khoa học: Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins pptx
... disrupting the specific interactions between TbPEX14 and other peroxins, e.g TbPEX5 or other T brucei peroxins still to be identified and characterized (e.g PEX13, PEX7) 10 11 12 13 14 15 16 17 Acknowledgements ... mislocalization of all three enzymes in these cells clearly shows the involvement of PEX14 in the targeting of PTS -1, PTS-2 and I-PTS proteins to the glycosome To further analyse the effect of the destruction ... TbPEX14-N,H was located in the band This may be due to diffusion of some complexed protein as the band migrates in the native gel Band contains the excess of TbPEX14-N,H In a second experiment, the...
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Tài liệu Báo cáo Y học: The b-1,4-endogalactanase A gene from Aspergillus niger is specifically induced on arabinose and galacturonic acid and plays an important role in the degradation of pectic hairy regions pdf
... for the identification and isolation of the galA containing phage clones and Matthew Illsley for the analysis of a-L -1, 5-arabinofuranosidase activity in the endogalactanase preparation 14 15 16 17 ... control of the xylanolytic activator protein [32, 41] The increase in expression levels of galA in the CREA mutant, indicates that at least one of the detected putative CREA binding sites in the promoter ... Expression of lacA is also detected in the presence of these compounds, but in the presence of D-xylose and xylan as well This can be explained by the structure of the polysaccharides Xylan contains single...
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Báo cáo Y học: Functional expression of human liver cytosolic b-glucosidase in Pichia pastoris Insights into its role in the metabolism of dietary glucosides ppt
... 0.30 0. 01 31. 8 2.9 42.2 3.2 274 21 34 16 1. 1 1. 30 1. 30 2.85 1. 46c 1. 53 0.05 1. 17 0. 01 3.05 0.07 ND 21. 5 1. 6 10 0.06 50 3.2 ND 71 117 61 ND 0.93 0.90 2.60 0. 01 1.26 0.03 ... (lmolámin )1 mg )1) kcat (s )1) Km (lM) kcat/Km (mM )1 s )1) 0 .17 1 0. 015 ND ND ND ND ND ND 1. 73 2.75 0.038 1. 53 0.04 3.55 0 .16 0.24 0. 01 35 2.9 11 8 11 3230 13 0 44 30 0.075 1. 19 0.77 0.21b 1. 08 0.02 ... following gradients were used: incubations containing arbutin or salicin as substrate; 10 0% C initial, increasing D to 20% (10 min), 50% (15 min), 10 0% (5 min), held at 10 0% (5 min); cyanodin glycosides;...
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Báo cáo khoa học: Molecular dissection of the biosynthetic relationship between phthiocerol and phthiodiolone dimycocerosates and their critical role in the virulence and permeability of Mycobacterium tuberculosis doc
... peaks at m ⁄ z 18 64, 18 78, 18 92, 19 06, 19 20, 19 34, 19 48, 19 62, 19 76, 19 90, 2004, and 2 018 ) (Fig 4) Because the Rv2951c gene was shown to be involved in the modification of the keto group of DIM B to ... concentration of 1. 25 · 10 5 CFUÆmL )1 for each strain in a final volume of 500 lL The actual CFUs of each strain in both inocula were determined by plating serial dilutions on 7H 11 plates containing either ... mutation in the pks15 ⁄ gene, and production of PGL-tb can be restored by introducing a functional pks15 ⁄ gene into these strains [13 ] Accordingly, both the PMM74 and wild -type strains were...
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Play and it’s role in the mental development of the child
... dominating to a subordinate position 17 Thus, in play the child creates the structure meaning/object, in which the semantic aspect – the meaning of the word, the meaning of the thing – dominates ... in the form of other things But the moment the stick – i.e., the thing – becomes the pivot for severing the meaning of “horse” from a real horse, the child makes one thing influence another in ... examining a piece of candy, putting it in one’s mouth, chewing it, and then spitting it out In play the object, to win, is recognized in advance At the end of play development, rules emerge; and...
