structure activity profile of the osteogenic proteins of the transforming growth factor supergene family
Báo cáo y học: "Identification of new autoantibody specificities directed at proteins involved in the transforming growth factor b pathway in patients with systemic sclerosis" pot
... transforming growth factor b1; TPI1: triosephosphate isomerase 1; VIM: vimentin reference gel of the total protein extract Therefore, a number of proteins were probably lost at each step of the ... respectively Proteins of interest are indicated by the protein ID provided by ImageMaster 2D Platinum 6.0 software or their SwissProt accession numbers (see Tables 2, and for the names of these proteins) ... most of the experiments and drafted the manuscript HD contributed to the experiments and revised the manuscript MCT contributed to the study design and the interpretation of data and revised the...
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Báo cáo y học: "Constitutive upregulation of the transforming growth factor-β pathway in rheumatoid arthritis synovial fibroblasts" doc
... further activation by the respective cytokines or growth factors, for example, transforming growth factor (TGF)β To enhance the significance of the array analysis, the mRNA data of the most important ... on the existence of two distinct gene expression profiles in SFBs, one of which is characterized by the expression of TGF-β/activin A-inducible genes [7] Although hierarchical clustering of the ... the RA SM [27] In addition, there is strong evidence that the isoforms have different functions, as demonstrated by the non-overlapping phenotypes of the isoform-specific null mice [27] Together,...
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Báo cáo y học: "Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees" potx
... dose of the luciferase virus (B) The naïve rabbit left knee with a low dose of the Ad.TGF-β1 virus and the right knee with a low dose of the luciferase virus These images were taken when the rabbits ... clinical applications of transforming growth factor- beta (TGF-beta) Growth Factors 1993, 8:1-9 Assoian RK, Komoriya A, Meyers CA, Miller DM, Sporn MB: Transforming growth factor- beta in human ... growth factor beta (rhTGF-β1) enhances healing and strength of granulation skin wounds Growth Factors 1990, 3:267-275 Prud’homme GJ, Piccirillo CA: The inhibitory effects of transforming growth factor- beta-1...
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Tài liệu Báo cáo khoa học: Second messenger function and the structure–activity relationship of cyclic adenosine diphosphoribose (cADPR) doc
... properties of derivatives modified in the northern ribose of cADPR in permeabilized T-cells, it was observed that replacement of the hydroxyl group at C2¢¢ [for clarity atoms of the ‘northern ribose’ ... between the base adenine (or hypoxanthine) and the diphospho-bridge, as they can be replaced by much simpler ether strands These ether strands mimic the distance between the nucleobase and the diphospho-bridge, ... starting point for their identification in the near future The use of novel inosine-based cyclic nucleotides significantly added to our understanding of the structure activity relationship of cADPR Finally,...
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Tài liệu Báo cáo khoa học: Structure-activity relationships of a-conotoxins targeting neuronal nicotinic acetylcholine receptors ppt
... values of 0.27 and 0.36 A The second study extended the investigation to examine the role of different disulfide bond isomers in determining structures The structures of PnIA, PnIB and the desulfated ... the residue type and in the case of loop in both the type and number of residues The N- and C-termini are labeled (B) On the left is the three-dimensional structure of the 4/6 framework a-conotoxin, ... residues Analysis of the surface features of a-conotoxins reveals the fact that the cysteine residues are significantly more buried than the other residues, although the small size of the molecules prevents...
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Báo cáo khoa học: Structural diversity of angiotensin-converting enzyme Insights from structure–activity comparisons of two Drosophila enzymes docx
... procedures The enzyme activity is expressed as percentage of the maximum activity recorded at pH in the absence of NaCl Values are the mean of three assays and the percentage standard error of the mean ... at the S2¢ pocket The replacement of Val372 of ACER with the polar Thr364 in ANCE probably contributes towards the lack of inhibitory activity of RXPA380 This supports the hypothesis that the ... inhibitors of human ACE A model of the structure of ACER has been generated, which provides explanations for some of these biochemical differences Results Hydrolysis of AI The effect of NaCl on the...
