stage 4 small cell lung cancer with metastases to the liver and brain
Báo cáo khoa học: " Absence of toxicity with hypofractionated 3-dimensional radiation therapy for inoperable, early stage non-small cell lung cancer" pot
Ngày tải lên :
09/08/2014, 10:21
... considered to have N1 disease
close to the primary lung tumor. In 19 cases (59%) the
tumor was in the right lung. In 22 cases (69%) the tumor
was located in the upper lobes.
Radiotherapy was delivered ... normal lung and to facilitate monitoring the respi-
ratory motion.
The median area of the fields was 72 cm
2
(typically 8 cm
ì 9 cm) and the median PTV volume was 150 cm
3
(range:
28–1110). The ... as lung cancer. It is more convenient for the patients and reduces health care costs.
This study reports our results on patients with medically inoperable, early stage, non -small cell lung
cancer...
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Báo cáo hóa học: " Detection of EGFR mutations with mutation-specific antibodies in stage IV non-small-cell lung cancer" pdf
Ngày tải lên :
18/06/2014, 16:20
... [10,11].
Methods
Sources of cell lines and culture
The PC-9 lung tumor cell line was kindly provided by
Roche (Basel, Switzerland); the A 549 and H460 cell lines
were purchased from the American Type Culture ... the H1975 cell line and five of
the H1650 cell line with 4- μ m sections for IHC analysis
from the Cell Signaling Technology laboratory.
Study population and tumor pathology
Twenty-six stage IV ... compared with IHC results in five non -small- cell
lung cancer (NSCLC) cell lines and tumor samples from 78 stage IV NSCLC patients.
Results: IHC correctly identified del 19 in the H1650 and PC9 cell...
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Báo cáo khoa học: "The effect of bioequivalent radiation dose on survival of patients with limited-stage small-cell lung cancer" pdf
Ngày tải lên :
09/08/2014, 09:20
... radiotherapy (TRT) com-
bined with chemotherapy represents the standard of
car e in the management of limited -stage small- cell lung
cancer (LS-SCLC), the optimal radiation schedule and
total ... radiotherapy is feasible concurrent with
chemotherapy for limited -stage small- cell lung cancer: analysis of
Cancer and Leukemia Group B study 39808. Int J Radiat Oncol Biol Phys
20 04, 59 :46 0 -46 8.
7. ... interruptions to palliate the
toxicity from concurrent chemoradiation for limited small cell lung
cancer decreases survival and disease control. Lung Cancer 2001,
33: 249 -258.
26. Cisplatin, etoposide, and...
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- 0
Báo cáo khoa học: " Comparison of outcomes in patients with stage III versus limited stage IV non-small cell lung cancer" docx
Ngày tải lên :
09/08/2014, 09:20
... Rad iotherapy, Oligometastases, Non -Small Cell Lung Cancer
Background
Non -small cell lung cancer (NSCLC) is the leading
cause of cancer mortality in the United States [1].
Patients with stage ... Standard therapy for metastatic non small cell lung cancer (NSCLC) includes palliative systemic
chemotherapy and/ or radiotherapy. Recent studies of patients with limited metastases treated with ... categorized
as stage III NSCLC, 38 patients (26.0%) with initial lim-
ited stage IV NSCLC and 14 patients (9.6%) with stage
I/II NSCLC who progressed to limited metastatic stage
IV. Fifty-five of the 94 patients...
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- 0
Báo cáo khoa học: " Stereotactic, single-dose irradiation of stage I non-small cell lung cancer and lung metastases" docx
Ngày tải lên :
09/08/2014, 10:21
... primary tumors of the liver and of the lungs and
metastases in the liver and lungs [1,2]. At the same time,
laser-induced thermotherapy (LITT) or high frequency-
induced thermotherapy (HITT) became ... (range: 1.6
to 16 .4 %) and 5.3% (range: 1.2 to 14. 3%), respectively.
Yet, these volumes and the planning target volumes were
still small in comparison to the total volume of the lungs
and, up to this ... with peripheral stage I
non -small cell lung cancer. Lung Cancer 1999, 26:137- 142 .
23. Slotman BJ, Antonisse IE, Njo KH: Limited field irradiation in
early stage (T1-2N0) non -small cell lung cancer. ...
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báo cáo hóa học:" Randomized phase II study with two gemcitabine- and docetaxel-based combinations as first-line chemotherapy for metastatic non-small cell lung cancer" docx
Ngày tải lên :
18/06/2014, 15:20
... 16 (46 ) 16 (47 )
Time to progression (TTP) (A) and overall survival (OS) (B)Figure 1
Time to progression (TTP) (A) and overall survival (OS) (B).