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Báo cáo khoa học: "The role of Bcl-xL and nuclear factor-kB in the effect of taxol on the viability of dendritic cells" ppsx
... survival and maturation of DCs [11 ,17 ,20] To investigate further the mechanisms of taxol-induced changes, the viablity of TPCK, an inhibitor of the serine protease that inhibit NF-κB signaling pathway ... viability These findings provide a basic rationale for the use of taxol in DC immunotherapy and insights into the development of combinational DC therapies with other anticancer drugs that not harm the ... Lett 2008, 11 5, 13 8 -14 3 10 Kim YM, Paik SG Induction of expression of inducible nitric oxide synthase by Taxol in murine macrophage cells Biochem Biophys Res Commun 2005, 326, 410 - 416 11 Kriehuber...
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Báo cáo y học: "γ The role of the complement and the FcγR system in the pathogenesis of arthritis" pdf
... QLG1-CT-20 01- 015 36 and QLG1-CT-20 01- 014 07 to HI References 10 11 12 13 14 15 16 17 13 4 Feldmann M, Brennan FM, Maini RN: Rheumatoid arthritis Cell 19 96, 85:307- 310 St Clair EW: Therapy of rheumatoid arthritis: ... collagen-induced arthritis is dependent on distinct Fcγ receptors J Exp Med 2000, 19 1 :16 11- 1 616 γ 36 Corr M, Crain B: The role of FcγR signaling in the K/B x N serum transfer model of arthritis ... activity in RA, and between C2 and C3 expression in RA synovium and inflammation [19 ,20] Furthermore, studies have shown high levels of C5a in SF [ 21] and correlation of the levels of C5a with the...
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Báo cáo y học: " Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b" doc
... the TNF-α-induced increase in Cyp7b activity We further investigated a putative role for MAPKs in the TNFα-induced increase in Cyp7b activity by using the MEK1 inhibitor PD98059 and the p38 inhibitor ... and signal transducer and activator of transcription (STAT )1 (Fig 5) The presence of putative bindings sites for NF-κB and AP -1 within the Cyp7b promoter are in accordance with the findings in ... demonstrate an involvement of the AP -1 complex in the TNF-α-induced Cyp7b expression and activity in FLS from RA patients An involvement of NF-κB and AP -1 in the TNF-αinduced Cyp7b activity is in accordance...
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Báo cáo y học: "Dipeptidyl peptidase IV activity and/or structure homologs: Contributing factors in the pathogenesis of rheumatoid arthritis" doc
... processes, it would nevertheless be useful for testing of such novel approaches to the control of local inflammation in the synovium 11 12 13 14 15 Competing interests JSD-C is inventor on United States ... in vivo activity of certain chemokines Proc Natl Acad Sci USA 2003, 10 0 :18 85 -18 90 12 1 Wollheim FA: Predictors of joint damage in rheumatoid arthritis Apmis 19 96, 10 4: 81- 93 12 2 Nestorov I: Clinical ... extravasate into the extracellular space Once in the vicinity of the synovium, the DPPIV activity would be able to initiate amino-terminal degradation of the increased levels of proinflammatory...
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Báo cáo y học: " Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus" potx
... JD and Moncada S: The effect of nitric oxide on cell respiration: a key to undertanding its role in cell survival, or death Proc Natl Acad Sci U S A 2000, 26 :14 602 -14 607 11 12 13 14 15 16 17 18 ... for increased endogenous NO synthesis, suggesting that overproduction of NO may be important in the pathogenesis of RA The in amed joint in RA is the predominant source of NO [45,46] Several investigators ... the TCR ζ chain in SLE T cells [64], which may explain the enhanced T-cell-activation-induced Ca2+ fluxing The potential role of NO in the regulation of FcR gamma expression clearly needs further...
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Báo cáo sinh học: "New investigations around CYP11A1 and its possible involvement in an androstenone QTL characterised in Large White pigs" pdf
... analysis in the CYP11A1 region Sow 65472 was genotyped for the 21 SNP (M1-M14 and SNP related to CYP11A1) and for two microsatellites (located 5’ of CYP11A1 and SW1 418 ) With the exception of M12, M13 ... differential expression of CYP11A1 in the testes of boars with various extreme androstenone levels in fat The cDNA of CYP11A1 is known in pig (NM_ 214 427) and the sequencing of BAC CH242-402H17 is underway ... report the results of the quantification of CYP11A1 expression in the testis [Cyp11A1]; contrary to animals in family A, in family B, the level of CYP11A1expression in descendants could be distinguished...
