spectral structure activity relationship spectral sar assessment of ionic liquids in silico e
APPLICATIONS OF IONIC LIQUIDS IN SCIENCE AND TECHNOLOGY ppt
Ngày tải lên :
29/06/2014, 09:20
... antiproliferative effect (Kadota & Tezuka, 2004) Immature green coffee beans are not marketed as coffee because contamination of these beans negatively affects the flavor However, they contain appreciable ... remove or reduce the lignin content in order to take advantage of the stored energy in lignocellulosic cellulose The problems of dissolving cellulose or reducing the lignin content have to be ... fuels remains a major concern Hence, there is an urgent need for us to seek alternative renewable and greener energy sources; the answer lies in biomass which possesses huge amounts of stored chemical...
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Tài liệu Báo cáo khoa học: Second messenger function and the structure–activity relationship of cyclic adenosine diphosphoribose (cADPR) doc
Ngày tải lên :
20/02/2014, 01:20
... of many cADPR analogues have been published [16,53–55] and the reader interested in more complete coverage of the subject may refer to these review articles However, I will focus on an interesting ... synthesis described above, several reports suggest expression of either cytosolic or membrane-bound enzymes not related to CD38 or CD157 [18,27–31] None of these enzymes have been identified on the ... homogenates [59] Indeed, Ca2+ release activity of inosine derivatives was first described for a series of 4593 Second messenger function of cADPR A H Guse Fig Ca2+-releasing activity of some southern and...
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Báo cáo y học: "Spectral counting assessment of protein dynamic range in cerebrospinal fluid following depletion with plasma-designed immunoaffinity columns" doc
Ngày tải lên :
13/08/2014, 13:20
... 432 peptides and 107 proteins were commonly identified in both depleted samples The differences between proteins identified in the IgYHSA-depleted replicates and undetected in the IgY14-depleted ... metrics The number of MS1 and MS2 spectra acquired during the retention time period over which the middle 50% of the identified peptides elute, are direct measures of the effective speed of sampling ... insight into the protein profiling distinctiveness of the three protein depletion strategies, we used the modified spectral counting technique APEX (v1.2)[16] This approach makes use of a machine-learning...
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Design, optimization and structure activity relationship study of CD2 derived peptides for immunomodulation
Ngày tải lên :
04/10/2015, 15:46
... binding epitopes may be sufficient to block a large protein-protein interface For example, the interface peptides with the same sequence as key regions at the interface can modulate the protein-protein ... they serve as the functional epitope However, the binding specificity was severely compromised by alanine mutagenesis of these charged residues [50] It is therefore believed that the favorable ... of binding is not evenly distributed across interfaces Instead, there are hot spots of binding energy made up of a small subset of residues enriched in tryptophan, tyrosine and arginine These hot...
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Mechanistic studies of anti malarial spiroindolones and synthesis and structure activity relationship studies of an inhibitor of dengue proliferation
Ngày tải lên :
26/11/2015, 10:48
... The isolation of these imine intermediates allowed the investigation of the influence of the imine geometry on the diastereoselectivity of the reaction In conclusion, the synthesis of indoline-spiro-tetrahydro-β-carboline ... determining the influence of the configuration of the imine intermediate on the diastereoselectivity of the Pictet-Spengler reaction The synthesis of NITD20 commenced from the reaction between ... atovaquone (Figure 1) were subsequently introduced between the 1950s and 1990s to dampen the effects of chloroquine resistance The emergence of resistance to these newer drugs proved to be even faster...
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Multi target selection and high throughput quantitative structure activity relationship model development
Ngày tải lên :
09/09/2015, 10:09
... monotherapy of cancers, the effectiveness of these agents seem to be moderate or be reduced with the development of drug resistance This may be partially attributed to the existence of feedback ... noradrenaline transporter, H3 receptor, 5-HT1a receptor, 5-HT1b receptor, 5-HT2c receptor, Melanocortin receptor and Neurokinin receptor respectively The percentage value behind each target-pair indicates ... frameworks of two selective molecules.106 However, this method may in some cases generate large, complex and less drug-like molecules.106 Druglikeness can be retained if the degree of framework...