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Báo cáo khoa học: Structure–activity relationships of fowlicidin-1, a cathelicidin antimicrobial peptide in chicken docx
... Solution structure of fowlicidin-1 (A) Ribbon stereo-diagram of the restrained minimized average structure of fowlicidin-1 (B) Stereo-diagrams of the backbone trace of the 20 lowest energy structures ... that the two lytic sites (residues 5–7 and 16–23) act in a synergistic manner in the lysis of eukaryotic cells (i.e the presence of one determinant facilitates the action of the other) The single ... in between (Fig 3B,C) The superimposition of the two short helical segments of the 20 final structures against an averaged structure resulted in a rmsd ˚ value of backbone of < 0.5 A (Table 1)...
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báo cáo khoa học: "Promising cytotoxic activity profile of fermented wheat germ extract (Avemar®) in human cancer cell lines" pot
... data points of the single drug curve Synergy could be assumed if the hypothetical curve runs above the combination curve and antagonism is indicated if the hypothetical curve runs below the combination ... the Hill equation Drug interaction was assessed using the model of Drewinko [16] In brief, a hypothetical curve was calculated by multiplying the ratio of treated and untreated control with the ... 1) Detection of the mode of cell death induced by FWGE in a panel of cell lines In order to distinguish the mode of cell death induced by FWGE we treated a representative panel of human cancer...
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Báo cáo khoa học: Calmodulin-mediated regulation of the epidermal growth factor receptor doc
... [72] The binding of these proteins could prevent the interaction of the Ca2+ ⁄ CaM complex to the receptor if the CaMBD were occluded at least in part Nevertheless, the docking of these adaptor proteins ... control of ligand binding [86] This is a result of the interaction of the distal segment of the JM, particularly the E663–S671 residues, with the C-terminal lobe of the kinase domain of the apposed ... kinase PYK2 to the EGFR [115] Carbachol also induces the association of Src to the EGFR [115] The implication of CaM in the transactivation of the EGFR by other members of the GPCR family has also...
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Báo cáo Y học: Characteristics of binding of insulin-like growth factor (IGF)-I and IGF-II analogues to the type 1 IGF receptor determined by BIAcore analysis pptx
... bind to the IGF1R Previously we have expressed a recombinant form of the human IGF1R by fusing the cDNA encoding the receptor ectodomain (residues 1±944) to the cDNA of the mouse Fc domain of immunoglobulin ... Miller, R.E & Cascieri, M.A (1990) The roles of tyrosines 24, 31, and 60 in the high anity binding of insulin-like growth factor- I to the type insulin-like growth factor receptor J Biol Chem 265, ... receptor af®nity but rather with the dissociation rate or occupancy time of receptor [31,32] In the present study, the analysis of association and dissociation rates of the IGF analogues did not...
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Báo cáo khoa học: Phosphorylation of Hrs downstream of the epidermal growth factor receptor docx
... before the cells were washed and Hrs was immunoprecipitated from the lysate We chose to stimulate the cells with the growth factors for min, as the growth factor- stimulated phosphorylation of Hrs ... 3–4), the phosphorylation was much weaker than that detected at 37 °C, supporting the idea that endocytosis of the receptor/ligand complex is important for the phosphorylation of Hrs Nevertheless, ... While EGF remains bound to the receptor at the acidic endosomal pH, thus activating the receptor kinase, transforming growth factor a (TGFa) rapidly dissociates and leaves the EGF receptor inactive...
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Báo cáo y học: Identification of an element within the promoter of human selenoprotein P responsive to transforming growth factor-b ppt
... As the CAGA box at position 21811 is located at the very margin of the known SeP promoter sequence, the 50 flanking bases not represent the context of the genomic promoter but the sequence of the ... between the assessment of the SeP mRNA expression and the measurement of luciferase activity exist For example, whereas in the first case the species assessed is the mRNA (i.e the respective cDNA) of ... of mg per well The figures in the bottom row are means of two independent replicates and represent densitometric values normalized to the intensity of the coamplified GAPDH fragment either of the...
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Báo cáo hóa học: " The emerging role of insulin-like growth factor 1 receptor (IGF1r) in gastrointestinal stromal tumors (GISTs)" pdf
... tyrosine kinase In theory, if they work both should block receptor activation, and thereby block the intracellular pathways Of course, direct inhibition of the molecules of these pathways, such ... IGF1Rinhibitors and the effect of the combination with standard front line therapies [52] These analyses are particularly necessary to confirm the putative oncogenic role of IGF1R in WT GISTs Indeed the possibility ... insulin-like growth factors such as the pro-IGF-IIE and insulin-like growth factor- binding proteins have been described in GISTs, and they may become more important in patient management because of a...