0 4 8 121620 242 8323 640 444 852
Weeks
0
0.2
0 .4
0.6
0.8
1
TTP
Patients ... G,
Gozzelino F, Tonato M: Gemcitabine and cisplatin versus mito-
mycin, ifosfamide, and cisplatin in advanced non -small- cell
lung cancer: a randomized phase III study of the Italian Lung
Cancer Project. ... ( 14. 6)
Site of disease
Lung ± lymph nodes 14 (35) 14 ( 34. 1)
Lung and 1 metastatic site 12 (30) 15 (36.6)
Lung and ≥ 2 metastatic sites 9 (22.5) 10 ( 24. 4)
Extra-pulmonary disease 5 (12.5) 2 (4. 9)
Previous...
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Báo cáo khoa học: "Pathological complete response induced by first-line chemotherapy with single agent docetaxel in a patient with advanced non small cell lung cancer" pptx
Ngày tải lên :
09/08/2014, 03:21
... tumor
shrinkage, with no additional toxicity, and gave the
patient the possibility to undergo a lobectomy rather
than a pneumectomy, with the obvious advantages of a
less invasive and more limited surgical ... appeared to measure 65 ì 41 mm.
The safety profile was good, with patient reporting
grade 1 ane mia, grade 3 neutropenia without fever,
weight loss inferior to 10% and asthenia. Therefore,
the treatment ... chemotherapy with single agent
docetaxel in a patient with advanced non small
cell lung cancer
Ferdinando Riccardi
1*
, Giuseppe Di Lorenzo
1
, Carlo Buonerba
1
, Guglielmo Monaco
2
, Roberto Monaco
3
,
Mimma...
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- 303
- 0
Báo cáo khoa học: "Analysis of clinical and dosimetric factors associated with severe acute radiation pneumonitis in patients with locally advanced non-small cell lung cancer treated with concurrent chemotherapy and intensity-modulated radiotherapy" pot
Ngày tải lên :
09/08/2014, 08:23
... factors associated with SARP.
The incidences of SARP in the group with NTCP > 4. 2% and NTCP 4. 2% were 43 .5% and 1 .4% , respectively (p < 0.01).
The incidences of SARP in the group with ... for 94 patients; the incidences of
SARP in the group with NTCP > 4. 2% and NTCP ≤ 4. 2%
were 43 .5% and 1 .4% , respectively (p < 0.01); the inci-
dences of SARP in the group with V10 ≤50% and ... statisti-
cally; the incidences of SARP in the group with NTCP >
4. 2% and NTCP ≤ 4. 2% were 43 .5% and 1 .4% , respectively
(p < 0.01). The incidences of SARP in the group with V10
≤ 50% and V10 >50%...
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Báo cáo khoa học: "Clinical outcomes of stereotactic body radiotherapy for stage I non-small cell lung cancer using different doses depending on tumor size" ppsx
Ngày tải lên :
09/08/2014, 09:20
... all
patients, and it was 81% for the stage IA patients treated
with 48 Gy and 74% for the stage IB patients, with no
significant diffe rence between them ( p =0.35).Two
stage IA patients treated with 44 ... 70
all patients
stage IA patients treated with 48 Gy in 4 fractions
stage IB patients treated with 52 Gy in 4 fractions
all patients
stage IA patients treated with 48 Gy in 4 fractions
stage IB patients ... 1 24 NSCLC patients treated with SBRT, 87 had
stage IA and 37 had stage IB disease. Tw o stage IA
patients with tumors of less than 1.5 cm in diameter
were treated with 44 Gy in 4 fractions, and...
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Báo cáo khoa học: "Clinical Analysis of stereotactic body radiation therapy using extracranial gamma knife for patients with mainly bulky inoperable early stage non-small cell lung carcinoma" pot
Ngày tải lên :
09/08/2014, 09:20
... .002 .961 4. 638 .031 .895 . 344
3~5 cm .002 .961 10.977 .001 4. 541 .033
5~7 cm 4. 638 .031 10.977 .001 .108 . 742
>7 cm .895 . 344 4. 541 .033 .108 . 742
Wu et al. Radiation Oncology 2011, 6: 84
http://www.ro-journal.com/content/6/1/ 84
Page ... mortality of the patients with
stage II was 4. 0 64 times higher than that of the patients
with stageI (p = 0.015). Systemic chemotherapy increased
the risk of death of the patients with early stage NSCLC
in ... (range, 142 .8~ 240 .0 Gy) in 24 patients with
tumor size of 3~5 cm, 165.5 Gy (range, 142 .8~212.2 G y)
in 10 patients with tumor size of 5~7 cm and 144 .0 Gy
(range, 142 .8~1 84. 8 Gy) in 9 patients with...