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Multi faceted structure activity relationship analysis using graphical representations
Ngày tải lên :
19/11/2015, 15:56
... data into 2D or 3D reference spaces.21 These reference spaces can either be coordinate-based or coordinatefree, depending on the dimension reduction method that is used One of the most common techniques ... Molecular Representation Test compounds are initially projected into a low-dimensional chemical reference space For this purpose, we define a coordinate-free reference space based on Euclidean ... 2Nij where Ni and Nj denote the number of fingerprint features present in molecules i and j, respectively, and Nij denotes the number of features shared by both molecules The Euclidean distance is...
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Computational methods for structure activity relationship analysis and activity prediction
Ngày tải lên :
26/11/2015, 09:53
... string representations of chemical structures and properties, which are often encoded in binary formats The presence and absence of a given feature in the molecule is indicated by setting the ... evolved from applications using relatively simple linear regression methods to more complex non-linear machine learning techniques.28 However, even in the presence of similar compounds these methods ... the SPP principle These observations suggest that there are fundamental differences in the nature of SARs To deconvolute the complex SAR patterns in the data, descriptive approaches have been...
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Structure activity relationship studies on the factor XIIIa inhibitor tridegin
Ngày tải lên :
26/11/2015, 10:18
... Massenspektrometrie aufgeklọrt und es wurde gezeigt, dass drei verschiedene disulfidverbrỹckte Isomere gebildet wurden Anschlieòend wurde eine computergestỹtzte Modellierung aller drei Isomere sowie ein ... cleaves fibrin after selected lysine and arginine residues These free C-terminal lysine residues enhance the formation of plasmin from plasminogen, thereby increasing fibrinolysis 36,68 TAFIa eliminates ... relatively low Besides lysine side chains in peptides or proteins, small amines or even water are accepted Therefore, the enzyme-substrate complex can be resolved by the formation of an isopeptide bond,...
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Assessment of Mercury Contamination in the Kahayan River, Central Kalimantan, Indonesia
Ngày tải lên :
05/09/2013, 09:38
... sampling point in 2004 (Fig 2) We collected one sample of river water and sediments from each sampling points, and seven fish species Five of them are presented in Fig Water and sediments samples ... contaminants in fish are of considerable interest because of the potential effects on the fish themselves or the organisms that consume them, including people Levels of contaminants, particularly methyl ... the measurements RESULTS AND DISCUSSIONS Mercury concentrations in water and sediment samples from the Kahayan River Our interview with miners in 2007 revealed that they used g of elemental mercury...
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Technical Assessment of the Man-in-Simulant Test Program potx
Ngày tải lên :
16/03/2014, 17:20
... the original typesetting files Page breaks are true to the original; line lengths, word breaks, heading styles, and other typesetting-specific formatting, however, cannot be retained, and some ... separately from routine ensemble testing Once the criteria for suit performance have been established, decision points should be entered in a flow chart to reveal where additional work is needed ... the development of future testing methodologies All relevant parties should participate in the planning phase with the objective of reaching a consensus on research objectives, design procedures,...
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Detection of actual and assessment of potential plantations in Lao PDR using GIS and remote sensing technologies doc
Ngày tải lên :
17/03/2014, 11:20
... there are differences between Laos and the Chinese example, especially concerning the influence of the market The challenge Laos is facing at the moment is the balancing of the different potentials ... market price of rubber However, increasing the area of rubber plantations means increasing the dependence on the demand of China and on the rubber price, while income diversification and a greater ... income of the rural population However, there are differences regarding the rubber production between the two countries The Chinese rubber industry was established in order to achieve selfsufficiency...
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A BASELINE SURVEY & NEEDS ASSESSMENT OF BEER PROMOTERS IN PHNOM PENH pot
Ngày tải lên :
22/03/2014, 10:20
... manage power differences.15 Beer promoters presented a complex yet pragmatic view of the relative degree of control they feel they have in the relationships that develop between themselves and venue ... read a pre prepared sentence to the interviewer to determine their ability to read The results are reflected in Table 1.1.8 Although the percentage of beer promoters that have never attended school ... has been challenged The term indirect sex worker has been widely and often indiscriminately used to describe women working as beer promoters In the course of the research the term indirect sex...
