structural dynamics of picornaviral rdrp complexes implications for the design of antivirals

Báo cáo khoa học: NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist Structural implications for the MHC II (I-Au)–peptide complex from docking calculations ppt

Ngày tải lên : 07/03/2014, 16:20

... studies of the epitope of MBP therefore we may conclude that the conformation of epitopes of the integral protein must be affected by posttranslational modiﬁcations Docking calculations of the MBP(74–85) ... was the case in water, the key characteristic of the structure of the native epitope in Me2SO is the presence of a large number of electrostatic interactions, especially in the central region of ... between the side chains of Arg78 and Glu82/Asp81 independently of the nature of the solvent (protic or nonprotic) This might come from the peptide conformation, which drives the orientation of these...

15
447
0

Tài liệu Faultlines of Conflict in Central Asia and the South Caucasus - Implications for the U.S. Army docx

Ngày tải lên : 17/02/2014, 11:20

... understand the “rules of the game” the way the United States does That is one interpretation of both the crude Chinese nuclear threats over the Taiwan crisis and Chinese views of the U.S bombing of the ... Russia and the United States and the rest of NATO suggest the danger of further friction in the future 26 Future Roles of U.S Nuclear Forces: Implications for U.S Strategy So far, there has been ... trademark The views expressed in this report are those of the authors and not reflect the official policy or position of the Department of Defense or the United States Air Force Cover design by...

152
649
1

Tài liệu China’s Holdings of U.S. Securities: Implications for the U.S. Economy pptx

Ngày tải lên : 20/02/2014, 20:20

... (4.9%) 19 The report is prepared jointly by the Department of the Treasury, the Federal Reserve Bank of New York, and the Board of Governors of the Federal Reserve System 20 Department of the Treasury, ... depreciate If the value of the dollar depreciated, the trade deficit would decline, as the price of U.S exports fell abroad and the price of imports rose in the United States.52 The magnitude of these ... have been the main components of China’s rapid accumulation of FX reserves.9 For a discussion of the implications of a possible global sell-off of U.S securities, see CRS Report RL34319, Foreign...

22
586
0

Unfolding the Future of the Long War - Motivations, Prospects, and Implications for the U.S. Army docx

Ngày tải lên : 06/03/2014, 20:20

... our understanding of the components of the long war, provided the basis for a set of seven strategy options for the United States in the long war xvi Unfolding the Future of the Long War Divide ... on by agencies other than the Army, but it has often been fulﬁlled by the Army Broad Observations From the consideration of the implications of the proposed trajectories for the United States, ... Agency for International Development, the State Department, the Peace Corps, the Department of Agriculture, and the Department of Justice would become the focus of the new U.S strategy Implications...

230
490
0

Báo cáo khoa học: Enzymatic investigation of the Staphylococcus aureus type I signal peptidase SpsB – implications for the search for novel antibiotics ppt

Ngày tải lên : 07/03/2014, 01:20

... preliminary analysis of secreted proteins indicated in the genomic sequence data of S aureus The criteria for selection of the substrate were a good prediction of the presence and location of the signal ... in the Fig SPase recognition sequence and cleavage sites of the SpsB substrates used in the present study: Showing part of the sequence of the IsaA precursor (upper row) and the sequence of the ... amount of preprotein processed at varying pH did not yield sufcient quantitative data, and therefore the FRET assay was used to study the effect of pH on the enzyme The stability of the synthetic...

13
464
0

Báo cáo khoa học: Discovery and characterization of a Coenzyme A disulﬁde reductase from Pyrococcus horikoshii Implications for the disulﬁde metabolism of anaerobic hyperthermophiles doc

Ngày tải lên : 07/03/2014, 17:20

... results in reduction of the enzyme-bound FAD, forming the EH4 or EH4ÆNAD(P)+ species In the case of a true oxidase, it makes sense for the enzyme to stabilize the EH4 form, since the reduced flavin ... During the anaerobic reduction of the S aureus enzyme there is loss of roughly 50% of the absorbance at 452 nm In that case, the loss of absorbance is attributed to an asymmetric reduction of the ... difficult to determine directly from the spectrum the fate of the reduced pyridine nucleotide During the addition of the first equivalent of NADPH, there is a blue shift in the 380 nm peak and subsequent...

