step 1 in the pivottable wizard
Báo cáo khoa học: Death inducer obliterator protein 1 in the context of DNA regulation Sequence analyses of distant homologues point to a novel functional role docx
... (Fig 1) To root the tree, we used inhibitor of growth protein (ING3) PHD, which is another domain involved in chromatin binding and clearly more divergent (e-value 0. 019 ) from DIDO and the other ... maintain transcription The PHF3 protein was recovered in initial analyses and also contains a TFS2M domain showing the same architecture as the DIDO1 long isoform, although lacking the dPHD The ... Dawid IB (19 90) The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains Proc Natl Acad Sci USA 87, 211 2– 211 6 14 Tripoulas...
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Báo cáo khoa học: Calpain 1–titin interactions concentrate calpain 1 in the Z-band edges and in the N2-line region within the skeletal myofibril doc
... of the I-band region of titin (skeletal isoform), including the N-terminal extremity Titin fragments (T150, T800, Z1–Z2, Z9–I1) as the antibody epitopes (KK16, ET19, T12, 9D10) are indicated in ... obtained in the presence of EGTA (Fig 6B, inset) Labeling of the Z-band periphery by the CP1 Ig (Fig 4) is consistent with the binding of calpain in a region restrained by the Z-band and the N1-line ... residues (T150), containing at least the Z8–I5 domains and which includes the N1-line related region; and secondly a recombinant fragment (Z9–I1) located between the Z-line and the N1-line (Fig 1) Calpain...
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Báo cáo khoa học: A steady-state competition model describes the modulating effects of thrombomodulin on thrombin inhibition by plasminogen activator inhibitor-1 in the absence and presence of vitronectin ppt
... demonstrated in this study, binding of TM does sterically hinder PAI -1 binding to thrombin (–VR1tPA) Therefore, the binding of PAI -1 to thrombin either involves a small part of the VR1 loop that ... thrombin and PAI -1 These findings leave a role for TM open in altering the initial binding step between thrombin and PAI -1 or in changing the ability of thrombin to catalyze subsequent steps that ... reduced The minor effect of TM on the rate of thrombin-VR1tPA inhibition by PAI -1 suggests that the binding between thrombin and TM, involving the VR1 loop of thrombin, is affected in the substitution...
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Báo cáo khoa học: Dual expression of mouse and rat VRL-1 in the dorsal root ganglion derived cell line F-11 and biochemical analysis of VRL-1 after heterologous expression pptx
... expressed in individual F -11 cells fits well with this result In F -11 parental cell line N18TG2 we detected the expression of mouse VRL -1 due to its murine origin Therefore we propose that in the F -11 ... corresponded to rat VRL -1 (Acc No AF12 911 3) the mouse VRL -1 mRNA (Acc No NM_ 011 706) Graphical alignment of the open reading frames of rat VRL -1 (Acc No AF12 911 3) and mouse VRL -1 (Acc No NM_ 011 706) shows ... VRL -1 are both expressed in F -11 cells To prove that the full length VRL -1 mRNA is present in F -11 cells we examined the rat VRL -1 corresponding to Acc No AF12 911 3 in overlapping PCR fragments after...
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Báo cáo khoa học: "Increased phosphorylation of caveolin-1 in the spinal cord of irradiated rats" pdf
... synthesis at h and 24 h in vitro [7] IL -1 induces the phosphorylation of caveolin -1 in HIT-T15 cells [12 ] Therefore, it is highly probable that IL -1 induces the phosphorylation of caveolin -1 in ... demonstrating an increase in the level of caveolin -1 phosphorylation in irradiated rats located primarily in the microglial and vascular endothelial cells of the spinal cord The findings suggest that the ... antigen-presenting cells by means of caveolin -1 Proc Natl Acad Sci USA 2004, 10 1, 14 186 -14 1 91 11 Okamoto T, Schlegel A, Scherer PE, Lisanti MP Caveolins, a family of scaffolding proteins for organizing...
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Báo cáo y học: "The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration" pdf
... and reversing disc degeneration 10 11 12 Competing interests The author(s) declare that they have no competing interests 13 Authors' contributions CLM participated in the design of the study, ... age in proteoglycan synthesis in cells cultured in vitro from the inner and outer rabbit annulus fibrosus Responses to interleukin -1 and interleukin1 receptor antagonist protein Spine 2000, 25 :16 6 -16 9 ... T: Inflammatory cytokines in the herniated disc of the lumbar spine Spine 19 96, 21: 218 -224 Solovieva S, Kouhia S, Leino-Arjas P, Ala-Kokko L, Luoma K, Raininko R, Saarela J, Riihimaki H: Interleukin...
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Báo cáo y học: "Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis" ppt
... aspects of HIF -1 signaling should be also studied to further clarify the role of HIF -1 in the pathogenesis of OA References 10 11 12 13 Conclusion Taken together, our findings show for the first time ... stress-induced expression of HIF -1 in chondrocytes are consistent with these findings These findings suggest that HIF -1 may, at least in part, have some role in the pathogenesis of inflammatory ... HIF -1 mRNA in chondrocytes was observed in degenerating regions than in intact regions from the same articular cartilage samples Our findings in human articular cartilage tissues indicate for the...
