... medical statisticians and they should be consulted as early as possible in the research process Competing interests None declared References Altman DG: Practical Statistics for Medical Research London: ... it is vital that researchers recognise their own limitations and seek professional advice whenever it is needed, if only for reassurance Medical statistics is a scientific discipline in its own ... Medical Statistics, edn Oxford: Oxford University Press; 2001 Campbell MJ, Machin D: Medical Statistics: A Commonsense Approach, edn London: John Wiley & Sons Ltd; 1993 Kirkwood BR Essentials of Medical...
... present study could represent a valuable starting-point for focused investigations aiming to better understand the key issues of PD pathogenesis Materials and methods Cells Human neuroblastoma SH-SY5Y ... network, as well as statistically significant functional association with GO classifications [16] Western blotting Expression of a-synuclein and HSP70 was determined by western blotting Proteins (80 ... silver-stained gel images revealed 28 spots whose intensity was significantly different in at least one of the four groups considered (Fig 2) Two groups of spots showing remarkable changes in the isoform...
... for HMS/HSDM instructors, assistant professors, or associate professors who currently have responsibility for a research grant, laboratory, educational course, or clinical unit This course is intended ... patients and families •Referring clinicians •Other medical specialists, subspecialists and allied health professionals •Prospective faculty, staff, residents, fellows and interns •Researchers ... Children sHospital is established to assist fellows—both clinical and research—to access resources and network both at Children sHospital and in the Greater Boston area The OFT organizes events, such...
... the Punishments of Sins Last Longer Than the Sins Themselves Lasted p 659 Of the Greatness of the First Transgression, on Account of Which Eternal Punishment is Due ... Editor s Preface ST AUGUSTIN S CITY OF GOD: Translated by the Rev Marcus Dods, D.D., of Glasgow Translator s Preface Table of Contents The City of God ST AUGUSTIN S CHRISTIAN DOCTRINE: Translated ... “City of God” is the masterpiece of the greatest genius among the Latin Fathers, and the best known and most read of his works, except the “Confessions.” It embodies the results of thirteen years...
... middle of Montana, I saw my son thrust his fingers under his sister s nose “Hey, Willa,” he said, sounding quite sinister, “smell this part of my body.” “Devin, God damn it!” I said “It s disgusting ... first season, Gagliardi won six of his seven conference games—including a 21-7 thumping of the Lutherans at Gustavus Adolphus—and the cochampionship of the MIAC, the first time St John s had tasted ... awareness, before asking her to list some of them, just a moment ago (She wasn’t amused.) Her response to my exhaustion: at least you’re writing She envies me and resents her own lot I pity myself...
... then searches the lists of possible antecedents in prior utterances in a similar fashion The primary structure employed in the language-only model is a ranked entity list sorted by linguistic salience ... Effects of head-mounted and scene-oriented video systems on re- mote collaboration on physical tasks In Proceedings of Human Factors in Computing Systems (CHI '03), pp 513520 ACM Press Fussell, S ... patterns in the presence of various forms of shared visual information Finally, we make use of a corpus gathered from laboratory studies that allow us to decompose the various features of shared visual...
... act distinctions correspond to three components that a plan-based modelof reference must possess, z Any such model must contain the following: CRITERIA How is the referential to be distinguished ... individuating set is the result of the speaker 's beliefs, not a mirror of what is actually the case A speaker may possess two distinct individuating sets that, unbeknownst to him, determine the same object ... Barwise and John Perry Situations and Attitudes The Massachsetts Institute of Technology Press, Cambridge, Massachusetts, 1983 [4] Philip R Cohen Referring as requesting In Proceedings of the...
... functioning, sleep, pain, social functioning, daily activities, sexuality, vitality, positive emotions, depressive emotions and aggressiveness Each item consists of two parts: the first part assesses the ... (4.2) Diagnosis: Asthma Survivors of brain tumor Diabetes Down syndrome Duchenne muscular dystrophy End stage renal disease Metabolic diseases Profound complex handicap Sickle cell disease Spina Bifida ... conceptual models of caregiver process and caregiver burden [10,11,14] including socioeconomic status, child characteristics, caregiver strain, psychosocial and coping factors In line with these models,...
... actions of NSAIDs whereas inhibition of the constitutively expressed form (COX-1) is responsible for the gastrointestinal side effects [25] In this study we used the intrastriatal administration of ... Figure Astroglial response in the striatum Astroglial response in the striatum Photomicrographs of representative sections of the ipsilateral (A, B) and contralateral (C, D) striatum of an animal ... clearing and coverslipping Design based stereology was performed on the stained sections using an integrated Axioskop microscope (Carl Zeiss, Thornwood, NY) and Stereo Investigator image capture...