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Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx
... angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ... well and then added 20 µl of acetic acid The absorbance of the reaction mixture was immediately read at 340 nm against a blank consisting of 200 µl of phosphate-buffered saline, 10 µl of 1.16 ... suggests that these drugs improve endothelium injury A decrease of sVCAM-1 by nifedipine was previously reported in SSc [24] The improvement of all these markers and the correlation between the values...
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Báo cáo y học: "Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes" ppt
... and the addition of IGFBP-3 blocked the effects of IGF-1 [31] According to the growing evidence that IGFBPs (and especially IGFBP-3) are involved in the decline of the synthesizing responses of ... cultured factor (IGF)-1 to IGF-binding proteins (IGFBPs), in insulin-like of NBI-31772, a small-molecule inhibitor of the binding of priActivitygrowth rabbit chondrocytes lin-like growth factor ... Further addition of NBI-31772 antagonized the neutralizing effect of IGFBP-3 on the anabolic effect of IGF-1 NBI31772 (1 µM) increased proteoglycan synthesis over that measured in the presence of...
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Báo cáo y học: "Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers" doc
... angiostatic factors The aim of the present study was to analyze whether a decrease of the angiogenic factors VEGF and bFGF and an increase of the angiostatic factor endostatin contribute to the impaired ... increases the synthesis of VEGF in a variety of cell types via an accumulation of the transcription factor hypoxia inducible factor [31] In addition, a variety of cytokines (e.g interleukin-1, transforming ... According to the hypothesis that the angiogenic effects of VEGF are inhibited by a concomitant increase of angiostatic factors, another strategy for the treatment of ischemic symptoms in SSc is the inhibition...
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báo cáo khoa học: "Sustained complete remission of human epidermal growth factor receptor 2-positive metastatic breast cancer in the liver during long-term trastuzumab (Herceptin) maintenance therapy in a woman: a case report" docx
... epidermal growth factor receptor 2; MBC: metastatic breast cancer Authors’ contributions JS collected and analyzed the data of the study and wrote the manuscript AD collected the data of the patient, ... time of approximately two years [4] The prognosis is poorer in patients with HER2-positive MBC [5] Trastuzumabbased therapies have greatly improved the survival rates of these patients, with the ... maintenance therapy [9,10] The duration of remission in these cases ranges from four months to eight years, and in all cases, maintenance therapy was based on trastuzumab One of these cases also...
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Báo cáo y học: "Gender-based reciprocal expression of transforming growth factor-β1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis" ppsx
... beginning of day and then stabilize for the remainder of the day Values at baseline in female rats (empty black dot) did not change over the course of the day The levels of NO products in urine of CYP ... elevation of NO reaction products in the urine of CYP-treated rats when compared to the levels observed in control rats collected at the same time point of the day The levels of NO2-/NO3- in the urine ... secretion of active TGF-β1 in the urine The levels of active TGF-β1 in the urine were generally correlated with the levels of latent/total TGF-β1 in the urine of both males and females (with the possible...
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báo cáo khoa học: " The impact of hyperbaric oxygen therapy on serological values of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF)" pptx
... study focuses on the relevant mediators of angiogenesis which are vascular endothelial growth factor (VEGF) and basic growth factor (bFGF) In angiogenesis, a number of growth factors (for example ... on the growth factor profile of fibroblasts Arch Facial Plast Surg 2004, 6:31-5 22 Ladoux A, Frelin C: Hypoxia is a strong inducer of vascular endothelial growth factor mRNA expression in the heart ... tumour growth; mainly in hypoxic tumour regions raised VEGF levels could be scored [16,17] The idea of the present study was to characterize and to quantify the effect of HBO on the expression of the...
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Study of the effect of transforming growth factor 1 on the gap junction protein connexin 43 in hepatic stellate cells
... platelet-derived growth factor (PDGF), basic fibroblast growth factor (bFGF) and endothelial growth factor (EGF) (Friedman, 2008c) 1.3 Transforming Growth Factor- β1 (TGF-β1) The TGF-β1 peptide belongs to the ... approximately 15% of the total cell population in the liver, HSCs are located in the space of Disse between the hepatocytes and the endothelial cells in the liver (Fig 1.1) As the name implies, ... TGF-β superfamily of cytokines, which consists of three isoforms of TGF-β (TGF-β1, β2, β3), bone morphogenetic proteins, activins and growth differentiation factors TGF-β isoforms and their receptors...
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