12
420
0

Báo cáo khoa học: Structure of a trypanosomatid mitochondrial cytochrome c with heme attached via only one thioether bond and implications for the substrate recognition requirements of heme lyase potx

Ngày tải lên : 23/03/2014, 04:21

... vinyl), as is observed for the C-terminal cysteine of the typical CXXCH c-type cytochrome heme-binding motif [1,13] The heme iron is coordinated by the Ne of the histidine of the ‘AXXCH’ (actually ... blue) Also shown are the heme ligands (histidine and methionine in each case), the cysteines that form thioether bonds to the heme, and the methyl group of the alanine of the C fasciculata AXXCH ... phases from the ﬁnal model of the halfreduced form, is contoured at the 1.5r level, where r represents the ˚ rms electron density for the unit cell Contours more than 1.5 A from any of the displayed...

11
513
0

Báo cáo khoa học: The structural comparison of the bacterial PepX and human DPP-IV reveals sites for the design of inhibitors of PepX activity pot

Ngày tải lên : 23/03/2014, 13:20

... known for the bacterial PepX One of the immediate consequences of the structural similarities between the two active sites is to search for putative inhibitors of PepX, using the knowledge of DPP-IV ... lactis The results are presented in Table and Fig 4A For the cluster of lowest energy, both the position and the conformation of the ligand are close to those observed in the 3D structure of the ... into the active site of the human DPP-IV; 3, docked into the active site of the crystalline structure of PepX from L lactis; and 4, docked into the active site of the modeled structure of PepX...

10
561
0

Báo cáo khoa học: The crystal structure of pyruvate decarboxylase from Kluyveromyces lactis Implications for the substrate activation mechanism of this enzyme ppt

Ngày tải lên : 30/03/2014, 10:20

... relative to the other For comparison, the corresponding angle found for (nonactivated) KlPDC is 36° The main difference between KlPDC and the activated form of ScPDC is the flexibility of the loop ... of the two dimers within the tetramer: the D2 symmetry of the nonactivated ScPDC is broken, and an open and a closed side of the tetrameric molecule is formed Two different binding sites of the ... The cofactors are depicted in space-filling mode The positions of the N-terminal and C-terminal amino acid residues of the model, the position of the flexible loop region, which is omitted in the...

11
374
0

Báo cáo hóa học: " ICP0 antagonizes Stat 1-dependent repression of herpes simplex virus: implications for the regulation of viral latency" potx

Ngày tải lên : 20/06/2014, 01:20

... 105 pfu per eye of HSV-1 strain KOS-GFP or GFP relationship of the genotype and phenotype of these mice is defined in Table c The mean ± standard error of the mean of the logarithm of infectious ... compromised the integrity of the tissue Thus, consistent with other results, the Stat signaling pathway was essential to restrict the spread of wild-type HSV-1 from the site of inoculation to the TG ... [41-43] Given the dearth of evidence that the LAT or L/ST genes actually antagonize the synthesis of ICP0 and ICP34.5, further work will be required to address these hypotheses Clinical implications...

23
413
0

báo cáo hóa học:" Association of measured physical performance and demographic and health characteristics with self-reported physical function: implications for the interpretation of self-reported limitations" pdf

Ngày tải lên : 20/06/2014, 16:20

... the study, designed the study, performed the statistical analysis, interpreted the results, and drafted the manuscript All authors read and approved the final manuscript Competing interests The ... physical functioning, before they had the physical examination and performance testing Analytic framework To maximize the specificity of the association between physical performance tests and self-reported ... meters and then dividing by the time in seconds needed to complete the test We categorized performance on both tests into quartiles, with the bestperforming quartile as the reference group The lock...

13
374
0

Báo cáo khoa học: "Variation in the phenology of shoot elongation between geographic provenances of maritime pine (Pinus pinaster) - implications for the synchrony with the phenology of the twisting rust fungus" potx

Ngày tải lên : 08/08/2014, 19:21

... for the different tested variables in each of the [site x year] combinations of the study, for each stage and each provenance The coefficients of variation (CV), ie the ratio of the mean to the ... multivariate approach (Moser et al, 1990) The non-violation of the assumptions of the analysis of variance, particularly the adequacy of the model and the homogeneity of residual variances, were checked ... standard deviation of these values, were then calculated The approach using the standard error of prediction is based on the comparison between observed and predicted dates of the onset of phenological...

16
417
0

Báo cáo y học: "Duration of bed occupancy as calculated at a random chosen day in an acute care ward. Implications for the use of scarce resources in psychiatric care" pps

Ngày tải lên : 08/08/2014, 21:20

... illness, whereas of 12 not waiting had a psychotic illness Duration of stay was composed of the days preceding the chosen day and the number of days of further treatment in the acute ward Twenty-three ... difference between cost of residency in the acute ward and the chosen secondary facility This cost was withdrawn from the cost of the acute ward stay for each patient The costs used in the calculations ... in training at the time of the study, was aware of the registration of time from the senior psychiatrists decision to the actual day of referral to the next step in the treatment chain, called...