... performed on sections processed at the same time Single ANOVA statistical analysis was used to assess the significance of the differences in plaque area, glial and C3 activation products reactivity ... assisted with perfusions and animal care; OY performed immunohistochemistry and image analysis; DC assisted with the design of the study and manuscript preparation; CG contributed to the design of ... immunogens and performed immunoassays, S. W performed image analysis, data analysis and manuscript preparation; IH performed immunohistochemistry, image analysis, data analysis and presentation and assisted...
... ANOVA showed significant differences, pairwise comparisons between means were tested by Bonferroni post hoc testing Statistical significance was set at p < 0.05 for all analyses Results Valdecoxib ... curve in the plot of time on the rod versus rotation speed [23] Statistical analysis All data were analyzed using an IBM-based personal computer statistical package (SYSTAT 10, SPSS Inc, Chicago, ... counts were performed by using a computer-assisted image analysis system consisting of a Zeiss Axioskop2Plus photomicroscope equipped with a MS-2000 (Applied Scientific Instrumentation, Eugene,...
... determinations in each experiment One-way ANOVA, followed by a post hoc Tukey s multiple comparison tests was used to examine the statistical significance of in vitro assays Repeated measure test and post ... NAPE-PLD expression is elevated on blood vessels and in reactive astrocytes distributed closely around them suggests the synthesis of AEA by brain endothelium in MS [43] In other models of brain injury ... course of MS have been suggested to represent a protective physiological strategy [13,18,49,50] the role of endocannabinoids in MS remains uncertain While most of studies on ECS and MS focused...
... Diseases & key Laboratory of Stem Cell Biology, Institute of Health Science, Shanghai Institutes of Biological Sciences (SIBS), Chinese Academy of Science (CAS) & Shanghai Jiao Tong University ... the two control groups Taken together, these data suggest that BAb administration shifts stage or stage microglia to stage in SN These results also show a distinct population of activated microglia ... M-O Representative microglia in different stages (stage1-4) of CD11b immunostaining are shown in yellow circles (stage1: P1; stage2: P2; stage3: P3; stage4: P4), and a representative of stage MHC...
... the West, whose stock brings fancy prices, opposes artificial heat and says they are better without it Other breeders use oil stoves in the severe weather and some of the largest Caviaries have ... purposes generally the demand is enormous, thousands and thousands of them being used every year Many of the large hospitals and laboratories have been compelled to establish breeding pens of their ... more in Pet Stock Shows A good show animal is worth all the way from $10 to $100 As a hobby the raising of Guinea Pigs is most interesting and instructive as there are so many experiments that can...
... needs to avoid undue exposure to the sun, use sunscreens and wear protective clothing (avoid sleeveless attires and use long sleeved attires as much as possible) during periods of sun exposure ... occupation, duration of symptoms, distribution of lesions, treatment offered and rate of completion of treatment were extracted Data were analyzed using descriptive statistics Results A total of twenty ... problems Background Imo State University Teaching Hospital is located in Orlu, a sub-urban town in Eastern Nigeria It is one of the few tertiary health institutions offering Plastic surgery services...
... iteration of the EM algorithm consists of two steps, the expectation or E step and the maximization or M step In the Gaussian mixed model, this separates the computation into two simple pieces The E-step ... class of models First, the “sire-maternal grandsire” model (or SMGS model) as described by Bertrand and Benyshek [3], y = Xβ + Zs us + Zt ut + e, (4) where us and ut refer to (q × 1) vectors of ... parturition Thus, statistically we must consider the sire and the maternal grandsire contributions of a male, not as simple multiples of each other (i.e., the first twice that of the second), but as two...
... each group is expressed as mean ± s. e.m for each condition All statistical tests were performed with SPSS statistical software (version 15) Statistical significance was evaluated using oneway ... CatWalk system, has been used to detect footfall patterns, as well as selected time and distance measurements of persons with early-stage Parkinson 's disease [41] The GaitRite system comprises an ... exogenous cells may provide better long-term results Stem cells are viewed as a possible source of neurons for cell-based therapies of neurodegenerative disorders, such as Parkinson 's disease and Alzheimer's...
... analysis of variance (ANOVA) and Bonferroni post hoc tests All statistical tests required a level of significance of at least P < 0.05 Results Body weights Table shows the mean body weight of all ... http://www.jbiomedsci.com/content/17/1/62 data suggest that the mechanism for increasing GLT1 expression is still functional even in late stage HD Acknowledgements This research was supported by NINDS (R01 NS35663; F31 NS064791) ... administrative assistance Author details Program in Neuroscience, Indiana University, 1101 East 10th Street, Bloomington, IN, USA 2Department of Psychological and Brain Sciences, Indiana University,...
... measurements across multiple wards are not required to accurately assess these dimensions of context in a hospital Although Estabrooks’ study [14] found no difference in these dimensions of context ... dimensions such as leadership, culture, feedback Page 10 of 11 processes and organisational slack Interventions seeking to strengthen context in hospitals should consider the benefits of focussing ... not individual nursing staff within the ward While CCA is infrequently used in nursing research, its availability in modern statistical software packages such as SPSS and Stata has placed it well...