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HUMAN CARBOXYLESTERASE 2 SPLICE VARIANTS: EXPRESSION, ACTIVITY, AND ROLE IN THE METABOLISM OF IRINOTECAN AND CAPECITABINE
... coefficient of 12 .2 mM -1 cm -1 Specific activity was calculated using the results of the 4-MUA assay and the Bio-Rad protein assay Units of specific activity were in μmol mg -1 min -1 Each lysate ... localization of CES2 variants 38 VII The role of CES2, CES1, TOPO I, TP, TS, DPD, β-GUS, and UGT1A1 in the inter-individual variation in response to treatment of rectal cancer with irinotecan and ... 86 II The role of CES2, CES1, TOPO I, TP, TS, DPD, β-GUS, and UGT1A1 in the inter-individual variation in response to treatment of rectal cancer with irinotecan and capecitabine ...
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verma (ed.) - recession and its aftermath; adjustments in the united states, australia, and the emerging asia (2013)
... 2007Q1 948 1, 013 2007Q2 939 1, 302 2007Q3 842 1, 349 2007Q4 7 21 1,226 2 01 129 215 14 2 10 7 13 5 16 0 212 237 213 16 3 15 2 394 2 41 244 348 319 19 5 99 12 1 2 91 109 320 229 Average (2005–2007) 2008Q1 2008Q2 ... the length and intensity of the US recessions in 19 53 19 55, 19 57 19 59, 19 60 19 61, 19 69 19 70, and 19 73 19 75 US (Lewis 19 62; Sharp and Khan 19 80) If we link fiscal policies and TTP, then the budget ... −24 12 5 95 13 2 84 13 4 −34 12 9 242.5 485 390 1, 978 2 ,10 4 1, 550 1, 9 51 1,3 71 903 1, 602 2,003 1, 396 Average (2008Q4–2 010 Q3) 2 010 Q4 2 011 Q1 − 417 .9 −76 −2 71 205 435 1, 690.2 19 1 −72 − 1, 320 736 Households...
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CHARACTERISATION OF GLUTAMYL TRANSPEPTIDASE AND ELUCIDATING ITS ROLES IN THE PATHOGENESIS OF HELICOBACTER PYLORI
... 4 .10 .6 Role of GGT in affecting nuclear GSH levels in AGS cells 14 0 4 .10 .6 .1 Inhibition of endocytosis of GGT 14 4 4 .10 .6.2 Inhibition of nuclear import of GGT 14 5 4 .11 Role of H pylori GGT in ... clathrin-dependent pathway 4 .10 .5 Nuclear import of GGT is dependent on importin 1 1 31 135 4 .10 .5 .1 GGT forms a complex with host protein importin 1 135 4 .10 .5.2 siRNA knockdown of importin 1 137 ... with H pylori 15 0 4 .11 .3 Cellular vacuolation in various cell types infected with H pylori 15 1 4 .11 .4 Involvement of GGT, VacA and urease in cellular vacuolation 15 4 4 .11 .5 Role of ammonia produced...
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Identification and characterization of protein kinase CK2 as a novel interacting protein of neuronal CDK5 kinase and its functional role in microtubule dynamics
... CK2:Composition and Structure 1. 1 .1 Tissue-specific distribution and subcellular localization 1. 1.2 Regulation of CK2 1. 1.3 Biological effects of CK2 13 1. 1.3 .1 Regulation of adhesive proteins 13 1. 1.3.2 ... specifically inhibit cyclin D-associated kinases, and the KIP (kinase inhibitor protein) family members, p21cip1/waf1, p27kip1 and p57kip2, bind and inhibit the activity of cyclin E/Cdk2, cyclin A/Cdk2 and ... combinations with specific small inhibitory proteins, the Cdk inhibitors (CKIs) There are two families of CKIs: the INK4 (inhibitor of Cdk4) family members, p16ink4a, p15ink4b, p18ink4c and p19ink4d,...
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