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Báo cáo y học: " Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b" doc
... (STAT )1 (Fig 5) The presence of putative bindings sites for NF-κB and AP -1 within the Cyp7b promoter are in accordance with the findings in this report that NF-κB and AP -1 are involved in the TNF-α-enhanced ... activity We further investigated a putative role for MAPKs in the TNFα-induced increase in Cyp7b activity by using the MEK1 inhibitor PD98059 and the p38 inhibitor SB203580 The p38 inhibitor (SB203580) ... Figure α-induced Cyp7b activity by SN50 In order to investigate a role for AP -1, we used the JNK inhibitor SP60 012 5 [17 ] The results demonstrate an involvement of the AP -1 complex in the TNF-α-induced...
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Báo cáo y học: " Overexpression of sICAM-1 in the Alveolar Epithelial " pps
... approved the final manuscript Page 12 of 12 10 11 12 13 14 15 16 17 18 19 Competing interests The authors declare that they have no competing interests 20 Received: 20 April 2 010 Accepted: 19 January ... killing It is possible that, in mice overexpressing sICAM -1 in the lung, competitive binding of sICAM -1 to the normal counter receptors of mICAM -1 on AM, CD11a/CD18 (LFA -1) and CD11b/CD18 (Mac -1) , ... organisms in SPC-sICAM -1 Mendez et al Respiratory Research 2 011 , 12 :12 http://respiratory-research.com/content /12 /1/ 12 a Page of 12 b Lung Burden 30min 10 10 10 CFU/ml (Log) CFU/ml (Log) 10 10 10 10 10 ...
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Báo cáo y học: "The role of high-mobility group box-1 (HMGB-1) in the management of suspected acute appendicitis: useful diagnostic biomarker or just another blind alley?" docx
... Medicine 2 011 , 19 :28 http://www.sjtrem.com/content /19 /1/ 28 10 11 12 13 14 15 16 17 18 19 Page of Gaini S, Pedersen SS, Koldkjaer OG, Pedersen C, Moller HJ: High mobility group box -1 protein in ... acute appendicitis Acad Emerg Med 2 010 , 17 (3):333-336 doi :10 .11 86 /17 57-72 41- 19-28 Cite this article as: Søreide: The role of high-mobility group box -1 (HMGB -1) in the management of suspected acute ... symptoms Whether this may truly prove a useful diagnostic biomarker among the increasing number of alternatives investigated [17 -19 ], or merely be yet another blind alley in the surge for the correct...
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Role of poly (ADP ribose) polymerase 1 and copper homeostasis factor, antioxidant protein 1 in the maintenance of genomic integrity
... .14 1. 1.2.3 Radiation 18 1. 1.3 Mechanisms for preventing genomic instability 20 1. 1.3 .1 Poly (ADP-ribose) polymerase (PARP -1) 21 1 .1. 3 .1. 1 Role of PARP -1 at the telomeres 24 1. 1.4 ... .xvii Chapter 1: Introduction 1. 1 Review of Literature 1. 1 .1 1 .1. 2 Inducers of genomic instability 10 1. 1.2 .1 Oxidative stress 10 1. 1.2.2 Arsenic-induced oxidative ... 1. 1.4 Copper metabolism and disease 27 1. 1.4 .1 PARP -1 and Copper metabolism .29 1. 1.5 1. 2 1. 3 1. 4 Genomic Instability 1. 1 .1. 1 Telomere mediated genomic instability .2 1. 1 .1. 1.1...
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Regulation of DNA (cytosine 5) methyltransferase 1 in the cell cycle and its role(s) in doxorubicin mediated micronuclei formation
... Methyltransferases 1. 2 .1 DNMT1 DNMT1 variants 1. 2.2 10 1. 2.3 DNMT3a and DNMT3b 11 1. 2.4 1. 3 DNMT2 Cooperation among the DNMTs 12 Roles of DNA Methylation 1. 3 .1 Genomic imprinting 13 1. 3.2 X-chromosome inactivation ... PCNA 27 1. 4.6 1. 5 Regulation of DNMT1 expression DNMT1 and p21WAF1 29 Regulation of p21WAF1 Expression 1. 5 .1 p53-dependent trancriptional regulation of p21WAF1 WAF1 31 1.5.2 31 1.5.3 1. 6 p53-independent ... assay 61 Chapter 3: 3 .1 RESULTS AND DISCUSSION Regulation of DNMT1 expression in the Cell Cycle 3 .1. 1 Inverse relationship between DNMT1 and p21WAF1 in the 63 cell cycle 3 .1. 1 .1 3 .1. 1.2 DNMT1 expression...