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THE PERFORMANCE OF CREDIT RATING SYSTEMS IN THE ASSESSMENT OF COLLATERAL USED IN EUROSYSTEM MONETARY POLICY OPERATIONS pot
Ngày tải lên :
22/03/2014, 20:20
... therefore combine the variance of the ex-ante estimated probability of default of the rating source and that of the benchmark in one measure in order to conduct the backtesting The difference of ... the trigger level, then the rating source is in the red zone, indicating that the realised default frequency is unequivocally not in line with the PD forecast We see the backtesting techniques ... few exceptions, these averages lie within the confidence intervals (see Table 2) For the exceptions it can be argued (1) that not all values have to be within the limits of the confidence intervals...
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Báo cáo khoa học: "Automatic Assessment of Coverage Quality in Intelligence Reports" doc
Ngày tải lên :
23/03/2014, 16:20
... to demonstrate the feasibility of assessing the e ectiveness of information retrieval systems During the workshop, seven intelligence analysts were each asked to use one of several IR systems ... coverage score (where highest is considered best) 3.2 judges3 Since we are interested in ranking reports by coverage, we convert the scores from the original numerical scale to a ranked list We evaluate ... coverage E ective ways of representing content and ensuring coverage are the subject of ongoing research in the field (e. g., Gillick et al 2009, Haghighi and Vanderwende 2009) In our work, we draw...
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Combat Support Execution Planning and Control - An Assessment of Initial Implementations in Air Force Exercises doc
Ngày tải lên :
29/03/2014, 14:20
... assessment team members for each exercise.) The exercises themselves were not the focus of the assessment The assessment teams used the operational environments created by TF04 and AC04 to observe CSC2 ... Because the exercise schedule was accelerated, assessment team members did not have a separate orientation session with USAFE However, during the first two exercise phases, assessment team members ... to one, as would be the case when the information was transmitted in a formatted message, the feedback and fact-checking remained one to one During the exercises, we noted several instances in...
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báo cáo hóa học: " Occurrence of post traumatic stress symptoms and their relationship to professional quality of life (ProQoL) in nursing staff at a forensic psychiatric security unit: a cross-sectional study" potx
Ngày tải lên :
18/06/2014, 18:20
... violence exposed professions, acknowledge reduced retirement age such as is the case with police officers and firemen Competing interests The authors declare that they have no competing interests ... care or referred from general psychiatric care units because of severe mental disorder or severe learning disabilities together with severe behaviour problems, mainly of a violent character The ... B, C and D (re-experience, avoidance, increased arousal) Seventeen (24.3%) reported at least one symptom occurring within either cluster B (reexperience), C (avoidance) or D (increased arousal)...
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Báo cáo hóa học: " The Reflux Disease Questionnaire: a measure for assessment of treatment response in clinical trials" pdf
Ngày tải lên :
18/06/2014, 22:20
... change in scores was observed for those in the placebo group who indicated they were at least a good deal better on the OTE item Esomeprazole in either dose was markedly more effective than placebo ... preservation of content and clarity of the items Analytical Strategy There were three specific analytical objectives: 1) assessment of the responsiveness to treatment of selected RDQ scales; 2) assessment ... whole, were clearly lower than those in the active treatment group When split according to the OTE responses, which measure the patient's perception of improvement, the effect sizes were more or...
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Báo cáo hóa học: " Objective assessment of motor fatigue in multiple sclerosis using kinematic gait analysis: a pilot study" docx
Ngày tải lên :
19/06/2014, 08:20
... the end of the physical exertion test, respectively * indicates significant differences between mean values at the beginning and end of the test; † indicates significant differences between the ... moments about the joints of the lower extremities during walking Interestingly, functional imaging studies have reported increasing evidence that patients with MS experience greater cerebral activity ... differences between mean values at the beginning and end of the test; † indicates significant differences between the standard deviations at the beginning and end of the test (P < 0.005) Overall, seven...
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