6
505
0

Báo cáo y học: "Most nuclear systemic autoantigens are extremely disordered proteins: implications for the etiology of systemic autoimmunity" pps

Ngày tải lên : 09/08/2014, 07:20

... spreading to other epitopes in the Sm particle This view of the battle between the virus and the immune system is further amplified by the results of the analysis of MHC II T cell epitopes using the ProPred ... sequences in the B/B' polypeptide followed by spreading to the rest of the Sm particle To further explore the relevance of disorder to the idea of spreading we carried out a PONDR® analysis of the EBNA1 ... in the frequency of prospective epitopes in Fig 4c While the effect here is far less dramatic than in the case of the three other autoantigens pictured, the degree of disorder seen in Fig for...

15
413
0

Báo cáo y học: "Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration" ppt

Ngày tải lên : 09/08/2014, 14:20

... studied These studies investigated the protein expression of these receptors rather than gene expression and separated the groups according to age rather than Page of 10 (page number not for citation ... that the lack of TNF-R1 does not affect the incidence or severity of collagen-induced arthritis in the joints [27] Repeated injections of TNF-α into the joints of TNF-R1 knockout mice enhanced the ... the changes identified in the degeneration of the IVD, which include an upregulation in type I collagen protein in the NP region [20] The results of this study show that TNF-α downregulates the...

10
678
0

Báo cáo y học: "Closure of the NCBI SRA and implications for the long-term future of genomics data storage" doc

Ngày tải lên : 09/08/2014, 22:23

... being deleted RK: If there is a good chance that the data are going to be used by others, then yes, there is a good case for storing them Just storing the raw data for the sake of it, however, is ... where the US is paying to generate all these data - probably the majority of genomics data is coming from the US at Page of present - but where it’s not prepared to meet the cost of archiving the ... archiving project, one needs to con sider the cost of storage relative to the potential future reuse In the course of the 1000 Genomes project, for example, the raw sequencing reads have been realigned...

3
331
0

Báo cáo y học: "A quantitative evaluation of gross versus histologic neuroma formation in a rabbit forelimb amputation model: potential implications for the operative treatment and study of neuromas" ppt

Ngày tải lên : 10/08/2014, 10:20

... increase the number of neuromas created per animal (and thereby decrease the total number of animals sacrificed), and the amputation was performed in the proximal forelimb in order to mimic the clinical ... University for their assistance with animal care from the inception of the amputation model and throughout the course of this study The authors would also like to thank Linda Juarez at the University of ... specific for the needs of this model; XD performed critical macroscopic and microscopic analysis of the histologic specimens; and TK and GD participated in the design and coordination of the model...

10
433
0

báo cáo khoa học: " Pollen development in Annona cherimola Mill. (Annonaceae). Implications for the evolution of aggregated pollen" pdf

Ngày tải lên : 12/08/2014, 03:21

... concomitantly with the layering of the exine [54] and the formation of the pollen aperture is related to endoplasmic reticulum blocking the deposition of primexine [3] The callose remnant at the pollen ... cherimola, the confined space that permits the delay in the dissolution of the PMC wall and the tapetal chamber and pollen rotation that allows the adhesion of the sticky proximal faces by the formation ... afternoon of the following day when the flower enters the male stage Anther dehiscence occurs concomitantly in all stamens of a flower and, as the anthers dehisce, they detach from the flower...

10
338
0

Báo cáo y học: "Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies" ppsx

Ngày tải lên : 12/08/2014, 23:22

... reactivated in 60% of the patients tested (25 out of 42 patients) [302] These results constitute a proof -of- concept for the co-administration of (at least) two different categories of therapeutically ... Nucleotide (nt1) is the start of U3 in the 5'LTR The transcription start site corresponds to the junction of U3 and R (C) Schematic representation of the nucleosomal organization of the HIV-1 genome ... complexes couple the hydrolysis of ATP to structural changes of the nucleosome and are divided into three main classes based on their ATPase subunit: the SWI/SNF family, the ISWI family and the...

29
322
0

Báo cáo y học: "Capacity utilization and the cost of primary care visits: Implications for the costs of scaling up health interventions" pdf

Ngày tải lên : 13/08/2014, 11:22

... Benjamin Nganda for their efforts in gathering cost data at the country level; and Tessa Tan Torres for her input in the development of the methods used The work represents the views of the authors ... validity of the results for extrapolation to a wider number of countries We also recognize that the mathematical specification of the model we report here, the log-log form, does not allow the identification ... atypical of the country as a whole Moreover, they will also be wrong if they not allow the cost of an outpatient visit to change as coverage increases Because most of the studies of the costs of scaling...

9
495
0