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- 364
- 0
Báo cáo khoa học: "Recommendations for implementing stereotactic radiotherapy in peripheral stage IA non-small cell lung cancer: report from the Quality Assurance Working Party of the randomised phase III ROSEL study" pps
Ngày tải lên :
09/08/2014, 09:22
... 18 to 22 25 > 25 to 28
Oesophagus 1 24 > 24 to 27 27 > 27 to 28.5
Ipsilateral Brachial Plexus 1 24 > 24 to 26 27 > 27 to 29
Heart 1 24 > 24 to 26 27 > 27 to 29
Trachea and ... mini-
mum of 40 hours, in line with the RTOG protocol 0618.
Ratio of 50% Prescription Isodose Volume to the PTV (R
50%
) from a total of 22 patients with stage IA tumours and 4 patients with stage 1B ... stereotactic
radiotherapy. Therefore, an additional planning study was
performed in 22 stage IA and 4 stage 1B non -small cell
lung cancer patients in order to develop and evaluate the
planning guidelines...
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- 0
Báo cáo khoa học: " Exclusion of elective nodal irradiation is associated with minimal elective nodal failure in non-small cell lung cancer" potx
Ngày tải lên :
09/08/2014, 09:22
... retrospectively reviewed the records of 115 patients with non -small cell lung
cancer treated at our institution with definitive radiation therapy with or without concurrent
chemotherapy (CHT). All ... regional recurrence, and
distant metastases (DM).
Results: The median follow-up time was 18 months (3 to 44 months) among all patients and 27
months (6 to 44 months) among survivors. The median overall ... coded the patient data-
base, conducted the analysis and wrote the manuscript
draft. JYC designed the project, analyzed the data and
revised the manuscript. AK helped with the database and
data...
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- 0
Báo cáo khoa học: " Accelerated high-dose radiotherapy alone or combined with either concomitant or sequential chemotherapy; treatments of choice in patients with Non-Small Cell Lung Cancer" pps
Ngày tải lên :
09/08/2014, 10:21
... chemotherapy for stage III non -small- cell lung cancer. J
Clin Oncol 1995, 13 :45 2 -45 8.
34. Jeremic B, Shibamoto Y, Acimovic L, Milisavljevic S: Hyperfraction-
ated radiation therapy with or without ... Surg
20 04, 128 :41 4 -41 9.
39. The International Adjuvant Lung Cancer Collaborative Trial Group:
Cisplatin-based adjuvant chemotherapy in patients with
completely resected non -small cell lung cancer. ... modality trials of the Cancer and Leukemia Group B
in stage III non -small- cell lung cancer: analysis of factors
influencing survival and toxicity. Ann Oncol 20 04, 15:1033-1 041 .
22. Zatloukal P,...
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Báo cáo y học: "Clinical significance in the number of involved lymph nodes in patients that underwent surgery for pathological stage III-N2 non-small cell lung cancer" pot
Ngày tải lên :
10/08/2014, 09:22
... patients
with non -small cell lung cancer. J Thorac Oncol 2010, 5:825-9.
4. Ou SH, Zell JA: Validation study of the proposed IASLC staging revisions of
the T4 and M non -small cell lung cancer descriptors ... radiotherapy is the current
standard of care for pati ents with locally advan ced (stage
IIIA and stage IIIB) NSCLC. However, regardless of the
total dose of radiation and the optimal chemotherapy,
the ... Lung
Cancer Registry. Prognosis of 6 644 resected non -small cell lung cancers
in Japan: a Japanese lung cancer registry study. Lung Cancer 2005,
50:227- 34.
11. Andre F, Grunenwald D, Pignon JP, Dujon...
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báo cáo khoa học: "EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation with clinical features" pptx
Ngày tải lên :
10/08/2014, 10:21
... growth
factor receptor expression or activation in operable non -small cell lung
cancer. Lung Cancer 2005, 48 (1) :47 -57.
40 . Liu M, Yang SC, Sharma S, Luo J, Cui X, Peebles KA, Huang M, Sato M,
Ramirez ... 2-mediated
pathways and its implications for the chemoprevention of head and
neck cancer. Mol Cancer Ther 2005, 4( 9): 144 8-55, (Georgia).
7. Sahin M, Sahin E, Gümüslü S: Cyclooxygenase-2 in cancer and
angiogenesis. ... an
epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI),
and celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, in patients with
platinum refractory non -small cell lung cancer (NSCLC)....
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