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A study of the recombination activating gene 1 in the zebrafish nervous system
... clone 12 158 12 6 Figure 4 -10 Clone 12 158B matches to BAC clone CH 211 -206E6 12 9 Figure 4 -11 The 5’ part and 3’ part of 12 158B are unequally transcribed 13 1 Figure 4 -12 12 158A matches to the flanking ... regions of the CR1 -1 element in BAC CH 211 -206E6 13 2 Figure 4 -13 Blast result of the CR1 -1 and flanking regions 13 4 Figure 4 -14 12 158A and 12 158B are single-copy alleles and locate in the same locus ... apoptosis 13 9 5 .1. 3 Neuronal diversity 14 1 5 .1. 3 .1 OR genes 14 1 5 .1. 3.2 Protocadherins 14 3 5 .1. 4 Our data suggest a modification for the old hypothesis 14 3 5 .1. 4 .1 The restricted expression in zebrafish...
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THE ROLE OF ANNEXIN 1 IN THE REGULATION OF INFLAMMATORY STRESS RESPONSE IN MACROPHAGES
... involving HSP70 21 1.3 Toll like receptor signaling 22 1. 4 NFkB 25 1. 5 MAPK 26 1. 6 Introduction to Annexin -1 (ANXA1) 27 1. 6 .1 Functions of ANXA1 29 1. 6 .1. 1 ANXA1 in inflammation 29 1. 6 .1. 2 ANXA1 in ... (USA) 1: 1000 Cell Signaling (USA) 1: 1000 Cell Signaling (USA) 1: 1000 Cell Signaling (USA) 1: 1000 Cell Signaling (USA) 1: 1000 Cell Signaling (USA) 1: 1000 Cell Signaling (USA) 1: 1000 Cell Signaling ... apoptosis 31 1.6 .1. 3 ANXA1 in cancer 33 1. 6 .1. 4 ANXA1 in leukocyte migration 33 1. 6 .1. 5 ANXA1 in signaling 34 1. 6 .1. 6 ANXA1 and stress response 36 1. 7 Autophagy, heat stress and ANXA1 37 1. 8 Aims...
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Báo cáo y học: "PKC and PKA Phosphorylation Affect the Subcellular Localization of Claudin-1 in Melanoma Cells"
... A589G_G590C T100G_C102A T100G_C102A T205G_C206A 18 8 -19 0 18 8 -19 0 18 8 -19 1 18 8 -19 1 RKT RKT RKTT RKTT PKA PKC PKC PKA A568G_C569A_A570C A568G_C569A_A570C A571G_C572A A571G_C572A 18 9 -19 2 KTTS [R/K]X[pS/pT] ... and Furukawa Y Involvement of claudin -1 in the beta-catenin/Tcf 10 1 signaling pathway and its frequent upregulation in human colorectal cancers Oncol Res 20 01; 12 (11 -12 ): 469-476 19 Dissanayake ... Kallioniemi O.P., Meltzer P., Morin P.J., and Weeraratna A.T Claudin -1 overexpression in melanoma is http://www.medsci.org Int J Med Sci 2009, 6 10 11 12 13 14 15 16 17 18 regulated by PKC and contributes...
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Unit 1: A day in the life of. Listening
... WHILE-LISTENING Pre order these pictures WHILE-LISTENING Listen and order these pictures WHILE-LISTENING Listen again and decide whether the statements are True (T) or False (F) Mr Lam lives in District ... routine:/ru:'ti:n/ pedal:/'pedl/ office:/'ɔfis/ food stall:/fu:d stɔ:l/ purchase:/'pə:t∫əs/ drop:/drɔp/ passengers:/'pæsindʒə/ ride:/raid/ WHILE-LISTENING Look at the pictures and describe them ... PRE-LISTENING WHO IS HE? - He gets up very early - He has got a cyclo - He usually has meals at a foot stall - He drives passengers to everywhere they want HE IS A CYCLO DRIVER PRE-LISTENING Listen...
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Unit 1-A day in the life of...
... begin S + Ved landed stared announced took began Unit 1: A day in the life of Period 4: Writing 1. Task 1: Find all the verbs that are used in past simple and the connectors in the story Key: The ... announce (v): th«ng b¸o Unit 1: A day in the life of Period 4: Writing 1. Task 1: Read the passage and find all the verbs that are used in past simple and the connectors in the story Simple past Regular ... screamed in panic Unit 1: A day in the life of Period 4: Writing Task Task 2: The climax: We thought we had only minutes to live Unit 1: A day in the life of Period 4: Writing Task Task 2: The...
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Cooking in the Field 1 - Worksheet
... shallow hole in the ground Listen again and check the answers you gave After Listening Activity Write instructions on how to cook in the field using the information from the two listening texts ... of moving during the day The normal way of moving is THE WALK You move this way when you don’t think there is much danger For the walk the rifle is held in the alert position That is, the rifle ... nothing nearby ………………………… c) The outline of something ………………………… d) The place where the earth or buildings meet the sky …………………… Post Reading Activities In pairs: Prepare a short briefing on the...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25